Biosynthesis of regulatory peptides — evolutionary aspects

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

1983 • 2,290 citations

Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide

1982 • 2,244 citations

Transfer of Proteins Across Membranes

1981 • 894 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.

1986 • 686 citations

Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.

1982 • 608 citations

Hamster preproglucagon contains the sequence of glucagon and two related peptides

1983 • 602 citations

Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

1987 • 566 citations

Exon duplication and divergence in the human preproglucagon gene

1983 • 558 citations

N‐terminally extended somatostatin: The primary structure of somatostatin‐28

1980 • 516 citations

POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine Peptides

1984 • 497 citations

In Vivo Chemical Modification of Proteins (Post-Translational Modification)

1981 • 480 citations

Posttranslational Covalent Modification of Proteins

1977 • 364 citations

Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish

1980 • 337 citations

Purification of microsomal signal peptidase as a complex.

1986 • 313 citations

Human somatostatin I: sequence of the cDNA.

1982 • 279 citations

Proteolysis in Neuropeptide Processing and Other Neural Functions

1984 • 264 citations

The processing of peptide precursors

1986 • 249 citations

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem.

1982 • 249 citations

Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.

1982 • 234 citations

Secretion and processing of insulin precursors in yeast.

1986 • 227 citations

Mammalian pancreatic preproglucagon contains three glucagon-related peptides.

1983 • 218 citations

Rat pre-prosomatostatin. Structure and processing by microsomal membranes.

1983 • 218 citations

Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon.

1984 • 206 citations

Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides

1985 • 189 citations

Precursors for peptide hormones share common secondary structures forming features at the proteolytic processing sites

1986 • 183 citations

The Diabetic Pancreas

1977 • 173 citations

Proteolytic processing in the biosynthesis of insulin and other proteins.

1974 • 172 citations

Isolation of a Glucagon-containing Peptide: Primary Structure of a Possible Fragment of Proglucagon

1973 • 165 citations

Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin.

1980 • 163 citations

Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum

1982 • 157 citations

Sequence of the Human Somatostatin I Gene

1984 • 154 citations

Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.

1982 • 152 citations

Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum

1982 • 140 citations

Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary.

1984 • 139 citations

Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA.

1983 • 137 citations

Isolation, characterization, and DNA sequence of the rat somatostatin gene.

1984 • 125 citations

Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.

1984 • 117 citations

Characterization of proinsulin- and proglucagon-converting activities in isolated islet secretory granules.

1981 • 116 citations

The glucagon superfamily: Precursor structure and gene organization

1986 • 100 citations

Characterization of coho salmon (Oncorhynchus kisutch) islet somatostatins

1986 • 98 citations

Comparative Morphology of Pancreatic Islets in Animals

1977 • 91 citations

A Nonamidated Peptide Homologous to Porcine Peptide YY and Neuropeptide YY*

1985 • 91 citations

Isolation and structures of coho salmon (Oncorhynchus kisutch) glucagon and glucagon-like peptide

1986 • 87 citations

Purification and characterization of a paired basic residue-specific prohormone-converting enzyme from bovine pituitary neural lobe secretory vesicles.

1986 • 85 citations

Bacterial leader peptidase, a membrane protein without a leader peptide, uses the same export pathway as pre-secretory proteins

1984 • 84 citations

A novel protease from yeast with specificity towards paired basic residues

1984 • 82 citations

Sequence of a cDNA encoding pancreatic preprosomatostatin-22.

1982 • 82 citations

Isolation and structure of a peptide hormone predicted from a mRNA sequence. A second somatostatin from the catfish pancreas.

1981 • 81 citations

Isolation and structures of glucagon and glucagon-like peptide from catfish pancreas.

1985 • 80 citations

Post-translational processing of the porcine gastrin precursor by phosphorylation of the COOH-terminal fragment.

1987 • 79 citations

Characterization of a peptide alpha-amidation activity from rat anterior pituitary.

1984 • 76 citations

A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide.

1984 • 72 citations

Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules

1987 • 69 citations

The structure of cloned DNA complementary to catfish pancreatic somatostatin-14 messenger RNA.

1982 • 69 citations

Anglerfish preprosomatostatin II is processed to somatostatin-28 and contains hydroxylysine at residue 23.

1984 • 68 citations

Glucagon‐like peptides activate hepatic gluconeogenesis

1987 • 67 citations

Structure of a peptide from coho salmon endocrine pancreas with homology to neuropeptide Y

1986 • 66 citations

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

1986 • 65 citations

Nucleotide and amino acid sequence comparisons of preprosomatostatins.

1983 • 62 citations

Isolation and biogenesis of a new peptide from pancreatic islets

1981 • 62 citations

Ontogeny and Phylogeny of the Glucagon Cell

1983 • 61 citations

Biosynthesis of phosphorylated forms of corticotropin-related peptides.

1981 • 60 citations

Pancreatic Polypeptide from Rat Pancreas*

1984 • 59 citations

Processing of an anglerfish somatostatin precursor to a hydroxylysine-containing somatostatin 28.

1985 • 57 citations

Purification and chemical characterization of a glicentin-related pancreatic peptide (proglucagon fragment) from porcine pancreas

1982 • 56 citations

Enzymes processing somatostatin precursors: an Arg-Lys esteropeptidase from the rat brain cortex converting somatostatin-28 into somatostatin-14.

1984 • 55 citations

An elasmobranchian somatostatin: Primary structure and tissue distribution in Torpedo marmorata

1985 • 55 citations

Isolation and structures of alligator gar (Lepisosteus spatula) insulin and pancreatic polypeptide

1987 • 54 citations

A dynorphin-like opioid in the central nervous system of an amphibian.

1982 • 51 citations

Characterization of an amidated form of pancreatic polypeptide from the daddy sculpin (Cottus scorpius)

1986 • 48 citations

A neuropeptide of the blowfly Calliphora vomitoria with an amino acid composition homologous with vertebrae pancreatic polypeptide.

1982 • 48 citations

Primary structure of glucagon from an elasmobranchian fish, Torpedo marmorata

1985 • 47 citations

Mosaic evolution of prepropancreatic polypeptide.

1986 • 46 citations

The isolation, purification and amino‐acid sequence of insulin from the teleost fish Cottus scorpius (daddy sculpin)

1986 • 46 citations

Precursors to regulatory peptides: their proteolytic processing

1987 • 46 citations

Exons of the human pancreatic polypeptide gene define functional domains of the precursor.

1985 • 46 citations

Isolation and structure of the principal products of preproglucagon processing, including an amidated glucagon-like peptide.

1986 • 46 citations

Structural characterization of peptides derived from prosomatostatins I and II isolated from the pancreatic islets of two species of teleostean fish: the daddy sculpin and the flounder

1987 • 44 citations

Primary Structures of Somatostatins from the Islet Organ of the Hagfish Suggest an Anomalous Pathway of Posttranslational Processing of Prosomatostatin-1*

1988 • 44 citations

Species variations in the primary structure of glucagon

1976 • 44 citations

Neuropeptides derived from prosomatostatin that do not contain the somatostatin-14 sequence

1984 • 43 citations

Polypeptide secondary structure may direct the specificity of prohormone conversion

1978 • 42 citations

Primary structure of glucagon and a partial sequence of oxyntomodulin (glucagon-37) from the guinea pig

1985 • 42 citations

Evolution of glucagon genes.

1984 • 41 citations

Glucagon: Structure-Function Relationships Investigated by Sequence Deletions

1981 • 39 citations

Isolation of a cDNA clone encoding pancreatic polypeptide.

1985 • 39 citations

Primary structures of three fragments of proglucagon from the pancreatic islets of the daddy Sculpin (Cottus scorpius)

1987 • 38 citations

Comparison of prohormone-processing activities in islet microsomes and secretory granules: evidence for distinct converting enzymes for separate islet prosomatostatins.

1984 • 37 citations

Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor.

1984 • 35 citations

Fragments of prosomatostatin isolated from a human pancreatic tumour

1984 • 34 citations

Comparative Morphology of Pancreatic Islets in Animals

1985 • 33 citations

A proform of secretin with high secretin‐like bioactivity

1985 • 33 citations

The amino‐acid sequences of sculpin islet somatostatin‐28 and peptide YY

1987 • 33 citations

A glucagon-like peptide, structurally related to mammalian oxyntomodulin, from the pancreas of a holocephalan fish, Hydrolagus colliei

1987 • 30 citations

Cotranslational and posttranslational proteolytic processing of preprosomatostatin-I in intact islet tissue.

1986 • 29 citations

Post-translational processing of preprosomatostatin-II examined using fast atom bombardment mass spectrometry.

1987 • 27 citations

Primary structure of insulin and glucagon from the flounder (Platichthys flesus)

1987 • 26 citations

The complete amino‐acid sequence of anglerfish somatostatin‐28 II

1984 • 25 citations

A putative processing enzyme from aplysia that cleaves dynorphin A at the single arginine residue

1984 • 24 citations

Primary structure of glucagon from the gut of the common dogfish (Scyliorhinus canicula)

1987 • 23 citations

Primitive Islets Contain Two Populations of Cells with Differing Glucagon Immunoreactivity

1981 • 23 citations

Isolation and characterization of proSS_1–32, a peptide derived from the N‐terminal region of porcine preprosomatostatin

1985 • 21 citations

Glucagon-37 (oxyntomodulin) and glucagon-29 (pancreatic glucagon) in human bowel: Analysis by HPLC and radioreceptorassay

1984 • 20 citations

Cat pancreatic eicosapeptide and its biosynthetic intermediate Conservation of a monobasic processing site

1986 • 19 citations

Product inhibition of carboxypeptidase H.

1987 • 17 citations

Characterization of three peptides derived from prosomatostatin [prosomatostatin-(1–63)-, -(65–76)- and -(79–92)-peptides] in a human pancreatic tumour

1987 • 17 citations

Biological activities of catfish glucagon and glucagon-like peptide

1987 • 15 citations

Regulatory peptides (glucagon, somatostatin, substance P, and VIP) in the brain and gastrointestinal tract of Ambystoma mexicanum

1985 • 15 citations

Isolation of ovine pancreatic icosapeptide: a peptide product containing one cysteine residue

1984 • 14 citations

Isolation and structure of the second of two major peptide products from the precursor to an anglerfish peptide homologous to neuropeptide Y.

1986 • 12 citations

Primitive islets contain two populations of cells with differing glucagon immunoreactivity

1981 • 11 citations

Cyclic-AMP-dependent phosphorylation of glicentin

1984 • 8 citations

A truncated glucagon-like peptide I from Torpedo pancreas

1985 • 2 citations