Drug Plasma Levels and Clinical Effect [Abridged]

A RATING SCALE FOR DEPRESSION

1960 • 30,921 citations

The Diagnosis of Depressive Syndromes and the Prediction of E.C.T. Response

1965 • 933 citations

Genetic Control of Isoniazid Metabolism in Man

1960 • 792 citations

Effect of Psychotropic Drugs on the Uptake of H ³ -Norepinephrine by Tissues

1961 • 365 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds

1967 • 266 citations

SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).

1964 • 234 citations

Time-out from Positive Reinforcement

1961 • 233 citations

ON THE MECHANISM OF ANTIDEPRESSANT ACTION OF IMIPRAMINELIKE DRUGS

1962 • 168 citations

Plasma Levels of Imipramine and Desmethylimipramine during Therapy

1967 • 137 citations

ABSORPTION AND DISTRIBUTION OF DRUGS

1963 • 123 citations

Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil)

1961 • 113 citations

The total fate of a drug: kinetics of distribution, excretion, and formation of 14 metabolites in rats treated with imipramine.

1968 • 71 citations

A comparative study of the metabolism of desmethylimipramine, nortriptyline, and oxyphenylbutazone in man

1969 • 69 citations

Buccal absorption and other properties of pharmacokinetic importance of imipramine and its metabolites

1969 • 52 citations

Aspects of the Clinical Chemistry of Desmethylimipramine in Man

1963 • 49 citations

Pharmacogenetics

1963 • 46 citations

Imperfection: Biochemical Phobias and Metabolic Ambivalence

1959 • 40 citations

INDIVIDUAL VARIATIONS OF DRUG METABOLISM AS A FACTOR IN DRUG TOXICITY

1965 • 35 citations

PLASMA IMIPRAMINE LEVEL IN SYNDROMES OF DEPRESSION

1962 • 26 citations

Seven fatal cases involving imipramine in man

1964 • 21 citations

Comparison of the Effect of Imipramine and Desipramine on Some Symptoms of Depressive Illness

1965 • 19 citations

Methylation of desmethylimipramine by rabbit lung in vitro

1966 • 19 citations

Metabolism of the psychopharmacological agent tofranil

1960 • 18 citations

[EFFECT OF ANTIDEPRESSIVES AND GENETIC FACTORS].

1964 • 16 citations

[QUANTITATIVE METHODS FOR STUDYING THE METABOLISM OF TOFRANIL].

1963 • 11 citations

Treatment of Depression

1967 • 9 citations

[Activity of expired carbon dioxide, CNS and other organs after the administration of C14-labelled N-(gamma-dimethyl-aminopropyl)-iminodibenzyl (psychopharmacological drug Tofranil) to rats and dogs].

1962 • 2 citations

The Correlation Between Side-effects and Therapeutic Response to Antidepressant Drugs

1970 • 1 citations