Regulation of cholesterol biosynthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by chylomicron remnants in isolated hepatocytes and perfused liver.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Methods of Enzymatic Analysis

1974 • 6,512 citations

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

Methods of enzymatic analysis

1966 • 4,073 citations

Maturation of the head of bacteriophage T4

1973 • 3,781 citations

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

1972 • 1,831 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

Gluconeogenesis in the perfused rat liver

1966 • 726 citations

Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons

1970 • 496 citations

Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.

1980 • 428 citations

Micro assay for 3-hdyroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts

1974 • 408 citations

Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.

1980 • 372 citations

Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.

1980 • 365 citations

Regulation of Cholesterol Metabolism

1970 • 358 citations

Atherosclerosis: The low-density lipoprotein receptor hypothesis

1977 • 341 citations

Feedback Control of Mevalonate Synthesis by Dietary Cholesterol

1966 • 332 citations

Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat.

1975 • 320 citations

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

1979 • 309 citations

Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat

1967 • 296 citations

Isolation and characterization of Kupffer and endothelial cells from the rat liver

1977 • 246 citations

THE METABOLISM OF CHYLOMICRON CHOLESTEROL ESTER IN THE RAT

1962 • 221 citations

Cholesterol synthesis in the squirrel monkey: relative rates of synthesis in various tissues and mechanisms of control

1968 • 220 citations

Fatty Acid and 3-β-Hydroxysterol Synthesis in the Perfused Rat Liver

1973 • 213 citations

Characterization of the sinusoidal transport process responsible for uptake of chylomicrons by the liver.

1978 • 197 citations

Studies on the inhibition of hepatic lipogenesis by N6,O2′-dibutyryl adenosine 3′,5′-monophosphate

1975 • 196 citations

The mechanism of assimilation of constituents of chylomicrons, very low density lipoproteins and remnants - a new theory

1975 • 176 citations

Quantitative studies of the metabolism of chylomicron triglycerides and cholesterol by liver and extrahepatic tissues of sheep and dogs

1971 • 173 citations

METABOLISM OF CONSTITUENT LIPIDS OF DOG CHYLOMICRONS*

1963 • 163 citations

Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis

1974 • 161 citations

Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration

1970 • 119 citations

Measurement of rate of rat liver sterol synthesis in vivo using tritiated water.

1977 • 114 citations

Control of 3-Hydroxy-3-Methylglutaryl-CoA Reductase Activity in Cultured Human Fibroblasts by Very Low Density Lipoproteins of Subjects with Hypertriglyceridemia

1978 • 108 citations

Binding, interiorization and degradation of cholesterol ester-labelled chylomicron-remnant particles by rat hepatocyte monolayers

1977 • 107 citations

Regulation of Rat Liver β-Hydroxy-β-Methylglutaryl-CoA Reductase Activity by Cholesterol

1973 • 97 citations

High affinity binding of chylomicron remnants to rat liver plasma membranes.

1979 • 91 citations

The kinetic characteristics of inhibition of hepatic cholesterogenesis by lipoproteins of intestinal origin

1975 • 89 citations

Ability of six different lipoprotein fractions to regulate the rate of hepatic cholesterogenesis in vivo.

1975 • 87 citations

Metabolism of cholesterol-rich chylomicroms. Mechanism of binding and uptake of cholesteryl esters by the vascular bed of the perfused rat heart.

1978 • 79 citations

An in vitro model for the catabolism of rat chylomicrons

1975 • 66 citations

Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7α-hydroxylase activities

1977 • 59 citations

Distributio of chylomicron cholesteryl ester between parenchymal and Kupffer cells of rat liver

1971 • 47 citations

Suppression of 3-hydroxy-3-methylglutaryl-CoA reductase by low density lipoproteins produced in vitro by lipoprotein lipase action on nonsuppressive very low density lipoproteins.

1979 • 41 citations

Separation with uni-dimensional TLC of all neutral lipid classes

1966 • 38 citations

Lipoprotein regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in rat liver cell cultures.

1977 • 31 citations

Low and high density lipoproteins and chylomicrons as regulators of rate of cholesterol synthesis in rat liver in vivo

1979 • 30 citations

Alcohol and aldehyde metabolizing systems—IV

1981 • 27 citations

Regulation of lipogenesis in isolated hepatocytes by triglyceride-rich lipoproteins.

1977 • 24 citations

Effect of lipoprotein on 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity in rat liver cell culture: Special suppressant effect of a lipoprotein isolated from hypercholesterolemic rat plasma

1975 • 22 citations

Detection of Dietary Cholesterol-4-C¹⁴ in the Hepatic Reticulo-Endothelial Cell of the Rat

1955 • 18 citations