Metabolic and Pathological Aspects of Hypoxia in Liver Cells

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Defense Strategies Against Hypoxia and Hypothermia

1986 • 1,098 citations

Hepatotoxicity. The adverse effects of drugs and other chemicals on the liver

1980 • 683 citations

Hepatotoxicity: The adverse effects of drugs and other chemicals on the liver

2000 • 628 citations

Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes

1987 • 533 citations

Necrogenic Action of Carbon Tetrachloride in the Rat: A Speculative Mechanism Based on Activation

1966 • 457 citations

Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia.

1981 • 441 citations

Effect of a transient period of ischemia on myocardial cells. II. Fine structure during the first few minutes of reflow.

1974 • 434 citations

Pathological mechanisms in carbon tetrachloride hepatotoxicity

1985 • 422 citations

Regulation of Hepatic Metabolism

1986 • 394 citations

Allopurinol and oxypurinol are hydroxyl radical scavengers

1987 • 393 citations

Current Topics in Radiation Research

1968 • 378 citations

Role of oxygen-derived free radicals in digestive tract diseases.

1983 • 362 citations

Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity.

1966 • 358 citations

Free radicals in liver injury

1987 • 338 citations

Ischemic tissue injury.

1975 • 336 citations

Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals

1983 • 318 citations

Regulation of Hepatic Metabolism

1976 • 314 citations

LIVER PARENCHYMAL CELL INJURY

1963 • 288 citations

Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil.

1975 • 245 citations

Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver.

1983 • 213 citations

Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle.

1983 • 211 citations

The liver microsomal FAD-containing monooxygenase. Spectral characterization and kinetic studies.

1979 • 211 citations

Inhibition of surgically induced ischemia/reperfusion injury by oxygen free radical scavengers

1983 • 207 citations

Gradients of O2 concentration in hepatocytes.

1978 • 189 citations

Specificity of a phenobarbital-induced cytochrome P-450 for metabolism of carbon tetrachloride to the trichloromethyl radical

1982 • 182 citations

Binding of¹⁴C-Carbon Tetrachloride to Microsomal Proteinsin vitroand Formation of CHCl₃by Reduced Liver Microsomes

1973 • 177 citations

Quantitative dependence of mitochondrial oxidative phosphorylation on oxygen concentration: A mathematical model

1979 • 168 citations

Current Topics in Radiation Research

1969 • 166 citations

Determination of mitochondrial/cytosolic metabolite gradients in isolated rat liver cells by cell disruption

1977 • 164 citations

Possible role for cytotoxic oxygen metabolites in the pathogenesis of cardiac ischemic injury.

1982 • 160 citations

Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia.

1982 • 157 citations

Mitochondrial functions under hypoxic conditions: The steady states of cytochrome c reduction and of energy metabolism

1974 • 149 citations

Role of membrane phospholipids in myocardial injury induced by ischemia and reperfusion

1986 • 145 citations

Mitochondrial function under hypoxic conditions: The steady states of cytochrome a+a3 and their relation to mitochondrial energy states

1974 • 145 citations

Respiration rate of rat-liver cells at low oxygen concentrations

1957 • 134 citations

Accelerated phospholipid degradation in anoxic rat hepatocytes

1981 • 124 citations

Hypoxia and drug metabolism

1981 • 122 citations

The mechanism of chloroform and carbon monoxide formation from carbon tetrachloride by microsomal cytochrome P-450

1980 • 114 citations

Intracellular oxygen supply during hypoxia

1982 • 109 citations

The reaction pathway of membrane-bound rat liver mitochondrial monoamine oxidase

1973 • 109 citations

Biochemical studies on the metabolic activation of halogenated alkanes.

1985 • 105 citations

Effect of mitochondrial clustering on O2 supply in hepatocytes

1984 • 103 citations

Calcium and cell death

1983 • 102 citations

The effects of anoxia on cytosolic free calcium, calcium fluxes, and cellular ATP levels in cultured kidney cells.

1985 • 102 citations

Cytochrome P450 and biological hydroxylation reactions

2005 • 98 citations

Fructose prevents hypoxic cell death in liver

1987 • 98 citations

Metabolism of carbon tetrachloride in hepatic microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation.

1980 • 96 citations

Effects of extracellular calcium removal and anoxia on isolated rat myocytes

1982 • 94 citations

Halothane Hepatotoxicity: Relation Between Metabolic Activation, Hypoxia, Covalent Binding, Lipid Peroxidation and Liver Cell Damage

1983 • 94 citations

OXYGEN DIFFUSION AND OXYGEN DEPLETION PROBLEMS IN RADIOBIOLOGY.

1969 • 92 citations

The crucial role of low steady state oxygen partial pressures in haloalkane free-radical-mediated lipid peroxidation

1986 • 86 citations

Secondary bioenergetic hypoxia. Inhibition of sulfation and glucuronidation reactions in isolated hepatocytes at low O2 concentration.

1982 • 84 citations

Free-Radical Damage in Liver

1980 • 67 citations

Liver parenchymal cell injury. V. Relationships between patterns of chloromethane-C 14 incorporation into constituents of liver in vivo and cellular injury.

1967 • 65 citations

Oxygen Gradients During Hypoxie Steady States in Liver. Urate Oxidase and Cytochrome Oxidase as Intracellular O₂Indicators

1977 • 62 citations

Substrate-selective activation of rat liver mitochondrial mono amine oxidase by oxygen

1978 • 61 citations

Xanthine Oxidase is Not Responsible for Reoxygenation Injury in Isolated-Perfused Rat Heart

1987 • 59 citations

Oxygen dependence and subcellular partitioning of hepatic menadione-mediated oxygen uptake

1985 • 57 citations

The role of physiological oxygen partial pressures in lipid peroxidation. Theoretical considerations and experimental evidence

1987 • 56 citations

Effect of hypoxia on carbon tetrachloride hepatotoxicity

1982 • 56 citations

Tissue O2 Supply Under Normal and Pathological Conditions

1984 • 49 citations

O₂‐independent damage of cytochrome P450 by CCl₄‐metabolites in hepatic microsomes

1980 • 48 citations

Mitochondrial function and intracellular calcium in anoxic cardiac myocytes

1986 • 45 citations

Oxygen Transport to Tissue-V

1984 • 44 citations

Loss of latent activity of liver microsomal membrane enzymes evoked by lipid peroxidation. Studies of nucleoside diphosphatase, glucose-6-phosphatase, and UDP glucuronyltransferase

1985 • 43 citations

Biotransformation and Zonal Toxicity

1986 • 42 citations

Influence of hypoxia on the hepatotoxic effects of carbon tetrachloride, paracetamol, allyl alcohol, bromobenzene and thioacetamide

1980 • 37 citations

A computer-supported oxystat system maintaining steady-state O2 partial pressures and simultaneously monitoring O2 uptake in biological systems

1986 • 37 citations

The critical steady-state hypoxic conditions in carbon tetrachloride-induced lipid peroxidation in rat liver microsomes

1984 • 36 citations

The crucial role of hypoxia in halothane-induced lipid peroxidation

1984 • 34 citations

Halothane-induced Lipid Peroxidation and Glucose-6-phosphatase Inactivation in Microsomes under Hypoxic Conditions

1985 • 34 citations

Oxygen gradients: the problem of hypoxia

1987 • 25 citations

Liver ischemia increases the molecular order of microsomal membranes by increasing the cholesterol-to-phospholipid ratio.

1984 • 18 citations

Calcium requirement for anoxic liver cell injury.

1983 • 16 citations

Lobular Oxygen Gradients: Possible Role in Alcohol-Induced Hepatotoxicity

1986 • 15 citations

Dependence of hepatic gluconeogenesis on PO2: inhibitory effects of halothane

1987 • 12 citations

Evidence from aequorin for injury of metabolically inhibited myocytes independently of free Ca2+.

1985 • 9 citations

Alterations of the microsomal glucose-6-phosphatase system evoked by ferrous iron- and haloalkane free-radical-mediated lipid peroxidation

1986 • 9 citations

The Decisive Po_rlevels in Haloalkane-Mediated Liver Cell Injury

1987 • 7 citations