Receptor-Binding Profiles of Neuroleptics

Multiple receptors for dopamine

1979 • 3,739 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

[Biological psychiatry].

1980 • 1,087 citations

SCH 23390—The first selective dopamine D-1 antagonist

1983 • 738 citations

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

1980 • 543 citations

INCREASED DOPAMINE-RECEPTOR SENSITIVITY IN SCHIZOPHRENIA

1978 • 513 citations

Receptors for neurotransmitters and peptide hormones.

1980 • 373 citations

Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains

1978 • 351 citations

Dopaminergic behaviour stereospecifically promoted by the D1 agonist R-SK & F 38393 and selectively blocked by the D1 antagonist SCH 23390

1984 • 351 citations

Effects of neuroleptics on 3H-haloperidol and 3H-CIS (Z)-flupenthixol binding and on adenylate cyclase activity in vitro

1978 • 261 citations

Induction of oral dyskinesias in naive rats by D1 stimulation

1983 • 250 citations

Elevation of brain neuroleptic/dopamine receptors in schizophrenia

1980 • 220 citations

Monoamine Mechanisms in Chronic Schizophrenia: Post-Mortem Neurochemical Findings

1979 • 208 citations

Subcellular localization of dopamine-sensitive adenylate cyclase and dopamine receptor binding activities

1978 • 198 citations

Independent in vitro regulation by the D-2 dopamine receptor of dopamine-stimulated efflux of cyclic AMP and K+-stimulated release of acetylcholine from rat neostriatum

1982 • 184 citations

3H-flupenthixol binding in post-mortem brains of schizophrenics: Evidence for a selective increase in dopamine D2 receptors

1981 • 165 citations

Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions

1984 • 153 citations

Loss of rat striatal dopamine receptors with ageing is selective for D-2 but not D-1 sites: Association with increased non-specific binding of the D-1 ligand [3H]piflutixol

1984 • 115 citations

Abnormal Involuntary Movements in Schizophrenia

1982 • 104 citations

Coupling of Dopamine D ₁ Recognition Sites with Adenylate Cyclase in Nuclei Accumbens and Caudatus of Schizophrenics

1983 • 99 citations

Similarities between the binding of 3H-piflutixol and 3H-flupentixol to rat striatal dopamine receptors in vitro

1981 • 98 citations

Changes in apomorphine-induced stereotypy as a result of subacute neuroleptic treatment correlates with increased D-2 receptors, but not with increases in D-1 receptors

1983 • 82 citations

Distinct target size of dopamine D-1 and D-2 receptors in rat striatum

1984 • 58 citations

Dopamine receptor agonists

2020 • 58 citations

Kainate lesion dissociates striatal dopamine receptor radioligand binding sites

1981 • 50 citations

Decreased antistereotypic effect of neuroleptics after additional treatment with a benzodiazepine, a GABA agonist or an anticholinergic compound

1979 • 47 citations

Biochemical and pharmacological differentiation of neuroleptic effect on dopamine D-1 and D-2 receptors.

1983 • 42 citations

Differential reversal by scopolamine and thip of the antistereotypic and cataleptic effects of neuroleptics

1981 • 39 citations

Differential reversal by scopolamine of effects of neuroleptics in rats. Relevance for evaluation of therapeutic and extrapyramidal side-effect potential.

1981 • 26 citations

Preferential Labelling of Adenylate Cyclase Coupled Dopamine Receptors with Thioxanthene Neuroleptics

1982 • 24 citations

Neuroleptic Classification: Implications for Tardive Dyskinesia

2015 • 19 citations

GABA-dopamine/neuroleptic interaction after systemic administration

1980 • 15 citations

Abnormal neuroleptic/dopamine receptors in schizophrenia.

1980 • 15 citations