The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

1980 • 2,034 citations

The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors.

1986 • 733 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Multiple upstream AUG codons mediate translational control of GCN4

1986 • 654 citations

Structure and variation of human α1–antitrypsin

1982 • 616 citations

Complete sequence of the cDNA for human .alpha.1-antitrypsin and the gene for the S variant

1984 • 396 citations

α1-Antitrypsin deficiency detection by direct analysis of the mutation in the gene

1983 • 277 citations

New versatile cloning and sequencing vectors based on bacteriophage M13

1983 • 263 citations

Transcription and RNA processing by the DNA tumour viruses

1980 • 228 citations

Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats

1984 • 221 citations

Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages.

1985 • 204 citations

Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression

1987 • 204 citations

Cell-specific expression of a transfected human α1-antitrypsin gene

1985 • 188 citations

Alpha1-antitrypsin and its deficiency.

1974 • 156 citations

Structure of gene and pseudogenes of human apoferritin H

1986 • 132 citations

Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene.

1986 • 127 citations

Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α-antitrypsin, C8, and factor B

1980 • 122 citations

The Current Status of α-1-Antitrypsin, a Protease Inhibitor, in Gastrointestinal Disease

1976 • 118 citations

Cloning of the gene coding for human L apoferritin

1986 • 104 citations

The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA.

1985 • 99 citations

Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5′-flanking region contains hepatoma specific transcriptional signals.

1985 • 93 citations

SYNTHESIS AND SECRETION OF COMPLEMENT PROTEINS BY MACROPHAGES*

1979 • 93 citations

Transcription of the β-like globin genes and pseudogenes of the goat in a cell-free system

1981 • 65 citations

The two promoters of the mouse α-amylase gene Amy-1a are differentially activated during parotid gland differentiation

1985 • 52 citations

T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.

1986 • 46 citations

Cloning of several cDNA segments coding for human liver proteins.

1983 • 40 citations

Molecular dissection of the human transferrin receptor

1985 • 12 citations