Animal models of Parkinson’s disease in rodents induced by toxins: an update

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Anesthesiology

1997 • 2,182 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

Parkinson's Disease

1998 • 1,953 citations

Progressive Supranuclear Palsy

1964 • 1,864 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1968 • 1,419 citations

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1988 • 1,235 citations

Parkinson's Disease

1998 • 1,150 citations

Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

2001 • 1,036 citations

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

1999 • 1,035 citations

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

1984 • 1,005 citations

FRONTAL LOBE DYSFUNCTION IN PARKINSON'S DISEASE

1986 • 904 citations

COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSON'S DISEASE

1983 • 807 citations

Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat

1994 • 786 citations

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

2001 • 775 citations

Pathology of Parkinson’s disease

1991 • 674 citations

COGNITIVE IMPAIRMENT IN EARLY, UNTREATED PARKINSON'S DISEASE AND ITS RELATIONSHIP TO MOTOR DISABILITY

1991 • 630 citations

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1995 • 608 citations

Time course of nigrostriatal degeneration in parkinson's disease

1976 • 561 citations

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1998 • 517 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

Is the mesocortical dopaminergic system involved in Parkinson disease?

1980 • 412 citations

The Inflammatory Reaction Following 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Intoxication in Mouse

1999 • 372 citations

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

2001 • 360 citations

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

1986 • 347 citations

BRAIN, SKELETAL MUSCLE AND PLATELET HOMOGENATE MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

1992 • 341 citations

Glial cells and inflammation in parkinson's disease: A role in neurodegeneration?

1998 • 328 citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the common marmoset

1984 • 324 citations

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

2003 • 323 citations

Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment

2001 • 312 citations

Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease

2000 • 303 citations

STRIATONIGRAL DEGENERATION

1990 • 291 citations

The clinical and pathological spectrum of Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy): a reappraisal

1995 • 277 citations

MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences.

2000 • 248 citations

Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease

1988 • 240 citations

Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey

1991 • 219 citations

Studies on the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on central catecholamine neurons in C57 BL/6 mice. Comparison with three other strains of mice

1987 • 202 citations

Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra

1997 • 200 citations

Continuous dopamine-receptor stimulation in early Parkinson's disease

2000 • 198 citations

Interdependence of the Nigrostriatal Dopaminergic Systems on the Two Sides of the Brain in the Cat

1977 • 184 citations

A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey

1997 • 159 citations

[The tropical localization and content of noradrenalin and dopamine (3-hydroxytyramine) in the substantia nigra of normal persons and patients with Parkinson's disease].

1963 • 143 citations

Chronic nicotine treatment counteracts nigral cell loss induced by a partial mesodiencephalic hemitransection: An analysis of the total number and mean volume of neurons and glia in substantia nigra of the male rat

1993 • 129 citations

Evaluation of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 black mouse model for parkinsonism

1990 • 112 citations

Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkey

1995 • 103 citations

Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin

2003 • 98 citations

Influence of the mesocortical dopaminergic system on activity, food hoarding, social^agonistic behavior, and spatial delayed alternation in male rats.

1989 • 95 citations

Chronic exposure to low doses of MPTP. II. Neurochemical and pathological consequences in cognitively-impaired, motor asymptomatic monkeys

1990 • 95 citations

Behavioral changes are not directly related to striatal monoamine levels, number of nigral neurons, or dose of parkinsonian toxin MPTP in mice

2003 • 93 citations

Brain monoamines and parkinsonism.

1975 • 92 citations

Dégénérescences nigro-striées et cerebello-nigro-striées; pp. 219–232

1961 • 91 citations

Influence of the mesocortical dopaminergic system on activity, food hoarding, social-agonistic behavior, and spatial delayed alternation in male rats.

1989 • 84 citations

An electron microscopic study of MPTP-induced inclusion bodies in an old monkey

1988 • 84 citations

Hemispheric Processing and Methylphenidate Effects in Attention-Deficit Hyperactivity Disorder

1994 • 78 citations

Histochemical, biochemical and behavioural consequences of MPTP treatment in C-57 black mice

1987 • 77 citations

MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study

1985 • 69 citations

Cognitive Changes in Mice Following Moderate MPTP Exposure

1998 • 64 citations

Effects of MPTP on locomotor activity in mice

1990 • 59 citations

MPTP-induced deficits in motor activity: Neuroprotective effects of the spintrapping agent, ?-phenyl-tert-butyl-nitrone (PBN)

1997 • 51 citations

Inhibitors of Type IV Phosphodiesterases Reduce the Toxicity of MPTP in Substantia Nigra Neurons In Vivo

1995 • 50 citations

Clinical Lewy Body Syndromes

2000 • 50 citations

Symptoms and behavioral features induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in an old java monkey [Macaca cynamolgus fascicularis (Raffles)]

1986 • 47 citations

Dissociation of serotoninergic and dopaminergic components in acute effects of 1-methy 1-4-pheny 1-1,2,3,6-tetrahydropyridine in mice

1992 • 46 citations

Ipsilateral and contralateral subthalamic activity after unilateral dopaminergic lesion

2000 • 44 citations

Nicotine, but not cotinine, partially protects dopaminergic neurons against MPTP-induced degeneration in mice

2001 • 43 citations

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 5,7-dihydroxytryptamine on the locomotor activity and striatal amines in C57BL/6 mice

1996 • 38 citations

Nondopaminergic neurons in Parkinson's disease.

2003 • 38 citations

Bilateral 6‐Hydroxydopamine‐induced Lesion of the Nigrostriatal Dopamine Pathway Reproduces the Effects of Unilateral Lesion on Substance P but not on Enkephalin Expression in Rat Basal Ganglia

1996 • 37 citations

EFFECTS OF NICOTINE ON 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE-INDUCED DEPRESSION OF STRIATAL DOPAMINE CONTENT AND SPONTANEOUS LOCOMOTOR ACTIVITY IN C57 BLACK MICE

1998 • 33 citations

Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies

2001 • 33 citations

Neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the substantia nigra and the locus coeruleus in BALB/c mice.

1991 • 31 citations

The acute effect on levels of catecholamines and metabolites in brain, of a single dose of MPTP in 8 strains of mice

1989 • 29 citations

Electrophysiological and neurochemical correlates of the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on central catecholamine neurons in the mouse

1985 • 17 citations