Ethanol and Carcinogenesis

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Hepatic Microsomal Ethanol-oxidizing System

1970 • 824 citations

Toxicology. The basic science of poisons

1976 • 758 citations

Association of Cancer Sites With Tobacco and Alcohol Consumption and Socioeconomic Status of Patients: Interview Study From the Third National Cancer Survey

1977 • 673 citations

Environmental factors of cancer of the colon and rectum

1967 • 572 citations

The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx

1972 • 510 citations

A study of the etiological factors in cancer of the mouth

1957 • 487 citations

Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.

1971 • 412 citations

A study of etiological factors in cancer of the esophagus

1961 • 390 citations

MEASUREMENT OF RATE OF GASTRIC EMPTYING USING CHROMIUM-51

1966 • 361 citations

Alcohol and Mortality

1981 • 354 citations

Dentition, Diet, Tobacco, and Alcohol in the Epidemiology of Oral Cancer 2

1977 • 344 citations

[Cancer of the esophagus].

1953 • 331 citations

Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane

1977 • 328 citations

Quantitative Relationship between Amount of Dietary Fat and Severity of Alcoholic Fatty Liver

1970 • 313 citations

Evidence That Hepatitis B Virus Has a Role in Liver-Cell Carcinoma in Alcoholic Liver Disease

1982 • 253 citations

Prospective Study of Alcohol Consumption and Cancer

1984 • 234 citations

Environmental factors in cancer of the larynx.A second look

1976 • 223 citations

Small Intestinal Damage and Changes in Cell Population Produced by Ethanol Ingestion in the Rat

1974 • 214 citations

Alcohol-related diseases and carcinogenesis.

1979 • 214 citations

Geographic Correlations Between Cancer Mortality Rates and Alcohol-Tobacco Consumption in the United States 2

1974 • 211 citations

The role of colon anaerobes in the metabolism of bile acids and steroids, and its relation to colon cancer

2006 • 199 citations

Toxicology: the Basic Science of Poisons

1976 • 196 citations

Cancer morbidity and causes of death among danish brewery workers

1979 • 184 citations

A study of environmental factors in cancer of the larynx

1956 • 178 citations

Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication

1979 • 176 citations

Cirrhosis and hepatoma in alcoholics.

1966 • 171 citations

Clinics in Gastroenterology

1980 • 163 citations

Epidemiology of alcohol and cancer.

1979 • 158 citations

Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption.

1981 • 156 citations

Effects of dietary constituents on the metabolism of chemical carcinogens.

1975 • 155 citations

The effect of chronic habitual alcohol intake on the development of liver cirrhosis and hepatocellular carcinoma: Relation to hepatitis B surface antigen carriage

1982 • 153 citations

Alcohol and the Gastrointestinal Tract

1980 • 151 citations

Alcohol as a co-factor in the etiology of cancer

1979 • 141 citations

The role of alcohol and tobacco in multiple primary cancers of the upper digestive system, larynx and lung: A prospective study

1974 • 141 citations

Effect of type and amount of dietary fat and 1,2-dimethylhydrazine on biliary bile acids, fecal bile acids, and neutral sterols in rats.

1977 • 134 citations

Etiological and preventive implications in alcohol carcinogenesis.

1979 • 134 citations

A REVIEW AND UPDATE<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1979 • 130 citations

The relationship of the use of tobacco and alcohol to cancer of the oral cavity, pharynx or larynx

1963 • 127 citations

Contamination of beer with trace quantities of N-nitrosodimethylamine

1979 • 125 citations

Causes of death of blue-collar workers at a Dublin brewery, 1954-73

1979 • 124 citations

Cancer Morbidity Among Two Male Cohorts With Increased Alcohol Consumption in Finland2

1974 • 120 citations

Metabolic Aspects of Alcoholism

1976 • 115 citations

Ethanol metabolism and ethanol-drug interactions

1976 • 110 citations

Brief Communication: Inhibition of Dimethylhydrazine-Induced Neoplasia of the Large Intestine by Disulfiram2

1975 • 103 citations

Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone.

1971 • 100 citations

Aetiological Factors in Mouth Cancer

1957 • 97 citations

Cancer of the oesophagus: Further evidence of the relation to drinking habits in France

1970 • 97 citations

Frontiers in Liver Disease

1982 • 96 citations

Colorectal cancer and beer drinking

1977 • 96 citations

A case-control investigation of alcohol, tobacco, and diet in head and neck cancer

1975 • 94 citations

Spontaneous regression of hepatocellular carcinoma

1982 • 93 citations

Immunohistochemical Localization of Alcohol Dehydrogenase in the Human Gastrointestinal Tract

1983 • 89 citations

Effects of disulfiram and related compounds on the metabolism in vivo of the colon carcinogen, 1,2-dimethylhydrazine

1977 • 88 citations

Clinical and pathologic features of adenocarcinoma of the gastric cardia

1972 • 87 citations

Enhanced pulmonary and intestinal activation of procarcinogens and mutagens after chronic ethanol consumption in the rat

1981 • 87 citations

Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450.

1975 • 84 citations

EFFECTS OF ENVIRONMENTAL CHEMICALS ON THE METABOLISM OF DRUGS, CARCINOGENS, AND NORMAL BODY CONSTITUENTS IN MAN

1971 • 83 citations

Differential effect of chronic ethanol consumption on the carcinogenicity of N-nitrosopyrrolidine and N'-nitrosonornicotine in male Syrian golden hamsters.

1981 • 82 citations

INTESTINAL FUNCTION IN CHRONIC ALCOHOLISM*

1975 • 80 citations

Chronic alcoholism and carcinoma of the pancreas. A correlative hypothesis.

1968 • 80 citations

2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically "nonresponsive" at Ah locus.

1978 • 73 citations

Activation of carcinogens and mutagens by rat colon mucosa.

1978 • 69 citations

Enhancement of 1,2-Dimethylhydrazine-Induced Rectal Carcinogenesis Following Chronic Ethanol Consumption in the Rat

1984 • 68 citations

Early Onset of Oral Cancer among Women who Drink and Smoke

1976 • 67 citations

Effect of chronic ethanol ingestion on intestinal metabolism and mutagenicity of benzo(α)pyrene

1978 • 67 citations

EPIDEMIOLOGICAL APPROACH TO THE ETIOLOGY OF CANCER OF THE LARYNX

1956 • 66 citations

Differences in Sex Ratio According to Cancer Site and Possible Relationship With Use of Tobacco and Alcohol. Review of 65,000 Cases

1964 • 62 citations

The Mechanisms of Action of the Carcinogenic Nitroso and Related Compounds

1973 • 62 citations

Certain mortality patterns of esophageal cancer in the United States, 1930-67.

1971 • 61 citations

Correlation between cancer mortality and alcoholic beverage in Japan

1979 • 60 citations

Cirrhosis of the liver, alcoholism and heavy smoking associated with cancer of the mouth and pharynx

1967 • 60 citations

Organ-specific effects of the carcinogen methylazoxymethanol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases.

1977 • 60 citations

Effects of alcohol in mouse neoplasia.

1963 • 59 citations

Metabolic Effects of Alcohol on the Liver

1977 • 57 citations

Influence of ethyl alcohol on carcinogenesis with N-nitrosodimethylamine

1981 • 55 citations

INCREASES IN LARYNGEAL CANCER IN BRITAIN AND AUSTRALIA IN RELATION TO ALCOHOL AND TOBACCO CONSUMPTION TRENDS

1978 • 55 citations

Enhanced metabolism and mutagenesis of nitrosopyrrolidine in liver fractions isolated from chronic ethanol-consuming hamsters.

1979 • 55 citations

The effect of dietary protein deficiency on the ability of isolated hepatic microsomes to alter the mutagenicity of a primary and a secondary carcinogen.

1974 • 54 citations

Examination of Fibres in Beer

1968 • 51 citations

Inhibition of the metabolism of the colon carcinogen, azoxymethane, by pyrazole.

1978 • 49 citations

Primary Carcinoma of the Liver

1975 • 48 citations

Inhibitory Effects of Butylated Hydroxyanisole on Methylazoxymethanol Acetate-Induced Neoplasia of the Large Intestine and on Nicotinamide Adenine Dinucleotide-Dependent Alcohol Dehydrogenase Activity in Mice<xref ref-type="fn" rid="fn2">2</xref>

1979 • 47 citations

Inhibition of the hepatocarcinogenic activity of diethylnitrosamine (DENA) by ethanol in rats.

1981 • 46 citations

Nutrition and Aflatoxin Carcinogenesis

1971 • 45 citations

Ethanol oxidation by intestinal microsomes: Increased activity after chronic ethanol administration

1979 • 45 citations

Hypothesis: Metabolic Activity of the Colonic Bacteria Influences Organ Injury from Ethanol

2007 • 44 citations

Long-term ethanol administration and short- and long-term liver regeneration after partial hepatectomy.

1981 • 44 citations

The acute and chronic effects of ethanol administration on bile secretion in the rat.

1973 • 44 citations

Local Effect of Alcohol in Combination with DMBA on Hamster Cheek Pouch

1966 • 44 citations

Carcinogenesis in the esophagus. II. Experimental production of esophageal cancer by administration of ethanolic solution of carcinogens.

1965 • 40 citations

Enhancement of NNM-induced carcinogenesis in the rat liver by phenobarbital: a combined morphological and enzyme histochemical approach

1983 • 39 citations

Investigations on esophageal carcinogenicity by methylphenyl-nitrosamine and ethyl alcohol in rats

1975 • 37 citations

Effects of cytochrome P-448 and P-450 inducers on microsomal dimethylnitrosamine demethylase activity and the capacity of isolated microsomes to activate dimethylnitrosamine to a mutagen

1976 • 37 citations

The effect of liver imbalance on the development of oral tumors in mice following the application of benzpyrene or tobacco tar

1964 • 37 citations

Metabolism of the carcinogen 1,2-dimethylhydrazine by isolated human colon microsomes and human colon tumor cells in culture

1983 • 36 citations

Effect of ethanol and vinyl chloride on the induction of liver tumors: preliminary report.

1977 • 36 citations

The influence of various factors on the methylation of DNA by the oesophageal carcinogen N-nitrosomethylbenzylamine. I. The importance of alcohol

1983 • 36 citations

Effect of ethanol on microsomal metabolism of dimethylnitrosamine

1980 • 34 citations

Alcoholism and cancer. I. Effects of long-term exposure to alcohol on spontaneous mammary adenocarcinoma and prolactin levels in C3H/St mice.

1979 • 34 citations

Mutagenicity of Primary and Secondary Carcinogens Altered by Normal and Induced Hepatic Microsomes

1973 • 33 citations

Sex dependent effect of chronic ethanol consumption in rats on hepatic microsome mediated mutagenicity of benzo[a]pyrene

1981 • 32 citations

Effect of chronic alcohol consumption on tumor incidence due to dimethylnitrosamine administration

1983 • 32 citations

The Effect of Chronic Alcohol Intake Upon the Hepatic Microsomal Carcinogen-activation System

1978 • 31 citations

Oesophageal Lesions in the Alcoholic

1981 • 31 citations

Effect of ethanol administration on the metabolism of aflatoxin B1

1979 • 30 citations

Cancer of the gastrointestinal tract. Etiological and environmental factors

1973 • 30 citations

Etiological and Environmental Factors

1973 • 30 citations

Effect of ethanol on dimethylnitrosamine activation and DNA synthesis in rat liver

1982 • 29 citations

Metabolic activation of DMH by colonic microsomes: A process influenced by type of dietary fat

1982 • 28 citations

Mortality from Cancer of the Oesophagus in Brittany

1973 • 28 citations

Metabolism of 1,2-dimethylhydrazine in isolated perfused rat liver

1982 • 26 citations

Alcohol and Cancer

1974 • 26 citations

Ethanol- or acetone-pretreatment of mice strongly enhances the bacterial mutagenicity of dimethylnitrosamine in assays mediated by liver subcellular fraction, but not in host-mediated assays

1981 • 25 citations

Microsomal ethanol oxidation in the colonic mucosa of the rat

1982 • 24 citations

Metabolism of 1,2‐dimethylhydrazine by cultured rat colon epithelial cells

1983 • 23 citations

A biochemical approach to the etiology of alcohol related cancers of the head and neck.

1978 • 23 citations

Biochemistry of Carcinogenesis

1959 • 22 citations

Primary hepatic cancer in alcoholics.

1981 • 21 citations

Influence of 3-methylcholanthrene on liver carcinogenesis in rats ingesting DL-ethionine, 3'-methyl-4-dimethylaminoazobenzene, and N-2-fluorenylacetamide.

1967 • 19 citations

Effect of Various Xenobiotics and Steroids on Aryl Hydrocarbon Hydroxylase Activity of Intestinal and Hepatic Microsomes from Male Rats

1982 • 19 citations

THE TUMORIGENIC EFFECT OF ETHANOL

1969 • 17 citations

Ethanol, 30 Per Cent, and Hamster Pouch Carcinogenesis

1966 • 16 citations

Effects of gallic acid and of ethanol on formation of nitrosodiethylamine.

1976 • 16 citations

Sterol Metabolism in the Rat: Effect of Alcohol on Sterol Metabolism in Two Strains of Rats

1981 • 16 citations

Carcinogens in Scotch

1979 • 15 citations

Metabolism of N-2-fluorenylacetamide in the hamster

1964 • 14 citations

Peliosis hepatis

1980 • 14 citations

Carcinogenesis in the esophagus. 3. Polycyclic aromatic hydrocarbons and phenols in whisky.

1966 • 13 citations

Colon carcinogenesis and the role of dehydrogenase enzyme activity: Inhibition of tumorigenesis by pyrazole

1980 • 12 citations

Chronic alcoholism and carcinoma of the pancreas. A correlative hypothesis

1968 • 12 citations

Gastrointestinal and Hepatobiliary Cancer.

1983 • 11 citations

Changes in gastrointestinal DNA synthesis produced by acute and chronic ethanol consumption in the rat: a biochemical study.

1983 • 10 citations

Stimulation of Thymidine Incorporation in Isolated Rat Intestinal Mucosal Cells by Feeding an Ethanol-Containing Liquid Diet

1982 • 10 citations

Cancer of the Endolarynx (Analysis of 415 cases)

1974 • 8 citations

Gastrointestinal and Hepatobiliary Cancer

1984 • 7 citations

Pancreatic Cancer and Alcohol

1981 • 5 citations

Use of Inverted Intestinal Sacs to Assess the Effect of Gastrointestinal Insult on Carcinogen Absorption

1981 • 3 citations

Modes of alcohol administration appropriate for the study of the role of alcohol in carcinogenesis.

1979 • 2 citations