Endothelin blockade augments pulmonary vasodilation in the ovine fetus

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

1992 • 880 citations

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 • 691 citations

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 • 650 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells

1993 • 386 citations

Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

1989 • 354 citations

Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia

1994 • 255 citations

Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus

1992 • 229 citations

Endothelin‐converting enzymes

1992 • 223 citations

Gestational changes in pulmonary vascular responses in fetal lambs in utero.

1976 • 211 citations

Fluid flow decreases preproendothelin mRNA levels and suppresses endothelin-1 peptide release in cultured human endothelial cells

1991 • 198 citations

Normobaric hypoxia stimulates endothelin-1 gene expression in the rat

1992 • 182 citations

Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs.

1989 • 180 citations

Ligating the Ductus Arteriosus before Birth Causes Persistent Pulmonary Hypertension in the Newborn Lamb

1989 • 165 citations

Endothelin-1 Release from Endothelial Cells in Culture Is Elevated Both Acutely and Chronically by Short Periods of Mechanical Stretch

1994 • 160 citations

Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation.

1994 • 138 citations

BQ123, an ET_A Receptor Antagonist, Inhibits Endothelin-1-mediated Proliferation of Human Pulmonary Artery Smooth Muscle Cells

1993 • 130 citations

Endothelin 1: Mitogenic Activity on Pulmonary Artery Smooth Muscle Cells and Release from Hypoxic Endothelial Cells

1992 • 126 citations

Disruption of cytoskeletal structures mediates shear stress-induced endothelin-1 gene expression in cultured porcine aortic endothelial cells.

1993 • 119 citations

The endothelin peptides ET-1, ET-2, ET-3 and sarafotoxin S6b are co-mitogenic with platelet-derived growth factor for vascular smooth muscle cells

1990 • 118 citations

Pressure Enhances Endothelin-1 Release From Cultured Human Endothelial Cells

1995 • 117 citations

In Vitro Biological Profile of a Highly Potent Novel Endothelin (ET) Antagonist BQ-123 Selective for the ETA Receptor

1992 • 116 citations

Acute effects of partial compression of ductus arteriosus on fetal pulmonary circulation

1989 • 104 citations

Tone-dependent responses to endothelin in the isolated perfused fetal sheep pulmonary circulation in situ

1991 • 88 citations

Endothelial cell storage and release of endothelin as a cardioregulatory mechanism.

1994 • 88 citations

Leukotriene end organ antagonists increase pulmonary blood flow in fetal lambs

1985 • 82 citations

Role of prostaglandins, thromboxanes, and leukotrienes in the control of the pulmonary circulation in the fetus and newborn.

1987 • 74 citations

Chronic hypoxia changes the ratio of endothelin to ATP release from rat aortic endothelial cells exposed to high flow

1992 • 64 citations

Chronic Intrauterine Pulmonary Hypertension Alters Endothelin Receptor Activity in the Ovine Fetal Lung

1996 • 63 citations

Involvement of endothelin‐1 in hypoxic pulmonary vasoconstriction in the lamb.

1995 • 63 citations

Isolated pulmonary resistance vessels from fetal lambs. Contractile behavior and responses to indomethacin and endothelin-1.

1992 • 60 citations

Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb

1993 • 60 citations

The Role of Endothelin and Endothelin Receptor Subtypes in Regulation of Fetal Pulmonary Vascular Tone

1994 • 57 citations

Hemodynamic effects of endothelin-1 on ovine fetal pulmonary circulation

1991 • 57 citations

Endothelins stimulate mitogen-activated protein kinase cascade through either ETA or ETB

1994 • 55 citations

Pulmonary hemodynamics at birth: effect of acute cyclooxygenase inhibition in lambs

1988 • 54 citations

Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation

1991 • 53 citations

Effect of Phosphoramidon (Endothelin Converting Enzyme Inhibitor) and BQ-123 (Endothelin Receptor Subtype A Antagonist) on Blood Pressure in Hypertensive Rats

1993 • 50 citations

Characterization of endothelin receptors in newborn piglet lung

1995 • 49 citations

Endothelinb Receptor Agonists Produce Pulmonary Vasodilation in Intact Newborn Lambs with Pulmonary Hypertension

1995 • 47 citations

Effect of Lung Expansion on the Fetal Lamb Circulation

1966 • 46 citations

The effects of phosphoramidon on the regional haemodynamic responses to human proendothelin [1–38] in conscious rats

1991 • 42 citations

Endothelin-1-induced pulmonary arterial dilation is reduced by N omega-nitro-L-arginine in fetal lambs

1992 • 36 citations

Systemic and pulmonary hemodynamic effects of big endothelin-1 and phosphoramidon in the ovine fetus

1994 • 30 citations

Direct pulmonary vascular responses in the conscious newborn lamb

1980 • 28 citations

Pulmonary Hypoxia Increases Endothelin-1 Gene Expression in Sheep

1994 • 26 citations

Enzyme immunometric assay for endothelin using tandem monoclonal antibodies

1993 • 26 citations

Adaptation of Fetal Pulmonary Blood Flow to Local Infusion of Tolazoline

1986 • 24 citations

Endothelin Receptor Blockade Does Not Alter the Increase in Pulmonary Blood Flow Due to Oxygen Ventilation in Fetal Lambs

1996 • 22 citations

Characterization of rat lung endothelin receptor subtypes which are coupled to phosphoinositide hydrolysis.

1992 • 20 citations

Ontogeny of Big endothelin-1 effects in newborn piglet pulmonary vasculature

1993 • 13 citations

The role of atrial natriuretic peptide and endothelin in hypoxia induced pulmonary hypertension.

1994 • 4 citations