Central Cholinergic Transmission: The Physiological Evidence

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Nerve, Muscle and Synapse

1966 • 1,431 citations

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

1980 • 1,423 citations

An analysis of the end‐plate potential recorded with an intra‐cellular electrode

1951 • 1,389 citations

Cholinergic and inhibitory synapses in a pathway from motor‐axon collaterals to motoneurones

1954 • 1,172 citations

THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS

1967 • 1,116 citations

Voltage-clamp analysis of muscarinic excitation in hippocampal neurons

1982 • 1,061 citations

The statistical nature of the acetylcholine potential and its molecular components

1972 • 960 citations

Chemical transmission in invertebrate central nervous systems and neuromuscular junctions.

1973 • 823 citations

The organization and some projections of cholinergic neurons of the mammalian forebrain

1982 • 821 citations

A patch‐clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine.

1982 • 820 citations

The mechanism of excitation by acetylcholine in the cerebral cortex

1971 • 698 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

Iontophoretic studies of neurones in the mammalian cerebral cortex

1963 • 659 citations

Cholinergic Mechanisms

1981 • 609 citations

THE ACTION OF CERTAIN ESTERS AND ETHERS OF CHOLINE, AND THEIR RELATION TO MUSCARINE

1914 • 604 citations

Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry

1984 • 586 citations

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis

1984 • 576 citations

ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION

1961 • 552 citations

Confirmation from choline acetylase analyses of a massive cholinergic innervation to the rat hippocampus

1967 • 469 citations

CENTRAL EFFECTS OF CENTRIPETAL IMPULSES IN AXONS OF SPINAL VENTRAL ROOTS

1946 • 434 citations

Acetylcholine‐sensitive cells in the cerebral cortex

1963 • 416 citations

Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells.

1985 • 415 citations

Neurochemical characteristics of early and late onset types of Alzheimer's disease.

1984 • 411 citations

The physiology of nerve cells

1975 • 410 citations

Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in alzheimer's disease

1985 • 407 citations

Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance

1986 • 391 citations

Cholinergic modulation of the functional organization of the cat visual cortex

1983 • 387 citations

The spontaneous and evoked release of acetylcholine from the cerebral cortex

1963 • 386 citations

The shape and arrangement of the cholinergic neurons in the rabbit retina

1984 • 382 citations

The Physiology of Nerve Cells

1957 • 380 citations

Acetylcholine Mediates a Slow Synaptic Potential in Hippocampal Pyramidal Cells

1983 • 378 citations

Cholinesterase-Containing Systems of the Brain of the Rat

1963 • 356 citations

Characterization of a slow cholinergic post‐synaptic potential recorded in vitro from rat hippocampal pyramidal cells.

1984 • 354 citations

Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro.

1987 • 353 citations

ACTIVE PHASE OF FROG'S END-PLATE POTENTIAL

1959 • 348 citations

Cholinergic excitation of mammalian hippocampal pyramidal cells

1982 • 328 citations

Pharmacological properties of acetylcholine‐sensitive cells in the cerebral cortex

1963 • 321 citations

BIOCHEMICAL STUDIES ON MUSCARINIC ACETYLCHOLINE RECEPTORS

1976 • 314 citations

Slow conductances in neurons from cat sensorimotor cortex in vitro and their role in slow excitability changes

1988 • 313 citations

Recurrent inhibition of interneurones monosynaptically activated from group Ia afferents

1971 • 312 citations

Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine

1985 • 305 citations

Two types of muscarinic response to acetylcholine in mammalian cortical neurons.

1985 • 302 citations

Cholinergic and non-cholinergic septohippocampal pathways

1985 • 297 citations

Autoradiographic identification of acetylcholine in the rabbit retina.

1979 • 286 citations

‘Starburst’ amacrine cells and cholinergic neurons: mirror-symmetric ON and OFF amacrine cells of rabbit retina

1983 • 285 citations

Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons.

1987 • 285 citations

Pharmacological analysis of directionally sensitive rabbit retinal ganglion cells

1982 • 282 citations

The distribution of acetylcholine in the peripheral and the central nervous system

1941 • 280 citations

Responses to acetylcholine of ganglion cells in an isolated mammalian retina

1976 • 260 citations

The excitatory action of acetylcholine on hippocampal neurones of the guinea pig and rat maintained in vitro

1981 • 244 citations

Microcircuitry of the Cat Retina

1983 • 241 citations

Pharmacological investigations on a central synapse operated by acetylcholine

1956 • 239 citations

Synaptic excitation and inhibition resulting from direct action of acetylcholine on two types of chemoreceptors on individual amphibian parasympathetic neurones

1977 • 233 citations

Muscles and their neural control

1983 • 228 citations

The excitation of Renshaw cells by pharmacological agents applied electrophoretically

1958 • 228 citations

Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus

1978 • 223 citations

Acetylcholine receptor kinetics

1981 • 223 citations

Muscles and Their Neural Control

1984 • 221 citations

Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons

1986 • 219 citations

Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors

1981 • 219 citations

Intracellular observations on the disinhibitory action of acetylcholine in the hippocampus

1981 • 215 citations

PRESENT VIEWS ON THE MODE OF ACTION OF ACETYLCHOLINE IN THE CENTRAL NERVOUS SYSTEM

1945 • 210 citations

Cholinergic synapses in the rat brain: a correlated light and electron microscopic immunohistochemical study employing a monoclonal antibody against choline acetyltransferase

1984 • 208 citations

The pharmacology of cholinergic excitatory responses in hippocampal pyramidal cells

1984 • 206 citations

Effects of acetylcholine and cyclic GMP on input resistance of cortical neurons in awake cats

1978 • 206 citations

Effects of acetylcholine and other medullary secretagogues and antagonists on the membrane potential of adrenal chromaffin cells: an analysis employing techniques of tissue culture

1967 • 202 citations

On the negative inotropic effect in the cat's auricle

1953 • 202 citations

Synaptic events in sympathetic ganglia

1978 • 202 citations

The functions of acetylcholine in the rabbit retina

1984 • 201 citations

Individual cells in the nucleus basalis-diagonal band complex have restricted axonal projections to the cerebral cortex in the rat

1983 • 199 citations

A histochemical study of cholinergic fibres in the cerebral cortex.

1965 • 198 citations

Acetylcholine hyperpolarizes central neurones by acting on an M2 muscarinic receptor

1986 • 196 citations

Biochemical Evidence for the Neural Function of Acetylcholine

1957 • 193 citations

Acetylcholine-synthesizing amacrine cells: identification and selective staining by using radioautography and fluorescent markers

1984 • 186 citations

On and off pathways through amacrine cells in mammalian retina: The synaptic connections of “starburst” amacrine cells

1983 • 183 citations

Acetylcholine raises excitability by inhibiting the fast transient potassium current in cultured hippocampal neurons.

1986 • 181 citations

The cholinergic innervation of the rat fascia dentata: Identification of target structures on granule cells by combining choline acetyltransferase immunocytochemistry and Golgi impregnation

1986 • 181 citations

NEUROTRANSMITTER SYSTEMS IN THE RETINA

1982 • 176 citations

The pharmacological properties of some crustacean neuronal acetylcholine, gamma‐aminobutyric acid, and L‐glutamate responses.

1978 • 174 citations

The cholinergic influence on the function of the cat dorsal lateral geniculate nucleus (dLGN)

1983 • 169 citations

Electrophysiological and pharmacological characteristics of facilitation of hippocampal population spikes by stimulation of the medial septum

1982 • 160 citations

Cholinergic disinhibition in hippocampal slices of the rat

1982 • 158 citations

The acetylcholine receptors of Renshaw cells

1966 • 157 citations

Effects of cholinergic drugs on receptive field properties of rabbit retinal ganglion cells

1982 • 154 citations

Disinhibitory action of acetylcholine in the rat's hippocampus: Extracellular observations

1981 • 151 citations

Multiple actions of acetylcholine at a muscarinic receptor studied in the rat hippocampal slice

1982 • 150 citations

The synaptic excitation of Renshaw cells

1966 • 150 citations

Acetylcholine permits long-term enhancement of neuronal responsiveness in cat primary somatosensory cortex

1987 • 147 citations

Cholinergic and non-cholinergic septo-hippocampal projections: a double-label horseradish peroxidase-acetylcholinesterase study in the rabbit

1984 • 146 citations

Muscarine affects calcium-currents in rat hippocampal pyramidal cells in vitro

1987 • 144 citations

Effect of Undercutting on the Acetylcholinesterase and Choline Acetyltransferase Activity in the Cat's Cerebral Cortex

1963 • 142 citations

Inhibitory effects of acetylcholine on neurones in the feline nucleus reticularis thalami.

1976 • 139 citations

Electrophysiological investigations on Renshaw cells

1961 • 138 citations

Rat hippocampal neurons in culture: responses to electrical and chemical stimuli

1983 • 138 citations

Cholinergic mechanisms in the rat somatosensory cerebral cortex

1972 • 136 citations

The excitation of Renshaw cells by cholinomimetics

1966 • 131 citations

Alpha-bungarotoxin, cobra neurotoxin and excitation of Renshaw cells by acetylcholine

1976 • 130 citations

Effects of cholinergic depletion on neuron activities in the cat visual cortex

1987 • 130 citations

Effect of stimulation with light on synthesis and release of acetylcholine by an isolated mammalian retina

1976 • 129 citations

Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells.

1984 • 125 citations

Two kinds of recurrent inhibition of cat spinal alpha‐motoneurones as differentiated pharmacologically.

1981 • 121 citations

Morphological Identification of Renshaw Cells

1971 • 121 citations

The Coupling of the Neuronal Muscarinic Receptor to Responses

1984 • 120 citations

Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory protein

1985 • 119 citations

Presynaptic action of acetylcholine in thin sections from the guinea pig dentate gyrus in vitro

1967 • 116 citations

Excitatory effect of acetylcholine on different types of neurons in the first somatosensory neocortex of the rat: Laminar distribution and pharmacological characteristics

1982 • 115 citations

Acetylcholine induced modulation of hippocampal pyramidal neurons

1981 • 115 citations

Muscarinic agonists inactivate potassium conductance of guinea‐pig myenteric neurones.

1982 • 111 citations

Synaptic transmission in the sympathetic ganglion of the frog

1963 • 111 citations

A morphological study of the axons and recurrent axon collaterals of cat alpha‐motoneurones supplying different hind‐limb muscles.

1978 • 110 citations

Identification of delayed potassium and calcium currents in the rat sympathetic neurone under voltage clamp.

1985 • 109 citations

Slow cholinergic excitation of guinea pig hippocampal neurons is mediated by two muscarinic receptor subtypes

1986 • 103 citations

Muscarinic synaptic potentials in guinea‐pig myenteric plexus neurones.

1982 • 102 citations

Acetylcholinesterase in the developing forebrain.

1966 • 102 citations

Neurochemistry of Cholinergic Terminals

1976 • 101 citations

Some properties of conductance changes at the end‐plate membrane during the action of acetylcholine

1963 • 97 citations

The Pharmacology of the Synaptic and Acetylcholine‐Induced Excitation of Ventrobasal Thalamic Neurones

1964 • 93 citations

Septal modulation of the population spike in the fascia dentata produced by perforant path stimulation in the rat

1982 • 92 citations

Acetylcholine Receptor Synthesis in Retina and Transport to Optic Tectum in Goldfish

1986 • 91 citations

The effect of topically applied atropine on resting and evoked cortical acetylcholine release

1969 • 90 citations

Septohippocampal disinhibition

1988 • 88 citations

Chemical transmission in the rat interpeduncular nucleus in vitro.

1983 • 87 citations

The activity of identified supraoptic neurones and their response to acetylcholine applied by iontophoresis

1972 • 84 citations

A cholinergic mechanism in the spinal cord of cats

1974 • 84 citations

Acetylcholine depression of cortical neurons

1964 • 83 citations

Cholinergic transmission in cat parasympathetic ganglia.

1982 • 81 citations

Effects of Ba²⁺ and tetraethylammonium on cortical neurones

1971 • 81 citations

An ultrastructural study of the synaptic contacts of α-motoneurone axon collaterals. I. Contacts in lamina IX and with identified α-motoneurone dendrites in lamina VII

1981 • 80 citations

Synaptic activation of phasic bursting in rat supraoptic nucleus neurones recorded in hypothalamic slices.

1983 • 80 citations

ACETYLCHOLINE AND PROSTIGMINE ELECTROPHORESIS AT VISUAL CORTEX NEURONS

1963 • 80 citations

Electrical changes in the membrane in junctional transmission

1973 • 77 citations

Certain Slow Synaptic Responses: Their Properties and Possible Underlying Mechanisms

1980 • 75 citations

M-current in human neocortical neurones

1986 • 75 citations

The Interpeduncular Nucleus

1986 • 73 citations

Input‐output relations in the pathway of recurrent inhibition to motoneurones in the cat.

1979 • 72 citations

The role of the septal nuclei in the release of acetylcholine from the rabbit cerebral cortex and dorsal hippocampus and the effect of atropine

1977 • 68 citations

Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures

1987 • 67 citations

Selective antagonism of nicotine actions in the rat cerebellum with α-bungarotoxin

1987 • 66 citations

The action of cholinomimetic substances on impulse conduction in the habenulointerpeduncular pathway of the rat in vitro.

1984 • 62 citations

Intersegmental and intrasegmental distribution of mutual inhibition of Renshaw cells.

1971 • 59 citations

Muscarinic modulation of calcium dependent plateau potentials in rat neostriatal neurons

1986 • 57 citations

Proceedings: Influences of the septum on the hippocampal dentate area which are unaccompanied by field potentials.

1975 • 56 citations

Multiple actions of acetylcholine on hippocampal pyramidal cells in organotypic explant cultures

1982 • 54 citations

Protein kinase C activators inhibit the inositol trisphosphate‐mediated muscarinic current responses in rat lacrimal cells.

1987 • 53 citations

Pharmacological characteristics of facilitation of hippocampal population spikes by cholinomimetics

1982 • 52 citations

The release of acetylcholine from rabbit hippocampus.

1972 • 52 citations

Neurotransmitters and the Hippocampus

1975 • 51 citations

Characterization of Presynaptic Muscarinic Receptors in Central Cholinergic Neurons

1978 • 49 citations

Effects of mecamylamine on the Golgi recurrent collateral—Renshaw-cell synapse in the spinal cord

1961 • 49 citations

The Case for the Renshaw Cell;pp. 5–26

1971 • 48 citations

Phosphatidic acid metabolism and active transport of sodium.

1963 • 46 citations

Cholinergic mechanisms and neurotransmission in the cerebellum of the rat. An in vitro study

1982 • 45 citations

Transmitters and identified neurons in the mammalian central nervous system

1975 • 44 citations

Muscarinic agonists block five different potassium conductances in guinea‐pig sympathetic neurones

1987 • 43 citations

Slow excitatory post‐synaptic currents in bull‐frog sympathetic neurones.

1984 • 43 citations

Slow cholinergic and peptidergic transmission in sympathetic ganglia.

1981 • 37 citations

An ultrastructural study of the synaptic contacts ofα1-motoneuron axon collaterals. II. Contacts in lamina VII

1981 • 36 citations

Axon trajectories of Renshaw cells in the lumbar spinal cord of the cat, as reconstructed after intracellular staining with horseradish peroxidase

1979 • 36 citations

Modulation of voltage-dependent currents by muscarinic receptor in sympathetic neurones of bullfrog

1982 • 36 citations

The Pharmacology of Thalamic and Geniculate Neurons

1971 • 34 citations

Neurotoxins and the ganglionic (C6) type of nicotinic receptor.

1979 • 33 citations

Disinhibition in the rat septum mediated by M1 muscarinic receptors

1988 • 33 citations

Facilitation by acetylcholine of tetrodotoxin-resistant spikes in rat hippocampal pyramidal cells

1984 • 33 citations

THE ROLE OF ACETYLCHOLINE IN BRAIN METABOLISM AND FUNCTION

1957 • 31 citations

The effects of various ?nicotine-like? agents in the cat superior cervical ganglion in situ

1974 • 30 citations

Presynaptic suppression of excitatory postsynaptic potentials in rat ventral horn neurons by muscarinic agonists

1986 • 29 citations

On the transmitter repertoire of sympathetic neurons in culture.

1980 • 28 citations

Recurrent inhibition of motoneurons in decerebrate cats during controlled treadmill locomotion.

1980 • 27 citations

Intracellular studies on transmitter effects on neurones in isolated brain slices

1980 • 26 citations

FUNCTION OF NEUROTRANSMITTERS IN THE RETINA

1982 • 24 citations

Ionic mechanism of muscarinic cholinergic depolarization of mouse spinal cord neurons in cell culture

1983 • 23 citations

An ultrastructural study of serially sectioned renshaw cells. I. Architecture of the cell body, axon hillock, initial axon segment and proximal dendrites

1982 • 19 citations

Modulation of inhibition in the hippocampus in vivo

1985 • 19 citations

Assessment of acetylcholine as an optic nerve neurotransmitter in Bufo marinus

1979 • 19 citations

Ultrastructural characteristics of a central cholinergic synapse in the cat

1978 • 18 citations

Hemicholinium impairs septo-hippocampal facilitatory action

1983 • 12 citations

Effects of intracellular antibodies to cGMP on responses of cortical neurons of awake cats to extracellular application of muscarinic agonists

1984 • 11 citations