Spheroids for Studies of Drug Effects

A simplified method for production and growth of multicellular tumor spheroids.

1977 • 501 citations

Cloning of Human Tumor Stem Cells

1981 • 269 citations

Radiation response of multicell spheroids--an in vitro tumour model.

1976 • 236 citations

Resistance to adriamycin in multicellular spheroids

1979 • 227 citations

Selective dissociation and characterization of cells from different regions of multicell tumor spheroids.

1980 • 202 citations

Spheroids in Cancer Research

1984 • 176 citations

Selective chemotherapy of noncycling cells in an in vitro tumor model.

1974 • 170 citations

Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy.

1980 • 155 citations

Demonstration of an extracellular matrix in multicellular tumor spheroids.

1984 • 142 citations

Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro.

1981 • 134 citations

Pharmacokinetics and metabolism of vinblastine in humans.

1977 • 126 citations

Use of Hoechst 33342 for cell selection from multicell systems.

1982 • 120 citations

Cloning of human tumor stem cells

1980 • 119 citations

A fluorometric assay for daunomycin and adriamycin in animal tissues

1973 • 108 citations

Proliferation and viability in cellular spheroids of human origin.

1978 • 106 citations

Increased radioresistance of cells in cultured multicell spheroids. I. Dependence on cellular interaction

1981 • 91 citations

Penetration of substances into tumor tissue—A methodological study on cellular spheroids

1981 • 83 citations

Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids.

1984 • 73 citations

Growth and Radiation Survival Characteristics of V79-171b Chinese Hamster Cells: A Possible Influence of Intercellular Contact

1973 • 63 citations

Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model

1976 • 55 citations

Development of a 9L Rat Brain Tumor Cell Multicellular Spheroid System and Its Response to 1,3-Bis(2-chloroethyl)-1-nitrosourea and Radiation2

1980 • 53 citations

Survival of Irradiated Glia and Glioma Cells Studied with a New Cloning Technique

1980 • 53 citations

Response to chemotherapy of EMT6 spheroids as measured by growth delay and cell survival

1980 • 47 citations

Oxygen Transport to Tissue—IV

1983 • 44 citations

In vitro drug assay: pharmacologic considerations.

1980 • 43 citations

Resistance to vincristine of human cells grown as multicellular spheroids

1980 • 42 citations

Relationship between Surviving Fractions Using the Colony Method, the LD 50 , and the Growth Delay after Irradiation of Human Melanoma Cells Grown as Multicellular Spheroids

1981 • 40 citations

In vitro analysis of the response of multicellular tumor spheroids exposed to chemotherapeutic agents in vitro or in vivo.

1978 • 37 citations

In vitro cytotoxic drug sensitivity testing of human tumour xenografts grown as multicellular tumour spheroids

1982 • 33 citations

Increased radioresistance of cells in cultured multicell spheroids

1983 • 32 citations

Human lymphoblastoid interferon in the treatment of small cell lung cancer

1983 • 32 citations

Cell Kinetic Characteristics In Different Parts of Multicellular Spheroids of Human Origin

1981 • 32 citations

Penetration of substances into tumor tissue: A methodological study with microelectrodes and cellular spheroids

1983 • 28 citations

Activity of 4'-(9-acridinylamino)methanesulfon-m-anisidide against Chinese hamster cells in multicellular spheroids.

1981 • 28 citations

A Method to Measure the Radio and Chemosensitivity of Human Spheroids

1983 • 26 citations

Radiobiological Studies of Cells in Multicellular Spheroids Using a Sequential Trypsinization Technique

1981 • 25 citations

Growth delay in small EMT6 spheroids induced by cytotoxic drugs and its modification by misonidazole pretreatment under hypoxic conditions

1982 • 25 citations

Timing of assays: An important consideration in the determination of clonogenic cell survival both in vitro and in vivo

1979 • 24 citations

The multicellular spheroid system as a tumor model for studies of radiation sensitizers

1980 • 22 citations

Use of a bacterial neutral protease for disaggregation of mouse tumours and multicellular tumour spheroids

1980 • 19 citations

A study of factors related to the action of 1-Propargyl-5-chloropyrimidin-2-one (NY 3170) and vincristine in human multicellular spheroids

1981 • 15 citations

Double-barrell ion-sensitive microelectrodes with extra thin tip diameters for intracellular measurements.

1980 • 14 citations

Combination adriamycin/misonidazole toxicity in V79 spheroids

1982 • 10 citations

Different sensitivity to cytotoxic agents of internal and external cells of spheroids composed of thioguanine-resistant and sensitive cells

1981 • 10 citations

The response of EMT6 tumor spheroids to combined treatment with misonidazole and either nitrogen mustard, adriamycin, or BCNU.

1980 • 8 citations

Multicellular tumour spheroids from human brain tumours. A model for experimental chemotherapy in vitro?

1981 • 3 citations