A point mutation in the CYC1 UAS1 creates a new combination of regulatory elements that activate transcription synergistically.

Experiments in molecular genetics

1972 • 28,260 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

[10] Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast

1983 • 1,095 citations

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

1984 • 891 citations

Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site

1983 • 667 citations

Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements

1987 • 637 citations

Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae.

1988 • 511 citations

Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae

1984 • 501 citations

The yeast UASG is a transcriptional enhancer in human hela cells in the presence of the GAL4 trans-activator

1988 • 362 citations

GAL4 activates gene expression in mammalian cells

1988 • 355 citations

Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae.

1985 • 342 citations

A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation

1987 • 332 citations

Yeast HAP1 activator binds to two upstream activation sites of different sequence

1987 • 317 citations

The SV40 enhancer contains two distinct levels of organization

1988 • 286 citations

GAL4 derivatives function alone and synergistically with mammalian activators in vitro

1988 • 274 citations

Transcription and regulatory signals at the mating type locus in yeast

1984 • 256 citations

Multiple Global Regulators Control HIS4 transcription in Yeast

1987 • 246 citations

Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene

1987 • 245 citations

Yeast promoters: Positive and negative elements

1984 • 227 citations

Cooperative DNA binding of the yeast transcriptional activator GAL4.

1988 • 227 citations

A general upstream binding factor for genes of the yeast translational apparatus.

1985 • 222 citations

REGULATORY PROTEINS IN YEAST

1987 • 173 citations

Two DNA-Binding Factors Recognize Specific Sequences at Silencers, Upstream Activating Sequences, Autonomously Replicating Sequences, and Telomeres in Saccharomyces cerevisiae

1988 • 170 citations

Cloning of random-sequence oligodeoxynucleotides

1986 • 162 citations

Specific binding of TUF factor to upstream activation sites of yeast ribosomal protein genes.

1987 • 135 citations

One cell-specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer.

1987 • 127 citations

Identification of proteins involved in the regulation of yeast iso- 1-cytochrome C expression by oxygen.

1985 • 86 citations

Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins: a binding site for the HAP1 (CYP1) protein in the UAS region of the yeast catalase T gene (CTT1).

1988 • 85 citations

Transcription Elements and Factors of Rna Polymerase B Promoters of Higher Eukaryote

1988 • 82 citations

Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation.

1987 • 67 citations

Analysis of upstream activation sites of yeast ribosomal protein genes

1987 • 66 citations

The overproducing CYP1 and the underproducing hap1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromes c

1986 • 53 citations

Réseau d'interactions entre des gènes non liés: régulation synergique ou antagoniste de la synthèse de l'iso-l-cytochrome c, de l'iso-2-cytochrome c et du cytochrome b2

1976 • 50 citations

A factor discriminating between the wildtype and a mutant polyomavirus enhancer

1987 • 43 citations

Analytical studies of ‘mixed sequence’ oligodeoxyribonucleotides synthesized by competitive coupling of either methyl- or β-cyanoethyl-N,N-diisopropylamino phosphoramidite reagents, including 2′-deoxyinosine

1985 • 42 citations

A single Saccharomyces cerevisiae upstream activation site (UAS1) has two distinct regions essential for its activity.

1986 • 39 citations

A point mutation in the CYC1 UAS1 creates a new combination of regulatory elements that activate transcription synergistically.

1989 • 15 citations

Organization of the Regulatory Region of the Yeast CYC7 Gene: Multiple Factors Are Involved in Regulation

1987 • 15 citations

Solid-supported ligation primer

1988 • 14 citations

Preparation and use of a universal primed Sepharose for the purification of DNA‐binding proteins

1989 • 13 citations

A Single Saccharomyces cerevisiae Upstream Activation Site (UAS1) Has Two Distinct Regions Essential for Its Activity

1986 • 7 citations