From mice to man: the preclinical history of mycophenolate mofetil

Bioavailability improvement of mycophenolic acid through amino ester derivatization.

1990 • 258 citations

RS-61443—A PHASE I CLINICAL TRIAL AND PILOT RESCUE STUDY 1

1992 • 245 citations

RS-61443—A NEW, POTENT IMMUNOSUPPRESSIVE AGENT

1991 • 239 citations

Mycophenolic acid morpholinoethylester (RS-61443) is a new immunosuppressant that prevents and halts heart allograft rejection by selective inhibition of T- and B-cell purine synthesis.

1990 • 207 citations

Lymphocyte‐Selective Antiproliferative and Immunosuppressive Effects of Mycophenolic Acid in Mice

1991 • 193 citations

The design and development of an immunosuppressive drug, mycophenolate mofetil

1993 • 143 citations

RS-61443 (Mycophenolate Mofetil) A Multicenter Study for Refractory Kidney Transplant Rejection

1992 • 138 citations

THE USE OF MYCOPHENOLATE MOFETIL (RS-61443) IN HUMAN HEART TRANSPLANT RECIPIENTS

1993 • 132 citations

Immunosuppressive Activity of Mycophenolate Mofetil

1993 • 97 citations

Immunosuppressive effects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and nonhuman primate recipients of heart allografts.

1991 • 94 citations

A LONG-TERM STUDY OF ALLOGENEIC RAT HINDLIMB TRANSPLANTS IMMUNOSUPPRESSED WITH RS-61443

1993 • 73 citations

RS-61443 reverses acute allograft rejection in dogs.

1991 • 67 citations

Experience with Mycophenolate Mofetil (RS61443) in Renal Transplantation at a Single Center

1993 • 60 citations

Inhibition of chronic vascular rejection in primate cardiac xenografts using mycophenolate mofetil

1994 • 57 citations

New small molecule immunosuppressants for transplantation: review of essential concepts.

1993 • 54 citations

Lymphocyte-selective antiproliferative and immunosuppressive activity of mycophenolic acid and its morpholinoethyl ester (RS-61443) in rodents.

1991 • 50 citations

Effects of immunosuppressive therapy on the rat aortic allograft model.

1993 • 50 citations

SUPPRESSION OF SYNTHESIS OF NATURAL ANTIBODIES BY MYCOPHENOLATE MOFETIL (RS-61443)

1993 • 46 citations

Immunosuppressive drugs: Developments in anti-rejection therapy

1994 • 46 citations

RS-61443 allows islet allografting and specific tolerance induction in adult mice.

1990 • 45 citations

EFFICACY OF RS-61443 IN REVERSING ACUTE REJECTION IN A RAT MODEL OF HINDLIMB ALLOTRANSPLANTATION

1994 • 40 citations

FACILITATION OF SPECIFIC TOLERANCE INDUCTION IN ADULT MICE BY RS-61443

1992 • 39 citations

Inhibitors of de novo purine and pyrimidine synthesis as immunosuppressive drugs.

1993 • 39 citations

RS-61443 for treatment-resistant human liver rejection.

1993 • 38 citations

EVALUATION OF CYCLOSPORINE, MYCOPHENOLATE MOFETIL, AND BREQUINAR SODIUM COMBINATION THERAPY ON HAMSTER-TO-RAT CARDIAC XENOTRANSPLANTATION

1994 • 38 citations

Maintenance immunosuppression with prednisone and RS-61443 alone following liver transplantation.

1993 • 36 citations

One-year follow-up results of a phase I trial of mycophenolate mofetil (RS61443) in cadaveric renal transplantation.

1993 • 29 citations

THE INFLUENCE OF RS-61443 ON ANTIBODY-MEDIATED REJECTION

1992 • 26 citations

PROLONGATION OF CANINE INTESTINAL ALLOGRAFT SURVIVAL WITH RS-61443, CYCLOSPORINE, AND PREDNISONE

1993 • 26 citations

RS-61443/cyclosporine combination therapy prolongs canine liver allograft survival.

1993 • 21 citations

ENHANCEMENT OF ALLOGRAFT SURVIVAL BY COMBINATION RS-61443 AND DUP-785 THERAPY

1993 • 20 citations

RS-61443: a new immunosuppressive agent.

1994 • 19 citations

Immunosuppressant Combinations in Primate Cardiac Xenografts^a

1993 • 18 citations

RS-61443 studies: review and proposal.

1991 • 18 citations

THE INCIDENCE OF SUBSEQUENT ACUTE REJECTION FOLLOWING THE TREATMENT OF REFRACTORY RENAL ALLOGRAFT REJECTION WITH MYCOPHENOLATE MOFETIL (RS61443)

1994 • 15 citations

Effect of mycophenolate mofetil on islet allografting to chemically induced or spontaneously diabetic animals.

1992 • 12 citations

Controlled trial of RS-61443 in renal transplant patients receiving cyclosporine monotherapy.

1993 • 9 citations

Prolongation of allograft and xenograft survival with mycophenolate mofetil (RS-61443) and brequinar sodium (DUP-785).

1993 • 8 citations

Small bowel transplantation in rats using RS-61443: effect on GVHD and rejection.

1992 • 7 citations

Effect of mycophenolate mofetil on allograft arteriosclerosis (chronic rejection).

1994 • 7 citations

Heterotopic rat intestinal transplantation: effect of cyclosporine and RS-61443 on graft-vs-host disease and rejection.

1994 • 4 citations