Pharmacogenetic aspects of psychoactive drugs: Facts and fancy

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

The Pharmacological Basis of Therapeutics

1971 • 1,765 citations

THE PHARMACOLOGICAL BASIS OF THERAPEUTICS

1967 • 1,039 citations

Alcohol Problems in Adoptees Raised Apart From Alcoholic Biological Parents

1973 • 895 citations

Huntington's Chorea

1973 • 845 citations

Genetic Control of Isoniazid Metabolism in Man

1960 • 792 citations

A Survey of Drug-Induced Extrapyramidal Reactions

1961 • 756 citations

DRUG REACTIONS, ENZYMES, AND BIOCHEMICAL GENETICS

1957 • 437 citations

Moderne Probleme der Humangenetik

1959 • 391 citations

Grundlagen der Pharmakokinetik

1968 • 377 citations

Ethnic Differences in Alcohol Sensitivity

1972 • 373 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

FACTORS AFFECTING DRUG METABOLISM

1971 • 342 citations

PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSE

1972 • 263 citations

Biological Basis of Alcoholism

1972 • 241 citations

Pharmacogenetics. Heredity and the Response to Drugs.

1963 • 233 citations

Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man

1969 • 224 citations

The genetic basis of the normal human electroencephalogram (EEG)

1970 • 223 citations

Genetic and environmental factors affecting ethanol metabolism in man

1971 • 207 citations

Genetic Control of Platelet and Plasma Monoamine Oxidase Activity

1973 • 204 citations

Correlation of Subjective Side Effects with Plasma Concentrations of Nortriptyline

1970 • 203 citations

Average heterozygosity per locus in man: an estimate based on the incidence of enzyme polymorphisms

1972 • 185 citations

Insufficient parahydroxylation as a cause of diphenylhydantoin toxicity

1964 • 184 citations

PLASMA-NORTRIPTYLINE LEVELS IN ENDOGENOUS DEPRESSION

1973 • 172 citations

DIFFERENTIATION OF TWO GENETICALLY SPECIFIC TYPES OF DEPRESSION BY THE RESPONSE TO ANTI-DEPRESSANTS

1962 • 165 citations

Brain Sensitivity to Alcohol in Inbred Mouse Strains

1966 • 162 citations

Drugs and behaviour

2005 • 162 citations

Alcoholism IV: is There More Than One Type of Alcoholism?

1971 • 161 citations

Reduced Plasma Dopamine-β-Hydroxylase Activity in Familial Dysautonomia

1971 • 158 citations

Vasomotor sensitivity to alcohol in diverse Mongoloid populations.

1973 • 157 citations

Ethanol Metabolism in Various Racial Groups

1976 • 125 citations

Biological Sciences: Human Brain Monoamine Oxidase: Multiple Forms and Selective Inhibitors

1972 • 121 citations

Pharmacokinetics of desmethylimipramine and nortriptyline in man after single and multiple oral doses ? A cross-over study

1972 • 112 citations

BIOCHEMICAL AND GENETIC FACTORS REGULATING DILANTIN METABOLISM IN MAN*

1971 • 109 citations

PSYCHOTROPIC EFFECTS OF CAFFEINE IN MAN. I. INDIVIDUAL DIFFERENCES IN SENSITIVITY TO CAFFEINE-INDUCED WAKEFULNESS.

1965 • 107 citations

Factors Affecting Chlorpromazine Plasma Levels in Psychiatric Patients

1970 • 106 citations

Differentiation of two genetically specific types of depression by the response to antidepressant drugs.

1971 • 103 citations

A clinical analysis of the effects of tofranil in depression

1961 • 100 citations

Genetic control of plasma dopamine- β -hydroxylase

1973 • 97 citations

The influence of acetylator phenotype on the effects of treating depression with phenelzine

1965 • 95 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

Genetic control of nortriptyline kinetics in man: a study of relatives of propositi with high plasma concentrations.

1971 • 86 citations

A familial factor in minimal brain dysfunction

1973 • 85 citations

Ethanol metabolism in subiects possessing typical and atypical liver alcohol dehydrogenase

1967 • 84 citations

ACETYLATOR STATUS AND RESPONSE TO PHENELZINE IN DEPRESSED PATIENTS

1973 • 82 citations

�ber die Erbbedingtheit der intraindividuellen Konstanz der Isoniazidausscheidung beim Menschen (Untersuchungen an eineiigen und zweieiigen Zwillingen)

1957 • 78 citations

MEASUREMENT OF PLEIOTROPIC EFFECTS IN PHENYLKETONURIA

1951 • 77 citations

Induction of Abortion by Extra-amniotic Administration of Prostaglandins E2 and F2

1972 • 76 citations

PREDICTIVE TEST FOR HUNTINGTON'S CHOREA

1970 • 75 citations

Pharmacogenetics: Heredity and the Response to Drugs.

1963 • 74 citations

Plasma levels of chlorpromazine and some of its relatively non-polar metabolites in psychiatric patients

1968 • 67 citations

INHERITANCE OF ALCOHOLISM Its Association with Colour-blindness

1966 • 67 citations

Acute effects of diphenylhydantoin in relation to plasma levels: Behavioural and psychophysiological studies

1972 • 62 citations

Pharmacokinetics of Drug Action

1972 • 61 citations

A Pharmacokinetic Approach to the Treatment of Depression

1971 • 57 citations

The Metabolic Fate of Drugs

1964 • 56 citations

Ethyl alcohol: Blood levels and performance decrements after oral administration to man

1971 • 54 citations

INDIVIDUAL DIFFERENCES IN THE PHARMACOKINETICS OF MONOMETHYLATED TRICYCLIC ANTIDEPRESSANTS: ROLE OF GENETIC AND ENVIRONMENTAL FACTORS AND CLINICAL IMPORTANCE*

1971 • 52 citations

Time relations of the effects of alcohol compared to placebo

1968 • 52 citations

Hereditary Predisposition in Drug-Induced Parkinsonism

1962 • 52 citations

Die Bedeutung von Kumulation und Elimination für die Dosierung von Phenytoin (Diphenylhydantoin)

1969 • 51 citations

Acute enhancement of dopamine-?-hydroxylase activity in human plasma after maximum work load

1973 • 51 citations

Drug Plasma Levels and Clinical Effect [Abridged]

1971 • 48 citations

Wakefulness caused by caffeine

1964 • 44 citations

Advances in pharmacogenetics.

1973 • 44 citations

A Pharmacokinetic Approach to the Treatment of Depression

1972 • 43 citations

Toxicology and the Biomedical Sciences

1965 • 42 citations

Pharmacokinetics and Biological Effects of Nortriptyline in Man

1971 • 39 citations

Phenothiazines: Metabolism and Analytical Detection

1972 • 38 citations

ETHANOL CONSUMPTION AND PREFERENCE IN MICE: A GENETIC ANALYSIS

1972 • 38 citations

Drug Plasma Levels and Clinical Effect [Abridged]

1971 • 35 citations

FAMILY HISTORY AND HALF‐SIBLING RESEARCH IN ALCOHOLISM*

1972 • 35 citations

Electroencephalographic changes in man during use and withdrawal of barbiturates in moderate dosage

1958 • 34 citations

Clinical and Metabolic Studies with Imipramine in Man

1971 • 34 citations

GENETICS AS A TOOL IN ALCOHOL RESEARCH

1972 • 33 citations

Kinetics of Meprobamate Elimination in Humans

1964 • 30 citations

Some pharmacological consequences of species variation in rates of metabolism.

1967 • 29 citations

Experimentelle Untersuchungen zur Abhängigkeit der Wirkung psychotroper Substanzen von Persönlichkeitsmerkmalen

1964 • 28 citations

PHARMACOKINETIC ASPECTS OF DRUG METABOLISM

1971 • 28 citations

Genetic and environmental factors affecting drug response in man.

1972 • 27 citations

A BIOCHEMICAL AND GENETIC APPROACH TO ALCOHOLISM

1972 • 26 citations

The 4–5 c/sec rhythm

1969 • 25 citations

[An unusual syndrome in the oral region caused by administration of megaphen].

1956 • 21 citations

The Biochemical Bases of Psychoses or The Serotonin Hypothesis about Mental Diseases

1963 • 17 citations

N-Acetyl-transferase and Serotonin Metabolism in Man and, other Species, I

1969 • 17 citations

Inter-patient variation in chlorpromazine metabolism.

1965 • 16 citations

Objective effects of dexamphetamine and amobarbital and their relations to psychasthenic personality traits

1970 • 14 citations

Interpatient variation and significance of plasma levels of chlorpromazine in psychotic patients.

1972 • 14 citations

The determination and possible significance of plasma levels of chlorpromazine in psychiatric patients.

1968 • 13 citations

Chlorpromazine Metabolism II: Determination of Nonconjugated Metabolites in Blood of Schizophrenie Patients

1972 • 13 citations

ALTERED DRUG RESPONSE IN FAMILIAL DYSAUTONOMIA

1968 • 13 citations

Experimental pharmacogenetics : physiopathology of heredity and pharmacologic responses

1963 • 12 citations

GENETIC APPROACHES TO THE SYNDROME OF MINIMAL BRAIN DYSFUNCTION*

1973 • 12 citations

Y. Israel u. J. Mardones: Biological Basis of Alcoholism. 453 Seiten, Wiley‐Interscience, a Division of John Wiley & Sons, Inc. New York, London, Sidney, Toronto 1971. Preis: 9,50 £

1973 • 12 citations

Acetylation of serotonin in vitro by a human N-acetyltransferase

1969 • 12 citations

Chlorpromazine Metabolism V: Disposition of Free and Conjugated Metabolites in Blood Fractions of Schizophrenic Patients

1972 • 11 citations

X-BORNE RECESSIVE GENES IN ALCOHOLISM

1967 • 11 citations

DEFINITIONS OF ALCOHOLISM AND GENETIC RESEARCH

1972 • 10 citations

MOLECULAR MODELS FOR PHARMACOLOGICAL TOLERANCE AND ADDICTION*

1971 • 8 citations

Pneumococcal Vaccine

1971 • 6 citations

PERSONALITY DIFFERENCES IN THE RESPONSE TO STIMULANT DRUGS ADMINISTERED DURING A SLEEP-DEPRIVED STATE

1970 • 5 citations

Book Review: The Biochemical Bases of Psychoses or the Serotonin Hypothesis about Mental Diseases

1963 • 5 citations

Disposition zur neuroleptischen Schwelle

1968 • 5 citations

PERSONALITY AND REACTIVITY TO STIMULANTS AND DEPRESSANTS

1972 • 4 citations

On the forensic-psychiatric significance of alcohol loading tests under EEG control.

1971 • 2 citations

Morphine adaptation, hexobarbital, alcoholism general remarks

1970 • 1 citations