Cell-cell adhesion in invasion and metastasis of carcinomas

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Integrins.

1991 • 1,369 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule

1989 • 973 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA

1987 • 752 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

1989 • 680 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Evidence for the identity of human scatter factor and human hepatocyte growth factor.

1991 • 651 citations

A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells

1986 • 634 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.

1989 • 598 citations

A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

1989 • 568 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation

1987 • 555 citations

Changes in integrin receptors on oncogenically transformed cells

1989 • 548 citations

E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

1991 • 536 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer.

1990 • 511 citations

A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.

1986 • 510 citations

The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression

1991 • 501 citations

New light on Myc and Myb. Part II. Myb.

1990 • 487 citations

Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.

1993 • 457 citations

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

1990 • 456 citations

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

1991 • 455 citations

Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity

1990 • 444 citations

Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44

1992 • 417 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

Expression of immunoreactive E-cadherin adhesion molecules in human cancers.

1991 • 379 citations

Molecular organization of the uvomorulin-catenin complex.

1992 • 378 citations

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.

1991 • 364 citations

Expression of E- and P-cadherin in gastric carcinomas.

1991 • 345 citations

Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness.

1992 • 337 citations

New light on Myc and Myb. Part I. Myc.

1990 • 325 citations

In Vitro and in Vivo Consequences of VLA-2 Expression on Rhabdomyosarcoma Cells

1991 • 323 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1988 • 311 citations

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

1990 • 292 citations

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

1985 • 286 citations

A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis.

1991 • 252 citations

Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.

1991 • 232 citations

The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element.

1991 • 216 citations

Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes.

1990 • 213 citations

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

1990 • 208 citations

Reexpression of poly(sialic acid) units of the neural cell adhesion molecule in Wilms tumor.

1988 • 187 citations

Down‐regulation of E‐cadherin expression in madin darby canine kidney (MDCK) cells inside tumors of nude mice

1991 • 183 citations

Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities.

1991 • 182 citations

Relationship of prediagnostic serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing premenopausal breast cancer.

1992 • 181 citations

Tumor dedifferentiation: An important step in tumor invasion

1985 • 181 citations

Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration.

1990 • 176 citations

Evidence for the identy of human scatter factor and human hepatocyte growth factor.

1991 • 163 citations

Regulation of a human epidermal keratin gene: sequences and nuclear factors involved in keratinocyte-specific transcription.

1990 • 144 citations

Mediation of lung metastasis of murine melanomas by a lung-specific endothelial cell adhesion molecule.

1991 • 133 citations

Identification of the metastasis-associated, galactoside-binding lectin as a chimeric gene product with homology to an IgE-binding protein.

1989 • 126 citations

Expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in normal human tissues and tumors.

1989 • 125 citations

Secreted or nonsecreted forms of acidic fibroblast growth factor produced by transfected epithelial cells influence cell morphology, motility, and invasive potential.

1991 • 124 citations

Regional assignment of the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16

1989 • 93 citations

Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas.

1992 • 71 citations

Cell Motility Factors

1991 • 39 citations

Interleukin-6 enhances motility of breast carcinoma cells

1991 • 30 citations