Biochemical Pharmacology of Alcohol

The membrane actions of anesthetics and tranquilizers.

1972 • 2,194 citations

THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES 1

1948 • 2,051 citations

Enzymatic Basis for Active Transport of Na⁺ and K⁺ Across Cell Membrane

1965 • 2,008 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

Zur Theorie der Alkoholnarkose

1899 • 1,008 citations

Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels

1971 • 1,006 citations

Phase transitions and fluidity characteristics of lipids and cell membranes

1975 • 774 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

Ketone-body utilization by adult and suckling rat brain in vivo

1971 • 590 citations

Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding

1968 • 562 citations

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

1970 • 558 citations

Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase.

1975 • 546 citations

Drug Tolerance in Biomembranes: A Spin Label Study of the Effects of Ethanol

1977 • 511 citations

Effects of low concentrations of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes.

1977 • 458 citations

Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism

1970 • 441 citations

Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading the Withdrawal Reaction

1971 • 437 citations

Studien über die Narkose : zugleich ein Beitrag zur allgemeinen Pharmakologie

1901 • 401 citations

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.

1975 • 381 citations

Free Tryptophan in Plasma and Brain Tryptophan Metabolism

1972 • 380 citations

Tetrahydroisoquinoline Alkaloids: in vivo Metabolites of L-Dopa in Man

1973 • 369 citations

ETHANOL METABOLISM AND PRODUCTION OF FREE ACETATE IN THE HUMAN LIVER

1962 • 346 citations

Inhibition of hepatic gluconeogenesis by ethanol

1969 • 345 citations

THE CEREBRAL CIRCULATION

1936 • 319 citations

Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo

1973 • 312 citations

Reversible lipid titrations of the activity of pure adenosine triphosphatase-lipid complexes

1974 • 296 citations

Bioenergetics Bulletin Prospers

1970 • 281 citations

Effect of ethanol on plasma corticosterone levels.

1966 • 279 citations

Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase.

1975 • 265 citations

Spin-label studies of the excitable membranes of nerve and muscle.

1968 • 249 citations

Increased cholesterol content of erythrocyte and brain membranes in ethanol-tolerant mice

1978 • 248 citations

A Unitary Theory of Anesthesia Based on Lateral Phase Separations in Nerve Membranes

1977 • 235 citations

ALTERATIONS IN THE TURNOVER OF BRAIN NOREPINEPHRINE AND DOPAMINE IN ALCOHOL‐DEPENDENT RATS

1974 • 231 citations

Temperature Control of Phospholipid Biosynthesis in Escherichia coli

1971 • 227 citations

The Effect of Fatty Acids on the Binding of Tryptophan to Plasma Protein

1973 • 221 citations

Equilibrium relations between the oxidation—reduction reactions and the adenosine triphosphate synthesis in suspensions of isolated liver cells

1974 • 218 citations

Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.

1973 • 213 citations

Corticosterone Regulation of Tryptophan Hydroxylase in Midbrain of the Rat

1969 • 203 citations

Morphine and Ethanol: Selective Depletion of Regional Brain Calcium

1974 • 203 citations

The diuretic action of alcohol in man1

1942 • 201 citations

Adaptation of biological membranes to temperature. The effect of temperature acclimation of goldfish upon the viscosity of synaptosomal membranes

1977 • 201 citations

Effects of ethanol on neurotransmitter release by rat brain cortical.

1975 • 199 citations

Alterations in phospholipid-dependent (Na++K+)-ATPase activity due to lipid fluidity

1975 • 196 citations

The alteration of serotonin metabolism to 5-hydroxytryptophol by ethanol ingestion in man.

1967 • 192 citations

Effects of ethanol on central and peripheral noradrenergic neurons.

1974 • 188 citations

Effect of ethanol on plasma free fatty acids in man.

1962 • 184 citations

Currents in Alcoholism.

1978 • 179 citations

Synaptosomal membrane lipids of mice during continuous exposure to ethanol

1977 • 169 citations

Brain acetaldehyde after ethanol administration

1976 • 169 citations

Zur Theorie der Alkoholnarkose

1901 • 165 citations

The effects of alcohols on lipid bilayers: a spin label study.

1972 • 163 citations

Correlations between behavioral temperature adaptations of goldfish and the viscosity and fatty acid composition of their synaptic membranes

1977 • 162 citations

Effects of ethanol on Na, K, Mg-stimulated microsomal atpase activity

1965 • 161 citations

Alcohol and opiates : neurochemical and behavioral mechanisms

1977 • 157 citations

Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin

1968 • 150 citations

Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication

1975 • 149 citations

The lipid environment of the glucagon receptor regulates adenylate cyclase activity

1976 • 146 citations

BRAIN LEVELS AND TURNOVER RATES OF PRESUMPTIVE NEUROTRANSMITTERS AS INFLUENCED BY ADMINISTRATION AND WITHDRAWAL OF ETHANOL IN MICE¹

1974 • 143 citations

EFFECTS OF ETHANOL ON THE ACTIVITY OF ADENOSINE TRIPHOSPHATASE AND ACETYLCHOLINESTERASE IN SYNAPTOSOMES ISOLATED FROM GUINEA-PIG BRAIN

1970 • 139 citations

Effect of ethanol on the metabolism of brain catecholamines

1973 • 137 citations

Adrenal Function and Alcoholism

1971 • 135 citations

The acetaldehyde content in rat brain during ethanol metabolism

1974 • 133 citations

BRAIN CONCENTRATIONS OF BIOGENIC AMINE METABOLITES IN ACUTELY TREATED AND ETHANOL‐DEPENDENT RATS

1976 • 131 citations

Ethanol-induced alterations of norepinephrine metabolism in man.

1967 • 131 citations

General Depressant Drug Dependency: A Biophysical Hypothesis

1975 • 129 citations

The acute effect of ethanol on albumin, fibrinogen and transferrin synthesis in the rat

1972 • 128 citations

Changes in cation transport and (Na + K)-activated adenosine triphosphatase produced by chronic administration of ethanol.

1970 • 125 citations

Ethyl alcohol metabolism in animal tissues

1938 • 125 citations

Alcohol-induced depression of albumin synthesis: reversal by tryptophan

1971 • 120 citations

Tetrahydropapaveroline : Formation and in rat brain

1974 • 117 citations

ENZYMES CATALYSING ETHANOL METABOLISM IN NEURAL AND SOMATIC TISSUES OF THE RAT

1972 • 117 citations

The Metabolism of Alcohol

1976 • 116 citations

Effects of ethanol and pentobarbital on release of acetylcholine from cerebral cortex slices.

1967 • 114 citations

Interaction of general anesthetics with phospholipid vesicles and biological membranes

1977 • 114 citations

CHANGES IN MONOAMINE CONCENTRATIONS IN MOUSE BRAIN ASSOCIATED WITH ETHANOL DEPENDENCE AND WITHDRAWAL

1974 • 112 citations

The Finnish Foundation for Alcohol Studies

1989 • 112 citations

Reversal of Catecholamine Refractoriness by Inhibitors of RNA and Protein Synthesis

1974 • 111 citations

Calcium: Is It Required for Transmitter Secretion?

1971 • 109 citations

EFFECTS OF ETHYL ALCOHOL ON CEREBRAL BLOOD FLOW AND METABOLISM

1953 • 108 citations

Alteration of cortical and reticular acetylcholine release by ethanol in vivo.

1973 • 108 citations

The dopamine-releasing actions of neuroleptics and ethanol.

1974 • 107 citations

Inhibition of brain microsomal adenosine triphosphatases by general depressants

1967 • 103 citations

Sodium-stimulated adenosinetriphosphatase in microsomes from rat brain

1961 • 102 citations

Ethanol inhibits testosterone biosynthesis by direct action on Leydig cells.

1979 • 99 citations

Control of Membrane Permeability to Potassium in Red Blood Cells

1968 • 99 citations

Preference for alcohol evoked by tetrahydropapaveroline (THP) chronically infused in the cerebral ventricle of the rat

1977 • 98 citations

Effects of acute and chronic ethanol intake on synaptosomal glutamate binding activity

1978 • 97 citations

Prolonged Ethanol Consumption Increases Testosterone Metabolism in the Liver

1976 • 97 citations

Formation of 1-methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline under physiological conditions

1961 • 96 citations

Drug Addiction I

1977 • 94 citations

Acetaldehyde—an inhibitor of the enzymatic oxidation of 5-hydroxyindoleacetaldehyde

1969 • 93 citations

Effects of Ethanol

1984 • 93 citations

Effect of acute and chronic administration of ethanol on the 5-hydroxytryptamine turnover and tryptophan hydroxylase activity of the mouse brain

1971 • 92 citations

Alterations in Phospholipid Composition in Ethanol Tolerance and Dependence

1979 • 90 citations

Reduction of striatal dopamine release during an ethanol withdrawal syndrome

1977 • 89 citations

Urinary epinephrine and levarterenol excretion during acute sublethal alcohol intoxication in dogs.

1957 • 88 citations

Effects of acute and chronic ethanol administration on ribosomal protein synthesis in mouse brain and liver

1971 • 87 citations

EFFECTS OF ETHANOL ON SEROTONIN METABOLISM IN BRAIN

1974 • 85 citations

Selective Activation by Short Chain Alcohols of Glucagon Responsive Adenyl Cyclase in Liver

1970 • 83 citations

Effect of liposomes containing cholesterol on adenylate cyclase activity of cultured mammalian fibroblasts

1978 • 83 citations

Alcohol Tolerance in a Cholinergic Nerve Terminal: Relation to the Membrane Expansion-Fluidization Theory of Ethanol Action

1977 • 82 citations

Alterations in dopamine receptor sensitivity by chronic ethanol treatment

1977 • 82 citations

THE EFFECTS OF INTOXICATING DOSES OF ETHANOL UPON INTERMEDIARY METABOLISM IN RAT BRAIN

1972 • 80 citations

Studies on brain metabolism

1937 • 79 citations

INHIBITION OF THE TRANSPORT OF 5‐HYDROXYINDOLEACETIC ACID FROM BRAIN BY ETHANOL¹

1975 • 79 citations

Effect of Ethanol Dependence and Withdrawal on the Catecholamines in Rat Brain and Heart

1975 • 78 citations

DECREASED RATE OF GLUCOSE UTILIZATION BY RAT BRAIN IN VIVO AFTER EXPOSURE TO ATMOSPHERES CONTAINING HIGH CONCENTRATIONS OF CO₂

1975 • 78 citations

A comparison of the effects of chronic administration of ethanol and acetaldehyde to mice: evidence for a role of acetaldehyde in ethanol dependence

1974 • 77 citations

The binding of Ca2+ to the cell membrane increased by volatile anesthetics (alcohols, acetone, ether) which induce sensitization of nerve or muscle

1971 • 76 citations

Noradrenergic sensitivity of the cerebral cortex after chronic ethanol ingestion and withdrawal.

1975 • 75 citations

Effect of catecholamines and angiotensin on cyclic AMP in rat aorta and tail artery

1971 • 75 citations

The effect of ethanol ingestion on serotonin-C14 metabolism in man

1967 • 73 citations

Brain (Na+ + K+)-activated adenosine triphosphatase activity and neurotransmitter uptake in alcohol-dependent rats

1973 • 72 citations

THE EFFECTS OF ALIPHATIC ALCOHOLS ON THE RESPIRATION OF RAT BRAIN CORTEX SLICES AND RAT BRAIN MITOCHONDRIA

1958 • 71 citations

Influence of the metabolism of ethanol on the lactate/pyruvate ratio of rat-liver slices

1966 • 71 citations

Effect of ethanol on respiration of rat-brain-cortex slices

1960 • 70 citations

Dopamine receptor function after chronic ingestion of ethanol

1978 • 70 citations

Properties of the Ca²⁺‐ATPase activity of mammalian synaptic membrane preparations

1976 • 68 citations

5-Hydroxytryptamine and 5-hydroxyindolylacetic acid content in brain of rat strains selected for their alcohol intake

1972 • 68 citations

The effect of ethanol on the amino acids of the rat brain with a reference to the administration of glutamine

1961 • 66 citations

Inhibitory Influence of Ethanol on Serotonin Metabolism

1960 • 66 citations

SELECTIVE ACTION OF ALCOHOLS ON CEREBRAL CALCIUM LEVELS

1976 • 66 citations

Effect of ethanol administration on cyclic 3',5'-adenosine monophosphate metabolism in brain

1973 • 65 citations

“Adaptation” of the Central Nervous System to Varying Concentrations of Alcohol in the Blood

1941 • 65 citations

Ethanol and brain protein synthesis

1971 • 64 citations

Effect of acute ethanol treatment on transmitter synthesis and metabolism in central dopaminergic neurons

1976 • 64 citations

Ethanol-Induced Depletion of Cerebellar Guanosine 3′,5′-Cyclic Monophosphate

1976 • 63 citations

Effects of chronic alcohol ingestion on the fatty acid composition of the heart

1973 • 63 citations

Stimulation of jejunal adenyl cyclase by ethanol.

1971 • 62 citations

Involvement of biogenic amine metabolism in ethanol addiction.

1975 • 62 citations

ACUTE TOLERANCE TO INTRAVENOUS ANESTHETICS IN DOGS

1960 • 61 citations

Alcohol Dependence and Opiate Dependence: Lack of Relationship in Mice

1971 • 61 citations

PROTEIN AND RIBONUCLEIC ACID METABOLISM IN BRAINS OF MICE FOLLOWING CHRONIC ALCOHOL CONSUMPTION*

1973 • 61 citations

Toxic effects of ethanol: Possible role of acetaldehyde, tetrahydroisoquinolines, and tetrahydro-β-carbolines

1975 • 60 citations

Inhibition of the brain microsomal adenosinetriphosphatase by depolarizing agents

1961 • 60 citations

Effects of acute and chronic ethanol administration and withdrawal on adenosine 3':5'-monophosphate and guanosine 3':5'-monophosphate levels in the rat brain.

1977 • 60 citations

Effect of short periods of hypoxia, hyperoxia, and hypercapnia on brain O 2 supply.

1971 • 60 citations

Regional brain acetylcholine levels in rats acutely treated with ethanol or rendered ethanol-dependent

1976 • 59 citations

Accumulation of amino acids by the perfused rat liver in the presence of ethanol

1973 • 57 citations

Acetaldehyde on vascular smooth muscle: Possible role in vasodilator action of ethanol

1978 • 55 citations

Identification of an Isoquinoline Alkaloid after Chronic Exposure to Ethanol

1978 • 55 citations

Inactivation of coenzyme a by ethanol—I

1969 • 54 citations

Changes in activity and hormonal sensitivity of brain adenyl cyclase following chronic ethanol administration

1972 • 52 citations

EXPERIMENTAL ALCOHOLISM IN RATS: PROTEIN SYNTHESIS IN SUBCELLULAR FRACTIONS FROM CEREBELLUM, CEREBRAL CORTEX AND LIVER AFTER LONG TERM TREATMENT¹

1972 • 51 citations

5‐Hydroxytryptamine metabolism in brain and liver slices and the effects of ethanol

1969 • 51 citations

A spin label study of rat brain membranes effects of temperature and divalent cations

1976 • 50 citations

Activation of Tyrosine Hydroxylase from Central Noradrenergic Neurons by Calcium

1975 • 49 citations

Properties of A (Mg2+ + Ca2+)-dependent ATPase of bovine brain cortex Effects of detergents, freezing, cations and local anesthetics

1973 • 49 citations

Modification of glycoprotein residues as Ca2+ receptor sites after chronic ethanol exposure

1977 • 49 citations

The effect of central nervous system agents on rat-brain γ-aminobutyric acid level

1961 • 47 citations

The effect of pargyline and other monoamine oxidase inhibitors on blood acetaldehyde levels in ethanol-intoxicated mice.

1976 • 47 citations

METABOLIC CONSEQUENCES OF ETHANOL OXIDATION IN BRAINS FROM MICE CHRONICALLY FED ETHANOL

1973 • 46 citations

THE EFFECT OF ETHANOL ON THE CONCENTRATION OF γ-AMINOBUTYRIC ACID IN THE RAT BRAIN

1967 • 46 citations

THE METABOLISM OF ALCOHOL

1933 • 46 citations

Reduction in brain gamma-aminobutyric acid and in barbital narcosis during ethanol withdrawal.

1973 • 45 citations

Effects of Prostaglandin E₁Ethanol and TSH on the Adenylate Cyclase Activity of Beef Thyroid Plasma Membranes and Cyclic AMP Content of Dog Thyroid Slices¹

1974 • 45 citations

Enhancement of Alcohol Withdrawal Convulsions in Mice by Haloperidol

1976 • 44 citations

Effect of ethanol on cyclic AMP levels in the rat brain

1973 • 44 citations

Absence of formation of brain salsolinol in ethanol-dependent mice.

1977 • 42 citations

EFFECTS OF CHRONIC ETHANOL INGESTION ON BRAIN AMINOACYL‐tRNA SYNTHETASES AND tRNA

1975 • 42 citations

Acute antilipolytic effects of ethyl alcohol and acetate in man.

1968 • 42 citations

Physical dependence on alcohol in mice.

1975 • 41 citations

Alterations in brain cyclic guanosine 3':5'-monophosphate levels after acute and chronic treatment with ethanol.

1977 • 41 citations

Effect of ethanol on dopamine synthesis and release from rat corpus striatum

1976 • 40 citations

Effect of chronic administration of ethanol on (Na + K)‐activated ATPase activity in six areas of the cat brain

1972 • 40 citations

Effect of ethanol administration on adenosinetriphosphatase activity of subcellular fractions of mouse brain and liver

1971 • 40 citations

Effects of ethanol withdrawal, stress and amphetamine on rat brain (Na+ + K+-ATPase

1978 • 40 citations

Increased membrane fluidity implicated in acceleration of decay of post-tetanic potentiation by alcohols

1976 • 39 citations

Adaptative Changes in Ca++-Membrane Interactions Following Chronic Ethanol Exposure

1977 • 37 citations

Gamma aminobutyric acid in different strains of mice effect of ethanol

1976 • 37 citations

Protein and ribonucleic acid metabolism in brain of mice following chronic alcohol consumption.

1973 • 37 citations

Acetaldehyde mediation in the mechanism of ethanol-induced changes in norepinephrine metabolism.

1970 • 36 citations

Ethanol Oxidation: Effect on the Redox State of Brain in Mouse

1972 • 36 citations

The effeect of ethanol on GABA content of rat brain

1962 • 35 citations

Effects of ethanol on mouse brain (Na+K)-activated adenosine triphosphatase.

1972 • 35 citations

Effect of Ethanol on Membranes: A Fluorescent Probe Study

1979 • 34 citations

NEURAMINIDASE‐RELEASABLE SURFACE SIALIC ACID OF CULTURED ASTROBLASTS EXPOSED TO ETHANOL

1976 • 34 citations

CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE IN GUINEA PIG CEREBRAL CORTICAL SLICES: POSSIBLE REGULATION OF PHOSPHODIESTERASE ACTIVITY BY CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE AND CALCIUM IONS

1975 • 33 citations

Effect of ethanol on the kinetics of rat brain (Na+ K+) ATPase and K+-dependent phosphatase with different alkali ions

1978 • 33 citations

INCORPORATION OF [1‐¹⁴C]OLEIC ACID AND [1‐¹⁴C]ARACHIDONIC ACID INTO LIPIDS IN THE SUBCELLULAR FRACTIONS OF MOUSE BRAIN

1976 • 33 citations

Effect of alcohol on albumin synthesis by the isolated perfused rat liver

1973 • 33 citations

Lack of relationship between brain (Na + + K +)-activated adenosine triphosphatase and the development of tolerance to ethanol in rats.

1973 • 33 citations

The effects of acetaldehyde on serotonin metabolism

1967 • 31 citations

Alcohol, sludge, and hypoxic areas of nervous system, liver and heart

1968 • 29 citations

Effect of ethanol on fatty acid composition of hepatic phosphatidylcholine and phosphatidylethanolamine and on microsomal fatty acyl-CoA:Lysophosphatide transferase activities in rats fed corn oil or coconut oil

1969 • 28 citations

Effect of Ethanol on Serum Cholesterol Concentration in Dog and Man

1960 • 28 citations

EFFECTS OF ALIPHATIC ALCOHOLS AND ALDEHYDES ON THE METABOLISM OF POTASSIUM-STIMULATED RAT BRAIN CORTEX SLICES

1965 • 28 citations

Alcohol intake in the rat after lowering brain 5-hydroxtryptamine content by electrolytic midbrain raphé lesions, 5, 6-dihydroxytryptamine or p-chlorophenylalanine.

1976 • 28 citations

EFFECTS OF DRUGS AFFECTING ENDOGENOUS AMINES OR CYCLIC NUCLEOTIDES ON ETHANOL WITHDRAWAL HEAD TWITCHES IN MICE

1976 • 28 citations

Sustained Tolerance to a Specific Effect of Ethanol on Posttetanic Potentiation in Aplysia

1976 • 28 citations

Metabolism of [14C]-serotonin in the caudate nucleus, hypothalamus and reticular formation of the rat after ethanol administration

1973 • 28 citations

The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action

1977 • 27 citations

Increase in the γ-Aminobutyric Acid Content of Rat Brain After Ingestion of Ethanol

1959 • 27 citations

EFFECTS OF CATECHOLAMINE SYNTHESIS INHIBITION ON ETHANOL‐INDUCED WITHDRAWAL SYMPTOMS IN MICE

1974 • 27 citations

Ethanol-Induced Changes in Cation-Stimulated Adenosine Triphospha-Tase Activity and Lipid-Proteolipid Labeling of Brain Microsomes

1975 • 26 citations

The Effects of Acute Ethanol Intoxication on Cerebral Energy Metabolism

1975 • 26 citations

Marked prolongation of post-tetanic potentiation at a transition temperature and its adaptation

1975 • 25 citations

EXPERIMENTAL ALCOHOLISM IN RATS. EFFECT OF ACUTE ETHANOL INTOXICATION ON THE IN VITRO INCORPORATION OF [³H]LEUCINE INTO NEURONAL AND GLIAL PROTEINS

1972 • 24 citations

THE CEREBRAL CIRCULATION

1937 • 23 citations

Neurochemical aspects of ethanol dependence and withdrawal reactions in mice.

1977 • 23 citations

Requirement for adrenal glucocorticoid in the ethanol-induced increase of tryptophan hydroxylase activity in mouse brain

1974 • 23 citations

Dissociation of EEG and behavioural effects of ethanol provide evidence for a noncholinergic basis of intoxication

1974 • 22 citations

Effect of ethanol on brain CoA and acetyl ‐CoA¹

1976 • 20 citations

Morphine, sedative/hypnotic and alcohol dependence

1977 • 20 citations

Dopamine-sensitive adenylate cyclase in homogenates of rat striata during ethanol and barbiturate withdrawal

1976 • 20 citations

INFLUENCE OF ETHANOL ON HUMAN CATECHOLAMINE METABOLISM

1976 • 20 citations

THE MOLECULAR WEIGHT OF POLYVINYL ACETATE

1958 • 19 citations

Urinary excretion of 5-HIAA in chronic alcoholism.

1962 • 19 citations

Adrenergic supersensitivity during ethanol withdrawal in the rat.

1973 • 18 citations

Effect of peripheral ethanol metabolism on the central nervous system.

1975 • 18 citations

Effects of Ethyl Alcohol on the Adenosine 3′, 5′-mono-phosphate System of the Human Gastric Mucosa

1976 • 18 citations

Changes in Receptor Sensitivity of the Cerebral Cortex and Liver During Chronic Ethanol Ingestion and Withdrawal

1977 • 17 citations

The cerebral oxidative metabolic response to acute ethanol administration in rats and cats

1977 • 17 citations

Activity of CNS depressants related to hydrophobicity

1974 • 17 citations

Calcium and Glycoprotein Metabolism as Correlates for Ethanol Preference and Sensitivity

1979 • 16 citations

The Binding of Alcohol to Brain Membranes

1975 • 16 citations

Ethanol-induced changes in activities of adenylate cyclase, guanylate cyclase and cyclic adenosine 3′,5′-monophosphate dependent protein kinase in the brain and liver

1977 • 16 citations

Effect of ethanol on dop amine synthesis in rat striatal synaptosomes

1977 • 15 citations

An approach to the molecular basis of nerve activity

1965 • 15 citations

Der DPN+- und DPN-H-Gehalt der Rattenleber w�hrend des Abbaues von �thanol und seine Beeinflussung durch Sulfonylharnstoff und Disulfiram

1961 • 14 citations

Effects of Acute and Chronic Alcohol Administration on Brain Membrane Transport Systems

1977 • 14 citations

Alteration in Cerebral Polynucleotide Metabolism Following Chronic Ethanol Ingestion

1975 • 13 citations

THE EFFECT OF ALCOHOL ON CEREBRAL METABOLISM

1940 • 12 citations

The effects of chronic ethanol administration on acyl group composition of mitochondrial phospholipids from guinea pig adrenal.

1978 • 12 citations

Cyclic nucleotides and ethanol tolerance and dependence

1979 • 11 citations

PHARMACOLOGY OF ISOQUINOLINE ALKALOIDS AND ETHANOL INTERACTIONS**This research was supported in part by a Defence Research Board of Canada grant. A.M. is a recipient of an Alcoholism and Drug Addiction Foundation Research scholarship.

1977 • 11 citations

Relationship between brain levels of cyclic nucleotides and γ-aminobutyric acid during ethanol withdrawal in rats

1977 • 11 citations

Effects of ethanol on tryptophan hydroxylase activity from striate synaptosomes

1974 • 11 citations

Elevation of serum free tryptophan, but not brain tryptophan, by serum nonesterified fatty acids.

1974 • 11 citations

Selective inhibition of protein synthetic activity of cerebral membrane-bound ribosomes as a consequence of ethanol ingestion.

1978 • 10 citations

Cyclic adenosine 3′,5′-monophosphate, adenylate cyclase and physical dependence on ethanol: Studies with tranylcypromine

1977 • 10 citations

Brain Polynucleotide Metabolism Following Long-Term Ethanol Ingestion

1977 • 10 citations

Concentrations of free amino acids in brains of mice during the induction of physical dependence on ethanol and during the ethanol withdrawal syndrome.

1977 • 8 citations

Alcohol and Cerebral Vasodilatation

1942 • 8 citations

A possible mechanism of action of ethyl alcohol on the central nervous system.

1961 • 8 citations

Effect of Ethanol Administration on Guanylate Cyclase Activities in Liver and Brain

1977 • 7 citations

The Synaptic Properties of Some Tetrahydroisoquinoline Alkaloids

1978 • 7 citations

The Availability of Ethyl Alcohol for Human Brain Oxidations

1940 • 3 citations

Cross-Tolerance to Effect of Ethanol and Temperature in Aplysia: Preliminary Observations

1979 • 3 citations

Alcohol and Brain Protein Synthesis

1977 • 2 citations