Structure and Properties of a Secretable Phospholipase A2 from Human Platelets

Signal sequences

1985 • 2,179 citations

Biology of interleukin 1

1988 • 1,547 citations

Intracellular protein topogenesis

1980 • 1,378 citations

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Intracellular phospholipases A

1980 • 989 citations

Structure and Properties of a Human Non-pancreatic Phospholipase A2

1989 • 668 citations

Cloning and Recombinant Expression of Phospholipase A2 Present in Rheumatoid Arthritic Synovial Fluid

1989 • 542 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

Structure and function of phospholiphase A2

1981 • 478 citations

The Role of Arachidonic Acid Oxygenation Products in Pain and Inflammation

1984 • 457 citations

Structure of bovine pancreatic phospholipase A2 at 1.7 Å resolution

1981 • 429 citations

Mediators of Inflammation

1983 • 419 citations

Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus. A new classification of phospholipases A2 based upon structural determinants.

1977 • 406 citations

A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom.

1985 • 396 citations

Chemical and biochemical aspects of platelet activating factor: A novel class of acetylated ether‐linked choline‐phospholipids

1985 • 359 citations

Phospholipase A2: Function and pharmacological regulation

1987 • 347 citations

Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium.

1978 • 302 citations

Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids.

1984 • 296 citations

Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: a possible signal for IL 1 action.

1986 • 259 citations

Separation and purification of a potent bactericidal/permeability-increasing protein and a closely associated phospholipase A2 from rabbit polymorphonuclear leukocytes. Observations on their relationship.

1979 • 247 citations

Pancreatic Phospholipase A₂: Isolation of the Human Gene and cDNAs from Porcine Pancreas and Human Lung

1986 • 225 citations

Increased plasma phospholipase-A2 activity in schizophrenic patients: Reduction after neuroleptic therapy

1987 • 216 citations

Interleukin 1 and tumor necrosis factor synergistically stimulate prostaglandin synthesis and phospholipase A2 release from rat renal mesangial cells

1989 • 193 citations

Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction.

1979 • 189 citations

Structure-function relationships of phospholipases. The anticoagulant region of phospholipases A2.

1987 • 176 citations

Purification and Characterization of Phospholipase A2 Released from Rat Platelets

1987 • 147 citations

Identification and purification of sheep platelet phospholipase A2 isoforms. Activation by physiologic concentrations of calcium ion.

1986 • 147 citations

Identification and isolation of a mammalian protein which is antigenically and functionally related to the phospholipase A2 stimulatory peptide melittin.

1987 • 136 citations

Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate

1986 • 134 citations

Purification and characterization of a membrane-associated phospholipase A2 from rat spleen. Its comparison with a cytosolic phospholipase A2 S-1.

1988 • 128 citations

Pathogenesis of hypotension in septic shock

1988 • 124 citations

Diacylglycerol potentiates phospholipase attack upon phospholipid bilayers: Possible connection with cell stimulation

1983 • 120 citations

Purification and Characterization of Extracellular Phospholipase A2 from Peritoneal Cavity of Caseinate-Treated Rat1

1987 • 114 citations

Novel intestinal phospholipase A2: purification and some molecular characteristics

1982 • 113 citations

Conformational properties of phospholipases A₂

1983 • 111 citations

The proinflammatory effect of intra-articular injection of soluble human and venom phospholipase A2.

1989 • 107 citations

Immunoaffinity purification, partial sequence, and subcellular localization of rat liver phospholipase A2

1989 • 107 citations

Stimulation of Ca2+-activated human platelet phospholipase A2 by diacylglycerol

1987 • 98 citations

Enhanced Activity and Altered Specificity of Phospholipase A₂by Deletion of a Surface Loop

1989 • 98 citations

Solubilization and properties of Ca2+-dependent human platelet phospholipase A2

1986 • 94 citations

Degradation of Microorganisms by Phagocytic Cells

1980 • 94 citations

The 2.5 A crystal structure of a dimeric phospholipase A2 from the venom of Crotalus atrox.

1981 • 91 citations

The Primary Structure of Rat Platelet Phospholipase A21

1988 • 88 citations

Interleukin‐1 activates phospholipase a₂ IN HUMAN SYNOVIAL CELLS

1988 • 87 citations

Serum phospholipase A2 correlates with disease activity in rheumatoid arthritis.

1988 • 87 citations

Purification of Rabbit Platelet Secretory Phospholipase A2 and Its Characteristics1

1989 • 87 citations

Selective Release of Phospholipase A2 and Lysophosphatidylserine- Specific Lysophospholipase from Rat Platelets1

1987 • 86 citations

Lipid mediators of inflammation and allergy.

1982 • 85 citations

The chemical basis for interfacial activation of monomeric phospholipases A2. Autocatalytic derivatization of the enzyme by acyl transfer from substrate.

1988 • 84 citations

Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2

1988 • 83 citations

The Phospholipases

1987 • 79 citations

Lipids and membranes

1974 • 79 citations

Are disturbances in lipid-protein interactions by phospholipase-A2 a predisposing factor in affective illness?

1989 • 72 citations

Dimerization and activation of porcine pancreatic phospholipase A2 via substrate level acylation of lysine 56

1989 • 55 citations

Proteins in Biology and Medicine

1982 • 50 citations

Possible role of phospholipase A2 in triggering histamine secretion from human basophils in vitro

1981 • 50 citations

Release of phospholipase A2 activity from rabbit peritoneal neutrophils by f-Met-Leu-Phe.

1983 • 46 citations

Extracellular phospholipase A2: causative agent in circulatory collapse of septic shock?

1988 • 46 citations

Phospholipase A2 activity of lysosomal origin secreted by polymorphonuclear leucocytes during phagocytosis or on treatment with calcium

1981 • 44 citations

Release of phospholipase A₂ activity from rat vascular smooth muscle cells mediated by cAMP

1989 • 43 citations

Amino Acid Composition and NH2-Terminal Amino Acid Sequence of Rat Platelet Secretory Phospholipase A21

1987 • 41 citations

A major role for phospholipase A2 in antigen-induced arachidonic acid release in rat mast cells

1987 • 41 citations

Purification and Characterization of Membrane-Bound Phospholipase A2 from Rat Platelets1

1988 • 39 citations

Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites.

1982 • 39 citations

Induction of alveolar epithelial injury by phospholipase A2

1989 • 33 citations

Importance of adenosine triphosphate in phospholipase A2-induced rabbit renal proximal tubule cell injury.

1988 • 32 citations

Facing up to Membranes: Structure/Function Relationships in Phospholipases

1987 • 32 citations

Phospholipases, lysophospholipases, and lipases and their involvement in various diseases

1987 • 27 citations

Chapter 10 On the mechanism of phospholipase A2

1982 • 26 citations

Production of Platelet-activating Factor, a Biologically Active Lipid, by Vascular Endothelial Cells

1987 • 25 citations

Signal response transduction in rabbit neutrophil leucocytes

1987 • 16 citations

Phospholipase A₂ induced airway hyperreactivity to cooling and acetylcholine in rat trachea: pharmacological modulation

1988 • 15 citations

Quinacrine prevention of intestinal ischaemic mucosal damage is partly mediated through inhibition of intraluminal phospholipase A2

1988 • 8 citations

Phospholipase A₂ (PLA₂) Releases Lipoxins and Leukotrienes from Endogenous Sources^a,^b

1988 • 7 citations

STRUCTURE-FUNCTION RELATIONSHIPS IN PHOSPHOLIPASES A2

1982 • 4 citations