T-cell antigenic sites of the malaria circumsporozoite protein

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

γ Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites

1987 • 699 citations

Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites

1987 • 512 citations

CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.

1988 • 477 citations

Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection.

1980 • 439 citations

The Immune Response Genes of the Major Histocompatibility Complex

1978 • 382 citations

Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes.

1983 • 311 citations

Construction of Synthetic Immunogen: Use of New T-Helper Epitope on Malaria Circumsporozoite Protein

1987 • 270 citations

Expression of Plasmodium falciparum Circumsporozoite Proteins in Escherichia coli for Potential Use in a Human Malaria Vaccine

1985 • 210 citations

Naturally Acquired Antibodies to Sporozoites Do Not Prevent Malaria: Vaccine Development Implications

1987 • 209 citations

Specificity of protection of man immunized against sporozoite-induced falciparum malaria

1973 • 201 citations

Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine.

1986 • 181 citations

Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria.

1979 • 160 citations

The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines.

1986 • 142 citations

Protein Antigenic Structures Recognized by T Cells; Potential Applications to Vaccine Design

1987 • 139 citations

Sequence variation in putative functional domains of the circumsporozoite protein of Plasmodium falciparum. Implications for vaccine development.

1987 • 111 citations

Immunity to sporozoite-induced malaria infeciton in mice. I. The effect of immunization of T and B cell-deficient mice.

1977 • 109 citations

A synthetic peptide induces long-term protection from lethal infection with herpes simplex virus 2.

1987 • 100 citations

Association between human serum-induced crisis forms in cultured Plasmodium falciparum and clinical immunity to malaria in Sudan

1983 • 85 citations

Strain variation in the circumsporozoite protein gene of Plasmodium falciparum

1987 • 80 citations

Epitopes recognized by human t lymphocytes on malaria circumsporozoite protein

1988 • 74 citations

The real difficulties for malaria sporozoite vaccine development: nonresponsiveness and antigenic variation

1988 • 63 citations

Human T cell recognition of polymorphic epitopes from malaria circumsporozoite protein.

1989 • 59 citations

Cellular mechanisms involved in recovery from acute malaria in Gambian children

1986 • 52 citations

Role of T cells in preventing transmission of rodent malaria.

1985 • 47 citations

Circumsporozoite gene of a Plasmodium falciparum strain from Thailand

1987 • 45 citations

Lack of cross-reactivity between variant T cell determinants from malaria circumsporozoite protein.

1988 • 42 citations

Human and murine CD4 T cell epitopes map to the same region of the malaria circumsporozoite protein: limited immunogenicity of sporozoites and circumsporozoite protein.

1988 • 23 citations