Opioid Peptides and Opioid Receptors in Cells of the Immune System

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

1979 • 1,758 citations

The Immune System

2000 • 1,647 citations

Endogenous Opioids: Biology and Function

1984 • 1,223 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Noradrenergic and peptidergic innervation of lymphoid tissue

1985 • 996 citations

Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor

1982 • 777 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity

1984 • 611 citations

Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes

1979 • 574 citations

The immune system as a sensory organ.

1984 • 555 citations

Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

1973 • 527 citations

The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties

1982 • 509 citations

Enhancement of natural cytotoxicity by beta-endorphin.

1983 • 457 citations

Regulation of the in vitro antibody response by neuroendocrine hormones

1982 • 405 citations

KINETIC PARAMETERS OF NARCOTIC AGONISTS AND ANTAGONISTS, WITH PARTICULAR REFERENCE TO N‐ALLYLNOROXYMORPHONE (NALOXONE)

1968 • 392 citations

Corticotropin releasing factor induction of leukocyte-derived immunoreactive ACTH and endorphins

1986 • 361 citations

ICI 174864: A highly selective antagonist for the opioid Δ-receptor

1984 • 361 citations

A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors

1974 • 316 citations

Beta-endorphin and met-enkephalin stimulate human peripheral blood mononuclear cell chemotaxis.

1984 • 292 citations

Effect of Morphine on Resistance to Infection

1983 • 282 citations

Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.

1980 • 275 citations

Activation of Mouse T-Helper Cells Induces Abundant Preproenkephalin mRNA Synthesis

1986 • 269 citations

The Opiate Receptors

1978 • 266 citations

B-endorphin modulates human immune activity via non-opiate receptor mechanisms

1982 • 234 citations

Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: in vivo evidence for opiate receptor sites on T lymphocytes.

1980 • 234 citations

A complete regulatory loop between the immune and neuroendocrine systems.

1985 • 227 citations

Peptide hormones shared by the neuroendocrine and immunologic systems

1985 • 226 citations

Involvement of brain opiate receptors in the immune-suppressive effect of morphine.

1986 • 222 citations

Pro-opiomelanocortin messenger ribonucleic acid and posttranslational processing of beta endorphin in spleen macrophages.

1986 • 221 citations

Interaction of ligands with the opiate receptors of brain membranes: Regulation by ions and nucleotides

1978 • 216 citations

Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: Evidence for opiate and nonopiate receptor participation

1984 • 201 citations

Site-directed alkylation of multiple opioid receptors. I. Binding selectivity.

1984 • 200 citations

Opiate receptors on lymphocytes and platelets in man

1983 • 190 citations

The interleukin-1 receptor

1987 • 189 citations

Endorphins stimulate normal human peripheral blood lymphocyte natural killer activity

1984 • 189 citations

Stress, opioid peptides, the immune system, and cancer

1985 • 188 citations

Modulation of macrophage-mediated tumoricidal activity by neuropeptides and neurohormones.

1985 • 183 citations

OPIOID PEPTIDES RAPIDLY STIMULATE SUPEROXIDE PRODUCTION BY HUMAN POLYMORPHONUCLEAR LEUKOCYTES AND MACROPHAGES

1985 • 176 citations

Immunoreactive beta-endorphin in a subpopulation of mouse spleen macrophages.

1984 • 172 citations

The Endocrinology of the Opioids

1985 • 170 citations

β-Endorphin is processed differently in specific regions of rat pituitary and brain

1982 • 169 citations

Opioid Peptides and their Receptors

1982 • 134 citations

Enkephalins and endorphins as modifiers of the immune system: present and future.

1985 • 132 citations

Proenkephalin mRNA in rat heart.

1986 • 126 citations

Characterization of the cell surface receptor for a multi-lineage colony-stimulating factor (CSF-2 alpha).

1986 • 122 citations

Lymphocyte production of endorphins and endorphin-mediated immunoregulatory activity

1985 • 120 citations

Opioid peptides modulate production of interferon γ by human mononuclear cells

1986 • 112 citations

Opioid peptides derived from food proteins

1986 • 101 citations

Effect of alpha-endorphin on the antigen-induced primary antibody response of human blood B cells in vitro.

1986 • 100 citations

Morphine and methadone impact on human phagocytic physiology

1985 • 96 citations

Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies of tolerance and cross-tolerance

1986 • 95 citations

Specific non-opiate binding sites for human β-endorphin on the terminal complex of human complement

1982 • 87 citations

Enhancement of the generation of cytotoxic T cells by endogenous opiates

1986 • 72 citations

Effect of chronic administration of morphine on primary immune response in mice

1980 • 70 citations

The effect of β-endorphin on natural cytotoxicity and antibody dependent cellular cytotoxicity

1984 • 54 citations

Influence of Beta-Endorphin, Somatostatin, Substance P and Vasoactive Intestinal Peptide on the Proliferative Response of Human Peripheral Blood T Lymphocytes to Mercuric Chloride

1986 • 49 citations

Leu-enkephalin binding to cultured human T lymphocytes

1984 • 46 citations

The in vitro effects of endogenous opiates on natural killer cells, antigen-specific cytolytic T cells, and T-cell subsets

1986 • 45 citations

Morphine depression of T cell E-rosetting: definition of the process.

1985 • 42 citations

Proenkephalin a-like mRNA in human leukemia leukocytes and CNS-tissues

1986 • 40 citations

Morphine increases metastatic tumor growth

1986 • 38 citations

Structural requirements for delta opioid receptor binding.

1987 • 37 citations

Opioid Peptides in Human Plasma: Evidence for Multiple Forms*

1982 • 37 citations

Stereospecific opiate binding in living human polymorphonuclear leucocytes

1985 • 36 citations

Enkephalins and endorphins: Activation molecules for the immune system and natural killer activity?

1985 • 34 citations

Evidence for an inhibitory role of β-endorphin and other opioids on human total T rosette formation

1984 • 34 citations

Plasma extravasation induced by dynorphin-(1–13) in rat skin

1986 • 32 citations

Opioid peptides: do they have immunological significance?

1985 • 31 citations

Modulation of human T-cell suppressor activity by beta endorphin and glycyl-L-glutamine

1986 • 31 citations

Opiate antinociception is altered by immunemodification: the effect of inteferon, cyclosporine and radiation-induced immune suppression upon acute and long-term morphine activity

1986 • 29 citations

Endorphins, immune function, and cancer.

1985 • 28 citations

The effect of enkephalins and prostaglandins on O2− release by neutrophils

1986 • 26 citations

The interaction between γ-type endorphins and HLA class I antigens

1986 • 26 citations

HLA, AND THE RESPONSE TO TREATMENT WITH γ‐TYPE ENDORPHINS IN SCHIZOPHRENIA

1982 • 23 citations

The effect of alpha-interferon, cyclosporine A, and radiation-induced immune suppression on morphine-induced hypothermia and tolerance

1986 • 22 citations

?-Endorphin-like immunoreactivity in plasma cells of the canine colonic mucosa

1980 • 18 citations

Immunoregulation by opioid peptides: I. Absence of classical opioid receptor on human mononuclear cells.

1985 • 15 citations

The hormonal nature of the interferon system.

1981 • 12 citations

Generation of Diversity of Opioid Peptides

1985 • 12 citations

Multiple opiate receptors: functional implications.

1985 • 9 citations

Methionine Enkephalin: Enhancement of T-Cells in Patients with Kaposis’ Sarcoma, Aids, and Lung Cancer

1986 • 6 citations

Episodic secretion of met-enkephalin immunoreactive material in human plasma and CSF

1986 • 5 citations