Structure, function, and molecular defects of factor IX

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

Vitamin K Dependent Modifications of Glutamic Acid Residues in Prothrombin

1974 • 750 citations

Complete nucleotide sequences of the gene for human factor IX (antihemophilic factor B)

1985 • 683 citations

VITAMIN K-DEPENDENT CARBOXYLASE

1985 • 466 citations

Characterization of a cDNA coding for human factor VII.

1986 • 450 citations

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

1984 • 303 citations

Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin

1983 • 299 citations

Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor).

1985 • 232 citations

Computer-generated models of blood coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases.

1982 • 220 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Gene deletions in patients with haemophilia B and anti-factor IX antibodies

1983 • 207 citations

Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C.

1983 • 202 citations

Inhibition of human factor IXa by human antithrombin

1975 • 179 citations

Carrier detection in haemophilia B using two further intragenic restriction fragment length polymorphisms

1984 • 145 citations

CHARACTERISATION AND USE OF AN INTRAGENIC POLYMORPHIC MARKER FOR DETECTION OF CARRIERS OF HAEMOPHILIA B (FACTOR IX DEFICIENCY)

1984 • 127 citations

Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid.

1984 • 101 citations

Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region.

1984 • 96 citations

Similarity between the vaccinia virus 19K early protein and epidermal growth factor

1985 • 95 citations

Identification of the molecular defect in factor IX Chapel Hill: substitution of histidine for arginine at position 145.

1983 • 93 citations

[Hemophilia B Leyden].

1986 • 92 citations

A coagulation pathway on bovine aortic segments leading to generation of Factor Xa and thrombin.

1984 • 90 citations

The occurrence of β-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens

1983 • 88 citations

Carrier detection of Hemophilia B by using a restriction site polymorphism associated with the coagulation Factor IX gene.

1984 • 86 citations

Evidence for a prevalent dimorphism in the activation peptide of human coagulation factor IX.

1985 • 85 citations

Hemophilia B: characterization of genetic variants and detection of carriers

1977 • 84 citations

Cooperative Ca2+ binding to human factor IX. Effects of Ca2+ on the kinetic parameters of the activation of factor IX by factor XIa.

1982 • 82 citations

Role of human factor VIII in factor X activation.

1982 • 76 citations

Amino-acid sequence of activation cleavage site in plasminogen: homology with "pro" part of prothrombin.

1975 • 68 citations

Kinetics of the Factor XIa catalyzed activation of human blood coagulation Factor IX.

1984 • 68 citations

A monoclonal antibody to factor IX that inhibits the factor VIII:Ca potentiation of factor X activation.

1985 • 65 citations

Congenital deficiency of blood clotting factors II, VII, IX, and X

1979 • 61 citations

Redetermination of the rate-limiting step in the activation of factor IX by factor XIa and by factor VIIa/tissue factor. Explanation for different electrophoretic radioactivity profiles obtained on activation of 3H- and 125I-labeled factor IX

1983 • 61 citations

Studies on a family with combined functional deficiencies of vitamin K-dependent coagulation factors.

1982 • 60 citations

CARRIER DETECTION BY DIRECT GENE ANALYSIS IN A FAMILY WITH HAEMOPHILIA B (FACTOR IX DEFICIENCY)

1984 • 58 citations

Plasma Thromboplastin Component (PTC) A Hitherto Unrecognized Blood Coagulation Factor Case Report of PTC Deficiency

1953 • 57 citations

Assignment of the haemophilia B (Factor IX) locus to the q26‐qter region of the X chromosome

1984 • 54 citations

Characterization of the clotting activities of structurally different forms of activated factor IX. Enzymatic properties of normal human factor IXa alpha, factor IXa beta, and activated factor IX Chapel Hill.

1985 • 51 citations

The interaction of Ca2+ with human factor IX

1981 • 49 citations

The contribution of Ca2+ and phospholipids to the activation of human blood-coagulation Factor X by activated Factor IX

1984 • 49 citations

Regional localization of the human factor IX gene by molecular hybridization

1983 • 48 citations

An intragenic deletion of the factor IX gene in a family with hemophilia B.

1985 • 47 citations

The human genes for hemophilia A and hemophilia B flank the X chromosome fragile site at Xq27.3.

1985 • 45 citations

Prenatal diagnosis of hemophilia B by an immunoradiometric assay of factor IX

1980 • 44 citations

Structure and Function of Factor IX: Defects in Haemophilia B

1985 • 42 citations

Immunoassays of factor IX antigen using monoclonal antibodies

1985 • 34 citations

Cleavage and inactivation of Factor IX by granulocyte elastase.

1983 • 33 citations

Characterization of three abnormal factor IX variants (Bm Lake Elsinore, Long Beach, and Los Angeles) of hemophilia-B. Evidence for defects affecting the latent catalytic site.

1985 • 30 citations

Purification and Properties of an Abnormal Blood Coagulation Factor IX (Factor IXBm)/Kinetics of Its Inhibition of Factor X Activation by Factor VII and Bovine Tissue Factor

1981 • 29 citations

Polymorphism of normal factor IX detected by mouse monoclonal antibodies.

1985 • 28 citations

Monoclonal antibodies to coagulation factor IX define a high-frequency polymorphism by immunoassays.

1985 • 21 citations

Phospholipids accelerate factor IX activation by surface bound factor XI_a

1984 • 20 citations

Proteolytic inactivation of blood coagulation factor IX by thrombin

1985 • 20 citations

Partial factor IX protein in a pedigree with hemophilia B due to a partial gene deletion.

1986 • 20 citations

Intragenic Factor IX restriction site polymorphism in hemophilia B variants

1985 • 19 citations

Factor IXa protects activated factor VIII against inactivation by activated protein C

1984 • 18 citations

Factor IX Deventer-Evidence for the Heterogeneity of Hemophilia BM

1982 • 18 citations

Structural and functional characteristics of activated human factor IX after chemical modification of gamma-carboxyglutamic acid residues.

1985 • 16 citations

Factor IX and prothrombin in amniotic fluid and fetal plasma: constraints on prenatal diagnosis of hemophilia B and evidence of proteolysis

1984 • 14 citations

Factor IX Zutphen. A genetic variant of blood coagulation factor IX with an abnormally high molecular weight.

1982 • 10 citations

[5] Conformation-specific antibodies: approach to the study of the vitamin K-dependent blood coagulation proteins

1982 • 9 citations

Activation of Factor IX by Factor XIa - A Spectrophotometric Assay for Factor IX in Human Plasma

1982 • 7 citations