Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA1

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

1993 • 598 citations

Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region

1985 • 502 citations

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.

1985 • 442 citations

Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator

1990 • 396 citations

trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.

1986 • 363 citations

Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

1992 • 344 citations

Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells

1991 • 297 citations

Crystal Structure of lac Repressor Core Tetramer and Its Implications for DNA Looping

1995 • 290 citations

Activation of BPV-1 replication in vitro by the transcription factor E2

1991 • 284 citations

Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells.

1985 • 277 citations

Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1.

1991 • 257 citations

A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection

1989 • 254 citations

Isolation of human sequences that replicate autonomously in human cells.

1989 • 244 citations

Viral latency and transformation: The strategy of Epstein-Barr virus

1989 • 241 citations

Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains.

1988 • 213 citations

Replication of latent Epstein-Barr virus genomes in Raji cells

1987 • 207 citations

Functional domains of Epstein-Barr virus nuclear antigen EBNA-1

1991 • 205 citations

Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.

1993 • 200 citations

Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin.

1993 • 165 citations

Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA

1990 • 164 citations

Overproduction, purification, and characterization of EBNA1, the origin binding protein of Epstein-Barr virus.

1991 • 149 citations

Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus.

1991 • 106 citations

DNA looping between the origin of replication of Epstein-Barr virus and its enhancer site: stabilization of an origin complex with Epstein-Barr nuclear antigen 1.

1991 • 103 citations

Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure

1993 • 101 citations

Sequence requirements of the Epstein-Barr virus latent origin of DNA replication

1994 • 101 citations

Constitutive binding of EBNA1 protein to the Epstein-Barr virus replication origin, oriP, with distortion of DNA structure during latent infection.

1993 • 84 citations

The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops.

1991 • 78 citations

EBNA1 distorts oriP, the Epstein-Barr virus latent replication origin

1992 • 75 citations

The bovine papillomavirus 1 E2 protein contains two activation domains: one that interacts with TBP and another that functions after TBP binding.

1995 • 73 citations

Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replication

1993 • 70 citations

Stabilization of the EBNA1 protein on the Epstein-Barr virus latent origin of DNA replication by a DNA looping mechanism.

1994 • 66 citations

Amino acids necessary for DNA contact and dimerization imply novel motifs in the papillomavirus E2 trans-activator.

1992 • 56 citations

Interaction of Epstein-Barr virus nuclear antigen 1 with the viral latent origin of replication

1992 • 52 citations

Crystallographic computing on an array processor

1982 • 43 citations

Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro

1995 • 39 citations

Overexpression, Purification, and Crystallization of the DNA Binding and Dimerization Domains of the Epstein-Barr Virus Nuclear Antigen 1

1995 • 32 citations

Delineation of a 16 Amino Acid Sequence That Forms a Core DNA Recognition Motif in the Epstein-Barr Virus EBNA-1 Protein

1994 • 19 citations