Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma.
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Abstract
References (51)
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
1991 • 2,437 citations
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Macrophages and angiogenesis
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Heparin protects basic and acidic FGF from inactivation
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Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.
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Establishment of an immature mast cell line from a patient with mast cell leukemia
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Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds
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Local Proliferation of Fibroblast‐Like Synoviocytes Contributes to Synovial Hyperplasia
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Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair.
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Immunohistochemical identification of mast cells in formaldehyde‐fixed tissue using monoclonal antibodies specific for tryptase
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1986 • 138 citations
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1983 • 135 citations
Mast cell-dependent amplification of an immunologically nonspecific inflammatory response. Mast cells are required for the full expression of cutaneous acute inflammation induced by phorbol 12-myristate 13-acetate.
1988 • 127 citations
Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury.
1993 • 115 citations
Characterization and functional studies of rheumatoid synovial mast cells: Activation by secretagogues, anti‐IgE, and a histamine‐releasing lymphokine
1986 • 100 citations
Alveolar macrophage stimulation of lung fibroblast growth in asbestos-induced pulmonary fibrosis.
1986 • 79 citations
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1993 • 69 citations
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1992 • 68 citations
Quantitative angiogenesis in spreads of intact rat mesenteric windows
1990 • 63 citations
Angiogenesis Induced by Mast Cell Secretion in Rat Peritoneal Connective Tissue Is a Process of Three Phases
1994 • 58 citations
Mast-cell secretion and angiogenesis, a quantitative study in rats and mice
1989 • 58 citations
Comparison of alveolar and interstitial macrophages in fibroblast stimulation after silica and long or short asbestos.
1991 • 57 citations
Basic fibroblast growth factor in Dupuytren's contracture.
1992 • 54 citations
The role of mast cells in inflammatory responses in the lung.
1993 • 52 citations
Immunoreactivity of normal and neoplastic human tissue mast cells with macrophage-associated antibodies, with special reference to the recently developed monoclonal antibody PG-M1
1993 • 52 citations
Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats.
1988 • 49 citations
Roles of mast cell tryptase and chymase in airway function
1989 • 46 citations
Mast Cells Are Essential for the Full Development of Silica-induced Pulmonary Inflammation: A Study with Mast Cell-deficient Mice
1993 • 44 citations
Histochemical and Immunohistochemical Characteristics of Mast Cells in Nasal Polyps
1992 • 43 citations
The role of mast cells in antigen induced arthritis in mice.
1988 • 42 citations
The Structure and Airway Biology of Mast Cell Proteinases
1991 • 40 citations
Functional heterogeneity of mast cells isolated from different microenvironments within nasal polyp tissue
1994 • 39 citations
Mast Cells Modulate Acute Ozone-induced Inflammation of the Murine Lung
1993 • 33 citations
Human dermal fibroblasts express multiple bFGF and aFGF proteins
1991 • 32 citations
The role of mast cells in antigen induced arthritis in mice.
1988 • 29 citations
Immunolocalization of heparinbinding growth factors (HBGF) types 1 and 2 in rat liver. Selective hyperexpression of HBGF‐2 in carbon tetrachloride‐induced fibrosis
1993 • 29 citations
Cytokine regulation of lung fibroblast proliferation. Pulmonary and systemic changes in asbestos-induced pulmonary fibrosis.
1986 • 25 citations
Immunolocalization of basic fibroblast growth factor and platelet-derived growth factor-A during adjuvant arthritis in the Lewis rat.
1994 • 21 citations
Increased angiogenesis in diabetes
1990 • 20 citations
Mast cell biochemical and functional heterogeneity.
1991 • 17 citations
Immunoreactivity of human tissue mast cells: nonspecific binding of primary antibodies against regulatory peptides by ionic linkage.
1990 • 15 citations