Leukotrienes: Biosynthesis, Metabolism, and Analysis

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes

1979 • 812 citations

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

1979 • 652 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica

1980 • 615 citations

Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.

1975 • 583 citations

Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.

1979 • 556 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.

1979 • 465 citations

Structure of slow-reacting substance of anaphylaxis from guinea-pig lung

1980 • 426 citations

Advances in Inflammation Research.

1980 • 393 citations

Stereospecific total synthesis of a "slow reacting substance" of anaphylaxis, leukotriene C-1

1980 • 369 citations

Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

1980 • 350 citations

Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid.

1980 • 330 citations

Identification and biological activity of novel ω‐oxidized metabolites of leukotriene B₄ from human leukocytes

1981 • 313 citations

Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

1983 • 308 citations

Structure of leukotriene C identification of the amino acid part

1979 • 304 citations

Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.

1984 • 304 citations

Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.

1980 • 301 citations

Metabolism of arachidonic acid in ionophore-stimulated neutrophils. Esterification of a hydroxylated metabolite into phospholipids.

1979 • 297 citations

Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.

1984 • 292 citations

The Lipoxygenase of Reticulocytes

1979 • 280 citations

Introduction of a nomenclature: Leukotrienes

1979 • 257 citations

Trihydroxytetraenes: A novel series of compounds formed from arachidonic acid in human leukocytes

1984 • 252 citations

Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages.

1982 • 247 citations

Regulation of arachidonic acid production: role of phospholipases C and A2

1982 • 239 citations

Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes.

1984 • 236 citations

Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes. Activation by adenosine 5'-triphosphate.

1983 • 215 citations

A radioimmunoassay for leukotriene B4

1982 • 210 citations

Biosynthesis and biological activity of leukotriene B5

1984 • 209 citations

Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.

1982 • 202 citations

Mouse peritoneal macrophages release leukotriene C in response to a phagocytic stimulus.

1980 • 199 citations

Chemical and enzymic syntheses of 5-HPETE, a key biological precursor of slow-reacting substance of anaphylaxis (SRS), and 5-HETE

1980 • 196 citations

Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid.

1982 • 196 citations

Arachidonic acid 15-lipoxygenase products from human eosinophils.

1982 • 193 citations

Slow Reacting Substances (SRSs): The structure identification of SRSs from rat basophil leukaemia (RBL-1) cells

1980 • 192 citations

Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.

1982 • 180 citations

Calcium stimulation of a novel lipoxygenase

1980 • 179 citations

IgE-dependent release of leukotriene C4 from alveolar macrophages

1982 • 178 citations

Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes.

1982 • 177 citations

Regulation of arachidonic acid metabolism by macrophage activation.

1982 • 176 citations

A novel leukotriene produced by stimulation of leukocytes with formylmethionylleucylphenylalanine.

1982 • 166 citations

Arachidonic acid 15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Partial purification and properties.

1981 • 165 citations

Formation of novel hydroxylated eicosatetraenoic acids in preparations of human polymorphonuclear leukocytes

1981 • 165 citations

Leukotriene a: Stereochemistry and enzymatic conversion to leukotriene B

1980 • 162 citations

Albumin stabilizes leukotriene A4.

1982 • 153 citations

Eosinophil peroxidase-mediated inactivation of leukotrienes B4, C4, and D4.

1982 • 149 citations

Synthesis of leukotriene C and other arachidonic acid metabolites by mouse pulmonary macrophages.

1982 • 146 citations

Transformation of arachidonic acid in leukocytes. isolation and structural analysis of a novel dihydroxy derivative

1981 • 145 citations

The leukotrienes: a major step in the understanding of immediate hypersensitivity reactions

1981 • 142 citations

Pharmacologic Inhibition of the Antigen-Induced Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) from Monkey Lung Tissues Mediated by Human IgE

1971 • 141 citations

Stereochemistry of leukotriene C-1

1980 • 134 citations

Ionophores stimulate prostaglandin and thromboxane biosynthesis

1977 • 133 citations

Leukotriene A. Isolation from human polymorphonuclear leukocytes.

1980 • 133 citations

Release of leukotrienes from guinea pig lung stimulated by C5ades Arg anaphylatoxin.

1982 • 124 citations

Enzymatic assembly of slow reacting substance

1980 • 122 citations

Preparation of pentafluorobenzyl esters of arachidonic acid lipoxygenase metabolites

1984 • 120 citations

Analysis of leukotrienes by high-pressure liquid chromatography

1981 • 119 citations

Interactions between prostaglandins and leukotrienes

1984 • 119 citations

Metabolism of leukotriene D by porcine kidney.

1981 • 118 citations

Arachidonate 12-lipoxygenase of porcine leukocyte with activity for 5-hydroxyeicosatetraenoic acid

1982 • 118 citations

Generation of leukotriene C4 from a subclass of mast cells differentiated in vitro from mouse bone marrow.

1982 • 116 citations

Regulation of the Arachidonic Acid Cascade

1977 • 115 citations

Eosinophil-rich human polymorphonuclear leukocyte preparations characteristically release leukotriene C4 on ionophore A23187 challenge

1984 • 114 citations

Specific leukotriene formation by purified human eosinophils and neutrophils

1984 • 113 citations

Identification of 15–hydroxy‐5,8,11,13–eicosatetraenoic acid (15–HETE) as a major metabolite of arachidonic acid in human lung

1980 • 112 citations

Novel leukotrienes: Products formed by initial oxygenation of arachidonic acid at C-15

1981 • 112 citations

Dynamics of leukotriene C production by macrophages.

1980 • 109 citations

New role for 15-hydroxyeicosatetraenoic acid. Activator of leukotriene biosynthesis in PT-18 mast/basophil cells.

1982 • 109 citations

Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes.

1983 • 108 citations

A second pathway of leukotriene biosynthesis in porcine leukocytes.

1981 • 102 citations

Teteraene and pentaene leukotrienes: Selective production from murine mastocytomo cells after dietary manipulation

1981 • 102 citations

Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase-catalyzed double oxygenation in rat mononuclear cells and human leukocytes.

1982 • 101 citations

Distribution and metabolism of 3H-labeled leukotriene C3 in the mouse.

1982 • 98 citations

Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis.

1981 • 96 citations

Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages.

1982 • 93 citations

Esterification of an endogenously synthesized lipoxygenase product into granulocyte cellular lipids

1981 • 93 citations

Contractile activities of structural analogs of leukotrienes C and D: role of the polar substituents.

1981 • 92 citations

12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, a chemotactic fatty acid, is incorporated into neutrophil phospholipids and triglyceride

1979 • 92 citations

Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids

1982 • 89 citations

New concepts in the modulation of leukotriene synthesis

1983 • 87 citations

The leukotrienes: a new group of biologically active compounds including SRS-A

1980 • 86 citations

Comparative biological activities of synthetic leukotriene b4 and its ω-oxidation products

1983 • 84 citations

Oxidative inactivation of leukotriene C ₄ by stimulated human polymorphonuclear leukocytes

1982 • 84 citations

Studies on the mechanism of formation of the 5S,12S-dihydroxy-6,8,10,14(E,Z,E,Z)-icosatetraenoic acid in leukocytes

1982 • 84 citations

Sequential conversion of the glutathionyl side chain of slow reacting substance (SRS) to cysteinyl-glycine and cysteine in rat basophilic leukemia cells stimulated with A-23187

1980 • 82 citations

Transformation of 15‐hydroperoxy‐5,9,11,13‐eicosatetraenoic acid into novel leukotrienes

1981 • 82 citations

Fatty acid structural requirements for leukotriene biosynthesis

1980 • 78 citations

Conversion of 5,8,11-eicosatrienoic acid to leukotrienes C3 and D3.

1981 • 76 citations

The development of sensitive and specific radioimmunoassays for leukotrienes

1984 • 76 citations

Metabolism of leukotriene C3 in the guinea pig. Identification of metabolites formed by lung, liver, and kidney.

1981 • 76 citations

Contractile activities of several cysteine-containing leukotrienes in the guinea-pig lung strip

1982 • 74 citations

Total synthesis of (.+-.)-5,6-oxido-7,9-trans,11,14-cis-eicosapentaenoic acid, a possible precursor of SRSA

1979 • 73 citations

Stereospecific removal of the DR hydrogen atom at the 10-carbon of arachidonic acid in the biosynthesis of leukotriene A4 by human leukocytes.

1982 • 68 citations

Release of prostaglandins, a prostaglandin metabolite, slow-reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines

1974 • 68 citations

Metabolism of leukotriene A4 by an enzyme in blood plasma: a possible leukotactic mechanism.

1983 • 67 citations

Arachidonic acid metabolism in glutathione-deficient macrophages.

1982 • 64 citations

Depletion of glutathione selectively inhibits synthesis of leukotriene C by macrophages.

1981 • 61 citations

Calcium stimulation of the 5-lipoxygenase from RBL-1 cells

1982 • 61 citations

Detection of leukotriene A₄ as an intermediate in the biosynthesis of leukotrienes C₄ and D₄

1980 • 60 citations

On the mechanism of biosynthesis of leukotrienes and related compounds

1982 • 60 citations

Leukotriene C4 and D4 formation by particulate enzymes.

1982 • 59 citations

Evidence for pulmonary release of 5-hydroxyeicosatetraenoic acid (5-HETE) during endotoxemia in unanesthetized sheep

1982 • 58 citations

From slow reacting substance of anaphylaxis (SRS-A) to leukotriene D4 (LTD4)

1980 • 57 citations

The conversion of leukotriene C4 to isomers of leukotriene B4 by human eosinophil peroxidase

1982 • 57 citations

Rapid invivo metabolism of Leukotriene C3 in the monkey, Macacairus

1981 • 57 citations

Stable isotope labelled 5-lipoxygenase metabolites of arachidoic acid: Analysis by negative ion chemical ionization mass spectrometry

1984 • 55 citations

Uptake and metabolism of leukotriene C3 by isolated rat organs and cells

1982 • 55 citations

Separation and quantitation of leukotrienes by reversed-phase high-performance liquid chromatography

1984 • 52 citations

Formation of the cysteinyl form of slow reacting substance (leukotriene E4) in human plasma

1980 • 51 citations

Release of platelet‐activating factor (PAF‐acether) and leukotrienes C and D from inflammatory macrophages

1982 • 48 citations

Characterization of slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) cells: effect of cysteine on SRS profile.

1980 • 47 citations

Mechanisms of leukotriene formation: Hemoglobin-catalyzed transformation of 15-HPETE into 8,15-diHETE and 14,15-diHETE isomers

1983 • 46 citations

Formation of Leukotrienes E₃, E₄,E₅ in Rat Basophilic Leukemia Cells

1981 • 46 citations

Kinetics of the conversion of leukotriene C by γ-glutamyl transpeptidase

1982 • 44 citations

11- leukotriene C: A naturally occurring slow reacting substance

1980 • 44 citations

Conversion of dihomo-gamma-linolenic acid to an isomer of leukotriene C3, oxygenated at C-8.

1981 • 40 citations

Relationship of biosynthesis of slow reacting substance to intracellular glutathione concentrations.

1980 • 39 citations

Slow reacting substance of anaphylaxis, SRS-A: Assignment of the stereochemistry

1980 • 39 citations

A novel leukotriene formed by transpeptidation of leukotriene E

1982 • 38 citations

Radioimmunoassay for leukotriene B ₄

1982 • 38 citations

Enzymatic inactivation of SRS-Cys-Gly (leukotriene D)

1981 • 38 citations

Slow reacting substances (leukotrienes): enzymes involved in their biosynthesis.

1982 • 35 citations

Leukotriene Formation by Eosinophil Leukocytes. Analysis with Ion-Pair High Pressure Liquid Chromatography and Effect of the Respiratory Burst

1983 • 34 citations

Metabolism of polyunsaturated fatty acids by mouse peritoneal macrophages: The lipoxygenase metabolic pathway

1981 • 32 citations

Separation of unlabeled metabolites of arachidonic acid from their deuterium- and tritium-labeled analogs by argentation high-pressure liquid chromatography

1983 • 31 citations

Synthesis and metabolism of leukotriene B₄ in human neutrophils measured by specific radioimmunoassay

1982 • 31 citations

Studies on the preparation of conjugates of leukotriene C4 with proteins for development of an immunoassay for SRS-A (1)

1982 • 30 citations

Chemotactic peptide stimulated endogenous arachidonic acid metabolism in HL60 granulocytes

1981 • 29 citations

Reversed-phase HPLC profiling and quantitation of lipoxygenase products

1984 • 29 citations

The Immunological Release of Slow-Reacting Substance of Anaphylaxis from Bovine Lung

1974 • 28 citations

Hemoprotein catalysis of leukotriene formation

1984 • 27 citations

Comparative activity of natural mono-, di- and tri-hydroxy derivatives of arachidonic acid on guinea-pig lungs: Myotropic effect and stimulation of cyclooxygenase activity

1982 • 26 citations

Conversion of 14C-labeled eicosapentaenoic acid (n-3) to leukotriene C5

1981 • 25 citations

Enzymatic formation of 14,15-leukotriene A and C(14)-sulfur-linked peptides

1982 • 24 citations

Metabolism of arachidonic acid in leukocytes: Isolation of a 5,15‐dihydroxy‐eicosatetraenoic acid

1982 • 21 citations

Liquid chromatographic determination of intact leukotriene A4

1982 • 20 citations

Stereospecific elimination of hydrogen at C-10 in eicosapentaenoic acid during the conversion to leukotriene C5.

1983 • 19 citations

Selective synthesis of octadeuterated (±)-5-HETE for use in GC-MS quantitation of 5-HETE

1982 • 14 citations

Incorporation of radiolabel from [1-14C]5-hydroperoxy-eicosatetraenoic acid into slow reacting substance

1980 • 12 citations

Semi-preparative high-performance liquid chromatography and spectroscopic characterisation of eight geometric isomers of leukotriene A methyl ester

1981 • 12 citations

Metabolic Requirements for Rabbit Polymorphonuclear Leucocyte Lipoxygenase Activity

1981 • 9 citations

Additions and Corrections

1977 • 9 citations

The release of prostaglandin and slow reacting substance from mouse macrophages

1981 • 8 citations

Formation of 11-trans slow reacting substances.

1981 • 6 citations

A comparative study of the physical properties and enzymatic reactions of slow reacting substance of anaphylaxis and some leukotriene D4 isomers

1982 • 4 citations