Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

Construction of artificial chromosomes in yeast

1983 • 448 citations

Chromosome-specific organization of human alpha satellite DNA.

1985 • 265 citations

A functional marker centromere with no detectable alpha-satellite, satellite III, or CENP-B protein: activation of a latent centromere?

1993 • 261 citations

Chromosomal localization of complex and simple repeated human DNAs

1978 • 237 citations

Isolation and characterization of an alphoid centromeric repeat family from the human Y chromosome

1985 • 236 citations

Genetics of somatic mammalian cells. V. Treatment with 5-bromodeoxyuridine and visible light for isolation of nutritionally deficient mutants.

1967 • 222 citations

Stringent sequence requirements for the formation of human telomeres.

1994 • 190 citations

Integration of human α-satellite DNA into simian chromosomes: Centromere protein binding and disruption of normal chromosome segregation

1992 • 187 citations

Functional reintroduction of human telomeres into mammalian cells.

1991 • 186 citations

A cloned sequence, p82H, of the alphoid repeated DNA family found at the centromeres of all human chromosomes

1985 • 162 citations

YACs, BACs, PACs and MACs: Artificial chromosomes as research tools

1994 • 142 citations

Telomere directed fragmentation of mammalian chromosomes

1993 • 140 citations

Structural instability of human tandemly repeated DNA sequences cloned in yeast artificial chromosome vectors

1990 • 139 citations

Molecular cytogenetic and clinical studies of 42 patients with marker chromosomes

1992 • 138 citations

Mammalian chromosome structure

1993 • 135 citations

Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomes

1994 • 131 citations

Telomere–associated chromosome fragmentation: applications in genome manipulation and analysis

1992 • 117 citations

Construction of functional artificial minichromosomes in the fission yeast Schizosaccharomyces pombe.

1989 • 115 citations

Pulsed-field gel analysis of α-satellite DNA at the human X chromosome centromere: High-frequency polymorphisms and array size estimate

1990 • 109 citations

High resolution mapping using fluorescence in situ hybridization to extended DNA fibers prepared from agarose-embedded cells.

1994 • 108 citations

Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing

1983 • 105 citations

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells.

1990 • 103 citations

Gene transfer by means of cell fusion : I. statistical mapping of the human X-chromosome by analysis of radiation-induced gene segregation

1977 • 102 citations

The structure of a subterminal repeated sequence present on many human chromosomes

1990 • 100 citations

Dissecting the centromere of the human Y chromosome with cloned telomeric DNA

1994 • 96 citations

De novo formation of several features of a centromere following introduction of a Y alphoid YAC into mammalian cells

1994 • 95 citations

Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line

1985 • 91 citations

A non-isotopic in situ hybridisation study of the chromosomal origin of 15 supernumerary marker chromosomes in man.

1992 • 87 citations

Targeted breakage of a human chromosome mediated by cloned human telomeric DNA

1992 • 80 citations

Tetrasomy 15q: two marker chromosomes with no detectable alpha-satellite DNA.

1994 • 78 citations

Small marker X chromosomes lack the X inactivation center: implications for karyotype/phenotype correlations.

1994 • 77 citations

Construction of a mouse yeast artificial chromosome library in a recombination–deficient strain of yeast

1992 • 77 citations

A stable acentric marker chromosome: possible existence of an intercalary ancient centromere at distal 8p.

1994 • 61 citations

Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22

1995 • 59 citations

Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement.

1990 • 57 citations

Human autoimmune sera recognize a conserved 26 kD protein associated with mammalian heterochromatin that is homologous to heterochromatin protein 1 ofDrosophila

1994 • 54 citations

33258 Hoechst enhancement of the photosensitivity of bromodeoxyuridine-substituted cells

1976 • 53 citations

Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing

1994 • 52 citations

Translocation (X;13)(p11.21;q12.3) in a girl with incontinentia pigmenti and bilateral retinoblastoma.

1985 • 49 citations

Mammalian artificial chromosomes: a new tool for gene therapy.

1994 • 48 citations

Mammalian artificial chromosomes

1992 • 47 citations

Translocation (X;9)(p11;q34) in a girl with incontinentia pigmenti (IP): implications for the regional assignment of the IP locus to Xp11?

1985 • 42 citations

Localization of DNA sequences to a region within Xp11.21 between incontinentia pigmenti (IP1) X-chromosomal translocation breakpoints.

1991 • 39 citations

Novel phenotypes arising from selection of hamster melanoma cells for resistance to BUdR

1977 • 37 citations

Isolation of a human repetitive sequence and its application to regional chromosome mapping.

1982 • 36 citations

Chinese hamster cells with a minichromosome containing the centromere region of human chromosome 1

1986 • 34 citations

Molecular characterization of human minichromosomes with centromere from chromosome 1 in human-hamster hybrid cells

1989 • 29 citations

Incontinentia pigmenti (IP) and r(X). Tentative mapping of the IP locus to the X juxtacentromeric region.

1985 • 28 citations

Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies

1993 • 24 citations

Number and size of human X chromosome fragments transferred to mouse cells by chromosome-mediated gene transfer.

1981 • 21 citations

33258 Hoechst enhances the selectivity of the bromodeoxyuridine—light method of isolating conditional lethal mutants

1977 • 19 citations

Partial Deletion of Alpha Satellite DNA Associated with Reduced Amounts of the Centromere Protein CENP-B in a Mitotically Stable Human Chromosome Rearrangement

1990 • 19 citations

Addition of functional human telomeres to YACs

1994 • 15 citations

Ordering Up Big MACs

1994 • 7 citations