Immunosuppressive Activity of Mycophenolate Mofetil

Plaque Formation in Agar by Single Antibody-Producing Cells

1963 • 2,385 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

GLYCOBIOLOGY

1988 • 1,107 citations

The Purine Path to Chemotherapy

1989 • 666 citations

The biochemistry of glycoproteins and proteoglycans

1980 • 651 citations

Lymphocyte‐Selective Cytostatic and Immunosuppressive Effects of Mycophenolic Acid in Vitro: Role of Deoxyguanosine Nucleotide Depletion

1991 • 393 citations

The inhibition of nucleic acid synthesis by mycophenolic acid

1969 • 369 citations

PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15)

1990 • 367 citations

Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.

1988 • 330 citations

Cellular Basis of Skin Allograft Rejection: An In Vivo Model of Immune-Mediated Tissue Destruction

1992 • 295 citations

Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor–IgG chimaera

1991 • 293 citations

Chromosomal Translocations in Lymphoid Malignancies Reveal Novel Proto-Oncogenes

1992 • 267 citations

Bioavailability improvement of mycophenolic acid through amino ester derivatization.

1990 • 258 citations

Two distinct cDNAs for human IMP dehydrogenase.

1990 • 256 citations

RS-61443—A PHASE I CLINICAL TRIAL AND PILOT RESCUE STUDY 1

1992 • 245 citations

Structure of Glycoproteins and Their Oligosaccharide Units

1980 • 243 citations

RS-61443—A NEW, POTENT IMMUNOSUPPRESSIVE AGENT

1991 • 239 citations

Carbohydrate ligands for endothelial-leukocyte adhesion molecule 1.

1991 • 236 citations

Mycophenolic acid for psoriasis

1987 • 235 citations

Methotrexate in rheumatoid arthritis. Toxic effects as the major factor in limiting long‐term treatment

1989 • 229 citations

Mycophenolic acid morpholinoethylester (RS-61443) is a new immunosuppressant that prevents and halts heart allograft rejection by selective inhibition of T- and B-cell purine synthesis.

1990 • 207 citations

Lymphocyte‐Selective Antiproliferative and Immunosuppressive Effects of Mycophenolic Acid in Mice

1991 • 193 citations

Proliferation-linked regulation of type II IMP dehydrogenase gene in human normal lymphocytes and HL-60 leukemic cells.

1992 • 146 citations

IMMUNOLOGICAL OBSERVATIONS ON PATENTS WITH LESCH-NYHAN SYNDROME, AND ON THE ROLE OF DE-NOVO PURINE SYNTHESIS IN LYMPHOCYTE TRANSFORMATION

1975 • 143 citations

Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.

1987 • 140 citations

In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443.

1991 • 126 citations

Expression of human IMP dehydrogenase types I and II in Escherichia coli and distribution in human normal lymphocytes and leukemic cell lines.

1991 • 126 citations

Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism.

1992 • 100 citations

Genetic and biochemical studies on the activation and cytotoxic mechanism of bredinin, a potent inhibitor of purine biosynthesis in mammalian cells

1983 • 95 citations

Immunosuppressive effects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and nonhuman primate recipients of heart allografts.

1991 • 94 citations

Action of bredinin on mammalian cells.

1975 • 88 citations

The Role of de novo Purine Synthesis in Lymphocyte Transformation

1977 • 87 citations

Purification, characterization, and kinetic analysis of inosine 5′-monophosphate dehydrogenase of Tritrichomonas foetus

1987 • 83 citations

RS-61443 reverses acute allograft rejection in dogs.

1991 • 67 citations

RS-61443 allows islet allografting and specific tolerance induction in adult mice.

1990 • 45 citations

Rapid increase of phosphoribosyl pyrophosphate concentration after mitogenic stimulation of lymphocytes

1975 • 44 citations

Antitumor and immunosuppressive effects of mycophenolic acid derivatives.

1976 • 43 citations

Maintenance immunosuppression with prednisone and RS-61443 alone following liver transplantation.

1993 • 36 citations

Purine Metabolism and Control of Cell Proliferation

1977 • 34 citations

Control of phosphoribosylpyrophosphate synthesis in human lymphocytes

1977 • 26 citations

Antipurines and Purine Metabolism

1988 • 20 citations

Organospecific activation of azathioprine in mice: role of liver metabolism in mutation induction

1988 • 20 citations

The Preparation and Purification of Pollen Extracts

1927 • 15 citations

Tolerance induction in adult mice: cyclosporine inhibits RS-61443-induced tolerance.

1991 • 10 citations