Neuropeptides in Primary Afferent Neurons

Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides

1988 • 1,673 citations

Chemical Neuroanatomy

1984 • 1,646 citations

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

DIRECT EVIDENCE FOR NEUROGENIC INFLAMMATION AND ITS PREVENTION BY DENERVATION AND BY PRETREATMENT WITH CAPSAICIN

1967 • 1,100 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

The sensory-efferent function of capsaicin-sensitive sensory neurons

1988 • 935 citations

Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

1989 • 934 citations

The neuropharmacology of capsaicin: review of some recent observations.

1986 • 833 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Isolation of a Sialogogic Peptide from Bovine Hypothalamic Tissue and Its Characterization as Substance P

1970 • 689 citations

Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells

1987 • 682 citations

Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27

1983 • 664 citations

Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.

1987 • 651 citations

Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat

1984 • 573 citations

Progress in Allergy.

1949 • 499 citations

Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy

1987 • 448 citations

Opioid Peptides and Opioid Receptors in Cells of the Immune System

1988 • 436 citations

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.

1988 • 396 citations

Zur Frage der zentralen �bertragung afferenter Impulse

1953 • 386 citations

Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey

1988 • 363 citations

Tachykinin antagonists

1994 • 356 citations

Pathway-specific patterns of the co-existence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea-pig

1987 • 352 citations

Antidromic vasodilatation and neurogenic inflammation

1988 • 343 citations

Neurochemical organization of the hypothalamic projection to the spinal cord in the rat

1988 • 337 citations

Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: Distribution and release by capsaicin

1987 • 334 citations

Neurotransmitter candidates of somatosensory primary afferent fibres

1983 • 331 citations

Coexistence of peptides with classical neurotransmitters

1987 • 327 citations

Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system

1988 • 316 citations

Differential expression of α-CGRP and β-CGRP by primary sensory neurons and enteric autonomic neurons of the rat

1988 • 314 citations

In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia.

1988 • 292 citations

Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea-pig

1988 • 289 citations

Multiple opioid systems and pain

1986 • 286 citations

Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia

1987 • 285 citations

Tissue-specific expression of the rat galanin gene.

1988 • 241 citations

Calcitonin gene-related peptide immunoreactivity in afferent neurons supplying the urinary tract: Combined retrograde tracing and immunohistochemistry

1986 • 236 citations

The effects of dorsal rhizotomy and spinal cord isolation on calcitonin gene-related peptide-labeled terminals in the rat lumbar dorsal horn

1988 • 224 citations

Advances in the biosciences

1990 • 222 citations

Antinociceptive effects of μ- and κ-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanism

1988 • 215 citations

Effect of peripheral nerve section and nerve crush on spinal cord neuropeptides in the rat; increased VIP and PHI in the dorsal horn

1984 • 213 citations

Regional distribution of substance P, neurokinin α and neurokinin β in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection

1985 • 211 citations

Peptides and neurogenic inflammation

1987 • 209 citations

Effects of intrathecal administration of neuropeptides on a spinal nociceptive reflex in the rat: VIP, galanin, CGRP, TRH, somatostatin and angiotensin II

1988 • 207 citations

Chapter 11 Neurochemistry and neural circuitry in the dorsal horn

1986 • 206 citations

Inflammation of rat molar pulp and periodontium causes increased calcitonin gene‐related peptide and axonal sprouting

1988 • 203 citations

An immunohistochemical and quantitative examination of dorsal root ganglion neuronal subpopulations

1985 • 202 citations

Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons

1986 • 199 citations

Noxious heating of the skin releases immunoreactive substance P in the substantia gelatinosa of the cat: A study with antibody microprobes

1987 • 195 citations

Immunohistochemical studies of substance P, cholecystokinin-octapeptide and somatostatin in dorsal root ganglia of the rat

1985 • 192 citations

A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry

1988 • 191 citations

Immunoreactive dynorphin in mammalian spinal cord and dorsal root ganglia.

1981 • 182 citations

Immunohistochemical study of neuropeptides in vagal and glossopharyngeal afferent neurons in the rat

1988 • 181 citations

Construction of a porcine adrenal medullary cDNA library and nucleotide sequence analysis of two clones encoding a galanin precursor.

1986 • 176 citations

Effects of Gastrin, Proglumide, and Somatostatin on Growth of Human Colon Cancer

1988 • 173 citations

Serotonin‐ and substance P‐containing projections to the nucleus tractus solitarii of the rat

1987 • 172 citations

The Endocrinology of the Opioids

1985 • 170 citations

Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats

1987 • 158 citations

A model of chronic pain in the rat: response of multiple opioid systems to adjuvant-induced arthritis

1986 • 150 citations

Multiple neuropeptides in nerves supplying mammalian lymph nodes: messenger candidates for sensory and autonomic neuroimmunomodulation?

1988 • 147 citations

Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons

1983 • 147 citations

Axotomy-induced alterations in the synthesis and transport of neurofilaments and microtubules in dorsal root ganglion cells

1988 • 137 citations

Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease.

1988 • 126 citations

Antinociception induced in rats by intrathecal administration of antiserum against calcitonin gene-related peptide

1988 • 122 citations

Substance P and somatostatin modulate spinal cord excitability via physiologically different sensory pathways

1986 • 120 citations

Does cholecystokinin-like immunoreactivity in rat primary sensory neurons represent calcitonin gene-related peptide?

1986 • 117 citations

Pharmacology and Nerve Endings

1935 • 116 citations

Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans

1988 • 116 citations

Calcitonin gene-related peptide messenger RNA is expressed in sensory neurones of the dorsal root ganglia and also in spinal motoneurones in man and rat

1988 • 111 citations

Induction of the gene encoding pro-dynorphin by experimentally induced arthritis enhances staining for dynorphin in the spinal cord of rats

1989 • 103 citations

Peptide neuroanatomy of adjuvant-induced arthritic inflammation in rat

1988 • 102 citations

A light and electron microscopic level analysis of calcitonin gene-related peptide (CGRP) in the spinal cord of the primate: An immunohistochemical study

1987 • 101 citations

Substance P and immunoregulation.

1987 • 100 citations

Intrathecal galanin increases the latency in the tail‐flick and hot‐plate tests in mouse

1988 • 97 citations

Characterization and localization of immunoreactive dynorphin, α-neo-endorphin, met-enkephalin and substance P in human spinal cord

1983 • 96 citations

Coexistence of peptide immunoreactivity in sensory neurons of the cat

1985 • 93 citations

Ultrastructure and distribution of substance P‐immunoreactive sensory collaterals in the guinea pig prevertebral sympathetic ganglia

1987 • 92 citations

A quantitative analysis of the interrelationships between subpopulations of rat sensory neurons containing arginine vasopressin or oxytocin and those containing substance P, fluoride-resistant acid phosphatase or neurofilament protein

1986 • 91 citations

Correlation of neuronal size and peptide immunoreactivity in the guinea-pig trigeminal ganglion

1986 • 89 citations

The effect of substance P on the regional lymph node antibody response to antigenic stimulation in capsaicin-pretreated rats.

1987 • 87 citations

Tachykinins, calcitonin gene-related peptide and neuropeptide Y in nerves of the mammalian thymus: interactions with mast cells in autonomic and sensory neuroimmunomodulation?

1989 • 87 citations

Identification of neuropeptides in pelvic and pudendal nerve afferent pathways to the sacral spinal cord of the cat

1986 • 87 citations

Immunoreactive dynorphin B in sacral primary afferent fibers of the cat

1986 • 86 citations

Substance P: From extract to excitement*

1988 • 84 citations

Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds

1988 • 81 citations

Distribution and origin of peptide-containing nerve fibers in the celiac superior mesenteric ganglion of the guinea-pig

1988 • 81 citations

The arthritic rat as a model of clinical pain?

1990 • 79 citations

Prodynorphin opioid peptides in small somatosensory primary afferents of guinea pig

1985 • 78 citations

Peptides as neuromodulators in primary sensory neurons

1987 • 76 citations

Immunohistochemical indications of gastrin releasing peptide - bombesin-like immunoreactivity in the nervous system of the rat. Codistribution with substance P-like immunoreactive nerve terminal systems and coexistence with substance P-like immunoreactivity in dorsal root ganglion cell bodies

1983 • 73 citations

Calcitonin gene‐related peptide immunostained axons provide evidence for fine primary afferent fibers in the dorsal and dorsolateral funiculi of the rat spinal cord

1988 • 70 citations

Substance P content in cultured neonatal rat vagal sensory neurons: the effect of nerve growth factor

1988 • 68 citations

Axonal transport and tissue contents of substance P in rats with long-term streptozotocin-diabetes. Effects of the aldose reductase inhibitor ‘statil’

1987 • 66 citations

Preproenkephalin mRNA in T‐Cells, macrophages, and mast cells

1987 • 64 citations

Co-existence of neuropeptides in sympathetic, cranial autonomic and sensory neurons innervating the iris of the guinea-pig

1987 • 62 citations

Increased staining of immunoreactive dynorphin cell bodies in the deafferented spinal cord of the rat

1988 • 61 citations

Antinociceptive and ‘neurotoxic’ actions of somatostatin in rat spinal cord after intrathecal administration

1988 • 60 citations

Observations on the morphology of axons and somata of slowly conducting dorsal root ganglion cells in the cat

1987 • 59 citations

Multiple peptides in cutaneous nerves: regulators under physiological conditions and a pathogenetic role in skin disease?

1988 • 56 citations

Neuronal pathways to the rat thyroid revealed by retrograde tracing and immunocytochemistry

1988 • 55 citations

Substance P and calcitonin gene-related peptide: immunohistochemical localisation and microvascular effects in rabbit skeletal muscle

1987 • 53 citations

Demonstration of calcitonin gene-related peptide immunoreactive axons contacting dynorphin A(1–8) immunoreactive spinal neurons in a rat model of peripheral inflammation and hyperalgesia

1988 • 48 citations

Non-myelinated afferent fibres do not originate exclusively from the smallest dorsal root ganglion cells in the cat

1986 • 47 citations

Distinctive patterns of release of neuroendocrine peptides after nasal challenge of allergic subjects with ryegrass antigen

1988 • 47 citations

Is substance P a primary afferent neurotransmitter for noniceptive input? II. Spinalization does not reduce and intrathecal morphine potentiates behavioral responses to substance P

1988 • 46 citations

Localization of immunoreactive dynorphin in neurons cultured from spinal cord and dorsal root ganglia.

1982 • 45 citations

Neuronal activity of the cat supraoptic nucleus is influenced by muscle small-diameter afferent (groups III and IV) receptors.

1988 • 44 citations

Columbus, Capsicum and capsaicin: past, present and future.

1987 • 42 citations

Co-localization of proenkephalin- and prodynorphin-derived opioid peptides in laminae IV/V spinal neurons revealed in arthritic rats

1988 • 42 citations

Biology and Chemistry of the Dynorphin Peptides**Research described here that was carried out in my laboratory was supported by grants DA-1199 from the National Institute on Drug Abuse, NS-18098 from the National Institutes of Health, and BNS-81-07237 from the National Science Foundation.

1984 • 38 citations

Intrathecal vasoactive intestinal polypeptide modulates spinal reflex excitability primarily to cutaneous thermal stimuli in rats

1987 • 36 citations

Chapter 21 Immunohistochemical evidence for a co-transmitter role of opioid peptides in primary sensory neurons

1988 • 32 citations

Trigeminal origin of β-preprotachykinin products in feline pial blood vessels

1987 • 30 citations

Altered lymphocyte proliferation of immunized rats after neurological manipulation with capsaicin

1988 • 30 citations

Species-related differences in the capsaicin-sensitive innervation of the rat and guinea-pig ureter

1988 • 29 citations

Neurokinin A and Galanin in the Thyroid Gland: Neuronal Localization*

1987 • 28 citations

Is substance P a primary afferent neurotransmitter for nociceptive input? III. Valproic acid and chlordiazepoxide decrease behaviors elicited by intrathecal injection of substance P and excitatory compounds

1988 • 27 citations

Multiple opioid ligands and receptors in the control of nociception

1985 • 26 citations

Is substance P a primary afferent neurotransmitter for nociceptive input? IV.2-Amino-5-phosphonovalerate (APV) and [d-Pro2, d-Trp7,9]-substance P exert different effects on behaviors induced by intrathecal substance P, strychnine and kainic acid

1988 • 26 citations

N- and C-terminal fragments of substance P: spinal effects in the rat tail flick test

1988 • 26 citations

Corticotropin-releasing factor immunostaining in the rat spinal cord and medulla oblongata: An unexpected form of cross-reactivity with substance P

1986 • 25 citations

The bradykinin-induced release of substance P from nerve fibre endings in the rat saphenous nerve neuroma is not related to electrophysiological excitation

1988 • 23 citations

Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation

1986 • 21 citations

Zur Frage der zentralen �bertragung afferenter Impulse

1952 • 21 citations

Atrial natriuretic factor-like immunoreactivity in spinal cord and in primary sensory neurons of spinal and trigeminal ganglia of guinea-pig: correlation with tachykinin immunoreactivity*

1989 • 20 citations

Opioid Peptides and Blood Pressure Control

1988 • 19 citations

Cigarette smoke-induced irritation in the airways in relation to peptide-containing, capsaicin-sensitive sensory neurons.

1988 • 18 citations

Nerve fibers surrounding intracranial and extracranial vessels from human and other species contain dynorphin-like immunoreactivity

1987 • 15 citations

Co-existence of prodynorphin--opioid peptides and substance P in primary sensory afferents of guinea-pigs.

1986 • 14 citations

Opioid Peptides and Blood Pressure Control

1988 • 14 citations

In vivo depression of lymphocyte traffic in sheep by VIP and HIV (AIDS)-related peptides

1988 • 13 citations

Presence of chromatographically identified oxytocin in human sensory ganglia

1987 • 12 citations

Loss of Spinothalamic Tract Neurons following Neonatal Treatment of Rats with the Neurotoxin Capsaicin

1986 • 12 citations

Multiplicity of Opioidergic Pathways Related to Cardiovascular Innervation: Differential Contribution of All Three Opioid Precursors

1988 • 11 citations

Tachykinin precursors and receptors: Molecular genetic studies

1988 • 9 citations

Isolation, identification and synthesis of a novel tripeptide, methionyl-tyrosyl-lysine, from spinal cord and dorsal root ganglia of sheep

1980 • 9 citations

Small peptides and nerve growth: Therapeutic implications

1987 • 7 citations

The effect of ovariectomy and oestrogen replacement on the anterior pituitary peptides 7B2 and galanin in the rat

1988 • 7 citations

Growth hormone-releasing factor (GRF)-like immunoreactivity in sensory ganglia of the rat

1987 • 7 citations

Light microscopic immunohistochemistry reveals species-dependent presence of tachykinins in intrinsic neurons in the mammalian respiratory tract

1988 • 6 citations

Peptide Neurotransmitters ‐ Redundant Vestiges?

1988 • 6 citations

Substance P in nerves supplying the immune system: A messenger role of tachykinins in sensory neuroimmunomodulation?

1988 • 4 citations

Opioid peptides are present in nerve fibres of the respiratory tract

1988 • 2 citations

Differential presence of opioid peptides in nerves supplying guinea-pig and rat urinary tract: Interrelation with non-opioid peptides

1988 • 2 citations

Distribution of human leumorphin-like immunoreactivity in the monkey spinal cord revealed by immunocytochemistry

1985 • 2 citations