Central nervous system regulation of liver and adipose tissue metabolism

Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis.

1979 • 1,145 citations

Neural control of the endocrine pancreas.

1974 • 630 citations

Identification of the Ca²⁺‐dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase

1978 • 619 citations

Food intake and chemical senses

1977 • 430 citations

Regulation of Pancreatic Insulin and Glucagon Secretion

1976 • 329 citations

AFFERENT IMPULSE DISCHARGES FROM GLUCORECEPTORS IN THE LIVER OF THE GUINEA PIG

1969 • 303 citations

Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels

1971 • 291 citations

Plasma glucose, non-esterified fatty acid and insulin concentrations in hypothalamic-hyperphagic rats

1964 • 285 citations

Acute Hyperinsulinemia and Its Reversal by Vagotomy after Lesions of the Ventromedial Hypothalamus in Anesthetized Rats*

1979 • 266 citations

Nervous Regulation of Food Intake

1961 • 237 citations

Reciprocal Influences of the Ventromedial and Lateral Hypothalamic Nuclei on Blood Glucose Level and Liver Glycogen Content

1966 • 236 citations

Hormonal and ionic control of the glycogenolytic cascade in rat liver

1977 • 198 citations

The Effects of Subdiaphragmatic Vagotomy in Rats With Ventromedial Hypothalamic Obesity

1977 • 187 citations

Adipose Tissue: Ability to Respond to Nerve Stimulation in vitro

1963 • 187 citations

Hypothalamic influence on insulin and glucagon release in the rat.

1977 • 181 citations

Regulation of glycogen metabolism in liver by the autonomic nervous system II. Neural control of glycogenolytic enzymes

1968 • 178 citations

Sensory functions of the liver--a review

1979 • 164 citations

Influences of hepatic portal receptors on hypothalamic feeding and satiety centers

1973 • 161 citations

Plasma insulin and triglyceride levels after hypothalamic lesions in weanling rats

1969 • 157 citations

Stimulation of hypothalamic nuclei has differential effects on lipid synthesis in brown and white adipose tissue

1980 • 154 citations

Effects of hypothalamic stimulation on gluconeogenesis and glycolysis in rat liver

1975 • 153 citations

Glycogen Synthetase Activity in Liver: Regulation by the Autonomic Nerves

1967 • 143 citations

Hepatocyte innervation in primates.

1977 • 142 citations

Ventromedial hypothalamus modulates fat mobilisation during fasting

1978 • 137 citations

Increased Activities of Glycogenolytic Enzymes in Liver after Splanchnic-Nerve Stimulation

1965 • 135 citations

Ventromedial Hypothalamic Lesions and the Mobilization of Fatty Acids

1978 • 134 citations

Correlation between Hyperinsulinemia and Hyperphagia in Rats with Ventromedial Hypothalamic Lesions

1972 • 134 citations

Hyperinsulinemia in tube-fed hypophysectomized rats bearing hypothalamic lesions

1970 • 126 citations

Mechanisms involved in alpha-adrenergic phenomena: role of calcium ions in actions of catecholamines in liver and other tissues

1980 • 118 citations

Regulation of glycogen metabolism in liver by the autonomic nervous systemV. Activation of glycogen synthetase by vagal stimulation

1971 • 117 citations

Regulation of glucogen metabolism in liver by the autonomic nervous system VI. Possible mechanism of phosphorylase activation by the splanchnic nerve

1975 • 115 citations

Transplantation of pancreatic beta-cells prevents development of hypothalamic obesity in rats.

1978 • 111 citations

The effect of isotonic glucose on eating as a function of feeding condition and infusion site

1974 • 111 citations

Regulation of glycogen metabolism in liver by the autonomic nervous system III. Differential effects of sympathetic-nerve stimulation and of catecholamines on liver phosphorylase

1968 • 89 citations

Central mechanism of feeding.

1973 • 81 citations

Cholinergic Stimulation of the Rat Hypothalamus: Effects of Liver Glycogen Synthesis

1976 • 80 citations

Stimulus-Response Coupling at α-Adrenergic Receptors

1978 • 78 citations

The Septo-Preoptico-Hypothalamic System and its Autonomic Function

1966 • 77 citations

Regulation of glycogen metabolism in liver by the autonomic nervous systemIV. Neural control of glycogen biosynthesis

1971 • 75 citations

Origin of endocrine‐metabolic changes in the weanling rat ventromedial syndrome

1976 • 74 citations

The hyperglycaemic response to stimulation of the hepatic sympathetic innervation in adrenalectomized cats and dogs

1972 • 73 citations

Factors modifying carbohydrate metabolism and effect of insulin in perfused rat liver

1971 • 70 citations

The glycogenolytic response to stimulation of the splanchnic nerves in adrenalectomized calves

1970 • 69 citations

Criteria for differentiation of brown and white fat in the rat

1969 • 62 citations

Effects of adrenergic blocking agents on lipid mobilization from canine subcutaneous adipose tissue after sympathetic nerve stimulation.

1968 • 60 citations

Mechanism of lipolysis induced by electrical stimulation of the hypothalamus in the rabbit

1976 • 60 citations

Studies on the effects of insulin and acetylcholine on activation of glycogen synthase and on glycogenesis in hepatocytes isolated from normal fed rats

1974 • 59 citations

Inactivation of phosphorylase phosphatase by a factor from rabbit liver and its chemical characterization as glutathione disulfide.

1978 • 57 citations

LIPID METABOLISM IN WARM-ACCLIMATED AND COLD-ACCLIMATED RATS EXPOSED TO COLD

1965 • 57 citations

Some observations on the nerve terminal on the liver parenchymal cell of the mouse as revealed by electron microscopy

1965 • 53 citations

Fiber connections in the hypothalamus and some autonomic functions.

1975 • 53 citations

Regulation of liver phosphorylase phosphatase by glutathione disulfide.

1980 • 51 citations

Sympathetic nervous control of adipose tissue lipolysis

1968 • 45 citations

alpha-Sympathetic control of glucose output of mouse liver perfused in situ.

1979 • 45 citations

Hypothalamic control of liver glycogen metabolism in adult and aged rats

1978 • 45 citations

Cholinergic regulation of hepatic tyrosine transaminase activity

1971 • 44 citations

The sensitivity of the hepatic glycogenolytic mechanism to stimulation of the splanchnic nerves

1972 • 43 citations

Chemical coding of the hypothalamic neurones in metabolic control. II. Norepinephrine-sensitive neurones and glycogen breakdown in liver

1980 • 36 citations

Nervous control of peripheral metabolism.

1979 • 36 citations

The effect of electric stimulation of hypothalamus on rabbit liver tryptophan pyrrolase

1962 • 35 citations

Vagal and splanchnic effects at the level of the ventromedian nucleus of the hypothalamus (VMH) in the cat

1980 • 32 citations

The α-adrenergic control of rabbit liver glycogenolysis

1979 • 30 citations

Anorexia produced by Direct-current Blockade of the Vagus Nerve

1963 • 28 citations

A central nervous system component of epinephrine hyperglycemia

1962 • 27 citations

Chemical coding of the hypothalamic neurones in metabolic control. I. Acetylcholine-sensitive neurones and glycogen synthesis in liver

1979 • 23 citations

RELEASE OF GLUCOSE FROM PERFUSED LIVER PREPARATION IN RESPONSE TO STIMULATION OF THE SPLANCHNIC NERVES IN THE TOAD

1973 • 23 citations

Effect of Acetylcholine on Glycogen Formation and the Activity of Glycogen Synthetase in Isolated, Perfused Rat Liver

1971 • 23 citations

Role of the Hypothalamus in the Induction of Tryptophan Pyrrolase Activity in Rabbit Liver<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1964 • 22 citations

Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats—I

1976 • 18 citations

Paradoxical increased feeding following glucose infusions in recovered lateral rats

1976 • 17 citations

Effect of high spinal cord section on epinephrine hyperglycemia

1968 • 16 citations

Epinephrine: a mediator of plasma glycerol elevation by hypothalamic stimulation.

1977 • 13 citations

[Control mechanism of feeding].

1969 • 6 citations

ROLE OF THE NOREPINEPHRINE- AND ACETYLCHOLINE-SENSITIVE NEURONS OF THE HYPOTHALAMUS IN THE REGULATION OF HEPATIC METABOLISM

1979 • 4 citations

Hypothalamic control of endocrine pancreas

1979 • 4 citations

Effect of a bovine hypothalamic extract on glucose utilization by rat adipocytes.

1978 • 3 citations