Biochemical Mechanisms of Thermogenesis

Submitted Publication

2022 • 1,326 citations

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

1984 • 724 citations

BROWN ADIPOSE TISSUE.

1965 • 466 citations

Adrenergic activation of triiodothyronine production in brown adipose tissue

1983 • 395 citations

Brown adipose tissue mitochondria

1979 • 369 citations

The biochemistry of an inefficient tissue: brown adipose tissue.

1985 • 315 citations

Isolation of the uncoupling protein from brown adipose tissue mitochondria

1980 • 262 citations

The Brown Fat Cell

1982 • 233 citations

A mitochondrial defect in brown adipose tissue of the obese (obob) mouse: Reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding

1978 • 212 citations

Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria

1982 • 211 citations

Brown‐adipose‐tissue mitochondria: the regulation of the 32 000‐M_r uncoupling protein by fatty acids and purine nucleotides

1983 • 183 citations

Increased purine nucleotide binding, altered polypeptide composition, and thermogenesis in brown adipose tissue mitochondria of cold-acclimated rats

1978 • 179 citations

CYTOLOGICAL RESPONSES OF BROWN FAT TISSUE IN COLD-EXPOSED RATS

1964 • 162 citations

Exclusive occurrence of thermogenin antigen in brown adipose tissue

1982 • 161 citations

Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis

1980 • 160 citations

Development of brown fat cells in monolayer culture

1983 • 154 citations

Fatty Acids as Acute Regulators of the Proton Conductance of Hamster Brown‐Fat Mitochondria

1982 • 140 citations

Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase

1977 • 138 citations

Oxidative Metabolism in Cells Isolated from Brown Adipose Tissue

1968 • 128 citations

The bioenergetics of brown adipose tissue mitochondria

1976 • 128 citations

Fatty acid synthesis in vivo in brown adipose tissue, liver and white adipose tissue of the cold‐acclimated rat

1979 • 126 citations

Roles of noradrenaline and protein synthesis in the cold-induced increase in purine nucleotide binding by rat brown adipose tissue mitochondria

1979 • 124 citations

The effect of propranalol on the calorigenic response in brown adipose tissue of new‐born rabbits to catecholamines, glucagon, corticotrophin and cold exposure

1966 • 121 citations

Metabolic relationships between lipolysis and respiration in rat brown adipocytes. The role of long chain fatty acids as regulators of mitochondrial respiration and feedback inhibitors of lipolysis.

1981 • 118 citations

Noradrenaline controls the concentration of the uncoupling protein in brown adipose tissue

1984 • 111 citations

Mitochondrien aus braunem Fettgewebe: Entkopplung der Atmungskettenphosphorylierung durch langkettige Fettsäuren und Rekopplung durch Guanosintriphosphat

1969 • 109 citations

Catecholamine sensitivity in brown fat cells from cold-acclimated hamsters and rats

1982 • 106 citations

Thermogenic Responses of Brown Adipocytes to Noradrenaline and Glucagon in Heat-acclimated and Cold-acclimated Rats

1979 • 95 citations

Cold adaptation in the rat: increased brown fat peroxisomal beta-oxidation relative to maximal mitochondrial oxidative capacity

1980 • 93 citations

Fatty acid synthesis in mouse brown adipose tissue the influence of environmental temperature on the proportion of whole-body fatty acid synthesis in brown adipose tissue and the liver

1981 • 88 citations

Measurement of rat brown-adipose-tissue mitochondrial uncoupling protein by radioimmunoassay: Increased concentration after cold acclimation

1983 • 86 citations

The Acute Regulation of Mitochondrial Proton Conductance in Cells and Mitochondria from the Brown Fat of Cold‐Adapted and Warm‐Adapted Guinea Pigs

1982 • 84 citations

Oxidative Metabolism in Cells Isolated from Brown Adipose Tissue

1968 • 84 citations

Norepinephrine‐Induced Shift in Levels of Adenosine 3′:5′‐monophosphate and ATP Parallel to Increased Respiratory Rate and Lipolysis in Isolated Hamster Brown‐Fat Cells

1976 • 84 citations

The regulation of fatty acid synthesis in brown adipose tissue by insulin

1982 • 83 citations

GDP-binding to the brown fat mitochondria of developing and cold-adapted rats

1980 • 83 citations

An immunological study of the uncoupling protein of brown adipose tissue mitochondria

1983 • 79 citations

Autonomic Regulation of Thermogenesis

1983 • 74 citations

Quantitative differentiation of α- and β-adrenergic respiratory responses in isolated hamster brown fat cells: Evidence for the presence of an α1-adrenergic component

1983 • 74 citations

Distinction of Brown from White Adipose Tissue

1966 • 74 citations

The β-adrenergic receptor

1976 • 68 citations

Effect of acclimation temperature on the concentration of the mitochondrial ‘uncoupling’ protein measured by radioimmunoassay in mouse brown adipose tissue

1983 • 67 citations

Control of Brown Fat Thermogenesis by the Sympathetic Nervous System

1978 • 67 citations

The mitochondrial ATPase of brown adipose tissue Purification and comparison with the mitochondrial ATPase from beef heart

1977 • 66 citations

A direct comparison between peroxisomal and mitochondrial preferences for fatty-acyl β-oxidation predicts channelling of medium-chain and very-long-chain unsaturated fatty acids to peroxisomes

1984 • 63 citations

Identification of [3H]prazosin binding sites in crude membranes and isolated cells of brown adipose tissue as α1-adrenergic receptors

1983 • 61 citations

High Number of High-Affinity Binding Sites for (-)-[3H]Dihydroalprenolol on Isolated Hamster Brown-Fat Cells. A Study of the beta-Adrenergic Receptors

1979 • 58 citations

Brown adipose tissue of cafeteria-fed rats

1981 • 58 citations

ELECTRICAL COUPLING BETWEEN FAT CELLS IN NEWT FAT BODY AND MOUSE BROWN FAT

1971 • 56 citations

Na⁺‐dependent, α‐adrenergic mobilization of intracellular (mitochondrial) Ca²⁺ in brown adipocytes

1984 • 55 citations

Abnormal brown adipose tissue in obese (ob/ob) mice: response to acclimation to cold

1980 • 54 citations

Alpha 1-adrenergic stimulation of hamster brown adipocyte respiration

1983 • 49 citations

Studies on Norepinephrine‐Induced Efflux of Free Fatty Acid from Hamster Brown‐Adipose‐Tissue Cells

1975 • 48 citations

Sodium-induced calcium release from mitochondria in brown adipose tissue.

1979 • 48 citations

Desensitisation of β‐Adrenergic Responsiveness in vivo

1982 • 48 citations

Changes induced by cold adaptation in the brown adipose tissue from several species of rodents, with special reference to the mitochondrial components

1979 • 47 citations

Impairment of trophic response of brown fat to cold in guanethidine-treated rats

1982 • 46 citations

Potassium-dependent Stimulation of Respiration in Brown Fat Cells by Fatty Acids and Lipolytic Agents

1968 • 46 citations

Fat metabolism in brown adipose tissue in vivo

1970 • 46 citations

Mechanism of action of norepinephrine in hamster brown adipocytes.

1982 • 44 citations

Does brown adipose tissue have a metabolic role in the rat?

1984 • 43 citations

The Relationship between Extramitochondrial Ca2+ Concentration, Respiratory Rate, and Membrane Potential in Mitochondria from Brown Adipose Tissue of the Rate

1983 • 41 citations

Alpha and beta‐adrenergic mediation of membrane potential changes and metabolism in rat brown adipose tissue.

1983 • 41 citations

Increased α1-adrenergic receptor density in brown adipose tissue of cold-acclimated rats and hamsters

1984 • 40 citations

Control of brown adipose tissue lipolysis and respiration by adenosine

1983 • 40 citations

Role of adenosine as an endogenous regulator of respiration in hamster brown adipocytes

1984 • 40 citations

Portein kinases in brown adipose tissue of developing rats. State of activation of protein kinase during development and cold exposure and its relationship to adenosine 3':5'-monophosphate, lipolysis, and heat production.

1977 • 37 citations

Alpha 1-adrenergic stimulation of phosphatidylinositol turnover and respiration of brown fat cells.

1984 • 37 citations

Interrelationship of cyclic AMP, lipolysis, and respiration in brown fat cells

1973 • 36 citations

PURINE NUCLEOTIDES AND FATTY ACIDS IN ENERGY COUPLING OF MITOCHONDRIA FROM BROWN ADIPOSE TISSUE

1973 • 36 citations

Characteristics of the uncoupling protein from brown-fat mitochondria

1984 • 36 citations

Effect in vivo of norepinephrine on the membrane resistance of brown fat cells

1971 • 35 citations

Presence of a Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance ofα1-adrenergic stimulation

1985 • 35 citations

Intracellular pH of perfused single frog skin: combined 19F- and 31P-NMR analysis

1984 • 35 citations

Alpha1-adrenergic activation of phosphatidylinositol labeling in isolated brown fat cells

1980 • 34 citations

Hormonal Stimulation of Substrate Utilization in Brown Adipose Tissue of Cold Acclimated Rats

1974 • 32 citations

Evidence against noradrenergic regulation of vasodilation in rat brown adipose tissue

1980 • 30 citations

Development and activation of brown fat in rats with pheochromocytoma PC 12 tumors

1983 • 30 citations

Effects of Cations on Brown Adipose Tissue in Relation to Possible Metabolic Consequences of Membrane Depolarisation

1981 • 29 citations

Thyroid cold acclimation influences on norepinephrine metabolism in brown fat.

1977 • 27 citations

α-Adrenergic effects on 86Rb+(K+) potentials and fluxes in brown fat cells

1984 • 26 citations

Abnormal brown adipose tissue in hamsters with muscular dystrophy

1980 • 26 citations

New Perspectives in Adipose Tissue

1985 • 26 citations

Adaptive changes in the concentration of the mitochondrial ‘uncoupling’ protein in brown adipose tissue of hamsters acclimated at different temperatures

1983 • 24 citations

Thermogenic response to glucagon in cold-acclimated mice.

1982 • 21 citations

THE BIOCHEMICAL MECHANISM OF THERMOGENESIS IN BROWN ADIPOSE TISSUE

1978 • 21 citations

The possible proton translocating activity of the mitochondrial uncoupling protein of brown adipose tissue

1983 • 20 citations

Brown adipose tissue: molecular mechanisms controlling activity and thermogenesis

1985 • 19 citations

Quantitative evaluation of gap junctions during development of the brown adipose tissue.

1980 • 19 citations

Increased α1 receptor density in brown adipose tissue of cafeteria-fed rats

1984 • 16 citations

Inhibition of acetyl-carnitine oxidation in rat brown-adipose-tissue mitochondria by erucoyl-carnitine is due to sequestration of CoA

1985 • 16 citations

A possible physiological role of the Na+/Ca2+ exchange mechanism of brown-fat mitochondria in the mediation of α1-adrenergic signals

1984 • 13 citations

The molecular basis for adrenergic desensitization in hamster brown adipose tissue: Uncoupling of adenylate cyclase activation

1984 • 12 citations

Brown Adipose Cells: Spontaneous Mobilization of Endogenously Synthesized Lipid

1969 • 12 citations

Cyclic GMP and cyclic GMP-dependent protein kinase in brown adipose tissue of developing rats

1979 • 12 citations

Quantitative evaluation of gap junctions in rat brown adipose tissue after cold acclimation

1984 • 9 citations

Increase in mitochondrial content of long-chain acyl-CoA in brown adipose tissue during cold-acclimation

1984 • 9 citations

Effect of cold stress and norepinephrine on the turnover of phospholipids in brown adipose tissue of the golden hamster (Mesocricetus auratus).

1981 • 8 citations

Chapter 10 Thermogenic mitochondria

1984 • 8 citations

Alanine-turnover and conversion to glucose of alanine in the hibernating, arousing and active hedgehog (Erinaceus europaeus)

1984 • 7 citations

Plasma Membrane Involvement in Brown Fat Thermogenesis

1978 • 5 citations

Evidence from radioimmunoassay for a decreased concentration of mitochondrial ‘uncoupling’ protein from brown adipose tissue of genetically obese (ob/ob) mice

1983 • 5 citations

Partial protection erucoyl-carnitine inhibition in hamster brown-adipose-tissue mitochondria is due to high CoA levels: A comparison with rat brown-adipose-tissue mitochondria

1986 • 5 citations

Hydrogenated marine fat, its influence on rat tissue lipids, compared to fish oil, rape seed oil and lard

1977 • 2 citations

Deleted Work

1955 • 0 citations