Electrical changes in the membrane in junctional transmission

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

The effect of sodium ions on the electrical activity of the giant axon of the squid

1949 • 3,479 citations

POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES

1943 • 2,733 citations

THE PHYSIOLOGY OF SYNAPSES

1964 • 1,932 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Nerve, Muscle and Synapse

1966 • 1,431 citations

An analysis of the end‐plate potential recorded with an intra‐cellular electrode

1951 • 1,389 citations

The release of neural transmitter substances

1969 • 1,134 citations

The statistical nature of the acetylcholine potential and its molecular components

1972 • 960 citations

Transmission at the giant motor synapses of the crayfish

1959 • 843 citations

Chemical transmission in invertebrate central nervous systems and neuromuscular junctions.

1973 • 823 citations

A study of supersensitivity in denervated mammalian skeletal muscle

1959 • 737 citations

The mechanism of excitation by acetylcholine in the cerebral cortex

1971 • 698 citations

Biological Membranes: The Physical Basis of Ion and Nonelectrolyte Selectivity

1969 • 686 citations

The release of neural transmitter substances

1970 • 685 citations

A quantitative description of end‐plate currents

1972 • 625 citations

Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons.

1967 • 598 citations

The binding of acetylcholine to receptors and its removal from the synaptic cleft

1973 • 576 citations

Control of ACh sensitivity by muscle activity in the rat

1972 • 526 citations

On the localization of acetylcholine receptors

1955 • 522 citations

The acetylcholine sensitivity of frog muscle fibres after complete or partial devervation.

1960 • 502 citations

Acetylcholine Receptors in Muscle Fibres

1971 • 443 citations

On the permeability of end‐plate membrane during the action of transmitter

1960 • 430 citations

The Harvey Lectures . Delivered under the Auspices of The Harvey Society of New York, 1906-4, by Professors A. E. Wright, C. A. Herter, W. T. Porter, J. G. Adami, F. G. Benedict, E. B. Wilson, George S. Huntington, W. T. Councilman, Friedrioh Muller and Dr. S. J. Meltzer. Pp. 1414 Philadelphia and London, J. B. Lippincott Company. 1908.

1908 • 422 citations

PERIPHERAL INHIBITION IN SKELETAL MUSCLE OF INSECTS

1965 • 409 citations

Three acetylcholine receptors in Aplysia neurones

1972 • 358 citations

Small‐nerve junctional potentials. The distribution of small motor nerves to frog skeletal muscle, and the membrane characteristics of the fibres they innervate*

1953 • 353 citations

Spontaneous and evoked activity of motor nerve endings in calcium Ringer

1969 • 352 citations

ACTIVE PHASE OF FROG'S END-PLATE POTENTIAL

1959 • 348 citations

The quantal nature of transmission and spontaneous miniature potentials at the crayfish neuromuscular junction

1961 • 328 citations

Dual mode of synaptic transmission in the avian ciliary ganglion

1963 • 326 citations

Electrophysiological Analysis of Synaptic Transmission

2022 • 300 citations

Electrophysiological Analysis of Synaptic Transmission

1970 • 275 citations

Electrical properties and activities of single sympathetic neurons in frogs

1960 • 260 citations

The effect of inhibitory nerve impulses on a crustacean muscle fibre

1953 • 259 citations

Inhibitory and excitatory effects of dopamine on Aplysia neurones

1972 • 254 citations

In Vitro excitation of purified membrane fragments by cholinergic agonists

1971 • 250 citations

Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser

1958 • 247 citations

On the mechanism of desensitization at cholinergic receptors.

1970 • 247 citations

Applications of Hodgkin-Huxley equations to excitable tissues.

1966 • 245 citations

Membrane permeability change during inhibitory transmitter action in crustacean muscle

1958 • 241 citations

Junctional and extra‐junctional acetylcholine receptors in skeletal muscle fibres

1960 • 232 citations

Anion permeability of the inhibitory post‐synaptic membrane of the crayfish neuromuscular junction

1967 • 227 citations

Ionic mechanism of a two‐component cholinergic inhibition in Aplysia neurones

1972 • 222 citations

Localized action of gamma‐aminobutyric acid on the crayfish muscle

1965 • 214 citations

Slow Synaptic Excitation in Sympathetic Ganglion Cells: Evidence for Synaptic Inactivation of Potassium Conductance

1970 • 206 citations

Effects of calcium on the conductance change of the end‐plate membrane during the action of transmitter

1963 • 196 citations

The time course of minimal excitatory post‐synaptic potentials evoked in spinal motoneurones by group la afferent fibres

1971 • 194 citations

The membrane change produced by the neuromuscular transmitter

1954 • 181 citations

Dependence of acetylcholine desensitization on the membrane potential of frog muscle fibre and on the ionic changes in the medium

1970 • 172 citations

The characteristics of ‘end‐plate noise’ produced by different depolarizing drugs

1973 • 171 citations

PROCEEDINGS OF THE PHYSIOLOGICAL SOCIETY

1960 • 159 citations

Ionic mechanisms of excitatory, inhibitory, and dual synaptic actions mediated by an identified interneuron in abdominal ganglion of Aplysia.

1971 • 152 citations

The synaptic excitation of Renshaw cells

1966 • 150 citations

On the contraction of muscle, chiefly in relation to the presence of ‘receptive’ substances

1907 • 139 citations

Ion movements in junctional transmission.

1967 • 135 citations

Transmission in invertebrate and vertebrate ganglia.

1967 • 127 citations

The effect of membrane polarization on the time course of the end‐plate current in frog sartorius muscle

1969 • 123 citations

Equivalent Circuits as Related to Ionic Systems

1963 • 118 citations

Autonomic Neuromuscular Transmission

2004 • 118 citations

Anionic permeability of cortical neurones

1969 • 117 citations

Further study on anion permeability of inhibitory post‐synaptic membrane of cat motoneurones

1962 • 116 citations

A Direct Synaptic Connection Mediating Both Excitation and Inhibition

1967 • 115 citations

The extraction of ions from muscle by water and sugar solutions with a study of the degree of exchange with tracer of the sodium and potassium in the extracts

1956 • 109 citations

The effect of carbachol on the permeability of depolarized smooth muscle to inorganic ions

1961 • 106 citations

AUTONOMIC NEUROMUSCULAR TRANSMISSION

1973 • 105 citations

An electrophysiological approach to drug-receptor mechanisms

1969 • 104 citations

Membrane Structure and Ion Permeation

1967 • 102 citations

An analysis of acetylcholine responses of junctional and extrajunctional receptors of frog muscle fibres. With an Appendix

1971 • 100 citations

On the analysis of pharmacological experiments in terms of an allosteric receptor model.

1973 • 99 citations

Some properties of conductance changes at the end‐plate membrane during the action of acetylcholine

1963 • 97 citations

A Kinetic Model for the Action of Xylocaine on Receptors for Acetylcholine

1968 • 96 citations

The effect of anion injection and changes in the external potassium and chloride concentration on the reversal potentials of the IPSP and acetylcholine

1964 • 95 citations

Contractures and permeability changes produced by acetylcholine in depolarized denervated muscle

1961 • 93 citations

Miniature End-plate Currents in Voltage-clamped Muscle Fibre

1968 • 85 citations

MEMBRANE CHANGES IN CRAYFISH STRETCH RECEPTOR NEURON DURING SYNAPTIC INHIBITION AND UNDER ACTION OF GAMMA-AMINOBUTYRIC ACID

1960 • 84 citations

Further observations on the distribution of acetylcholine‐reactive sites in skeletal muscle

1964 • 83 citations

Diphasic Postsynaptic Potential: A Chemical Synapse Capable of Mediating Conjoint Excitation and Inhibition

1972 • 82 citations

The action of the neuromuscular transmitter on the slow fibre membrane

1956 • 81 citations

Acetylcholine receptors: topographic distribution and pharmacological properties of two receptor types on a single molluscan neurone

1972 • 81 citations

Conductance change during the inhibitory potential in the guinea‐pig taenia coli

1972 • 81 citations

Competitive interaction of β‐guanidino propionic acid and γ‐aminobutyric acid on the muscle fibre of the crayfish

1971 • 80 citations

Slow post‐synaptic potentials recorded from the giant motor fibre of the crayfish

1959 • 77 citations

Analysis of sodium and potassium conductances in the procaine end‐plate potential

1966 • 76 citations

Induction of the action potential mechanism in slow muscle fibres of the frog

1971 • 76 citations

Long-lasting synaptic inhibition and its transmitter in the snail Helix aspersa

1969 • 73 citations

An attempt at an analysis of the factors determining the time course of the end‐plate current

1972 • 72 citations

Inhibition of Lysosomal Plasminogen Activator Activity in Experimental Shock

1973 • 66 citations

Ionic Permeability of the Inhibitory Postsynaptic Membrane of Lobster Muscle Fibers

1969 • 64 citations

The effect of noradrenaline on the permeability of depolarized intestinal smooth muscle to inorganic ions

1967 • 59 citations

THE IONIC MECHANISMS OF EXCITATORY AND INHIBITORY SYNAPTIC ACTION

1966 • 59 citations

Difference in effects of end-plate potentials between procaine and lidocaine as revealed by voltage-clamp experiments.

1971 • 54 citations

SOME IONIC FACTORS THAT INFLUENCE THE ACTION OF ACETYLCHOLINE AT THE MUSCLE END‐PLATE MEMBRANE*

1959 • 54 citations

Pharmacological Characteristics and Ionic Bases of a Two Component Postsynaptic Inhibition

1967 • 53 citations

Evidence for an Excitatory Transmitter Role of Serotonin in Molluscan Central Synapses

1968 • 52 citations

Ionic Mechanisms of Cholinergic Excitation in Molluscan Neurons

1967 • 51 citations

Transmitter Action in the Giant Synapse of the Squid

1969 • 47 citations

Influence of chloride ions on changes in membrane potential during prolonged application of carbachol to frog skeletal muscle

1973 • 43 citations

A chloride-dependent inhibitory postsynaptic potential in cat trochlear motoneurons.

1972 • 41 citations

Serotonin: Two Different Inhibitory Actions on Snail Neurons

1971 • 40 citations

The membrane electrical parameters of Nitella translucens

1969 • 40 citations

EFFECTS OF METHYL-AND ETHYL-DERIVATIVESOF NH4+ ON THE NEUROMUSCULAR JUNCTION

1959 • 38 citations

Receptor Mechanisms Fourth Gaddum Memorial Lecture, School of Pharmacy, University of London, January 1973

1973 • 38 citations

Comparative study of acetylcholine and 5-hydroxytryptamine receptors on single snail neurons.

1969 • 38 citations

Different action of atropine and some analogues on the end-plate potentials and induced acetylcholine potentials

1969 • 32 citations

Variation in the permeability properties of the inhibitory post‐synaptic membrane of the crayfish neuromuscular junction when activated by different concentrations of GABA

1971 • 31 citations

EFFECTS OF INTRACELLULARLY INJECTED ANIONS ON THE MAUTHNER CELLS OF GOLDFISH

1963 • 31 citations

The loci of α-bungarotoxin action on the muscle postjunctional membrane

1972 • 29 citations

The relative contribution of K and Cl to the total increase of membrane conductance produced by adrenaline on the smooth muscle of guinea‐pig taenia coli

1971 • 26 citations

Ionic mechanism of the inhibitory postsynaptic potential of crayfish giant motor fiber

1969 • 25 citations

Glutamic acid mimicking of synaptic inhibition on the giant serotonin neurone of the snail

1972 • 23 citations

IONIC MECHANISM ASSOCIATED WITH NONCHOLINERGIC SYNAPTIC INHIBITION IN MOLLUSCAN NEURONS

1965 • 23 citations

A study of the end‐plate potential in sodium‐deficient solution

1968 • 22 citations

Neuronal Responses to 5-Hydroxy-tryptamine resulting from Membrane Permeability Decreases

1973 • 21 citations

Inhibition of Membrane Permeability to Chloride by Copper in Molluscan Neurones

1967 • 20 citations

[Equilibrium potentials of the extrasynaptic membrane of denervated muscle during changes of the extracellular ionic medium].

1969 • 16 citations

The actions of McN-A-343, pilocarpine and acetyl-beta-methylcholine on sympathetic ganglion cells of the frog.

1965 • 14 citations

Response : Inactivation of Potassium Conductance in Slow Postsynaptic Excitation

1971 • 5 citations

[Equilibrium potentials of the postsynaptic membrane of the frog tonic fiber during changes in the extracellular ionic medium].

1971 • 3 citations