Distinct patterns of nitric oxide production in hepatic macrophages and endothelial cells following acute exposure of rats to endotoxin

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

1993 • 671 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Glutathione, free radicals and chemotherapeutic agents

1988 • 393 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

The Role of Endotoxin in Liver Injury

1975 • 291 citations

Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing.

1992 • 279 citations

Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization.

1993 • 275 citations

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

1991 • 275 citations

Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury

1992 • 274 citations

Cytokine-Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens

1991 • 267 citations

Quantitative analysis of cellular glutathione by flow cytometry utilizing monochlorobimane: some applications to radiation and drug resistance in vitro and in vivo.

1986 • 248 citations

Endotoxin-induced cytokine gene expression and excretion in the liver

1994 • 213 citations

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes

1990 • 179 citations

The role of cytokine mediators in septic shock.

1990 • 172 citations

Nonparenchymal Cells and Hepatotoxicity

1990 • 167 citations

Synthesis of nitric oxide from L-arginine: a recently discovered pathway induced by cytokines with antitumour and antimicrobial activity

1991 • 153 citations

Cytokine stimulation of nitric oxide formation and differential regulation in hepatocytes and nonparenchymal cells of endotoxemic rats

1994 • 116 citations

Characterization of interleukin-1 and interleukin-6 production by hepatic endothelial cells and macrophages

1993 • 96 citations

Accumulation of Activated Mononuclear Phagocytes in the Liver Following Lipopolysaccharide Treatment of Rats

1986 • 90 citations

Regulation of hepatic endothelial cell and macrophage proliferation and nitric oxide production by GM-CSF, M-CSF, and IL-1 beta following acute endotoxemia.

1994 • 75 citations

Lipopolysaccharide treatment of rats alters antigen expression and oxidative metabolism in hepatic macrophages and endothelial cells

1992 • 75 citations

A single exogenous stimulus activates resident rat macrophages for nitric oxide production and tumor cytotoxicity

1993 • 60 citations

Effect of endotoxin on rat liver. Analysis of acid phosphatase isozymes in the liver of normal and endotoxin-treated rats.

1980 • 53 citations

Uptake, distribution and fate of bacterial lipopolysaccharides in monocytes and macrophages: An ultrastructural and functional correlation

1992 • 32 citations

The distribution, induction and isoenzyme profile of glutathione S-transferase and glutathione peroxidase in isolated rat liver parenchymal, Kupffer and endothelial cells

1989 • 29 citations

On multiple forms of NO synthase and their occurence in human cells

1991 • 15 citations

Can the liver be induced to say no? Hortelano S, Genaro AM, Boscá L. Phorbol esters induce nitric oxide synthase activity in rat hepatocytes: antagonism with the induction elicited by lipopolysaccharide. J Biol Chem 1992; 267: 24937–24940

1993 • 13 citations

Deleted Work

1955 • 0 citations