Viral Plasmids in Mammalian Cells

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

2000 • 912 citations

Efficient Persistence of Extrachromosomal KSHV DNA Mediated by Latency-Associated Nuclear Antigen

1999 • 691 citations

A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells.

1984 • 685 citations

A DNA Helicase Activity Is Associated with an MCM4, -6, and -7 Protein Complex

1997 • 539 citations

Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region

1985 • 502 citations

Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state

1994 • 499 citations

Mitotic stability of yeast chromosomes: A colony color assay that measures nondisjunction and chromosome loss

1985 • 486 citations

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

The Expression Pattern of Epstein-Barr Virus Latent Genes In Vivo Is Dependent upon the Differentiation Stage of the Infected B Cell

2000 • 462 citations

A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.

1985 • 442 citations

Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator

1990 • 396 citations

Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus

1988 • 386 citations

trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.

1986 • 363 citations

The Latency-Associated Nuclear Antigen Tethers the Kaposi's Sarcoma-Associated Herpesvirus Genome to Host Chromosomes in Body Cavity-Based Lymphoma Cells

1999 • 351 citations

Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

1992 • 344 citations

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

1993 • 329 citations

Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell

1997 • 315 citations

The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication

1989 • 310 citations

Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells

1991 • 297 citations

Replication from oriP of Epstein-Barr Virus Requires Human ORC and Is Inhibited by Geminin

2001 • 283 citations

EUKARYOTIC DNA REPLICATION: Anatomy of An Origin

1993 • 280 citations

Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells.

1985 • 277 citations

Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1.

1991 • 257 citations

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Mediates Episome Persistence through cis -Acting Terminal Repeat (TR) Sequence and Specifically Binds TR DNA

2001 • 248 citations

Isolation of human sequences that replicate autonomously in human cells.

1989 • 244 citations

Viral latency and transformation: The strategy of Epstein-Barr virus

1989 • 241 citations

The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.

1993 • 236 citations

The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Supports Latent DNA Replication in Dividing Cells

2002 • 231 citations

Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus

1989 • 217 citations

Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus

2001 • 214 citations

Replication of latent Epstein-Barr virus genomes in Raji cells

1987 • 207 citations

Crystal Structure of the DNA-Binding Domain of the Epstein–Barr Virus Origin-Binding Protein, EBNA1, Bound to DNA

1996 • 206 citations

Functional domains of Epstein-Barr virus nuclear antigen EBNA-1

1991 • 205 citations

Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.

1993 • 200 citations

Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein–Barr virus

2001 • 198 citations

Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes

2002 • 197 citations

DNA replication in eukaryotic cells

1997 • 194 citations

DNA Binding and Modulation of Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus

2001 • 185 citations

Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.

1995 • 184 citations

Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation

1998 • 182 citations

Mapping EBNA-1 Domains Involved in Binding to Metaphase Chromosomes

1999 • 182 citations

Long-Term Episomal Maintenance of Bovine Papillomavirus Type 1 Plasmids Is Determined by Attachment to Host Chromosomes, Which Is Mediated by the Viral E2 Protein and Its Binding Sites

1999 • 179 citations

Bovine Papillomavirus Type 1 Genomes and the E2 Transactivator Protein Are Closely Associated with Mitotic Chromatin

1998 • 178 citations

Latency-associated Nuclear Antigen (LANA) Cooperatively Binds to Two Sites within the Terminal Repeat, and Both Sites Contribute to the Ability of LANA to Suppress Transcription and to Facilitate DNA Replication

2002 • 178 citations

Close but Distinct Regions of Human Herpesvirus 8 Latency-Associated Nuclear Antigen 1 Are Responsible for Nuclear Targeting and Binding to Human Mitotic Chromosomes

2001 • 170 citations

Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin.

1993 • 165 citations

Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA

1990 • 164 citations

EBP2, a Human Protein That Interacts with Sequences of the Epstein-Barr Virus Nuclear Antigen 1 Important for Plasmid Maintenance

1999 • 164 citations

Maintenance of Epstein–Barr virus (EBV) oriP -based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1

2001 • 162 citations

The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase.

1994 • 156 citations

Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator.

1996 • 153 citations

Visualization of DNA Replication on Individual Epstein-Barr Virus Episomes

2001 • 151 citations

Overproduction, purification, and characterization of EBNA1, the origin binding protein of Epstein-Barr virus.

1991 • 149 citations

Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies

2000 • 145 citations

Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA1

1995 • 145 citations

The Minimal Replicator of Epstein-Barr Virus oriP

2000 • 138 citations

The carboxy-terminal domain shared by the bovine papillomavirus E2 transactivator and repressor proteins contains a specific DNA binding activity.

1988 • 136 citations

Bovine papilloma virus plasmids replicate randomly in mouse fibroblasts throughout S phase of the cell cycle

1987 • 135 citations

Telomeric Proteins Regulate Episomal Maintenance of Epstein-Barr Virus Origin of Plasmid Replication

2002 • 135 citations

Subnuclear localization and phosphorylation of Epstein-Barr virus latent infection nuclear proteins

1990 • 132 citations

Up to 100-Fold Increase of Apparent Gene Expression in the Presence of Epstein-Barr Virus oriP Sequences and EBNA1: Implications of the Nuclear Import of Plasmids

1998 • 130 citations

The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator.

1993 • 127 citations

Epstein-Barr virus and the B cell: that's all it takes

1996 • 125 citations

Cells Expressing the Epstein-Barr Virus Growth Program Are Present in and Restricted to the Naive B-Cell Subset of Healthy Tonsils

2000 • 122 citations

Interaction of the Papillomavirus E2 Protein with Mitotic Chromosomes

2000 • 119 citations

Functional interactions between papillomavirus E1 and E2 proteins

1997 • 118 citations

Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1.

1994 • 117 citations

Separation of the DNA Replication, Segregation, and Transcriptional Activation Functions of Epstein-Barr Nuclear Antigen 1

2002 • 116 citations

Recruitment and loading of the E1 initiator protein: an ATP-dependent process catalysed by a transcription factor

1998 • 114 citations

A nuclear matrix attachment region organizes the Epstein-Barr viral plasmid in Raji cells into a single DNA domain.

1992 • 112 citations

The 68-kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitro

1991 • 112 citations

Two Epstein-Barr viral nuclear neoantigens distinguished by gene transfer, serology, and chromosome binding.

1983 • 109 citations

Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus.

1991 • 106 citations

Cellular factors required for papillomavirus DNA replication

1995 • 105 citations

Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell lines

1993 • 104 citations

DNA looping between the origin of replication of Epstein-Barr virus and its enhancer site: stabilization of an origin complex with Epstein-Barr nuclear antigen 1.

1991 • 103 citations

The DNA segregation mechanism of Epstein–Barr virus nuclear antigen 1

2000 • 102 citations

Sequence requirements of the Epstein-Barr virus latent origin of DNA replication

1994 • 101 citations

The Linking Regions of EBNA1 Are Essential for Its Support of Replication and Transcription

1999 • 101 citations

Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure

1993 • 101 citations

Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets

1998 • 101 citations

A dimer of BPV-1 E2 containing a protease resistant core interacts with its DNA target.

1988 • 99 citations

Nucleosomal structure of Epstein-Barr virus DNA in transformed cell lines

1979 • 99 citations

Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin- associated nuclear bodies

1999 • 98 citations

Plasmid maintenance of derivatives of oriP of Epstein-Barr virus

1995 • 96 citations

Coupling of Mitotic Chromosome Tethering and Replication Competence in Epstein-Barr Virus-Based Plasmids

2001 • 95 citations

Interactions of the Papovavirus DNA Replication Initiator Proteins, Bovine Papillomavirus Type 1 E1 and Simian Virus 40 Large T Antigen, with Human Replication Protein A

1999 • 95 citations

EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replication

1992 • 95 citations

Dominant-negative inhibitors of EBNA-1 of Epstein-Barr virus

1997 • 94 citations

Random association of Epstein-Barr virus genomes with host cell metaphase chromosomes in Burkitt's lymphoma-derived cell lines

1985 • 92 citations

Stable Episomal Maintenance of Yeast Artificial Chromosomes in Human Cells

1996 • 92 citations

Constitutive binding of EBNA1 protein to the Epstein-Barr virus replication origin, oriP, with distortion of DNA structure during latent infection.

1993 • 84 citations

Characterization of the DNA-Binding Domain of the Bovine Papillomavirus Replication Initiator E1

1998 • 81 citations

DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects

1993 • 81 citations

Crystal Structure of the DNA Binding Domain of the Replication Initiation Protein E1 from Papillomavirus

2000 • 80 citations

Initiation of Latent DNA Replication in the Epstein-Barr Virus Genome Can Occur at Sites other than the Genetically Defined Origin

1995 • 78 citations

Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication

1989 • 77 citations

Induction of structural changes in the bovine papillomavirus type 1 origin of replication by the viral E1 and E2 proteins.

1994 • 77 citations

Replication of bovine papillomavirus type 1 DNA initiates within an E2-responsive enhancer element

1990 • 75 citations

EBNA1 distorts oriP, the Epstein-Barr virus latent replication origin

1992 • 75 citations

Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex

2002 • 73 citations

Multiple regions within EBNA1 can link DNAs

1995 • 70 citations

Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replication

1993 • 70 citations

Essential role of human CDT1 in DNA replication and chromatin licensing

2002 • 70 citations

DNA binding specificity of the bovine papillomavirus E1 protein is determined by sequences contained within an 18-base-pair inverted repeat element at the origin of replication

1994 • 67 citations

Functional Analyses of the EBNA1 Origin DNA Binding Protein of Epstein-Barr Virus

2000 • 67 citations

Stabilization of the EBNA1 protein on the Epstein-Barr virus latent origin of DNA replication by a DNA looping mechanism.

1994 • 66 citations

Reconstitution of Epstein-Barr virus-based plasmid partitioning in budding yeast

2001 • 65 citations

The 2.2 Å structure of a permanganate-sensitive DNA site bound by the epstein-barr virus origin binding protein, EBNA1 1 1Edited by T. Richmond

1998 • 63 citations

The average number of molecules of Epstein-Barr nuclear antigen 1 per cell does not correlate with the average number of Epstein-Barr virus (EBV) DNA molecules per cell among different clones of EBV-immortalized cells

1990 • 60 citations

Role of EBNA-1 in arresting replication forks at the Epstein-Barr virus oriP family of tandem repeats.

1991 • 59 citations

EBNA1 Partitions Epstein-Barr Virus Plasmids in Yeast Cells by Attaching to Human EBNA1-Binding Protein 2 on Mitotic Chromosomes

2003 • 59 citations

Replication from oriP of Epstein-Barr Virus Requires Exact Spacing of Two Bound Dimers of EBNA1 Which Bend DNA

2001 • 57 citations

Separate domains in E1 and E2 proteins serve architectural and productive roles for cooperative DNA binding

2000 • 56 citations

Cooperative assembly of EBNA1 on the Epstein-Barr virus latent origin of replication

1996 • 56 citations

Human RPA (hSSB) interacts with EBNA1, the latent origin binding protein of Epstein-Barr virus

1998 • 55 citations

Rep*: a Viral Element That Can Partially Replace the Origin of Plasmid DNA Synthesis of Epstein-Barr Virus

1998 • 54 citations

Nucleoprotein Complexes and DNA 5′-Ends at oriP of Epstein-Barr Virus

1995 • 54 citations

Interaction of Epstein-Barr virus nuclear antigen 1 with the viral latent origin of replication

1992 • 52 citations

Human p32: A Coactivator for Epstein–Barr Virus Nuclear Antigen-1-Mediated Transcriptional Activation and Possible Role in Viral Latent Cycle DNA Replication

2000 • 50 citations

Initiation of DNA Replication within oriP Is Dispensable for Stable Replication of the Latent Epstein-Barr Virus Chromosome after Infection of Established Cell Lines

2000 • 50 citations

The E1 Initiator Recognizes Multiple Overlapping Sites in the Papillomavirus Origin of DNA Replication

2001 • 48 citations

An Imperfect Correlation between DNA Replication Activity of Epstein–Barr Virus Nuclear Antigen 1 (EBNA1) and Binding to the Nuclear Import Receptor, Rch1/importin α

1997 • 44 citations

Genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes

2002 • 44 citations

Two Domains of the Epstein-Barr Virus Origin DNA-binding Protein, EBNA1, Orchestrate Sequence-specific DNA Binding

2000 • 44 citations

Epstein-Barr nuclear antigen 1 binds and destabilizes nucleosomes at the viral origin of latent DNA replication

2001 • 42 citations

Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro

1995 • 39 citations

Origin DNA-binding proteins

1998 • 34 citations

The Replicator of the Epstein-Barr Virus Latent Cycle Origin of DNA Replication, oriP , Is Composed of Multiple Functional Elements

2001 • 34 citations

Identification of Epstein-Barr Virus Nuclear Antigen 1 Protein Domains That Direct Interactions at a Distance between DNA-bound Proteins

1995 • 34 citations

Two Patches of Amino Acids on the E2 DNA Binding Domain Define the Surface for Interaction with E1

2000 • 34 citations

Mechanistic studies on the DNA linking activity of Epstein-Barr nuclear antigen 1

1998 • 30 citations

Role of the EBNA-1 Protein in Pausing of Replication Forks in the Epstein-Barr Virus Genome

1996 • 29 citations

DNA binding activity is required for EBNA 1-dependent transcriptional activation and DNA replication

1992 • 26 citations

E1 recognition sequences in the bovine papillomavirus type 1 origin of DNA replication: interaction between half sites of the inverted repeats

1995 • 26 citations

E1 Protein of Bovine Papillomavirus Type 1 Interferes with E2 Protein-Mediated Tethering of the Viral DNA to Mitotic Chromosomes

2002 • 25 citations

Requirement of Replication Licensing for the Dyad Symmetry Element-Dependent Replication of the Epstein–Barr Virus oriP Minichromosome

1999 • 22 citations

Activation of TRAF5 and TRAF6 Signal Cascades Negatively Regulates the Latent Replication Origin of Epstein-Barr Virus through p38 Mitogen-Activated Protein Kinase

2001 • 21 citations

Sequences flanking the core DNA-binding domain of bovine papillomavirus type 1 E2 contribute to DNA-binding function

1997 • 20 citations

The cis -Acting Family of Repeats Can Inhibit as well as Stimulate Establishment of an oriP Replicon

2001 • 18 citations

An enhanced EBNA1 variant with reduced IR3 domain for long-term episomal maintenance and transgene expression of oriP-based plasmids in human cells

1998 • 17 citations

Requirements for Epstein-Barr Nuclear Antigen 1 (EBNA1)-induced Permanganate Sensitivity of the Epstein-Barr Virus Latent Origin of DNA Replication

1997 • 17 citations

Plasmid maintenance assay based on green fluorescent protein and FACS of mammalian cells.

1998 • 17 citations

Sequences Adjacent to oriP Improve the Persistence of Epstein-Barr Virus-Based Episomes in B Cells

2001 • 17 citations

Distinct Roles of Two Binding Sites for the Bovine Papillomavirus (BPV) E2 Transactivator on BPV DNA Replication

1998 • 13 citations