Human Retroviruses and Demyelinating Diseases

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 1,750 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes

1984 • 976 citations

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

1984 • 886 citations

Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells

1984 • 781 citations

The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4

1989 • 732 citations

Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice

1994 • 678 citations

Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.

1991 • 644 citations

Chronic progressive myelopathy associated with elevated antibodies to human T‐lymphotropic virus type I and adult T‐cell leukemialike cells

1987 • 634 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

1990 • 603 citations

Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III

1985 • 583 citations

Vacuolar Myelopathy Pathologically Resembling Subacute Combined Degeneration in Patients with the Acquired Immunodeficiency Syndrome

1985 • 548 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

The HIV A (sor) gene product is essential for virus infectivity

1987 • 475 citations

Infective dermatitis of Jamaican children: a marker for HTLV-I infection

1990 • 452 citations

Complete nucleotide sequence of the genome of bovine leukemia virus: its evolutionary relationship to other retroviruses.

1985 • 450 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

Clinical Course of Retrovirus-Associated Adult T-Cell Lymphoma in the United States

1983 • 431 citations

The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization

1989 • 400 citations

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR

1991 • 391 citations

The Acquired Immunodeficiency Syndrome Dementia Complex as the Presenting or Sole Manifestation of Human Immunodeficiency Virus Infection

1987 • 375 citations

Rearrangements of Genes for the Antigen Receptor on T Cells as Markers of Lineage and Clonality in Human Lymphoid Neoplasms

1985 • 367 citations

Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms

1993 • 367 citations

Regulation of human immunodeficiency virus env expression by the rev gene product

1989 • 365 citations

Characterization of Envelope and Core Structural Gene Products of HTLV-III with Sera from AIDS Patients

1985 • 356 citations

HTLV-1 AND POLYMYOSITIS IN JAMAICA

1989 • 336 citations

Pathogenesis of Diseases Induced by Human Lymphotropic Virus Type I Infection

1993 • 320 citations

Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells

1984 • 293 citations

HTLV‐I Uveitis: A Distinct Clinical Entity Caused by HTLV‐I

1992 • 292 citations

HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: Comparison with adult T-cell leukemia/lymphoma

1988 • 288 citations

A Second Isolate of HTLV-II Associated with Atypical Hairy-Cell Leukemia

1986 • 282 citations

Increasing Viral Burden in CD4+ T Cells from Patients with Human Immunodeficiency Virus (HIV) Infection Reflects Rapidly Progressive Immunosuppression and Clinical Disease

1990 • 281 citations

Functional role of human immunodeficiency virus type 1 vpu.

1989 • 280 citations

Detection of Human T-Cell Lymphoma/Leukemia Virus Type I DNA and Antigen in Spinal Fluid and Blood of Patients with Chronic Progressive Myelopathy

1988 • 279 citations

HIV-1 Tat protein trans-activates transcription in vitro

1990 • 277 citations

Chronic neurodegenerative disease associated with HTLV-II infection

1992 • 277 citations

Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

1988 • 273 citations

Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein

1989 • 267 citations

Endemic tropical spastic paraparesis associated with human T‐lymphotropic virus type I: A clinical and seroepidemiological study of 25 cases

1987 • 264 citations

Neuromuscular diseases associated with human immunodeficiency virus infection

1988 • 253 citations

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat

1987 • 251 citations

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

1987 • 245 citations

Pathology of HIV-1 Infection of the Central Nervous System. A review

1992 • 244 citations

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

1985 • 237 citations

The metabolic pathology of the AIDS dementia complex

1987 • 234 citations

The Immunopathogenesis of HIV Infection

1989 • 233 citations

Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus.

1990 • 217 citations

Immunopathogenesis of HIV infection

1991 • 213 citations

Integration is not necessary for expression of human immunodeficiency virus type 1 protein products

1990 • 208 citations

Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV‐I‐associated myelopathy

1988 • 203 citations

Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy.

1990 • 194 citations

Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection.

1990 • 194 citations

Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells.

1984 • 192 citations

Deleted HTLV-I Provirus in Blood and Cutaneous Lesions of Patients with Mycosis Fungoides

1991 • 188 citations

Mutational analysis of the human immunodeficiency virus vpr open reading frame

1989 • 183 citations

The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses

1986 • 182 citations

The epidemiology of the human T‐cell lymphotrophic virus type I and type II: etiologic role in human disease

1991 • 180 citations

Structure of 3′ Terminal Region of Type II Human T Lymphotropic Virus: Evidence for New Coding Region

1984 • 166 citations

DISTRIBUTION AND QUANTITATION OF HLA-ABC AND DR (Ia) ANTIGENS ON HUMAN KIDNEY AND OTHER TISSUES

1980 • 165 citations

Patterns of cerebral atrophy in HIV–1–infected individuals

1992 • 164 citations

T-Cell Lymphoproliferative Syndrome Associated with Human T-Cell Leukemia/Lymphoma Virus

1984 • 160 citations

Sequence homoiogy of the simian retrovirus genome with human t-cell leukemia virus type I

1985 • 157 citations

The nucleotide sequence of the env gene and post-env region of bovine leukemia virus

1984 • 151 citations

Retroviral Proteinases

1990 • 145 citations

Viruses in idiopathic inflammatory myopathies: absence of candidate viral genomes in muscle

1992 • 143 citations

Isolation of HTLV‐II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV‐I‐associated myelopathy/tropical spastic paraparesis

1993 • 133 citations

Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression

1986 • 129 citations

Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNA.

1989 • 129 citations

Immunological findings in neurological diseases associated with antibodies to HTLV-I: Activated lymphocytes in tropical spastic paraparesis

1988 • 127 citations

Location of cis-acting regulatory sequences in the human T-cell leukemia virus type I long terminal repeat.

1985 • 127 citations

Human immunodeficiency virus-associated meningitis

1987 • 126 citations

Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.

1990 • 124 citations

Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy.

1991 • 121 citations

Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.

1989 • 121 citations

Cytokine induction in HTLV‐I associated myelopathy and adult T‐cell leukemia: Alternate molecular mechanisms underlying retroviral pathogenesis

1991 • 117 citations

Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation.

1990 • 114 citations

Spastic ataxia associated with human T‐cell lymphotrophic virus type II infection

1993 • 112 citations

Gracile tract degeneration in patients with sensory neuropathy and AIDS

1988 • 112 citations

Latent HIV-1 infection in enriched populations of blood monocytes and T cells from seropositive patients.

1991 • 111 citations

Multiple sclerosis‐like illness occurring with human immunodeficiency virus infection

1989 • 110 citations

ANTIBODY TO HUMAN T-LYMPHOTROPIC VIRUS TYPE 1 IN WEST-INDIAN-BORN UK RESIDENTS WITH SPASTIC PARAPARESIS

1987 • 110 citations

Incidence of Hairy Cell Leukemia, Mycosis Fungoides, and Chronic Lymphocytic Leukemia in First Known HTLV-II-Endemic Population

1991 • 102 citations

Novel Viral Sequences Related to Human T-Cell Leukemia Virus in T Cells of a Seropositive Baboon

1984 • 95 citations

Reduced production of interleukin 2 and interferongamma and enhanced helper activity for IgG synthesis by cloned CD4⁺ T cells from patients with AIDS

1987 • 94 citations

Human T-Lymphotropic Virus Type I Antibodies in the Serum of Patients With Tropical Spastic Paraparesis in the Seychelles

1987 • 93 citations

Identification of two distinct elements in the long terminal repeat of HTLV-I responsible for maximum gene expression.

1987 • 91 citations

Pcr-Based Diagnostics in Infectious Disease

1994 • 87 citations

The expression of MHC antigens on oligodendrocytes: Induction of polymorphic H-2 expression by lymphokines

1986 • 84 citations

Transforming growth factor-beta and suppression of humoral immune responses in HIV infection.

1991 • 84 citations

Molecular Interactions among Herpesviruses and Human Immunodeficiency Viruses

1990 • 84 citations

Endemic Human T Cell Leukemia Virus Type II Infection in Southwestern US Indians Involves Two Prototype Variants of Virus

1993 • 83 citations

Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II.

1984 • 80 citations

Molecular cloning of a unique human T-cell leukemia virus (HTLV-IIMo).

1984 • 79 citations

Nucleotide sequence of the 3' region of an infectious human T-cell leukemia virus type II genome.

1984 • 79 citations

Human lymphotropic retroviruses associated with mycosis fungoides: evidence that human T-cell lymphotropic virus type II (HTLV-II) as well as HTLV-I may play a role in the disease

1992 • 75 citations

Detection of human T-lymphotropic virus-like particles in cultures of peripheral blood lymphocytes from patients with mycosis fungoides.

1991 • 74 citations

Pathological and immunological observations on tropical spastic paraparesis in patients from jamaica

1988 • 68 citations

Arthritis in a human T lymphotropic virus type I (HTLV-I) carrier.

1990 • 64 citations

Clinical Electrophysiologic Studies of HTLV-I-Associated Myelopathy

1987 • 62 citations

Inflammatory lesions of peripheral nerve in a patient with human T‐lymphotropic virus type I‐associated myelopathy

1988 • 62 citations

PCR Analysis of DNA from Multiple Sclerosis Patients for the Presence of HTLV-I

1989 • 59 citations

Intracellular distribution of the envelope glycoprotein of human immunodeficiency virus and its role in the production of cytopathic effect in CD4+ and CD4- human cell lines

1990 • 55 citations

Study of activated T cell in man

1986 • 53 citations

Multiple sclerosis, retroviruses, and PCR

1991 • 53 citations

Bronchoalveolar Lymphocytosis in Patients with Tropical Spastic Paraparesis Associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)

1988 • 53 citations

Cutaneous T-Cell Lymphoma in Patients With Human Immunodeficiency Virus Infection

1991 • 49 citations

Mechanisms of T-Cell Functional Deficiency in the Acquired Immunodeficiency Syndrome

1985 • 45 citations

Tropical spastic paraparesis in the Seychelles Islands

1987 • 44 citations

In Reply: PCR Analysis of DNA from Multiple Sclerosis Patients for the Presence of HTLV-I

1989 • 41 citations

Immunological Studies of HTLV-I Associated Myelopathy

1988 • 41 citations

Healthy HTLV‐I carriers in Japan: the haematological and immunological characteristics

1986 • 39 citations

Molecular Analysis of HTLV-I Proviral Integration and T Cell Receptor Arrangement Indicates That T Cells in Tropical Spastic Paraparesis Are Polyclonal

1989 • 37 citations

Clinical Correlation and Genetic Polymorphism of the Human Immunodeficiency Virus Proviral DNA Obtained after Polymerase Chain Reaction Amplification

1990 • 37 citations

Immunodeficiency in HIV infection and AIDS

1992 • 35 citations

No Detection of HTLV-I DNA in Punch Skin Biopsies from Patients with Cutaneous T-Cell Lymphoma by the Polymerase Chain Reaction

1992 • 34 citations

Expression of H-2 antigen on oligodendrocytes is induced by soluble factors from concanavalin A activated T cells

1985 • 26 citations

A clinical neurophysiologic study of tropical spastic paraparesis

1988 • 26 citations

Defective T-cell colony formation and IL-2 receptor expression at all stages of HIV infection.

1988 • 25 citations

Infection of human T-lymphotropic virus type I to astrocytes in vitro with induction of the class II major histocompatibility complex

1988 • 23 citations

Kaposi‧s sarcoma in human T-cell leukemia virus type I-associated adult T-cell leukemia

1990 • 22 citations

CLINICAL MANIFESTATIONS OF MULTIPLE SCLEROSIS: Taxonomy and Diagnostic Parameters in Multiple Sclerosis

1984 • 17 citations

Novel Complications with HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis: Interstitial Cystitis and Persistent Prostatitis

1992 • 15 citations

Retroviruses and multiple sclerosis. II.

1990 • 15 citations

No evidence for spumavirus or oncovirus infection in relapsing–remitting multiple sclerosis

1992 • 14 citations

Limiting dilution analysis of in vivo-activated (IL-2 responsive) peripheral blood lymphocytes in HIV-1-infected subjects

1989 • 14 citations

Human T lymphotrophic virus type I may not be associated with multiple sclerosis in Japan.

1990 • 12 citations

Human T-Cell Lymphotropic Virus Type I Sequences Detected by Nested Polymerase Chain Reactions Are Not Associated With Multiple Sclerosis

1991 • 12 citations

Central Nervous System Effects of Human Immunodeficiency Virus Type 1

1990 • 10 citations

Absence of highly homologous sequence to HTLV‐I in Japanese multiple sclerosis

1991 • 9 citations

Electroencephalographic Abnormalities in Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy

1989 • 9 citations

Retrovirus infections of the nervous system.

1993 • 7 citations

The Acquired Immunodeficiency Syndrome

1985 • 6 citations

A clinical, hematologic, and immunologic analysis of 21 HTLV-II- infected intravenous drug users [published erratum appears in Blood 1990 Nov 1;76(9):1901]

1990 • 3 citations

Neuropathies and myopathies complicating HIV infection

1991 • 2 citations