Autonomic Regulation of Thermogenesis

A role for brown adipose tissue in diet-induced thermogenesis

1979 • 1,587 citations

Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man

1981 • 1,168 citations

Brown fat and thermogenesis.

1969 • 696 citations

Physiology and Pathophysiology of the Human Sympathoadrenal Neuroendocrine System

1980 • 653 citations

Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline

1978 • 653 citations

Fasting, Feeding and Regulation of the Sympathetic Nervous System

1978 • 498 citations

The Distribution of Adrenergic Nerve Fibres to the Blood Vessels in Skeletal Muscle

1965 • 412 citations

Suppression of Sympathetic Nervous System During Fasting

1977 • 395 citations

STUDIES ON THE CONDITIONS OF ACTIVITY IN ENDOCRINE GLANDS

1924 • 353 citations

Effect of Diet and Cold Exposure on Norepinephrine Turnover in Brown Adipose Tissue of the Rat

1982 • 348 citations

Stimulation of the sympathetic nervous system during sucrose feeding

1977 • 334 citations

Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus

1981 • 321 citations

Reduced thermogenesis in obesity

1979 • 296 citations

Plasma Norepinephrine and Epinephrine in Untreated Diabetics, During Fasting and After Insulin Administration

1974 • 288 citations

Role of Adrenaline and Noradrenaline in Chemical Regulation of Heat Production

1957 • 284 citations

Induction of Tyrosine Hydroxylase in Peripheral and Central Adrenergic Neurones by Cold-exposure of Rats

1970 • 260 citations

Central nervous system regulation of liver and adipose tissue metabolism

1981 • 256 citations

Foreword

2005 • 246 citations

Thermic effect of feeding in man: Increased plasma norepinephrine levels following glucose but not protein or fat consumption

1981 • 231 citations

Enhanced plasma norepinephrine response to upright posture and oral glucose administration in elderly human subjects

1980 • 222 citations

THE CALORIGENIC RESPONSE OF COLD-ACCLIMATED WHITE RATS TO INFUSED NORADRENALINE

1960 • 213 citations

Role of the Sympathetic Nervous System in the Control of Chemical Regulation of Heat Production

1957 • 207 citations

Nitrogen and Sodium Balance and Sympathetic-Nervous-System Activity in Obese Subjects Treated with a Low-Calorie Protein or Mixed Diet

1980 • 203 citations

Noradrenaline turnover during under- and over-eating in normal weight subjects

1982 • 196 citations

Role of catecholamines in hypotensive response to dieting.

1979 • 190 citations

Insulin acting as a modulator of feeding through the hypothalamus

1981 • 188 citations

Studies on catecholamine-containing granules of specific cells in cyclostome hearts.

1961 • 188 citations

Monoamines, pyrogens and cations: their actions on central control of bodytemperature.

1974 • 174 citations

Hypothalamic mechanisms in thermoregulation.

1981 • 168 citations

Epinephrine plasma thresholds for lipolytic effects in man: measurements of fatty acid transport with [l-13C]palmitic acid.

1981 • 165 citations

Epinephrine, Norepinephrine, Glucagon, and Growth Hormone Release in Association with Physiological Decrements in the Plasma Glucose Concentration in Normal and Diabetic Man*

1980 • 165 citations

Temperature Regulation

1975 • 165 citations

Stimulation of hypothalamic nuclei has differential effects on lipid synthesis in brown and white adipose tissue

1980 • 154 citations

Effects of Total Energy Withdrawal (Fasting) on the Levels of Growth Hormone, Thyrotropin, Cortisol, Adrenaline, Noradrenaline, T₄, T₃, and rT₃ in Healthy Males

1977 • 149 citations

Chamber cold acclimatization in man

1961 • 148 citations

A role for insulin in the diet-induced thermogenesis of cafeteria-fed rats

1981 • 147 citations

Catecholamine Metabolism in Primary Anorexia Nervosa

1979 • 145 citations

Blood circulation in adipose tissue

1979 • 143 citations

Neuroendocrine Aspects of Thermoregulation

1973 • 142 citations

Effect of diet and cold exposure on norepinephrine turnover in pancreas and liver.

1979 • 136 citations

Effect of dietary fat on sympathetic nervous system activity in the rat.

1983 • 135 citations

Autonomic nervous system and adaptation to cold in man

1975 • 134 citations

Essential role of catecholamines in the mobilization of free fatty acids and glucose after exposure to cold

1962 • 129 citations

Impaired Suppression of Sympathetic Activity during Fasting in the Gold Thioglucose-treated Mouse

1980 • 128 citations

Metabolic Acclimation to Cold in Man

1958 • 127 citations

Mesenteric vasoactivity associated with eating and digestion in the conscious dog

1970 • 125 citations

Antagonistic changes of blood flow and sympathetic activity in different vascular beds following central thermal stimulation

1970 • 116 citations

Increased plasma norepinephrine concentrations and metabolic rates following glucose ingestion in man

1980 • 113 citations

Adrenoceptors and catecholamine action

1981 • 111 citations

Fate of H³-noradrenaline in skeletal muscle before and following sympathetic stimulation

1963 • 105 citations

Systemic and Regional Hemodynamic Changes during Food Intake and Digestion in Nonanesthetized Dogs

1968 • 103 citations

Metabolic Origins of Thermogenesis induced by Diet

1968 • 103 citations

Compensatory cardiovascular responses during an environmental cold stress, 5 degrees C.

1970 • 99 citations

Sympathetic nervous control of brown adipose tissue and heat production in the new‐born rabbit.

1965 • 98 citations

Response of lipoprotein lipase in various tissues to cold exposure

1971 • 96 citations

Antagonistic changes of blood flow and sympathetic activity in different vascular beds following central thermal stimulation

1970 • 94 citations

Inhibition of Insulin Release in Infants Undergoing Deep Hypothermic Cardiovascular Surgery

1968 • 93 citations

Control of adipose tissue lipase activity by the sympathetic nervous system

1963 • 93 citations

Sympathoadrenal Activity in Fasting Pregnant Rats

1979 • 92 citations

Effects of 2-Deoxy-D-Glucose on the Cardiac Sympathetic Nerves and the Adrenal Medulla in the Rat: Further Evidence for a Dissociation of Sympathetic Nervous System and Adrenal Medullary Responses*

1982 • 89 citations

Starvation-Induced Decreased Sensitivity of Resting Metabolic Rate to Triiodothyronine

1979 • 88 citations

Regulation of Depressed Metabolism and Thermogenesis.

1977 • 87 citations

Responses of cold-acclimatized men to infused norepinephrine

1963 • 87 citations

Circulatory changes and renin secretion in sheep in response to feeding

1969 • 86 citations

STUDIES ON THE CONDITIONS OF ACTIVITY IN ENDOCRINE GLANDS

1927 • 84 citations

Regional differentiation of sympathetic activity during hypothalamic heating and cooling in anesthetized rabbits

1971 • 83 citations

The Cell Membrane Sodium Pump as a Mechanism for Increasing Thermogenesis During Cold Acclimation in Rats

1977 • 83 citations

Effects of Hypermetabolism on Ventilation and Chemosensitivity

1977 • 82 citations

Body temperature, shivering, blood pressure and heart rate during a standard cold stress in Australia and Antarctica

1966 • 82 citations

The central control of shivering and non‐shivering thermogenesis in the rat.

1978 • 80 citations

Cellular basis of direct insulin action in the central nervous system

1981 • 79 citations

The sympathetic nervous system as a homeostatic mechanism. I. Absolute need for sympathetic nervous function in body temperature maintenance of cold-exposed rats.

1967 • 79 citations

Coronary and visceral vasoactivity associated with eating and digestion in the conscious dog

1970 • 79 citations

An Analysis of the Current‐Voltage Relationship in Excitable Nitella Cells

1961 • 79 citations

Lipid metabolism during cold‐exposure and during cold‐acclimation

1972 • 78 citations

Visceral afferents and metabolic function.

1981 • 78 citations

The Effect of Fasting on the Hormonal Response to Graded Exercise*

1981 • 77 citations

Cardiovascular and endocrine responses to feeding in the young calf.

1975 • 75 citations

PHYSIOLOGICAL VARIATIONS IN THE CARDIAC OUTPUT OF MAN

1929 • 71 citations

Instantaneous changes of alpha-adrenoceptor affinity caused by moderate cooling in canine cutaneous veins

1978 • 71 citations

PARTICIPATION OF SKELETAL MUSCLE AND KIDNEY DURING NONSHIVERING THERMOGENESIS IN COLD-ACCLIMATED RATS

1963 • 70 citations

Comparison of microspheres and ⁸⁶Rb⁺ as tracers of the distribution of cardiac output in rats indicates invalidity of ⁸⁶Rb⁺-based measurements

1978 • 69 citations

Acceleration of noradrenaline turnover in the mouse heart by cold exposure

1965 • 69 citations

Visceral afferents and metabolic function

1981 • 69 citations

Acute effects of food, 2-deoxy-d-glucose and noradrenaline on metabolic rate and brown adipose tissue in normal and atropinised lean and obese (fa/fa) Zucker rats

1981 • 67 citations

Beta-receptor sensitization by repeated injections of isoproterenol and by cold adaptation

1972 • 63 citations

Rapid rise in plasma glucagon induced by acute cold exposure in man and rat

1981 • 62 citations

Catecholamine-fuel interrelationships during exercise in fasting men

1980 • 62 citations

Physiological effects of cold exposure.

1977 • 57 citations

Involvement of 3?,5?-cyclic adenosine monophosphate in the increase of tyrosine hydroxylase activity elicited by cold exposure

1973 • 57 citations

Responses of the Superficial Limb Veins of the Dog to Changes in Temperature

1968 • 55 citations

Hypothalamic thermoregulatory pathways in the rat

1977 • 53 citations

PHYSIOLOGICAL VARIATIONS IN THE CARDIAC OUTPUT OF MAN

1929 • 53 citations

Seasonal acclimatization to cold in man

1961 • 51 citations

Diet-induced changes in sympathoadrenal activity: Implications for thermogenesis

1981 • 51 citations

BIOCHEMICAL CHANGES IN EXPOSURE AND ACCLIMATION TO COLD ENVIRONMENTS*

1961 • 50 citations

Adrenergic mechanisms in the metabolic adaptation to fasting and feeding: Effects of phlorizin on diet-induced changes in sympathoadrenal activity in the rat

1980 • 48 citations

ADRENERGIC FIBERS IN BROWN FAT OF COLD-ACCLIMATED RATS

1970 • 46 citations

Changes in the Adrenergic Control and the Rate of Lipolysis of Isolated Human Adipose Tissue during Fasting and after Re‐feeding

1976 • 46 citations

Total Body and Splanchnic Thermogenesis in Curarized Man During a Short Exposure to Cold

1980 • 44 citations

Regulation of depressed metabolism and thermogenesis

1978 • 44 citations

EFFECT OF CATECHOLAMINE REPLACEMENT WITH LEVODOPA ON THE METABOLIC RESPONSE TO SEMISTARVATION

1979 • 43 citations

Initiation, duration and dissipation of diet-induced changes in sympathetic nervous system activity in the rat

1982 • 42 citations

In Vivo Observations on the Lipolytic Effect of Noradrenaline during Therapeutic Fasting*

1981 • 41 citations

Cardiovascular and metabolic responses to noradrenaline in man, before and after acclimatization to cold in Antarctica

1966 • 40 citations

Primary afferent input from cutaneous thermoreceptors.

1981 • 37 citations

Central processing of cutaneous temperature information.

1981 • 36 citations

Effect of chronic exposure to cold on some responses to catecholamines

1977 • 36 citations

Letters to the Editor: Urinary Excretion of Catecholamines in Fasting Obese Subjects

1967 • 36 citations

Release of noradrenaline from brown fat of cold-acclimated rats

1967 • 35 citations

Adrenergic β-Receptors and Non-shivering Thermogenesis

1966 • 34 citations

Effect of concomitant fasting and cold exposure on sympathoadrenal activity in rats

1981 • 31 citations

Effect of environmental temperature on hamster body fat composition

1964 • 30 citations

Increased calcium uptake by muscle mitochondria of cold-acclimated rats

1978 • 29 citations

Insulin secretion in hypothermic dogs

1967 • 29 citations

Impact of Age on Basal and Diet-Induced Changes in Sympathetic Nervous System Activity of Fischer Rats

1981 • 29 citations

Spinal cord thermosensitivity and sorting of neural signals in cold-exposed rats

1977 • 29 citations

The role of adrenoceptors in norepinephrine-stimulated VO2 in muscle

1977 • 29 citations

Effects of beta-adrenergic blockade on the heart rate and energy expenditure of sheep during feeding and during acute cold exposure

1968 • 28 citations

Contribution of skeletal muscle to nonshivering thermogenesis in the dog

1967 • 28 citations

Potassium‐induced increase in oxygen consumption of brown adipose tissue from the rat.

1975 • 28 citations

Plasma norepinephrine concentration during submaximal and maximal exercise at lowered skin and core temperatures

1979 • 28 citations

Neurophysiology of temperature regulation: problems and perspectives.

1981 • 27 citations

Effects of thyroid hormones and cold exposure on turnover of norepinephrine in cardiac and skeletal muscle

1977 • 27 citations

Alpha-adrenergic inhibition of immunoreactive insulin release during deep hypothermia

1971 • 26 citations

CHEMICAL THERMOGENESIS IN THE FUNCTIONALLY EVISCERATED COLD-ACCLIMATED RAT

1958 • 25 citations

Influence of sympathetic nerves on oxygen uptake or resting mammalian skeletal muscle,

1976 • 25 citations

The effect of fasting on the adrenergic receptor activity of human adipocytes.

1979 • 25 citations

Baroreflexive depression of oxygen consumption in the squirrel monkey at 10 degrees C

1977 • 25 citations

Effect of denervation on brown adipose tissue metabolism

1970 • 25 citations

Fat loss in the cold--a controlled study

1979 • 25 citations

Role of ketone bodies in nonshivering thermogenesis in cold-acclimated rats

1977 • 24 citations

Peripheral vascular response to norepinephrine at temperatures from 2 to 40 degrees C

1975 • 24 citations

Contribution of skeletal muscle to the regulatory non-shivering thermogenesis in small mammals

1981 • 23 citations

Ouabain-sensitive liver and diaphragm respiration in cold-acclimated hamster

1977 • 23 citations

THE CALORIGENIC RESPONSE OF COLD-ACCLIMATED WHITE RATS TO INFUSED NORADRENALINE

1960 • 23 citations

The Effect of Cold Exposure on the Catecholamine Excretion of Adrenalectomized Rats Treated with Reserpine

1963 • 22 citations

PERIPHERAL VASCULAR RESPONSES IN MAN DURING DIGESTION

1941 • 22 citations

Nonshivering thermogenesis and its endocrine control

1960 • 22 citations

Calorigenesis from various organ systems in the whole animal.

1960 • 21 citations

Effect of Environmental Temperature on Glucose-induced Insulin Response in the Newborn Rat

1976 • 21 citations

Modifications du taux de renouvellement de la noradr�naline dans diff�rents organes p�riph�riques du rat au cours de l'exposition et de l'acclimatation au froid

1972 • 20 citations

Calorigenic responses to cold of rats after prolonged infusion of norepinephrine

1971 • 20 citations

Free fatty acid turnover and oxygen consumption. Effects of noradrenaline in nonfasted and nonanesthetized cold-adapted rats

1980 • 19 citations

Hypothalamic substances in the control of body temperature: general characteristics.

1981 • 19 citations

The calorigenic action of catecholamines in warm acclimated and cold acclimated non-shivering cats

1964 • 18 citations

The Rôle of Adrenal Secretion in the Chemical Control of Body Temperature

1924 • 18 citations

Norepinephrine turnover in heart and spleen of 7-, 22-, and 34 degree C-acclimated hamsters

1976 • 17 citations

Vasomotor thresholds in the squirrel monkey: effects of central and peripheral temperature

1980 • 17 citations

INCREASED VAGAL ACTIVITY IN COLD-ADAPTED ANIMALS

1967 • 17 citations

alpha-Stimulation protects exercise increment in skeletal muscle oxygen consumption

1980 • 17 citations

Catecholamines in dogs during cold adaptation by repeated immersions

1979 • 16 citations

Norepinephrine turnover in lung: effect of cold exposure and chronic hypoxia

1981 • 15 citations

Catecholamine Excretion in Adreno‐Demedullated Rats Exposed to Gold after Chronic Guanethidine Treatment

1966 • 14 citations

Morphological studies on denervated brown adipose tissue

1974 • 13 citations

Effects of alpha- and beta-adrenergic blockers on the actions of noradrenaline on body temperature in the newborn guinea-pig

1977 • 13 citations

Effect of cold and epinephrine on glucose kinetics in dogs

1977 • 12 citations

Changes in the Adenyl Cyclase System of Skeletal Muscle of Cold-Acclimated Rats

1974 • 11 citations

Evolution in vivo of the synthesis rate of catecholamines in various peripheral organs of the rat during cold exposure

1976 • 11 citations

Effect of Ambient Temperature and Dietary Amino Acids on Carcass Fat Deposition in Rats

1969 • 10 citations

Vergleich zwischen der Wirkung von Fett, Kohlenhydrat und Eiweiß auf den Kreislauf des Menschen¹

1932 • 10 citations

Creatine metabolism in skeletal muscle of cold-acclimated rats

1978 • 10 citations

Effect of sympathectomy on heat production in rats exposed to cold.

1976 • 8 citations

Microvascular responses to norepinephrine in skeletal muscle of cold-acclimated rats

1978 • 8 citations

Catecholamines in acclimation to cold: historical survey.

1963 • 7 citations

Newer putative central neurotransmitters: roles in thermoregulation. Hypothalamic substances in the control of body temperature: general characteristics

1981 • 6 citations

Catecholamine-synthesizing enzymes in adrenals of seasonally acclimatized voles

1978 • 6 citations

Tolerance to cold and glucose homeostasis in adrenal demedullated dogs

1977 • 5 citations

Effect of chemical sympathectomy on oxygen consumption by the cold-exposed rat

1965 • 5 citations

Influence of cold exposure on catecholamine depleting actions of hydroxylase inhibitors

1968 • 5 citations

Effect of epinephrine upon irreversible disposal and recycling of glucose in dogs

1977 • 4 citations

The effect of elevated temperature on the retention of 3H-norepinephrine in the hearts of normal and thyroidectomized rats

1968 • 4 citations