Systemic Sclerosis - a Microvascular Disorder?

Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)

1972 • 1,816 citations

LABORATORY INVESTIGATION

1956 • 1,491 citations

Pathologic observations in systemic sclerosis (scleroderma)

1969 • 1,071 citations

The Mechanics of the Circulation

2011 • 918 citations

Limited Joint Mobility in Childhood Diabetes Mellitus Indicates Increased Risk for Microvascular Disease

1981 • 434 citations

Pathogenesis of systemic sclerosis: A vascular hypothesis

1975 • 412 citations

Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders

1980 • 400 citations

Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulceration.

1982 • 350 citations

THE RELATIONSHIP OF HYPERTENSION AND RENAL FAILURE IN SCLERODERMA (PROGRESSIVE SYSTEMIC SCLEROSIS) TO STRUCTURAL AND FUNCTIONAL ABNORMALITIES OF THE RENAL CORTICAL CIRCULATION

1974 • 339 citations

Lymphokine stimulation of collagen accumulation.

1976 • 322 citations

Vascular Disease in Progressive Systemic Sclerosis (Scleroderma)

1970 • 312 citations

Widefield capillary microscopy. technique and rating scale for abnormalities seen in scleroderma and related disorders

1981 • 308 citations

Endothelial injury in scleroderma.

1979 • 289 citations

Increased Factor VIII/von Willebrand Factor Antigen and von Willebrand Factor Activity in Scleroderma and in Raynaud's Phenomenon

1981 • 220 citations

Total and Capillary Fingertip Blood Flow in Raynaud's Phenomenon

1971 • 197 citations

Skin capillary abnormalities as indicators of organ involvement in scleroderma (systemic sclerosis), Raynaud's syndrome and dermatomyositis

1976 • 185 citations

Acta Dermato-Venereologica, Stockholm

1964 • 172 citations

Development of a Scleroderma-like Illness during Therapy with L-5-Hydroxytryptophan and Carbidopa

1980 • 152 citations

Elevated Levels of Circulating Platelet Aggregates and Beta-Thromboglobulin in Scleroderma

1982 • 123 citations

Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud's phenomenon.

1982 • 111 citations

Human β-thromboglobulin inhibits PGI2 production and binds to a specific site in bovine aortic endothelial cells

1979 • 108 citations

Scleroderma-like Lesions and the Carcinoid Syndrome

1973 • 107 citations

Antibodies to collagen in scleroderma

1982 • 103 citations

Treatment of Raynaud's phenomenon by fibrinolytic enhancement.

1978 • 93 citations

Digital sclerosis in children with insulin‐dependent diabetes mellitus

1982 • 93 citations

Raynaud's Disease, Raynaud's Phenomenon, and Serotonin

1960 • 88 citations

Digital Arteries in Patients With Scleroderma

1972 • 87 citations

Connective Tissue and Ageing

1974 • 81 citations

Haemorrheological response to plasma exchange in Raynaud's syndrome.

1979 • 80 citations

Skin Capillary Changes in Early Systemic Scleroderma

1976 • 80 citations

Dermal Fibrosis Following Subcutaneous Injections of Serotonin Creatinine Sulphate.

1958 • 80 citations

Comparison of the microangiopathy of systemic lupus erythematosus, dermatomyositis, scleroderma, and diabetes mellitus.

1970 • 79 citations

Platelet adherence to subendothelium of human arteries in pulsatile and steady flow

1980 • 79 citations

ABNORMAL BLOOD VISCOSITY IN RAYNAUD'S PHENOMENON

1976 • 78 citations

Rheumatic disease sera reactive with capillaries in the mouse kidney

1972 • 78 citations

Skin capillary blood flow in scleroderma

1971 • 76 citations

Variable response to oral angiotensin‐converting‐enzyme blockade in hypertensive scleroderma patients

1982 • 75 citations

THE ACTION OF 5‐HYDROXYTRYPTAMINE ON THE BLOOD VESSELS OF THE HUMAN HAND AND FOREARM

1955 • 72 citations

Prognosis in Raynaud's Phenomenon After Sympathectomy

1965 • 71 citations

Treatment of liposclerosis of the leg by fibrinolytic enhancement: a preliminary report.

1977 • 70 citations

Abnormalities of Pulmonary Vascular Dynamics and Inflammation In Early Progressive Systemic Sclerosis

1981 • 68 citations

Successful Medical Treatment of Scleroderma Renal Crisis

1978 • 67 citations

Peripheral Venous Blood Concentrations of Epinephrine and Norepinephrine in Primary Raynaud's Disease

1959 • 66 citations

Connective tissue activation

1979 • 66 citations

Arthritis and rheumatism

1982 • 65 citations

Collagen types synthesized in dermal fibroblast cultures from patients with early progressive systemic sclerosis

1980 • 64 citations

Controlled trial of plasma exchange in treatment of Raynaud's syndrome.

1979 • 60 citations

Immunopathology of the renal vascular lesion of progressive systemic sclerosis (scleroderma).

1978 • 58 citations

5-Hydroxytryptamine and tryptamine pathways in scleroderma

1977 • 54 citations

Effect of prostaglandins I2 and E1 on red cell deformability in patients with Raynaud's phenomenon and systemic sclerosis.

1981 • 52 citations

Histamine, Norepinephrine, and Bradykinin Stimulation of Fibroblast Growth and Modification of Serotonin Response

1973 • 49 citations

Immune complexes in progressive systemic sclerosis (scleroderma)

1982 • 47 citations

The skin microcirculation and the pathogenesis of ischaemic necrosis and gangrene

1977 • 47 citations

Arterial thrombosis in scleroderma

1975 • 47 citations

Scleroderma and Microangiopathic Hemolytic Anemia

1973 • 45 citations

Hypersensitivity of scleroderma cutaneous vascular smooth muscle to 5-hydroxytryptamine

1976 • 40 citations

Studies of endogenous catecholamines in patients with Raynaud's phenomenon secondary to progressive systemic sclerosis (scleroderma)

1972 • 34 citations

Progressive systemic sclerosis and malignant hypertension. Immunohistochemical study of renal lesions.

1961 • 34 citations

Biogenic amines derived from tryptophan in systemic and cutaneous scleroderma

1979 • 34 citations

Environmental Factors and the Diffusing Capacity of the Lung in Progressive Systemic Sclerosis

1976 • 33 citations

Systemic sclerosis and cryoglobulinemia

1976 • 33 citations

Circulating immune complexes in patients with progressive systemic sclerosis

1982 • 30 citations

Blood hyperviscosity with reduced skin blood flow in scleroderma

1977 • 28 citations

BLOOD FIBRINOLYTIC ACTIVITY IN DISEASES OF SMALL BLOOD VESSELS AND THE EFFECT UF LOW MOLECULAR WEIGHT DEXTRAN

1969 • 26 citations

Effects of prostaglandin E1 on microvascular haemodynamics in progressive systemic sclerosis.

1982 • 26 citations

The Nerve Network of the Skin in Diffuse Scleroderma and Clinically Similar Conditions

1963 • 24 citations

Physiologic Studies in Systemic Sclerosis (Scleroderma)

1969 • 24 citations

Serotonin and Ribonucleic Acid and Collagen Metabolism of Fibroblasts in Vitro

1972 • 23 citations

Pulmonary Arteriosclerosis due to Serotonin

1958 • 21 citations

Cutaneous microcirculation in systemic sclerosis and response to intra-arterial reserpine.

1980 • 16 citations

Urinary 5-hydroxyindoleacetic Acid Excretion in Scleroderma**From the Division of Dermatology, Department of Medicine, University of Southern California School of Medicine, Los Angeles, California.

1963 • 13 citations

PERIPHERAL NEURITIS FOLLOWING ISONIAZID THERAPY

1955 • 11 citations

Influence of Cold On Catecholamine Response of Vascular Smooth Muscle Strips From Resistance Vessels of Scleroderma Skin

1977 • 5 citations