Extracellular Matrix and Its Enzymatic Degradation in Tumor Invasion

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Laminin–a glycoprotein from basement membranes.

1979 • 2,372 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

The pathogenesis of cancer metastasis

1980 • 1,750 citations

Fibronectins: multifunctional modular glycoproteins.

1982 • 1,334 citations

Structurally Distinct Collagen Types

1980 • 1,078 citations

Extracellular matrix biochemistry

1984 • 1,038 citations

Proteinases in mammalian cells and tissues

1978 • 981 citations

Tumor invasion and the extracellular matrix.

1983 • 960 citations

A Network Model for the Organization of Type IV Collagen Molecules in Basement Membranes

1981 • 889 citations

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

1981 • 792 citations

Fibronectin: current concepts of its structure and functions

1980 • 735 citations

Isolation of a heparan sulfate-containing proteoglycan from basement membrane.

1980 • 672 citations

Distribution of a major connective tissue protein, fibronectin, in normal human tissues.

1978 • 666 citations

Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix

1981 • 666 citations

Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen

1980 • 661 citations

The basement membrane in pathology.

1983 • 660 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Cancer metastasis

1982 • 567 citations

Presence of heparan sulfate in the glomerular basement membrane

1979 • 562 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

Biochemistry and Metabolism of Basement Membranes

1979 • 468 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

Immunohistochemical localization of short chain cartilage collagen (type X) in avian tissues.

1985 • 451 citations

Immunochemistry of the extracellular matrix

1982 • 447 citations

Fibrinolysis Associated with Oncogenic Transformation

1974 • 444 citations

Biology of Carbohydrates

1981 • 426 citations

Laminin receptor on human breast carcinoma cells.

1983 • 419 citations

Human skin collagenase: isolation of precursor and active forms from both fibroblast and organ cultures

1977 • 387 citations

Fetal membrane collagens: identification of two new collagen alpha chains.

1976 • 386 citations

Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line

1979 • 364 citations

Isolation of a laminin-binding protein from muscle cell membranes

1983 • 354 citations

Isolation of three collagenous components of probable basement membrane origin from several tissues

1976 • 350 citations

Tumour promotor induces plasminogen activator

1976 • 316 citations

Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules.

1980 • 279 citations

Morphogenesis and Pattern Formation

1981 • 277 citations

Nidogen: a new, self‐aggregating basement membrane protein

1983 • 275 citations

FIBRINOLYSIS ASSOCIATED WITH ONCOGENIC TRANSFORMATION

1973 • 261 citations

Purification and characterization of a murine basement membrane collagen-degrading enzyme secreted by metastatic tumor cells.

1983 • 245 citations

Macrophage plasminogen activator: induction by concanavalin A and phorbol myristate acetate

1977 • 241 citations

Structural studies on human type IV collagen.

1979 • 240 citations

NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.

1985 • 240 citations

Codistribution of collagen types IV and AB2 in basement membranes and mesangium of the kidney. an immunoferritin study of ultrathin frozen sections.

1980 • 233 citations

Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblasts.

1984 • 228 citations

Studies on the Biosynthesis of Laminin by Murine Parietal Endoderm Cells

1981 • 222 citations

Solubilization and degradation of subendothelial matrix glycoproteins and proteoglycans by metastatic tumor cells.

1982 • 222 citations

Lysyl Oxidase

1979 • 221 citations

Cancer invasion and metastasis : biologic and therapeutic aspects

1984 • 221 citations

Localization of The Collagenous Component in Skin Basement Membrane

1978 • 219 citations

Deposition of plasma fibronectin in tissues.

1981 • 214 citations

Cysteine proteinases and metastasis

1984 • 211 citations

Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin.

1979 • 206 citations

Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes. Analysis of their actions on soluble and insoluble collagens

1982 • 203 citations

Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.

1982 • 200 citations

Adhesion, growth, and matrix production by fibroblasts on laminin substrates.

1983 • 199 citations

Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells – role in metastasis

1982 • 195 citations

cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain.

1985 • 194 citations

The significance of the “tissue pressure” of normal testicular and of neoplastic (Brown‐Pearce carcinoma) tissue in the rabbit

1950 • 191 citations

Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment.

1982 • 182 citations

The structure of type IX collagen.

1985 • 180 citations

Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase.

1984 • 178 citations

The significance of theory

1990 • 178 citations

Tumor invasion and host extracellular matrix

1983 • 176 citations

Human skin fibroblast collagenase: chemical properties of precursor and active forms

1978 • 175 citations

Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.

1984 • 173 citations

Isolation and partial characterization of a new human collagen with an extended triple-helical structural domain.

1983 • 173 citations

Proteinases and tumor invasion

1980 • 170 citations

Biosynthesis of type IV procollagens

1980 • 169 citations

Purification and characterization of a collagenase extracted from rabbit tumours

1975 • 169 citations

Phorbol ester-induced morphological changes in transformed chick fibroblasts: Evidence for direct catalytic involvement of plasminogen activator

1979 • 168 citations

QUANTITATION AND IMMUNOCYTOCHEMICAL LOCALIZATION OF HUMAN SKIN COLLAGENASE IN BASAL CELL CARCINOMA

1977 • 166 citations

Amino acid sequence of the non‐collagenous globular domain (NC1) of the α1 (IV) chain of basement membrane collagen as derived from complementary DNA

1985 • 164 citations

Activation of human breast carcinoma collagenase through plasminogen activator

1980 • 160 citations

Tumor invasion and metastasis.

1986 • 156 citations

The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan structure and its susceptibility to proteolysis

1977 • 156 citations

Tumor Cell Collagenase and Its Inhibition by a Cartilage-Derived Protease Inhibitor

1977 • 143 citations

Effect of Natural Protease Inhibitors and a Chemoattractant on Tumor Cell Invasion In Vitro

1982 • 141 citations

Collagenase production by synovial fibroblasts treated with phorbol myristate acetate

1979 • 139 citations

Relationship Between Fibrinolysis of Cultured Cells and Malignancy2

1975 • 134 citations

Cell locomotion and tumor penetration

1977 • 127 citations

Structure of human‐basement‐membrane (type IV) collagen

1984 • 121 citations

Collagenolytic Enzymes and Their Naturally Occurring Inhibitors

1981 • 118 citations

The Degradation of Human Glomerular Basement Membrane with Purified Lysosomal Proteinases: Evidence for the Pathogenic Role of the Polymorphonuclear Leucocyte in Glomerulonephritis

1978 • 115 citations

Purification, characterization and inhibition of human skin collagenase

1978 • 114 citations

Purification of Rheumatoid Synovial Collagenase and Its Action on Soluble and Insoluble Collagen

1975 • 113 citations

Structural basis for apparent heterogeneity of collagens in human basement membranes: type IV procollagen contains two distinct chains.

1980 • 111 citations

Localization of type V collagen and type IV collagen in human cornea, lung, and skin. Immunohistochemical evidence by anti-collagen antibodies characterized by immunoelectroblotting.

1984 • 110 citations

Characterization of the tissue form of type V collagen from chick bone.

1985 • 107 citations

Biosynthetic and structural properties of endothelial cell type VIII collagen.

1983 • 104 citations

AN ELECTRON MICROSCOPIC STUDY OF THE INVASION OF ASCITES TUMOR CELLS INTO THE ABDOMINAL WALL.

1965 • 102 citations

Tumor-promoting phorbol esters and cell proliferation stimulate secretion of basement membrane (type IV) collagen-degrading metalloproteinase by human fibroblasts.

1985 • 96 citations

Laminin, Proteoglycan, Nidogen and Collagen IV: Structural Models and Molecular Interactions

1984 • 95 citations

Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas.

1979 • 95 citations

Basement membranes and cell movement.

1984 • 94 citations

Enzymic Degradation of Collagen

1976 • 91 citations

Effect of collagenolytic activity in basal cell epithelioma of the skin on reconstituted collagen and physical properties and kinetics of the crude enzyme.

1972 • 91 citations

Synergistic effect of tumor virus transformation and tumor promoter treatment on the production of plasminogen activator by chick embryo fibroblasts.

1978 • 85 citations

A Cysteine‐Rich Collagenous Protein from Bovine Placenta

1981 • 80 citations

Phorbol ester and mitogens stimulate human fibroblast secretions of plasmin-activatable plasminogen activator and protease nexin, an antiactivator/antiplasmin.

1983 • 78 citations

Histochemical localization of cathepsin B at the invasion front of the rabbit V2 carcinoma.

1981 • 78 citations

Electron microscopic observations of collagenolytic activity of basal cell epithelioma of the skin in vivo and in vitro.

1972 • 75 citations

Immunolocalization of collagenase in periodontal disease

1981 • 71 citations

The cellular target for the plasminogen activator, urokinase, in human fibroblasts - 66 000-dalton protein

1982 • 71 citations

Collagenase Activity in Epidermoid Carcinoma of the Oral Cavity and Larynx

1975 • 71 citations

Characterization of a latent cysteine proteinase from ascitic fluid as a high molecular weight form of cathepsin B

1983 • 67 citations

The invasive growth of malignant tumours as a purely mechanical process

1973 • 66 citations

The behavior of basement membranes in intraductal carcinoma of the breast.

1959 • 66 citations

Interaction of metastatic tumor cells with bovine lens capsule basement membrane.

1984 • 65 citations

Plasminogen activator and cancer

1984 • 65 citations

In vitro synthesis of laminin and entactin polypeptides.

1983 • 60 citations

Collagenase immunolocalization studies of cutaneous secondary melanomas

1980 • 60 citations

[32] Proteolysis of insoluble elastin

1982 • 57 citations

Etude ultrastructurale sur la pathogénie de l'invasion du muscle strié par des tumeurs transplantables

1976 • 53 citations

Biosynthesis of procollagen [(pro alpha 1 V)2 (pro alpha 2 V)] by chick tendon fibroblasts and procollagen (pro alpha 1 V)3 by hamster lung cell cultures.

1981 • 53 citations

Similarity in the Sequence of Escherichia coli Dihydrofolate Reductase with Other Pyridine Nucleotide-requiring Enzymes

1974 • 52 citations

Chondroitin SO4 catabolism in chick embryo chondrocytes

1979 • 52 citations

Heterogeneity of Pepsin-Solubilized Human Glomerular Basement Membrane Collagen

1978 • 50 citations

The activation of latent pig synovial collagenase

1981 • 45 citations

Collagenolytic activity of rabbit V2-carcinoma growing at multiple sites

1978 • 44 citations

Metabolism of Sulfated Glycosaminoglycans in Cultivated Bovine Arterial Cells. II. Quantitative Studies on the Uptake of³⁵SO₄-Labeled Proteoglycans

1975 • 42 citations

Regulation of Tumor Invasion by Cartilage-Derived Anti-Invasion Factor In Vitro<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 42 citations

Collagenase activity in rabbit carcinoma: Cell source and cell interactions

1983 • 42 citations

Basement membrane changes under neoplastic oral mucous membrane

1977 • 41 citations

Proteolytic Enzymes in Tumor Metastasis. II. Collagenase Type IV Activity in Subcellular Fractions of Cloned Tumor Cell Populations<xref ref-type="fn" rid="FN2">2</xref>

1985 • 41 citations

Analysis of elastin gene expression in the developing chick aorta using cloned elastin cDNA.

1982 • 40 citations

Isolation and characterization of A peptide containing the site of cleavage of the chick skin collagen α1[I] chain by animal collagenases

1979 • 39 citations

Purification and properties of a specific collagenase from rabbit synovial fibroblasts

1975 • 37 citations

Cathepsin B, the lysosomal thiol proteinase of calf liver

1969 • 35 citations

Biochemical mechanisms involved in tumor cell penetration of the basement membrane

1982 • 30 citations

Co‐operation between metastatic tumor cells and macrophages in the degradation of basement membrane (type IV) collagen

1983 • 27 citations

Objective measurement of basement membrane abnormalities in human neoplasms of colorectum and of breast

1978 • 24 citations

Metastatic cell attachment to and invasion of vascular endothelium and its underlying basal lamina using endothelial cell monolayers.

1983 • 23 citations

Relationship between multiple forms of plasminogen activator in human breast tumors and plasma and the presence of metastases in lymph nodes.

1984 • 23 citations

Synthesis of DNA from Vaccinia Messenger RNA Templates

1972 • 22 citations

Collagenase activity in cultures of rat prostate carcinoma

1979 • 19 citations

Enzymatic Degradation of Collagen^a

1962 • 18 citations

Host-tumor cell interactions and collagenase activity

1982 • 18 citations

The secretion of fibrinolysin by cultured rat ovarian tumor cells

1973 • 16 citations

Plasminogen activators and steroid receptor concentrations in normal, benign, and malignant breast and ovarian tissues.

1983 • 15 citations

Proteoglycans in Basement Membranes

1984 • 11 citations

Primary tumor growth and formation of spontaneous lung metastases in mice bearing Lewis carcinoma treated with proteinase inhibitors.

1984 • 9 citations

Studies on the Molecular Composition and Degradation of Type IV Procollagen

1984 • 8 citations

Collagenase immunolocalisation studies of human tomours

1982 • 7 citations

Human Collagenases: Comparative and Immunolocalization Studies

1980 • 7 citations

[Collagenase activity in an animal and a human carcinoma (author's transl)].

1977 • 5 citations

Meanwhile, at NCI the Search for Director Narrows

1977 • 3 citations

Chapter 23. Collagenases in Tumor Cell Extravasation

1984 • 3 citations

[Relationship of the collagenase activity to the DNA content in simple solid carcinoma of the breast].

1970 • 3 citations

Deleted Work

1955 • 0 citations