Metabolic zonation of liver parenchyma: Significance for the regulation of glycogen metabolism, gluconeogenesis, and glycolysis

Energy conservation in chemotrophic anaerobic bacteria

1977 • 3,509 citations

A QUANTITATIVE STEREOLOGICAL DESCRIPTION OF THE ULTRASTRUCTURE OF NORMAL RAT LIVER PARENCHYMAL CELLS

1968 • 723 citations

GLUCONEOGENESIS AND RELATED ASPECTS OF GLYCOLYSIS

1983 • 523 citations

Integrative functions of the autonomic nervous system

1980 • 434 citations

Functional Hepatocellular Heterogeneity

1982 • 367 citations

The effects of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations

1975 • 357 citations

Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway?

1983 • 314 citations

The glucose paradox. Is glucose a substrate for liver metabolism?

1984 • 273 citations

Splanchnic and Peripheral Disposal of Oral Glucose in Man

1983 • 271 citations

Central nervous system regulation of liver and adipose tissue metabolism

1981 • 256 citations

Influence of Oral Glucose Ingestion on Splanchnic Glucose and Gluconeogenic Substrate Metabolism in Man

1975 • 228 citations

Heterogeneity of liver parenchymal cells

1978 • 216 citations

Afferent and efferent neural roles in liver function

1983 • 205 citations

Hepatic nerves: a review of their functions and effects

1980 • 204 citations

THE CONVERSION OF FRUCTOSE-1-C14 AND SORBITOL-1-C14 TO LIVER AND MUSCLE GLYCOGEN IN THE RAT

1955 • 204 citations

CELL HETEROGENEITY WITHIN THE HEPATIC LOBULE OF THE RAT (STAINING REACTIONS)

1959 • 201 citations

Functional implications of liver cell heterogeneity

1981 • 201 citations

Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway.

1984 • 197 citations

Gradients of O2 concentration in hepatocytes.

1978 • 189 citations

CELL HETEROGENEITY WITHIN THE HEPATIC LOBULE (QUANTITATIVE HISTOCHEMISTRY)

1959 • 175 citations

Effects of hypothalamic stimulation on gluconeogenesis and glycolysis in rat liver

1975 • 153 citations

Direct Control of Glycogen Metabolism in the Perfused Rat Liver by the Sympathetic Innervation

1982 • 152 citations

Inductive Functions of the Nervous System

1974 • 151 citations

Hepatocyte innervation in primates.

1977 • 142 citations

Liver Cell Heterogeneity. The Distribution of Pyruvate Kinase and Phosphoenolpyruvate Carboxykinase (GTP) in the Liver Lobule of Fed and Starved Rats

1976 • 141 citations

Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration.

1982 • 140 citations

Glycogen synthesis in the perfused liver of the starved rat

1972 • 139 citations

Functional Heterogeneity of Periportal and Perivenous Hepatocytes

1986 • 138 citations

Control of gluconeogenesis and of enzymes of glycogen metabolism in isolated rat hepatocytes. A parallel study of the effect of phenylephrine and of glucagon

1978 • 123 citations

Heterogeneous reciprocal localization of fructose‐1,6‐bis‐phosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue

1977 • 123 citations

Intrahepatic distribution of nerves in the rat

1978 • 121 citations

Absorption and disposition of a glucose load in the conscious dog

1982 • 114 citations

Modulation of the Glucagon-Dependent Induction of Phosphoenolpyruvate Carboxykinase and Tyrosine Aminotransferase by Arterial and Venous Oxygen Concentrations in Hepatocyte Cultures

1981 • 106 citations

Autoregulatory Shift from Fructolysis to Lactate Gluconeogenesis in Rat Hepatocyte Suspensions. The Problem of Metabolic Zonation of Liver Parenchyma

1976 • 98 citations

Insulin regulation of hepatic glycogen synthase and phosphorylase

1978 • 95 citations

A portal‐arterial glucose concentration gradient as a signal for an insulin‐dependent net glucose uptake in perfused rat liver

1986 • 94 citations

Heterogeneous distribution of glucose‐6‐phosphatase in microdissected periportal and perivenous rat liver tissue

1977 • 92 citations

Reciprocal Innervation of the Liver: Its Significance in Metabolic Control

1983 • 89 citations

The Glucose/Glucose‐6‐Phosphate Cycle in the Periportal and Perivenous Zone of Rat Liver

1982 • 87 citations

Induction of glucokinase by insulin under the permissive action of dexamethasone in primary rat hepatocyte cultures

1979 • 84 citations

Induction in Primary Culture of ‘Gluconeogenic’ and ‘Glycolytic’ Hepatocytes Resembling Periportal and Perivenous Cells

1982 • 84 citations

CHANGES IN DISTRIBUTION OF ENZYMES WITHIN THE LIVER LOBULE DURING ADAPTIVE INCREASES

1972 • 81 citations

The Effects of Ingested and Intravenous Glucose on Forearm Uptake of Glucose and Glucogenic Substrate in Normal Man

1983 • 78 citations

Regulation of peripheral insulin/glucagon levels by rat liver

1984 • 77 citations

Long‐term effects of physiological oxygen concentrations on glycolysis and gluconeogenesis in hepatocyte cultures

1985 • 77 citations

Regulation of oxygen consumption and microcirculation by α‐sympathetic nerves in isolated perfused rat liver

1984 • 77 citations

Short‐term modulation of glycogen metabolism, glycolysis and gluconeogenesis by physiological oxygen concentrations in hepatocyte cultures

1983 • 74 citations

Increase of the Gluconeogenic and Decrease of the Glycolytic Capacity of Rat Liver with a Change of the Metabolic Zonation after Partial Hepatectomy

1978 • 73 citations

Dynamics of liver glycogen

1975 • 73 citations

Histochemical Distribution Pattern of Respiratory Enzymes in the Liver Lobule

1957 • 72 citations

Betrachtungen zur Pathophysiologie der Leberstruktur

1960 • 67 citations

Uptake and supply of purine compounds by the liver

1975 • 65 citations

Reciprocal Distribution of Hexokinase and Glucokinase in the Periportal and Perivenous Zone of the Rat Liver Acinus

1982 • 62 citations

Measuring rates of O2 uptake in periportal and pericentral regions of liver lobule: stop-flow experiments with perfused liver

1983 • 56 citations

Predominance of glycolysis in pericentral regions of the liver lobule

1984 • 55 citations

Distribution of Pyruvate Kinase Type L and M2 in Microdissected Periportal and Perivenous Rat Liver Tissue with Different Dietary States

1983 • 51 citations

Control of Glucose Balance in the Perfused Rat Liver by the Parasympathetic Innervation

1986 • 50 citations

Distribution of enzymes of fatty acid and ketone body metabolism in periportal and perivenous rat‐liver tissue

1983 • 50 citations

Release of creatine kinase from frog muscle by osmotic changes

1982 • 49 citations

Direction of carbon flux in starvation and after refeeding: in vitro and in vivo effects of 3-mercaptopicolinate.

1983 • 49 citations

Perinatal development of the metabolic zonation of hamster liver parenchyma

1976 • 49 citations

Heterogeneous distribution of phosphoenolpyruvate carboxykinase in rat liver parenchyma, isolated, and cultured hepatocytes.

1982 • 48 citations

Gluconeogenesis predominates in periportal regions of the liver lobule

1984 • 48 citations

Control of Oxygen Uptake, Microcirculation and Glucose Release by Circulating Noradrenaline in Perfused Rat Liver

1985 • 47 citations

Metabolic Zonation in Liver of Diabetic Rats. Zonal Distribution of Phosphoenolpyruvate Carboxykinase, Pyruvate Kinase, Glucose-6-Phosphatase and Succinate Dehydrogenase

1985 • 46 citations

Activation of glycogenolysis and norepinephrine overflow in the perfused rat liver during repetitive perivascular nerve stimulation

1982 • 43 citations

Alteration in zonation of succinate dehydrogenase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in regenerating rat liver

1984 • 40 citations

Short-term stimulation of net glycogen production by insulin in rat hepatocytes

1981 • 38 citations

Regulation of oxygen consumption in perfused rat liver: decrease by ?-sympathetic nerve stimulation and increase by the ?-agonist phenylephrine

1984 • 38 citations

糖尿病ラット肝臓の代謝の帯状分布 ホスホエノールピルビン酸カルボキシキナーゼ,ピルビン酸キナーゼ,グルコース‐6‐ホスファターゼ,こはく酸デヒドロゲナーゼの帯状分布

1985 • 37 citations

The Glucagon-Insulin Antagonism and Glucagon-Dexamethasone Synergism in the Induction of Phosphoenolpyruvate Carboxykinase in Cultured Rat Hepatocytes

1983 • 37 citations

Modulation by insulin and glucagon of the activation of glycogenolysis by perivascular nerve stimulation in the perfused rat liver

1982 • 36 citations

Differential roles of splanchnic and peripheral tissues in the pathogenesis of impaired glucose tolerance.

1984 • 35 citations

Short‐term regulation of glycolysis by insulin and dexamethasone in cultured rat hepatocytes

1983 • 34 citations

The effects of ingested and intravenous glucose on forearm uptake of glucose and glucogenic substrate in normal man

1983 • 32 citations

What the papers say: Role of hepatic glycolysis and gluconeogenesis in glycogen synthesis

1985 • 28 citations

Liver Structure and Innervation

1986 • 28 citations

Zonal Signal Heterogeneity and Induction of Hepatocyte Heterogeneity

1986 • 28 citations

Heterogeneous Distribution of ATP Citrate Lyase in Rat‐Liver Parenchyma

1983 • 27 citations

Hormone-induced effects on the rat liver microsomal glucose-6-phosphatase system in vitro

1981 • 26 citations

Perinatal development of the distributions of phosphoenolpyruvate carboxykinase and succinate dehydrogenase in rat liver parenchyma.

1983 • 25 citations

Diurnal rhythms of hepatic carbohydrate metabolism during development of the rat

1974 • 24 citations

Recovery of liver glycogen in fasted rats

1968 • 23 citations

Induction of phosphoenolpyruvate carboxykinase by sympathetic agents in primary cultures of adult rat hepatocytes

1981 • 22 citations

Control of Glycogen Metabolism by Insulin in Isolated Hepatocytes

1981 • 21 citations

Scanning microdensitometry of glycogen zonation in the livers of rats adapted to a controlled feeding schedule and to 30, 60, or 90% casein diets

1980 • 20 citations

Alteration with dietary state of the activity and zonal distribution of adenylate cyclase stimulated by glucagon, fluoride and forskolin in microdissected rat liver tissue

1984 • 18 citations

Developmental changes in the levels of hepatic enzymes and their relation to metabolic functions

1979 • 18 citations

POSSIBLE METABOLIC ZONATION OF LIVER PARENCHYMA INTO GLUCOGENIC AND GLYCOLYTIC HEPATOCYTES

1977 • 17 citations

Glucostat Capacity and Metabolie Zonation in Rat Liver after Portocaval Anastomosis

1985 • 12 citations

The pubertal sex-specific development of zonation of fatty acid synthase in rat liver.

1986 • 9 citations