Pharmacological modulation of ion transport across wild-type and ΔF508 CFTR-expressing human bronchial epithelia

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1993 • 1,432 citations

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

1992 • 1,230 citations

Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease

1998 • 1,136 citations

CFTR as a cAMP-Dependent Regulator of Sodium Channels

1995 • 1,074 citations

A human intermediate conductance calcium-activated potassium channel

1997 • 601 citations

Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis

1991 • 495 citations

Chemical chaperones correct the mutant phenotype of the ΔF508 cystic fibrosis transmembrane conductance regulator protein

1996 • 417 citations

hSK4, a member of a novel subfamily of calcium-activated potassium channels

1997 • 372 citations

Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line.

1986 • 321 citations

Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium

1991 • 317 citations

Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses

1993 • 303 citations

Bicarbonate and Chloride Secretion in Calu-3 Human Airway Epithelial Cells

1999 • 277 citations

ΔF508 CFTR protein expression in tissues from patients with cystic fibrosis

1999 • 265 citations

cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia.

1992 • 262 citations

Regulation by ATP and ADP of CFTR Chloride Channels That Contain Mutant Nucleotide-Binding Domains

1992 • 231 citations

Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel

1996 • 228 citations

Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator.

1996 • 207 citations

cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein

1995 • 207 citations

Genistein potentiates wild-type and delta F508-CFTR channel activity

1997 • 205 citations

Intracellular Cl- activity and cellular Cl- pathways in cultured human airway epithelium

1989 • 150 citations

Alternate stimulation of apical CFTR by genistein in epithelia

1996 • 146 citations

No added benefit from nebulized amiloride in patients with cystic fibrosis

1993 • 139 citations

Activation of an apical Cl- conductance by Ca2+ ionophores in cystic fibrosis airway epithelia

1989 • 139 citations

Direct action of genistein on CFTR

1997 • 139 citations

Chloride secretory response to extracellular ATP in human normal and cystic fibrosis nasal epithelia

1992 • 134 citations

A new class of inhibitors of cAMP-mediated Cl? secretion in rabbit colon, acting by the reduction of cAMP-activated K+ conductance

1995 • 132 citations

UTP inhibits Na⁺ absorption in wild-type and ΔF508 CFTR-expressing human bronchial epithelia

1999 • 130 citations

Phosphatidylinositol 3-Kinase Mediates the Inhibitory Effect of Epidermal Growth Factor on Calcium-dependent Chloride Secretion

1996 • 118 citations

Kinase-dependent Regulation of the Intermediate Conductance, Calcium-dependent Potassium Channel, hIK1

2000 • 114 citations

Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vivo

1998 • 113 citations

Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline.

1975 • 113 citations

Genotypic analysis of respiratory mucous sulfation defects in cystic fibrosis.

1995 • 106 citations

The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel

1994 • 105 citations

CFTR and differentiation markers expression in non-CF and delta F 508 homozygous CF nasal epithelium.

1995 • 103 citations

Effect of Aerosolized Uridine-5 ′ -Triphosphate on Airway Clearance with Cough in Patients with Primary Ciliary Dyskinesia

1999 • 96 citations

Amiloride Inhalation Therapy in Cystic Fibrosis: Influence on Ion Content, Hydration, and Rheology of Sputum

1993 • 93 citations

Novel pharmacologic therapies for cystic fibrosis

1999 • 91 citations

Identification of a splice site mutation (2789+5 G>A) associated with small amounts of normal CFTRmRNA and mild cystic fibrosis

1997 • 85 citations

Importance of basolateral K⁺ conductance in maintaining Cl⁻ secretion in murine nasal and colonic epithelia

1998 • 84 citations

Modulation of Cl- secretion by benzimidazolones. II. Coordinate regulation of apical GCl and basolateral GK

1996 • 81 citations

Calcium-mediated agonists activate an inwardly rectified K+ channel in colonic secretory cells

1993 • 76 citations

Differentiated and functional human airway epithelium regeneration in tracheal xenografts

2000 • 75 citations

Conductive pathways for HCO3- in basolateral membrane of salamander intestinal cells

1989 • 72 citations

Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers

1995 • 69 citations

Stimulation of Cl(-) secretion by chlorzoxazone.

2000 • 66 citations

Psoralens: novel modulators of Cl- secretion

1997 • 63 citations

Specific blockade of slowly activating I_sK channels by chromanols — impact on the role of I_sK channels in epithelia

1996 • 61 citations

Rescue of Dysfunctional ΔF508-CFTR Chloride Channel Activity by IBMX

1999 • 59 citations

Extracellular ATP and UTP Induce Chloride Secretion in Nasal Epithelia of Cystic Fibrosis Patients and Normal Subjects in vivo

1992 • 53 citations

Modulation of K⁺ channels by arachidonic acid in T84 cells. II. Activation of a Ca²⁺-independent K⁺ channel

1998 • 52 citations

KvLQT1 Potassium Channel but Not IsK Is the Molecular Target fortrans-6-Cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethyl-chromane

1997 • 48 citations

Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols

1991 • 47 citations

NS 004—an activator of Ca2+-dependent K+ channels in cerebellar granule cells

1994 • 46 citations

Mucociliary clearance in smokers.

1986 • 43 citations

Intracellular pH-regulating mechanism of the squid axon. Interaction between DNDS and extracellular Na+ and HCO3-.

1989 • 34 citations

Extracellular ATP stimulates K+ secretion across cultured human airway epithelium

1997 • 25 citations

Action of Tulobuterol and Fenoterol on the Mucociliary Clearance

1987 • 18 citations

Mucociliary Clearance from Central Airways in Patients with Excessive Sputum Production with and without Primary Ciliary Dyskinesia

1990 • 16 citations

Effect of the diglyceride lipase inhibitor, RG80267, on epithelial chloride secretion induced by various agents

1995 • 8 citations