Regulation of Carbohydrate Metabolism and Response to Hypoglycemia

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

Case 39-2000

2000 • 3,891 citations

Brain Metabolism during Fasting*

1967 • 1,590 citations

Effect of fatty acids on glucose production and utilization in man.

1983 • 1,056 citations

Potential mechanism of insulin action on glucose transport in the isolated rat diaphragm. Apparent translocation of intracellular transport units to the plasma membrane.

1981 • 852 citations

THE RELATION OF ADENOSINE-3', 5'-PHOSPHATE AND PHOSPHORYLASE TO THE ACTIONS OF CATECHOLAMINES AND OTHER HORMONES

1960 • 852 citations

The glucose-alanine cycle

1973 • 739 citations

Dose-response characteristics for effects of insulin on production and utilization of glucose in man

1981 • 712 citations

Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin Action*

1982 • 685 citations

Glucose metabolism during leg exercise in man

1971 • 601 citations

Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man.

1980 • 588 citations

The Metabolic Basis of Inherited Disease.

1966 • 547 citations

ON THE HORMONAL REGULATION OF CARBOHYDRATE METABOLISM; STUDIES WITH C14 GLUCOSE.

1963 • 540 citations

PROMOTION OF INSULIN SECRETION BY GLUCAGON

1965 • 501 citations

The Control of Glycogen Metabolism in the Liver

1976 • 438 citations

Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization

1982 • 434 citations

Control of Gluconeogenesis from Amino Acids in the Perfused Rat Liver

1969 • 431 citations

Role of Glucagon, Catecholamines, and Growth Hormone in Human Glucose Counterregulation

1979 • 417 citations

The control of glycogen metabolism in the liver

1970 • 414 citations

Case records of the massachusetts general hospital

1966 • 410 citations

Abnormal Glucose Counterregulation in Insulin-dependent Diabetes Mellitus: Interaction of Anti-Insulin Antibodies and Impaired Glucagon and Epinephrine Secretion

1983 • 398 citations

The Disposal of an Oral Glucose Load in Healthy Subjects: A Quantitative Study

1985 • 397 citations

A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man*

1967 • 396 citations

Effects of glucocorticoids on carbohydrate metabolism

1988 • 391 citations

EFFECT OF EPINEPHRINE ON RAT DIAPHRAGM

1950 • 389 citations

Metabolic and Hormonal Control of Phosphoenolpyruvate Carboxykinase and Malic Enzyme in Rat Liver

1963 • 388 citations

Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms.

1987 • 386 citations

Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus.

1976 • 370 citations

The role of the sympathetic nervous system in the metabolism of free fatty acids

1959 • 362 citations

Glucagon physiology and pathophysiology in the light of new advances

1985 • 360 citations

The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man.

1976 • 350 citations

Adrenergic Mechanisms for the Effects of Epinephrine on Glucose Production and Clearance in Man

1980 • 341 citations

Norepinephrine: hormone and neurotransmitter in man.

1978 • 339 citations

Origin and Possible Significance of Alanine Production by Skeletal Muscle

1974 • 335 citations

Role of Adenosine 3′,5′-Monophosphate in the Effects of Insulin and Anti-insulin Serum on Liver Metabolism

1968 • 328 citations

Gluconeogenesis

1972 • 317 citations

Characterization of the Insulin and Somatomedin-C Receptors in Human Placental Cell Membranes

1974 • 301 citations

The Formation of Glutamine and Alanine in Skeletal Muscle

1974 • 291 citations

Control of hepatic glycogenolysis.

1980 • 288 citations

Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range.

1984 • 282 citations

Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues.

1986 • 276 citations

Effect of Growth Hormone and Dexamethasone on Lipolysis and Metabolism in Isolated Fat Cells of the Rat

1965 • 274 citations

The glucose paradox. Is glucose a substrate for liver metabolism?

1984 • 273 citations

Glucagon Physiology and Pathophysiology

1971 • 266 citations

Amino Acid Metabolism and Its Disorders.

1974 • 255 citations

The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog.

1976 • 247 citations

Influence of Glucocorticoids on Glucagon Secretion and Plasma Amino Acid Concentrations in Man

1973 • 245 citations

Effects of Autoantibodies to the Insulin Receptor on Isolated Adipocytes

1977 • 244 citations

Liver Glycogen in Man –- the Effect of Total Starvation or a Carbohydrate-Poor Diet Followed by Carbohydrate Refeeding

1973 • 242 citations

Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action

1986 • 232 citations

Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon.

1975 • 224 citations

Metabolism of branched-chain amino acids in altered nutrition

1976 • 220 citations

Control of Gluconeogenesis in Liver

1969 • 217 citations

Alanine and glutamine synthesis and release from skeletal muscle. II. The precursor role of amino acids in alanine and glutamine synthesis.

1976 • 202 citations

Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway.

1984 • 197 citations

Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism.

1987 • 189 citations

Effect of Insulin on Utilization and Production of Circulating Glucose

1957 • 183 citations

Human forearm metabolism during progressive starvation

1971 • 175 citations

Receptors for Insulin, NSILA-s, and Growth Hormone: Applications to Disease States in Man

1975 • 174 citations

Physiological Concentrations of Growth Hormone Exert Insulin-Like and Insulin Antagonistic Effects on Both Hepatic and Extrahepatic Tissues in Man*

1981 • 173 citations

ROLES OF INSULIN AND GROWTH HORMONE, BASED ON STUDIES ON FOREARM METABOLISM IN MAN

1963 • 168 citations

Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man.

1987 • 167 citations

Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man.

1977 • 161 citations

Effect of Human Growth Hormone on Muscle and Adipose Tissue Metabolism in the Forearm of Man *

1965 • 153 citations

HYPOGLYCEMIA IN ASSOCIATION WITH EXTRAPANCREATIC TUMORS: DEMONSTRATION OF ELEVATED PLASMA NSILA–s BY A NEW RADIORECEPTOR ASSAY

1974 • 152 citations

Role of gluconeogenesis in epinephrine-stimulated hepatic glucose production in humans

1983 • 152 citations

Adrenergic Modulation of Pancreatic Glucagon Secretion in Man

1974 • 148 citations

Hormonal mechanisms in acute glucose counterregulation: The relative roles of glucagon, epinephrine, norepinephrine, growth hormone, and cortisol

1980 • 145 citations

Effects of Plasma Glucose Concentration on Glucose Utilization and Glucose Clearance in Normal Man

1981 • 142 citations

Differential Time Course of Glucagon's Effect on Glycogenolysis and Gluconeogenesis in the Conscious Dog

1981 • 139 citations

Hypoglycemia in infancy and childhood. Part I

1973 • 132 citations

Mechanism and Significance of Insulin Resistance in Non-insulin-dependent Diabetes Mellitus

1981 • 129 citations

More on Neuropathy from Pyridoxine Abuse

1984 • 129 citations

Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans.

1977 • 128 citations

Glucose Disposal during Insulinopenia in Somatostatin-Treated Dogs

1978 • 124 citations

The role of cyclic AMP in the control of liver metabolism

1968 • 124 citations

Action of the oral hypoglycemic agent 2-tetradecylglycidic acid on hepatic fatty acid oxidation and gluconeogenesis.

1979 • 123 citations

Measurement of Insulin-Like Growth Factor II by a Specific Radioreceptor Assay in Serum of Normal Individuals, Patients with Abnormal Growth Hormone Secretion, and Patients with Tumor-Associated Hypoglycemia*

1981 • 123 citations

Differential Sensitivity of Glycogenolysis and Gluconeogenesis to Insulin Infusions in Dogs

1976 • 120 citations

The Evolving Clinical Course of Patients with Insulin Receptor Autoantibodies: Spontaneous Remission or Receptor Proliferation with Hypoglycemia

1978 • 117 citations

Glucose-Lactate Inter-Relations in Man

1972 • 111 citations

Glucagon response to hypoglycemia in sympathectomized man.

1976 • 110 citations

Role of Epinephrine-mediated β-Adrenergic Mechanisms in Hypoglycemic Glucose Counterregulation and Posthypoglycemic Hyperglycemia in Insulin-dependent Diabetes Mellitus

1982 • 110 citations

Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions.

1984 • 108 citations

Effects of glucagon on plasma amino acids.

1984 • 108 citations

Role of Insulin in the Hepatic Handling of Glucose

1969 • 106 citations

Comparison of Glucose Counterregulation During Short-Term and Prolonged Hypoglycemia in Normal Humans

1986 • 95 citations

Evidence for an effect of insulin on the peripheral utilization of ketone bodies in dogs

1971 • 95 citations

Transient Stimulatory Effect of Sustained Hyperglucagonemia on Splanchnic Glucose Production in Normal and Diabetic Man

1977 • 94 citations

Effects of Hypopituitarism and Growth Hormone Replacement Therapy on the Production and Utilization of Glucose in Childhood*

1985 • 94 citations

Hyperglucagonemia and insulin-mediated glucose metabolism.

1987 • 91 citations

Amino Acids and Free Fatty Acids in Plasma in Diabetes

1966 • 87 citations

Ketotic Hypoglycemia: An Amino Acid Substrate Limited Disorder*

1974 • 85 citations

Branched Chain Amino Acids as a Major Source of Alanine Nitrogen in Man

1982 • 85 citations

Amino acid metabolism and its disorders

1974 • 82 citations

Metabolic zonation of liver parenchyma: Significance for the regulation of glycogen metabolism, gluconeogenesis, and glycolysis

1987 • 81 citations

Study and evaluation of regulation of enzyme activity and synthesis in mammalian liver

1963 • 79 citations

The control by insulin of amino acid accumulation in muscle

1970 • 79 citations

Comparison of glucose counterregulation during short-term and prolonged hypoglycemia in normal humans

1986 • 79 citations

A survey of growth hormone secretion and action

1973 • 79 citations

Role of hepatic autoregulation in defense against hypoglycemia in humans.

1985 • 78 citations

Adrenal corticosteroid involvement in the control of liver glycogen phosphorylase activity

1969 • 75 citations

Interaction of insulin and glucose in the control of hepatic glucose balance

1974 • 74 citations

Adrenergic mechanisms in recovery from hypoglycemia in man: adrenergic blockade.

1979 • 74 citations

Liver Glycogen Content in Man in the Postabsorptive State

1973 • 73 citations

THE EFFECTS OF GROWTH HORMONE ON CARBOHYDRATE AND LIPID METABOLISM IN THE DOG^*

1968 • 70 citations

Pathogenesis of Hypoglycemia in Insulinoma Patients: Suppression of Hepatic Glucose Production by Insulin

1981 • 68 citations

Vascular and metabolic effects of circulating epinephrine and norepinephrine. Concentration-effect study in dogs.

1979 • 67 citations

On gluconeogenesis of human liver

1976 • 64 citations

Peripheral lactate and oxygen metabolism in man: The influence of oral glucose loading

1987 • 60 citations

Fasting-mediated alteration studies in insulin action on lipolysis and lipogenesis in obese women

1987 • 60 citations

Protein Sparing in Skeletal Muscle During Prolonged Starvation: Dependence on Lipid Fuel Availability

1987 • 59 citations

Regulation of Sugar Transport in Eukaryotic Cells

1974 • 59 citations

The Acute Effect of Hydrocortisone on Hepatic Glucose Output and Peripheral Glucose Utilization*

1964 • 58 citations

Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man

1980 • 57 citations

Comparison of the hyperglycaemic and glycogenolytic responses to catecholamines with those to stimulation of the hepatic sympathetic innervation in the dog

1972 • 56 citations

Glucose load diverts hepatic gluconeogenic product from glucose to glycogen in vivo.

1978 • 54 citations

Effect of physiological elevation of plasma growth hormone levels on ketone body kinetics and lipolysis in normal and acutely insulin-deficient man

1984 • 53 citations

Important Role of Adrenergic Mechanisms in Acute Glucose Counterregulation Following Insulin-induced Hypoglycemia in Type I Diabetes: Evidence for an Effect Mediated by Beta-Adrenoreceptors

1982 • 52 citations

Effect of Cortisol on the Plasma Amino Nitrogen of Eviscerated Adrenalectomized-Diabetic Rats

1967 • 50 citations

Decreased Uptake of Glucose by Human Forearm During Infusion of Leucine, Isoleucine, or Threonine

1987 • 50 citations

Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man

1980 • 49 citations

Effect of growth hormone on acute glucagon and insulin release.

1979 • 47 citations

EFFECT OF INTRAVENOUS ADMINISTRATION OF HUMAN GROWTH HORMONE ON SULPHATION FACTOR ACTIVITY IN SERUM OF HYPOPITUITARY SUBJECTS

1971 • 45 citations

Sympathetic control of hepatic glycogenolysis during glucopenia in man

1975 • 45 citations

Lack of glucagon response in glucose counter-regulation in Type 1 (insulin-dependent) diabetics: Absence of recovery after prolonged optimal insulin therapy

1982 • 45 citations

Effects of Ketone Bodies on Basal and Insulin-Stimulated Glucose Utilization in Man*

1986 • 44 citations

Gluconeogenesis and amino acid metabolism. 3. Uptake of glutamine and output of alanine and ammonia by non-hepatic splanchnic organs of fasted rats and their metabolic significance.

1973 • 42 citations

Direct alpha-adrenergic stimulation of hepatic glucose production in human subjects

1983 • 42 citations

Counterregulatory Hormone Release and Glucose Recovery After Hypoglycemia in Non-insulin-dependent Diabetic Patients

1983 • 41 citations

The Adrenergic Contribution to Glucose Counterregulation in Type I Diabetes Mellitus: Dependency on A-Cell Function and Mediation Through Beta2-Adrenergic Receptors

1983 • 41 citations

Effects of adrenalectomy on hormone action on hepatic glucose metabolism. Impaired glucagon activation of glycogen phosphorylase in hepatocytes from adrenalectomized rats.

1979 • 38 citations

On the sympathetic innervation to the cat's liver and its role for hepatic glucose release

1980 • 38 citations

The adrenergic contribution to glucose counterregulation in type I diabetes mellitus. Dependency on A-cell function and mediation through beta 2-adrenergic receptors

1983 • 34 citations

INFLUENCE OF GROWTH HORMONE ON SPLANCHNIC GLUCOSE PRODUCTION IN MAN

1977 • 33 citations

The relation between plasma concentrations of glutamine and glycine and utilization of their nitrogens as sources of urinary ammonia.

1966 • 32 citations

Modulation of Basal Ketone Body Concentration by Cortisol in Diabetic Man*

1978 • 30 citations

Insulin-related growth factors

1978 • 30 citations

Glucose and Alanine Metabolism in Children with Maple Syrup Urine Disease

1978 • 29 citations

Autoregulation of Glucose Metabolism in the Isolated Perfused Rat Liver.

1967 • 29 citations

Mechanism of plasma cyclic AMP response to hypoglycemia in man

1976 • 28 citations

A problem in the radiochemical assay of glucose-6-phosphatase in muscle

1984 • 28 citations

Effects of Chronic Glucagon Excess on Hepatic Metabolism

1978 • 28 citations

Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man

1979 • 27 citations

Estimation of the relative contributions of enhanced production of oxalacetate and inhibition of pyruvate kinase to acute hormonal stimulation of gluconeogenesis in rat hepatocytes. An analysis of the effects of glucagon, angiotensin II, and dexamethasone on gluconeogenic flux from lactate/pyruvate.

1985 • 27 citations

The metabolism and hormonal responses of human eccrine sweat glands isolated by collagenase digestion

1983 • 27 citations

Insulin control of glycogen synthesis.

1978 • 26 citations

Diabetogenic and hypoglycemic effects of human growth hormone.

1960 • 22 citations

The Role of Autoregulation of the Hepatic Glucose Production in Man: Response to a Physiologic Decrement in Plasma Glucose

1986 • 22 citations

Effect of Catecholamines and Dibutyryl-cyclic-AMP on Glucose Turnover, Plasma Free Fatty Acids, and Insulin in Dogs Treated with Methylprednisolone

1972 • 22 citations

The Minimal Amino Acid Sequence of the Insulin-potentiating Fragments of Human Growth Hormone: Its Mechanism of Action

1980 • 18 citations

Lack of a direct alpha-adrenergic effect of epinephrine on glucose production in human subjects

1984 • 15 citations

Control of glycolysis and lipogenesis in the liver by glucagon at the phosphofructokinase-fructose 1,6-diphosphatase site

1980 • 14 citations

Origin of glucose released in the regulatory response against hypoglycemia

1982 • 10 citations

Case 9-1984

1984 • 9 citations

Multihormonal control of phosphoenolpyruvate carboxykinase gene transcription: the dominant role of insulin.

1984 • 6 citations

Glucagon release and glucose counter-regulation during hypoglycaemia

1985 • 4 citations