Enzymic Degradation of Collagen

A MODIFIED NINHYDRIN REAGENT FOR THE PHOTOMETRIC DETERMINATION OF AMINO ACIDS AND RELATED COMPOUNDS

1954 • 3,024 citations

Lysosomes in biology and pathology

1977 • 2,068 citations

COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY

1962 • 1,275 citations

The Chromatographic Separation and Amino Acid Composition of the Subunits of Several Collagens^*

1963 • 706 citations

Chemistry and molecular biology of the intercellular matrix

1970 • 626 citations

[α1(III)]3 Human Skin Collagen

1974 • 592 citations

The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen

1973 • 563 citations

Collagen Polymorphism: Characterization of Molecules with the Chain Composition [α1(III)] ₃ in Human Tissues

1974 • 524 citations

Structure and Biosynthesis of Basement Membranes

1973 • 519 citations

The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans

1973 • 448 citations

Book Review: Treatise on Collagen

1969 • 442 citations

Structural studies on cartilage collagen employing limited cleavage and solubilization with pepsin

1972 • 420 citations

Analysis of the primary structure of collagen for the origins of molecular packing

1973 • 413 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Isolation and characterization of a chick cartilage collagen containing three identical chains

1971 • 395 citations

Tadpole Collagenase. Preparation and Purification^*

1966 • 390 citations

The Nature of the Intramolecular Cross-Links in Collagen. The Separation and Characterization of Peptides from the Cross-Link Region of Rat Skin Collagen^*

1966 • 374 citations

Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies.

1971 • 369 citations

The Neutral Proteases of Human Granulocytes

1973 • 366 citations

Zur quantitativen Bestimmung der Kollagenase

1963 • 352 citations

Biological significance of the intermolecular crosslinks of collagen

1974 • 346 citations

Structure primaire de la caséine β bovine

1972 • 343 citations

Specific degradation of the collagen molecule by tadpole collagenolytic enzyme.

1965 • 339 citations

The Native and Denatured States of Soluble Collagen

1956 • 330 citations

CHICK CARTILAGE COLLAGEN: A NEW TYPE OF α1 CHAIN NOT PRESENT IN BONE OR SKIN OF THE SPECIES

1969 • 329 citations

BIOLOGICAL FUNCTIONS OF COLLAGEN

1961 • 309 citations

Collagenases

1974 • 303 citations

Evidence for the Linkage of a Disaccharide to Hydroxylysine in Tropocollagen

1966 • 298 citations

Identification of three genetically distinct collagens by cyanogen bromide cleavage of insoluble human skin and cartilage collagen

1971 • 292 citations

Isolation of a collagen from basement membranes containing three identical α-chains

1971 • 287 citations

The chemistry of the collagen cross-links. Age-related changes in the reducible components of intact bovine collagen fibres

1973 • 284 citations

Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera

1972 • 272 citations

Collagenase Production by Lymphokine-Activated Macrophages

1975 • 269 citations

An endopeptidase from rheumatoid synovial tissue culture

1972 • 252 citations

Some Properties of the Products of Reaction of Tadpole Collagenase with Collagen^*

1967 • 246 citations

The release of collagenase as an inactive proenzyme by bone explants in culture

1972 • 236 citations

On the Significance of the Extractable Collagens

1960 • 233 citations

Hydroxyproline content determines the denaturation temperature of chick tendon collagen

1973 • 224 citations

Human skin collagenase, isolation and mechanism of attack on the collagen molecule

1968 • 211 citations

C1q: Rapid Purification Method for Preparation of Monospecific Antisera and for Biochemical Studies

1971 • 206 citations

Hydroxyproline stabilizes the triple helix of chick tendon collagen

1973 • 201 citations

Characterization of Chick Bone Collagen and Compositional Changes Associated with Maturation

1967 • 195 citations

Zymogen of tadpole collagenase

1971 • 194 citations

Isolation of two distinct collagens from chick cartilage

1970 • 193 citations

Effects of Pepsin Treatment on the Interaction Properties of Tropocollagen Macromolecules^*

1965 • 189 citations

Chemistry of the collagen cross-links. Isolation and characterization of two intermediate intermolecular cross-links in collagen

1970 • 189 citations

Isolation and Characterization of the Cyanogen Bromide Peptides from the α1 Chain of Rat Skin Collagen^*

1967 • 187 citations

The Influence of Temperature and Fibril Stability on Degradation of Cartilage Collagen by Rheumatoid Synovial Collagenase

1974 • 187 citations

Catabolism of collagen and non-collagen protein in the rat uterus during post-partum involution

1962 • 179 citations

Tropocollagen: Significance of Protease-Induced Alterations

1963 • 170 citations

A specific collagenase from rabbit fibroblasts in monolayer culture

1974 • 168 citations

Purification and Properties of Clostridiopeptidase B (Clostripain)

1968 • 165 citations

Human aorta collagens: Evidence for three distinct species

1974 • 156 citations

Studies on the location of intermolecular crosslinks in collagen. Isolation of a cyanogen bromide peptide containing δ-hydroxylysinonorleucine

1972 • 154 citations

Properties of a collagen molecule containing three identical components extracted from bovine articular cartilage

1971 • 154 citations

The nature and location of intramolecular cross-links in collagen.

1966 • 153 citations

Isolation and characterization of the cyanogen bromide peptides from the αl(II) chain of bovine and human cartilage collagen

1973 • 152 citations

A Review of Biochemical Studies on the Genetically Distinct Collagens of the Skeletal System

1973 • 151 citations

Comparative Sequence Studies of Rat Skin and Tendon Collagen. I. Evidence for Incomplete Hydroxylation of Individual Prolyl Residues in the Normal Proteins^*

1967 • 149 citations

Preparation of type III procollagen and collagen from rat skin

1974 • 147 citations

Pyrrolidonyl peptidase. Enzyme for selective removal of pyrrolidonecarboxylic acid residues from polypeptides

1968 • 146 citations

The Amino Acid Sequence of Peptides from the Cross-Linking Region of Rat Skin Collagen^*

1967 • 146 citations

Animal collagenases: Specificity of action, and structures of the substrate cleavage site

1974 • 144 citations

Collagenases

1974 • 142 citations

Subunits of the collagen molecule

1961 • 135 citations

Collagen Heterogeneity

1972 • 129 citations

PURIFICATION AND SOME PROPERTIES OF PROLIDASE OF SWINE KIDNEY

1957 • 126 citations

Correlation Between Tensile Strength and Collagen Content in Rat Skin. Effect of Age and Cortisol Treatment

1974 • 124 citations

Animal and Human Collagenases**From the Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

1970 • 123 citations

Collagenase from rat uterus. Isolation and partial characterization

1970 • 123 citations

THE SEPARATION AND DETERMINATION OF CYCLIC IMINO ACIDS

1956 • 123 citations

The composition of collagen and acid-soluble collagen of bovine skin

1955 • 120 citations

Purification and partial characterization of collagenolytic enzymes from Clostridium histolyicum

1968 • 120 citations

Collagen heterogeneity within different growth regions of long bones of rachitic and nonrachitic chicks

1972 • 118 citations

The Staining Pattern of Collagen Fibrils: I. an Analysis of Electron Micrographs

1974 • 116 citations

Phagocytic Release and Activation of Human Leukocyte Procollagenase

1973 • 115 citations

Acid Soluble Calf Skin Collagen

1971 • 114 citations

BINDING OF MUCOPOLYSACCHARIDES AND DYES BY COLLAGEN

1951 • 113 citations

Collagenases

1974 • 112 citations

Intermediate labile intermolecular crosslinks in collagen fibres

1968 • 110 citations

Electron microscope studies of the effects of endo- and exopeptidase digestion on tropocollagen

1970 • 108 citations

The Formation of Triple‐Helical Collagen Molecules from α1 or α2 Polypeptide Chains

1969 • 108 citations

Characterization of the α-chains of chick skin collagen and the nature of the amino-terminal cross-link region

1969 • 108 citations

Resistance to collagenase: A characteristic of collagen fibrils cross-linked by formaldehyde

1972 • 107 citations

Band pattern of the segment-long-spacing form of collagen. Its use in the analysis of primary structure

1973 • 106 citations

On the Molecular Structure of Collagen

1969 • 105 citations

A PROTEOLYTIC ENZYME OF STREPTOMYCES GRISEUS

1960 • 104 citations

The Limited Cleavage of Native Collagen with Chymotrypsin, Trypsin, and Cyanogen Bromide^*

1966 • 102 citations

The nature of the collagenolytic cathepsin of rat liver and its distribution in other rat tissues

1972 • 100 citations

Purification and amino acid composition of monomeric and polymeric collagens

1967 • 96 citations

The effect of chelating agents on collagen interfibrillar matrix interactions in connective tissue

1967 • 95 citations

Collagenolytic protease from the hepatopancreas of the fiddler crab, Uca pugilator. Purification and properties

1973 • 95 citations

Collagen chain formation and peptidyl proline hydroxylation in monolayer tissue cultures of L-929 fibroblasts

1969 • 95 citations

Activation of leucocyte collagenase proenzyme by rheumatoid synovial fluid

1972 • 93 citations

The Covalent Structure of Collagen

1972 • 92 citations

Localization of Two Species Specific Antigenic Determinants on the Peptide Chains of Calf Skin Collagen

1970 • 92 citations

Collagenase and rheumatoid arthritis

1970 • 89 citations

The Properties of Molecular Fragments Obtained on Treating Calfskin Collagen with Collagenase from Clostridium histolyticum

1968 • 89 citations

Biochemistry of collagen crosslinking isolation of a new crosslink, hydroxylysinohydroxynorleucine, and its reduced precursor, dihydroxynorleucine, from bovine tendon

1970 • 88 citations

The amino acid sequence of the carboxyterminal nonhelical cross link region of the α 1 chain of calf skin collagen

1972 • 87 citations

The Renaturation of Soluble Collagen. Products Formed at Different Temperatures^*

1966 • 87 citations

Role of granulocyte collagenase in collagen degradation.

1972 • 86 citations

Lysosomal enzyme activity in rats with adjuvant-induced arthritis.

1970 • 85 citations

A PROTEOLYTIC ENZYME OF STREPTOMYCES GRISEUS

1960 • 82 citations

THE EFFECTS OF PROTEASES ON THE TROPOCOLLAGEN MACROMOLECULE AND ON ITS AGGREGATION PROPERTIES

1960 • 81 citations

Chemical studies on the cyanogen bromide peptides of rat skin collagen. Covalent structure of α1-CB5, the major hexose-containing cyanogen bromide peptide of α1

1970 • 80 citations

The Cleavage of Prolyl Peptides by Kidney Peptidases

1970 • 78 citations

High‐resolution analysis of the modified quarter‐stagger model of the collagen fibril

1974 • 76 citations

PEPTIDASES OF ERYTHROCYTES

1952 • 76 citations

The long range reorganization of gelatin to the collagen structure

1961 • 76 citations

An extractable collagenase from crustacean hepatopancreas

1969 • 75 citations

Isolation and characterization of the cyanogen bromide peptides from the α1 and α2 chains of human skin collagen

1970 • 75 citations

The isolation, and amino acid and carbohydrate composition, of polymeric collagens prepared from various human tissues

1971 • 73 citations

Amino acid sequence of cyanogen bromide peptides from the amino-terminal region of chick skin collagen

1970 • 72 citations

Localization of Antigenic Determinants in the Polypeptide Chains of Collagen

1969 • 72 citations

Comparative Electron‐Microscope Studies on the Collagens Extracted from Cartilage, Bone, and Skin

1972 • 72 citations

Structural Characterization of a Soluble Fraction from Lens‐Capsule Basement Membrane

1973 • 71 citations

Collagenase, procollagenase and activator relationships in tadpole tissue cultures

1972 • 70 citations

Separation of collagenase and peptidase activities of Tadpole tissues in culture

1970 • 70 citations

Characterization of the aldehydes present on the cyanogen bromide peptides from mature rat skin collagen

1971 • 70 citations

The purification of bovine cathepsin B1 and its mode of action on bovine collagens

1974 • 70 citations

Mouse bone collagenase

1973 • 69 citations

Isolation and characterization of cyanogen bromide peptides from basement membrane collagen

1972 • 68 citations

Partial Purification and Specificity of Iminodipeptidase

1953 • 67 citations

Collagen cross-linking. Isolation of cross-linked peptides from collagen of chicken bone

1973 • 66 citations

Gelatin: A Poor Substrate for a Mammalian Collagenase

1973 • 65 citations

The Covalent Structure of Collagen

1973 • 65 citations

Hydrolysis of synthetic peptides by collagenase

1960 • 65 citations

A Comparison of Glycopeptides Derived from Soluble and Insoluble Collagens

1968 • 65 citations

Quantitative bestimmung der kollagenase.

1963 • 64 citations

GAMMA TROPOCOLLAGEN: A REVERSIBLY DENATURABLE COLLAGEN MACROMOLECULE

1961 • 64 citations

Evidence for a non‐helical region at the carboxyl terminus of the collagen molecule

1971 • 64 citations

Direct evidence for a correlation between amino acid sequence and cross striation pattern of collagen

1970 • 63 citations

Collagenase in the cornea

1969 • 63 citations

A Collagenolytic Enzyme from Aspergillus oryzae

1968 • 61 citations

Molecular pathology of connective tissues

1973 • 60 citations

Effects of lysosomal collagenolytic enzymes, anti-inflammatory drugs and other substances on some properties of insoluble collagen

1969 • 58 citations

Multiple steps in the activation of the inactive precursor of bone collagenase by trypsin

1972 • 57 citations

Collagenase in carcinoma cells

1972 • 56 citations

The Covalent Structure of Collagen

1972 • 56 citations

Heterogeneity of the α Chains of Rat Skin Collagen and Its Relation to the Biosynthesis of Cross-Links^*

1966 • 55 citations

Collagen Synthesis and Turnover in the Growing Rat Under the Influence of Methyl Prednisolone.

1964 • 55 citations

THE DEVELOPMENTAL BIOLOGY OF VERTEBRATE COLLAGENS

1973 • 55 citations

Occurrence of type III collagen in inflamed synovial membranes: A comparison between non rheumatoid, rheumatoid, and normal synovial collagens

1975 • 54 citations

A collagenolytic system produced by primary cultures of rheumatoid nodule tissue

1972 • 53 citations

The degradation of acid-soluble collagen by rat-liver preparations

1962 • 53 citations

Action of Rheumatoid Synovial Collagenase on Cartilage Caollagen

1975 • 53 citations

Das quantitative Verhältnis zwischen α-und β-Komponente des denaturierten, löslichen Kollagens in der Ultrazentrifuge sowie Beschreibung einer schneller sedimentierenden γ-Komponente

1961 • 51 citations

Partial Hydroxylation of Certain Lysines In Collagen

1968 • 51 citations

The Effects of Acetic Acid on Collagen Cross-Links

1972 • 50 citations

Oestradiol inhibits collagen breakdown in the involuting rat uterus

1972 • 49 citations

Further study on the activation of collagen proline hydroxylase in cultures of L-929 fibroblasts

1970 • 49 citations

The effects of gamma irradiation on the structure and reactivity of native and cross-linked collagen fibres.

1973 • 48 citations

Mammalian Collagenases

1973 • 48 citations

Characterization of a collagenase from rat skin

1972 • 47 citations

Human Gingival Collagenase: Purification, Molecular Weight, and Inhibitor Studies

1972 • 47 citations

Cross‐Linkages in Collagen

1970 • 45 citations

Failure of human rheumatoid synovial collagenase to degrade either normal or rheumatoid arthritic polymeric collagen

1971 • 44 citations

The collagenolytic enzyme of the regenerating limb of the newtTriturus viridescens

1970 • 44 citations

The Cleavage of Prolyl Peptides by Kidney Peptidases

1970 • 44 citations

Intramolecular cross-link of chick skin collagen

1969 • 42 citations

The Site of Attachment of Hexose in Tropocollagen

1965 • 40 citations

A comparison between the reducible intermolecular crosslinks of the collagens from mature dermis and young dermal scar tissue of the guinea pig

1972 • 40 citations

Evidence for a Faster Degradation of an Atypical Hydroxyproline and Hydroxylysine Deficient Collagen Formed under the Effect of 2,2′‐Dipyridyl

1967 • 39 citations

`COLLAGENASE-LIKE' PEPTIDASE IN HUMAN, RAT AND BULL SPERMATOZOA

1973 • 39 citations

Carbohydrate content of bovine collagen preparations

1968 • 39 citations

Activation of latent collagenase by microbial plaque

1974 • 38 citations

Evidence for two antigenic determinants in the C‐terminal region of rat skin collagen

1970 • 38 citations

Hydroxylysine in the N-terminal regions of the α1- and α2-chains of various collagens

1971 • 38 citations

Darstellung von Prolinpeptiden, III. Ein neues Substrat zur Bestimmung der Kollagenase

1963 • 38 citations

Influence of proline hydroxylation upon the thermal stability of collagen fragment α1CB2

1973 • 37 citations

The solubilization of mature, polymeric collagen fibrils by lyotropic relaxation

1970 • 36 citations

The covalent structure of collagen. Amino acid sequence of the N‐terminal region of α2‐CB4 from calf and rat skin collagen

1972 • 36 citations

Simultaneous Quantification of 3H-Collagen Loss and 1H-Collagen Replacement During Healing of Rat Tendon Grafts

1972 • 34 citations

Different antigenic determinants in the polypeptide chains of human collagen

1971 • 33 citations

General Proteolytic Activity of Highly Purified Preparations of Clostridial Collagenase

1974 • 33 citations

Electron microscope studies on collagen

1964 • 32 citations

Factors affecting the interactions of collagen molecules as observed by in vitro fibril formation. II. Effects of species and concentration of anions.

1973 • 32 citations

Intermolecular Cross‐Links of Collagen

1973 • 31 citations

Kollagenase in Zellen höher entwickelter Tiere

1968 • 31 citations

Closest packing of two-stranded coiled-coils as a model for the collagen fibril

1975 • 31 citations

Estimation of mammalian collagenolytic activity with a synthetic substrate.

1967 • 29 citations

The effects of acetic acid and pepsin on the crosslinkages and ultrastructure of corneal collagen

1973 • 29 citations

Cartilage collagen: Inability to serve as a substrate for collagenases active against skin and bone collagen

1972 • 29 citations

Biosynthesis of the Intramolecular Cross-links in Rat Skin Collagen

1968 • 27 citations

The Degradation of Human Dentine Collagen by Trypsin

1974 • 27 citations

Molecular Fragments of Rat Skin Collagen Obtained on Collagenase Digestion

1968 • 27 citations

Hydroxylysine in the N-terminal telopeptides of skin collagen from chick embryo and newborn rat

1971 • 26 citations

Kollagenfibrillen mit anormalem Querstreifungsmuster

1964 • 25 citations

The Use of Synthetic Substrates for the Determination of Mammalian Collagenases. Is Collagenolytic Activity present in Mitochondria?

1969 • 25 citations

Comparative Studies on the Insoluble Collagens of Guinea-Pig Dermis and Dermal Scar Tissue

1972 • 24 citations

Reinigung von Kollagenase, III. Gewinnung enzymatisch einheitlicher Kollagenase

1966 • 24 citations

Polymeric Collagen of Skin in Normal Subjects and in Patients with Inherited Connective Tissue Disorders

1973 • 24 citations

The extraction of polymeric collagen from biopsies of human skin

1971 • 24 citations

Preparation of insoluble collagen from human cartilage (Short Communication)

1973 • 24 citations

The Covalent Structure of Collagen: Amino Acid Sequence of the N-Terminal Region of α2-CB3 from Rat Skin Collagen and α2-CB3.5 from Calf Skin Collagen

1974 • 23 citations

Single-stage partial depolymerisation of collagen fibrils

1966 • 22 citations

The cleavage of tyrosyl peptides by pepsin from collagen solubilised by the Nishihara technique

1965 • 22 citations

Depolymerisation of Human and Bovine Polymeric Collagen Fibrils

1972 • 21 citations

The Isolation of Collagenase and Its Enzymological and Physico-chemical Properties

1973 • 21 citations

Corneal Collagenase: Specific Cleavage of Types (α1)_2α2 and (α1)₃Collagens

1973 • 21 citations

SPECIFICITY OF PROLIDASE: EFFECT OF ALTERATIONS IN THE PYRROLIDINE RING OF GLYCYL-l-PROLINE

1954 • 20 citations

Elucidation of the Exact Sites of Cleavage of Tropocollagen by Rheumatoid Synovial Collagenase: Correlation of Cleavage Sites with Fibril Structure

1973 • 20 citations

A collagenase in extracts of the invertebrate Bipalium kewense

1973 • 19 citations

Homeostasis in Extracellular Tissues: Insights from Studies on Collage

1973 • 17 citations

Pseudocollagenase: A protease from Clostridium histolyticum

1968 • 17 citations

The Covalent Structure of Collagen

1973 • 16 citations

Action of human skin collagenase on cartilage collagen

1973 • 15 citations

The isolation and characterization of bovine corneal collagen

1974 • 15 citations

The action of crude bacterial α-amylase on tropocollagen

1971 • 14 citations

An improved enzymic hydrolysis of collagen

1971 • 14 citations

Enzyme system in rat leucocyte granules which degrades insoluble collagen.

1971 • 14 citations

Evidence for a new bacterial collagenolytic enzyme

1965 • 13 citations

Specificity of iminodipeptidase: Effect of alterations in in the pyrrolidine ring of l-prolylglycine

1955 • 13 citations

Collagenase-like peptidase activity in fibrotic liver tissue

1967 • 13 citations

Time-dependent Increase in Stability of Collagen Fibrils Formed in Vitro

1974 • 11 citations

Correlation between pronase susceptibility and hydroxy proline content of collagen fiber

1968 • 11 citations

The covalent structure of collagen: The tryptic, thermolytic and chymotryptic peptides of α1‐CB3 from calf skin collagen

1972 • 11 citations

Solubilization of collagen fibrils by human leucocyte collagenase activated by rheumatoid synovial fluid.

1974 • 10 citations

Action of crude bacterial α-amylase on tropocollagen

1970 • 9 citations

An enzyme system in the gastric secretion capable of reducing the viscosity of native soluble calf-skin collagen

1963 • 9 citations

A Comparative Study of the Crosslinking Precursors Present in Rat Skin and Tail Tendon Collagen

1974 • 9 citations

Peptidase in the cornea

1969 • 9 citations

The action of crude bacterial α-amylase on tropocollagen and on polymeric collagen

1970 • 8 citations

Role of Cathepsins in Granulation Tissue

1972 • 8 citations

The depolymerising action of pepsin on collagen. Column fractionation of the component polypeptide chains

1966 • 8 citations

In vitro formation of crosslinks in mature rat skin collagen in the absence of N-terminal peptides

1971 • 8 citations

Immunogenicity and specificity of collagen. IX. Resistance of different antigenic determinants of calf collagen to proteolytic treatment.

1970 • 7 citations

Limited Degradation of Gelatin Substrate by Cathepsin D

1972 • 7 citations

Proceedings: Abnormalities in rheumatoid synovial collagen: studies on synovial polymeric collagens (PC) from normal individuals and patients with rheumatoid and other arthropathies.

1974 • 6 citations

Evidence for intra-chain masked carboxyl groups in polymeric collagen

1972 • 6 citations

Enzymatic solubilization and separation of glomerular collagen and sialoprotein. Effect of contaminating enzymes present in commercial collagenase preparations.

1974 • 6 citations

Collagenolytic enzymes and acid-proteinase activity in granuloma tissue

1974 • 6 citations

Characterization of the large fragments from pepsin-digested, denatured collagen

1968 • 5 citations

The Degradation of Human Dentine Collagen by Enzymes Derived From Bacillus Subtilis

1974 • 4 citations

Fractionation of pepsin-digested, denatured collagen

1968 • 4 citations

Breakdown of Paraffin Wax by Bacteria: A Source of Error in Corrosion Tests

1943 • 3 citations

The Effects of pH and Borohydride Reduction on the Solubilization of Steer Hide Collagen by Pronase<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1973 • 2 citations

The Mechanism of Collagen Decomposition in Mammals

1974 • 1 citations