An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease.

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

1964 • 646 citations

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

1987 • 602 citations

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

1987 • 569 citations

Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

1989 • 433 citations

Quantitative assessment of cortical synaptic density in Alzheimer's disease

1990 • 415 citations

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease

1985 • 414 citations

Synaptic loss in Alzheimer's disease and other dementias

1989 • 406 citations

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

1988 • 381 citations

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex

1990 • 367 citations

Neuritic pathology and dementia in alzheimer's disease

1991 • 362 citations

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1987 • 348 citations

Aberrant neurofilament phosphorylation in Alzheimer disease.

1985 • 339 citations

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

1991 • 292 citations

Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.

1991 • 288 citations

Patterns of aberrant sprouting in alzheimer's disease

1991 • 241 citations

Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.

1984 • 227 citations

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.

1990 • 209 citations

Senile plaques in cortex of aged normal monkeys

1985 • 186 citations

Protein Kinase C Substrates from Bovine Brain

1989 • 182 citations

Three-Dimensional Analysis of the Relationship Between Synaptic Pathology and Neuropil Threads in Alzheimer Disease

1992 • 180 citations

Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomography

1984 • 180 citations

The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia^*†

1967 • 179 citations

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

1991 • 165 citations

Microtubular reorganization and dendritic growth response in alzheimer's disease

1989 • 159 citations

Phosphorylated Neurofilament Antigens in Neurofibrillary Tangles in Alzheimerʼs Disease

1986 • 158 citations

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1990 • 154 citations

Lewy Bodies Contain Epitopes Both Shared and Distinct from Alzheimer Neurofibrillary Tangles

1988 • 124 citations

Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.

1990 • 114 citations

Tau Epitopes are Incorporated into a Range of Lesions in Alzheimerʼs Disease

1987 • 97 citations

Senile plaques in aged squirrel monkeys

1987 • 93 citations

Localization of amyloid precursor protein in GAP43-immunoreactive aberrant sprouting neurites in Alzheimer's disease

1992 • 88 citations

Distribution of Neurofilament Antigens after Axonal Injury

1987 • 85 citations

Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads.

1991 • 82 citations

The cytoarchitectonic distribution of senile plaques in three aged monkeys

1990 • 53 citations

Evidence for axonal loss in regions occupied by senile plaques in Alzheimer cortex

1991 • 39 citations

Expression of neurofilament proteins by Purkinje cells: ultrastructural immunolocalization with monoclonal antibodies

1988 • 39 citations

Early and late appearance of neurofilament phosphorylation events in nerve regeneration

1989 • 24 citations

Immunostaining of neurofilament protein in human postmortem cortex: A sensitive and specific approach to the pattern analysis of human cortical cytoarchitecture

1985 • 23 citations

The axonal origin of a subpopulation of dystrophic neurites in Alzheimer's disease

1991 • 20 citations

Pathologic axons and synapses in human neuropsychiatric disorders

1975 • 19 citations

Alzheimer dementia: a study of the senile plaque with antisera and a monoclonal antibody specific for neurofilament proteins.

1987 • 8 citations