Specialized Genetic Recombination Systems in Bacteria: Their Involvement in Gene Expression and Evolution

A new method for sequencing DNA.

1977 • 7,941 citations

Molecular Biology of the Gene

1970 • 2,116 citations

[31] Electron microscope heteroduplex methods for mapping regions of base sequence homology in nucleic acids

1971 • 1,605 citations

DNA Insertion Elements, Plasmids and Episomes

1978 • 1,294 citations

CHROMOSOME ORGANIZATION AND GENIC EXPRESSION

1951 • 1,174 citations

Recalibrated linkage map of Escherichia coli K-12

1976 • 1,059 citations

A PROPOSAL FOR A UNIFORM NOMENCLATURE IN BACTERIAL GENETICS

1966 • 893 citations

Controlling Elements and the Gene

1956 • 837 citations

Genetic engineering in Vivo using translocatable drug-resistance elements

1977 • 625 citations

The Genetics of Bacteria and their Viruses

1969 • 606 citations

Evidence for transposition of dispersed repetitive DNA families in yeast

1979 • 580 citations

Uniform nomenclature for bacterial plasmids: a proposal

1976 • 575 citations

The Bacteriophage Lambda.

1971 • 573 citations

RECOMBINATION DEFICIENT MUTANTS OF E. COLI AND OTHER BACTERIA

1973 • 568 citations

DNA: Insertion Elements, Plasmids, and Episomes.

1977 • 530 citations

Genetic studies of the lac repressor

1978 • 517 citations

Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements.

1979 • 503 citations

Genetic studies of the lac repressor

1977 • 500 citations

Transfer of the drug-resistance transposon Tn5 to Rhizobium

1978 • 483 citations

Prophage lambda at unusual chromosomal locations

1972 • 425 citations

Transposition of ampicillin resistance from RP4 to other replicons

1974 • 409 citations

Mapping of Deletions and Substitutions in Heteroduplex DNA Molecules of Bacteriophage Lambda by Electron Microscopy

1969 • 408 citations

Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli

1972 • 389 citations

Transposition of R factor genes to bacteriophage lambda.

1975 • 389 citations

Recalibrated linkage map of Escherichia coli K-12.

1976 • 388 citations

Purified Escherichia coli recA protein catalyzes homologous pairing of superhelical DNA and single-stranded fragments.

1979 • 377 citations

Translocatable elements in procaryotes

1977 • 362 citations

BACTERIOPHAGE-INDUCED MUTATION IN ESCHERICHIA COLI

1963 • 362 citations

Molecular genetics of bacteriophage P22

1978 • 349 citations

Infectious multiple drug resistance.

1975 • 345 citations

Nucleic Acid-Protein Recognition

1977 • 343 citations

Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli

1973 • 339 citations

Plasmids of medical, environmental and commercial importance

1980 • 339 citations

The λδ sequence of F is an insertion sequence

1978 • 338 citations

Implications of RNA⋅RNA Splicing in Evolution of Eukaryotic Cells

1978 • 333 citations

Transcription and processing of intervening sequences in yeast tRNA genes

1978 • 332 citations

Nucleotide sequence of an insertion element, IS1.

1978 • 319 citations

Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition

1975 • 318 citations

Transposable genetic elements and plasmid evolution

1976 • 315 citations

Molecular Biology of the Gene.

1989 • 297 citations

Deletion mutants of bacteriophage lambda

1971 • 289 citations

Comprehensive Virology

1976 • 288 citations

Uniform nomenclature for bacterial plasmids: a proposal.

1976 • 287 citations

Viral Integration and Excision: Structure of the Lambda att Sites

1977 • 281 citations

Transposition of a deoxyribonucleic acid sequence encoding trimethoprim and streptomycin resistances from R483 to other replicons

1976 • 280 citations

A Comprehensive Molecular Map of Bacteriophage LAMBDA

1979 • 277 citations

Partial denaturation of thymine- and 5-bromouracil-containing λ DNA in alkali

1970 • 274 citations

Transposable genetic elements as agents of gene instability and chromosomal rearrangements

1977 • 271 citations

Recombination in bacteriophage λ

1968 • 269 citations

The control of gene action in maize

1965 • 259 citations

Isolation and characterization of conditional-lethal mutants of Sindbis virus

1966 • 254 citations

CHROMOSOME BREAKAGE ACCOMPANYING GENETIC RECOMBINATION IN BACTERIOPHAGE

1961 • 251 citations

Dissection of the transposition process: A transposon-encoded site-specific recombination system

1979 • 247 citations

The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.

1978 • 242 citations

Molecular Biology of Bacteriophage Mu

1975 • 239 citations

Oo and strong-polar mutations in the gal operon and insertions

1968 • 238 citations

IS1 is involved in deletion formation in the gal region of E. coli K12

1975 • 229 citations

Evolution, Genetics, and Man

1956 • 228 citations

Isolation and characterization of conditional lethal mutants of Escherichia coli defective in transcription termination factor rho.

1976 • 221 citations

Deletions affecting the transposition of an antibiotic resistance gene.

1977 • 220 citations

Polar mutations in lac, gal and phage λ consist of a few IS-DNA sequences inserted with either orientation

1972 • 210 citations

Mutations caused by the insertion of genetic material into the galactose operon of Escherichia coli

1969 • 208 citations

PROPERTIES OF THE TRANSLOCATABLE TETRACYCLINE-RESISTANCE ELEMENT Tn10 IN ESCHERICHIA COLI AND BACTERIOPHAGE LAMBDA

1978 • 202 citations

In vitro mutagenesis of a circular DNA molecule by using synthetic restriction sites.

1978 • 200 citations

Translocation of a plasmid DNA sequence which mediates ampicillin resistance: molecular nature and specificity of insertion.

1975 • 199 citations

Phase variation in Salmonella: genetic analysis of a recombinational switch.

1979 • 190 citations

Analysis of sequences transposed by complementation of two classes of transposition-deficient mutants of Tn3

1978 • 189 citations

IS2, a genetic element for turn-off and turn-on of gene activity in E. coli

1974 • 182 citations

The E. coli gene encoding heat stable toxin is a bacterial transposon flanked by inverted repeats of IS1

1979 • 178 citations

DRUG RESISTANCE OF ENTERIC BACTERIA IV

1964 • 178 citations

IS-Elements in Microorganisms

1976 • 177 citations

Electron microscope heteroduplex studies of sequence relations among bacterial plasmids: identification and mapping of the insertion sequences IS1 and IS2 in F and R plasmids

1975 • 174 citations

BACTERIOPHAGE MU AS A TRANSPOSITION ELEMENT

1976 • 174 citations

Site specific recA--independent recombination between bacterial plasmids: involvement of palindromes at the recombinational loci.

1975 • 173 citations

Molecular genetics of bacteriophage P22.

1978 • 172 citations

Nucleotide sequence of the transposable DNA-element IS2

1979 • 164 citations

Characterization of a translocation unit encoding resistance to mercuric ions that occurs on a nonconjugative plasmid in Pseudomonas aeruginosa

1977 • 163 citations

DNA sequence at the integration sites of the insertion element IS1

1978 • 158 citations

Deletion mutants of bacteriophage lambda

1971 • 155 citations

Rec-mediated recombinational hot spot activity in bacteriophage lambda

1975 • 154 citations

Activity of the Escherichia coli recA-gene Product

1979 • 153 citations

Plasmids of medical, environmental and commercial importance.

1979 • 151 citations

IS1 insertion generates duplication of a nine base pair sequence at its target site

1978 • 150 citations

Electron microscopy of polar insertions in the lac operon of Escherichia coli

1972 • 148 citations

Extrachromosomal elements as possible agents of adaptation and development

1976 • 147 citations

Effect of Rho on Transcription of Bacterial Operons

1973 • 146 citations

Two kinds of insertions in bacterial genes

1972 • 143 citations

Map of plasmid RP4 derived by insertion of transposon C

1977 • 142 citations

Inversion of the G DNA segment of phage Mu controls phage infectivity

1978 • 141 citations

Involvement of multiple translocating DNA segments and recombinational hotspots in the structural evolution of bacterial plasmids

1976 • 139 citations

Occurrence of insertion sequence (IS) regions on plasmid deoxyribonucleic acid as direct and inverted nucleotide sequence duplications

1975 • 137 citations

Multiple copies of the insertion-DNA sequences IS1 and IS2 in the chromosome of E. coli K-12

1973 • 135 citations

Sequence Analysis at IS1 Insertion Sites: Models for Transposition

1979 • 134 citations

Tn951: A new transposon carrying a lactose operon

1978 • 130 citations

Deletions and insertions in the immunity region of coliphage lambda: Revised measurement of the promoter-startpoint distance

1974 • 129 citations

dv: An Autonomously Replicating DNA Fragment

1968 • 128 citations

Nomenclature of transposable elements in prokaryotes

1979 • 127 citations

Genetic translocation in Staphylococcus aureus.

1979 • 122 citations

Drug Resistance of Enteric Bacteria

1968 • 120 citations

Inversions and deletions of the Salmonella chromosome generated by the translocatable tetracycline resistance element Tn10

1979 • 119 citations

The bacteriophage lambda int gene product. A filter assay for genetic recombination, purification of int, and specific binding to DNA.

1978 • 119 citations

Reversal of mutator phage Mu integration

1975 • 116 citations

Translocation of a discrete piece of deoxyribonucleic acid carrying an amp gene between replicons in Eschericha coli

1976 • 116 citations

Insertion mutations in microorganisms

1972 • 113 citations

Transposition of TnA does not generate deletions

1977 • 113 citations

DNA sequence of the transposable element IS1

1979 • 113 citations

Regulation of gene expression by site-specific inversion

1978 • 111 citations

MOLECULAR MECHANISMS IN GENETIC RECOMBINATION

1973 • 110 citations

State of prophage Mu DNA upon induction.

1977 • 109 citations

Recombination in bacteriophage λ

1968 • 108 citations

Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: independence from host rec functions and orientation of insertion

1976 • 107 citations

Transposition of plasmid DNA segments specifying hydrocarbon degradation and their expression in various microorganisms

1978 • 104 citations

Regional preference of insertion of Tn501 and Tn802 into RP1 and its derivatives

1978 • 102 citations

Translocation specificity of the Tn3 element: Characterization of sites of multiple insertions

1980 • 101 citations

Close vicinity of IS1 integration sites in the leader sequence of the gal operon of E. coli

1979 • 97 citations

Mu insertion duplicates a 5 base pair sequence at the host inserted site

1979 • 94 citations

Burrows Textbook of Microbiology

1980 • 93 citations

Characterisation of Tn501, a transposon determining resistance to mercuric ions

1978 • 93 citations

Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element

1977 • 93 citations

Involvement of supertwisted DNA in integrative recombination of bacteriophage lambda

1978 • 92 citations

Physical structures of Tn10-promoted deletions and inversions: Role of 1400 bp inverted repetitions

1979 • 90 citations

Heteroduplex structures of bacteriophage Mu DNA

1973 • 90 citations

DNA sequence analysis of Tn10 insertions: Origin and role of 9 bp flanking repetitions during Tn10 translocation

1979 • 89 citations

Extrachromosomal elements as possible agents of adaptation and development.

1976 • 88 citations

Integrative recombination function of bacteriophage λ: Evidence for a site-specific recombination enzyme

1968 • 87 citations

Rearrangements of Genetic Material in Escherichia coli As Observed on the Bacteriophage P1 Plasmid

1979 • 86 citations

Acquisition of a determinant for chloramphenicol resistance by coliphage lambda.

1975 • 83 citations

Identification and characterization of a self-regulated repressor of translocation of the Tn3 element.

1979 • 83 citations

Bacteriophage Mu-1: A tool to transpose and to localize bacterial genes

1976 • 82 citations

Electron microscopic characterization of DNAs of non-defective deletion mutants of bacteriophage Mu

1977 • 81 citations

Integration and Excision of Bacteriophage λ

1977 • 81 citations

PROGRESS TOWARD A METABOLIC INTERPRETATION OF GENETIC RECOMBINATION OF ESCHERICHIA COLI AND BACTERIOPHAGE LAMBDA

1974 • 81 citations

DNA REARRANGEMENTS IN PROCARYOTES

1977 • 81 citations

Electron microscope study of the structures of λdv DNAs

1974 • 78 citations

Involvement of phage Mu-1 early functions in Mu-mediated chromosomal rearrangements

1978 • 78 citations

Transposition of Pseudomonas toluene-degrading genes and expression in Escherichia coli

1978 • 78 citations

Restriction endonuclease mapping of a plasmid that confers oncogenicity upon Agrobacterium tumefaciens strain B6-806

1978 • 77 citations

Nucleotide-sequence Analysis of Tn3 (Ap): Implications for Insertion and Deletion

1979 • 77 citations

Characterisation of Tn1721, a new transposon containing tetracycline resistance genes capable of amplification

1979 • 76 citations

Site-specific DNA deletions occurring adjacent to the termini of a transposable ampicillin resistance element (Tn3)

1977 • 76 citations

Electron microscope heteroduplex study of the heterogeneity of Mu phage and prophage DNA

1974 • 75 citations

Tn402: a new transposable element determining trimethoprim resistance that inserts in bacteriophage lambda

1977 • 74 citations

Nomenclature of transposable elements in prokaryotes

1979 • 74 citations

Polypeptides expressed in Escherichia coli K-12 minicells by transposition elements Tn1 and Tn3

1979 • 71 citations

Electron Microscopic Evidence for Linear Insertion of Bacteriophage MU-1 in Lysogenic Bacteria

1971 • 71 citations

O o mutations in the galactose operon in E. coli

1967 • 71 citations

Translocation of the tetracycline resistance determinant from R100-1 to the Escherichia coli K-12 chromosome

1975 • 71 citations

SPECIFICITY OF INSERTION BY THE TRANSLOCATABLE TETRACYCLINE-RESISTANCE ELEMENT Tn10

1979 • 67 citations

Evolution, Genetics, and Man

1956 • 65 citations

Insertion mutations in the control region of the Gal operon of E. coli

1972 • 64 citations

Hotspots for generalized recombination in the Escherichia coli chromosome

1978 • 64 citations

Nearly precise excision: a new type of DNA alteration associated with the translocatable element Tn10

1979 • 62 citations

Electron microscopic studies of the mechanism of action of the restriction endonuclease of Escherichia coli B

1979 • 61 citations

Insertion of phage Mu. 1 within prophage λ: A new approach for studying the control of the late functions in bacteriophage λ

1969 • 61 citations

The transposon Tn9 generates a 9 bp repeated sequence during integration

1978 • 60 citations

DNA Sequence of the mini-insertion IS2–6 and its relation to the sequence of IS2

1978 • 57 citations

Tandem genetic duplications in phage lambda

1975 • 57 citations

Model for the enchancement of lambde-gal integration into partially induced Mu-1 lysogens

1975 • 56 citations

Deletion mutants of bacteriophage lambda

1971 • 56 citations

Two insertions in the galactose operon having different sizes but homologous DNA sequences

1969 • 55 citations

Site-specific Recombination in Phage Mu

1979 • 54 citations

Nucleotide sequence at the insertion sites of a kanamycin transposon

1978 • 53 citations

Transposition of DNA inserted into deletions of the Tn5 kanamycin resistance element

1979 • 52 citations

Thermal asymmetry of site-specific recombination by bacteriophage λ

1973 • 52 citations

Insertion of the tetracycline resistance translocation unit Tn10 in thelac operon ofEscherichia coli K12

1977 • 51 citations

Insertion sequence IS2 associated with int-constitutive mutants of bacteriophage lambda

1977 • 51 citations

Isolation and characterization of transducing coliphage fd carrying a kanamycin resistance gene

1978 • 51 citations

Identification and characterization of a small sequence located at two sites on the amplifiable tetracycline resistance plasmid pAMalpha1 in Streptococcus faecalis

1977 • 50 citations

ILLEGITIMATE RECOMBINATION IN BACTERIA AND BACTERIOPHAGE

1977 • 49 citations

Genetic characterization of Mu-like bacteriophage D108

1978 • 48 citations

A Transposon (Tn917) in Streptococcus faecalis That Exhibits Enhanced Transposition during Induction of Drug Resistance

1979 • 47 citations

Tandem Genetic Duplications in a Derivative of Phage Lambda

1971 • 46 citations

Two Naturally Occurring Transposons Indistinguishable from Tn7

1977 • 46 citations

IS4 is found between eleven or twelve base pair duplications

1979 • 45 citations

alphabeta sequence of F is IS31

1975 • 45 citations

Isolation and characterization of specialized transducing bacteriophages for the recA gene of Escherichia coli

1977 • 44 citations

DNA Recombination: In Vivo and In Vitro Studies

1979 • 42 citations

Underwound loops in self-renatured DNA can be diagnostic of inverted duplications and translocated sequences

1977 • 42 citations

Transposition of a beta-lactamase locus from RP1 into Pseudomonas putida degradative plasmids

1977 • 39 citations

Structural evolution of bacterial plasmids: role of translocating genetic elements and DNA sequence insertions.

1976 • 38 citations

Genetic Mapping of the Inversion Loop in Bacteriophage Mu DNA

1973 • 37 citations

Repetition of tetracycline resistance determinant genes on R plasmid pRSD1 in Escherichia coli

1979 • 36 citations

The dependence of temperate phage mu-1 upon replication functions of E. coli K12

1974 • 36 citations

Transposition and insertion of intact, deleted and enlarged ampicillin transposon Tn3 from mini-R1 (Rsc) plasmids into transfer factors

1977 • 35 citations

Enumeration and identification of IS3 elements in Escherichia coli strains

1979 • 34 citations

Suppression of polarity of insertion mutations within the gal operon of E. coli

1977 • 33 citations

Molecular characterization of the P group plasmid R68 and variants with enhanced chromosome mobilizing ability

1977 • 32 citations

Insertion of the Tn3 transposon into the genome of the single-stranded DNA phage M13

1978 • 32 citations

Mechanisms of recombination by the RecBC and the RecF pathways following conjugation in Escherichia coli K12

1979 • 31 citations

In vivo genetic engineering: the Mu-mediated transposition of chromosomal DNA segments onto transmissible plasmids

1977 • 31 citations

R-Factors: Their Properties and Possible Control

1977 • 31 citations

Genetic evidence for two types of gene arrangements in new λdv plasmid mutants

1974 • 30 citations

Research Article 12: Some Properties of Insertion Mutations in the lac Operon

1970 • 29 citations

Isolation of the mini insertions IS6 and IS7 of E. coli

1977 • 29 citations

Defective Lambda Particles Whose DNA Carries Only a Single Cohesive End

1971 • 29 citations

Integration of a transposable DNA sequence which mediates ampicillin resistance into Clo DF13 plasmid DNA: Determination of the site and orientation of TnA insertions

1978 • 28 citations

DISTRIBUTION OF GENETIC TYPES OF TRANSDUCING LAMBDA PHAGES

1963 • 28 citations

Chromosomal integration of phage lambda by means of a DNA insertion element.

1978 • 26 citations

Adjacent insertion sequences IS2 and IS5 in bacteriophage Mu mutants and an IS5 in a lambda darg bacteriophage

1978 • 25 citations

Involvement of DNA-dependent RNA polymerase in a recA-independent pathway of genetic recombination in Escheria coli.

1977 • 25 citations

Evidence for a common mechanism for the insertion of the Tn10 transposon and for the generation of Tn10-stimulated deletions

1978 • 24 citations

Studies of the Specificity and Control of Transposition of the Tn3 Element

1979 • 23 citations

BACTERIAL CONJUGATION AND EXTRACHROMOSOMAL ELEMENTS

1967 • 23 citations

Multiple integration sites for the lactose transposon Tn951 on plasmid RP1 and establishment of a coordinate system for Tn951

1979 • 23 citations

Translocation and Other Recombination Events Involving the Tetracycline-resistance Element Tn 10

1979 • 23 citations

Preparation of plasmids from lambdoid phages and studies on their incompatibilities

1978 • 23 citations

The Integration and excision of the bacteriophage Mu-1

1976 • 23 citations

Integration and Excision of Prophage Mediated by the IS1 Element

1979 • 22 citations

Properties of a transposon conferring resistance to penicillins and streptomycin

1977 • 21 citations

Mapping and characterization of an E. coli mutant defective in IS1-mediated deletion formation

1978 • 21 citations

DNA Sequence of IS2-7 and Generation of Mini-insertions by Replication of IS2 Sequences

1979 • 21 citations

lac Messenger RNA in lac Z gene mutants of Escherichia coli caused by insertion of bacteriophage Mu

1973 • 20 citations

The isolation of IS1 and IS2 DNA

1976 • 19 citations

Location of an ampicillin resistance transposon, Tn1701, in a group of small, nontransferring plasmids

1979 • 19 citations

The integration and excision of bacteriophage lambda

1974 • 18 citations

Transfer, maintenance, and expression of bacterial Ti-plasmid DNA in plant cells transformed with A. tumefaciens.

1977 • 18 citations

Integration of Bacteriophage Mu DNA

1979 • 18 citations

How Viruses Insert their DNA into the DNA of the Host Cell

1976 • 17 citations

Transposable Neomycin Phosphotransferases

1977 • 16 citations

Transposition of Tn1 to a broad-host-range drug resistance plasmid

1977 • 15 citations

Reversible translocation of antibiotic resistance determinants in Salmonella ordonez

1979 • 15 citations

Sequence arrangements of the Escherichia coli chromosome and of putative insertion sequences, as revealed by electron microscopic heteroduplex studies

1977 • 14 citations

Distribution of inverted IS-length sequences in the E. coli K12 genome

1976 • 14 citations

Integration and Excision of DNA Molecules

1978 • 14 citations

Chi

1979 • 14 citations

Intramolecular amplification of the tetracycline resistance determinant of transposon Tn1771 inEscherichia coli

1979 • 13 citations

Additive recombination in bacteria

1977 • 13 citations

Nucleotide sequences at the ends of bacteriophage Mu DNA

1978 • 11 citations

Invertible DNA in phage Mu

1978 • 11 citations

Fertility inhibition in Rhizobium lupini by the resistance plasmid RP4

1978 • 11 citations

Insertion of Phage Mu. 1 within Prophage ;%: A New Approach for Studying the Control of t)he Late Functions in Bacteriophage ;L

1969 • 10 citations

Site-specific recombination in bacteriophage lambda

1977 • 8 citations

Transposition of DNA sequences.

1977 • 7 citations

Transconjugant analysis: limitations on the use of sequence-specific endonucleases for plasmid identification

1978 • 7 citations

The Transposition of Ampicillin Resistance: Nature of Ampicillin Resistant Haemophilus influenzae and Neisseria gonorrhoeae

1977 • 6 citations

Integrative Recombination of Bacteriophage Lambda: Genetics and Biochemistry

1978 • 2 citations

Properties of DNA Insertion Elements of E. coli

1977 • 1 citations