Histamine Receptors in Brain

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Handbook of Neurochemistry

1969 • 940 citations

Neurotransmitter receptor binding

1978 • 822 citations

pA, A NEW SCALE FOR THE MEASUREMENT OF DRUG ANTAGONISM

1947 • 759 citations

Cimetidine—A Non-Thiourea H₂-Receptor Antagonist

1975 • 449 citations

Autonomic nerves, mast cells, and amine receptors in human brain vessels. A histochemical and pharmacological study

1976 • 443 citations

The influence of chemical agents on the accumulation of adenosine 3',5'-Phosphate in slices of rabbit cerebellum.

1968 • 435 citations

Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain.

1976 • 389 citations

Cyclic Nucleotides in the Nervous System

1977 • 297 citations

The distribution of histamine H1-receptors in the rat brain: An autoradiographic study

1981 • 290 citations

Histamine as a Neurotransmitter in Mammalian Brain: Neurochemical Evidence

1980 • 284 citations

Cyclic Nucleotide-dependent Protein Kinases

1972 • 282 citations

Chemical differentiation of histamine H1- and H2-receptor agonists

1975 • 261 citations

Brain histamine receptors as targets for antidepressant drugs

1978 • 258 citations

Psychopharmacology: A Generation of Progress

1978 • 252 citations

A possible correlation between drug-induced hallucinations in man and a behavioural response in mice

1967 • 250 citations

Dimaprit-[S-[3-(N,N-dimethylamino)propyl]isothiourea] —A highly specific histamine H2-receptor agonist. Part 1. Pharmacology

1977 • 240 citations

Inhibition of Histamine Release by Histamine controlled by H2 Receptor

1973 • 240 citations

PHARMACOKINETIC AND CLINICAL STUDIES IN PATIENTS WITH CIMETIDINE-ASSOCIATED MENTAL CONFUSION

1979 • 238 citations

Tricyclic antidepressant drugs block histamine H2 receptor in brain

1977 • 231 citations

HETEROGENEITY OF HISTAMINE Hi‐RECEPTORS: SPECIES VARIATIONS IN [³H]MEPYRAMINE BINDING OF BRAIN MEMBRANES

1979 • 225 citations

Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors

1978 • 220 citations

Handbook of Psychopharmacology

1978 • 219 citations

Histamine-sensitive adenylate cyclase in mammalian brain

1976 • 218 citations

Histamine as a transmitter in brain

1975 • 208 citations

Regional distribution of mast cells containing histamine, dopamine, or 5‐hydroxytryptamine in the mammalian brain

1977 • 189 citations

Central and peripheral regulation of prolactin function

1980 • 172 citations

THE BINDING OF [³H]MEPYRAMINE TO HISTAMINE H₁ RECEPTORS IN GUINEA‐PIG BRAIN

1978 • 170 citations

Regulation of Adenosine 3′:5′-Cyclic Monophosphate Concentration in Cultured Human Astrocytoma Cells by Catecholamines and Histamine

1971 • 168 citations

The dopamine receptor: Differential binding of d-LSD and related agents to agonist and antagonist states

1975 • 165 citations

Cellular receptors for hormones and neurotransmitters

1981 • 159 citations

Studies on a Capillary-Rich Fraction Isolated from Brain: Histaminic Components and Characterization of the Histamine Receptors Linked to Adenylate Cyclase

1980 • 152 citations

Discoveries in Biological Psychiatry

1971 • 139 citations

Correlation between plasma diphenhydramine level and sedative and antihistamine effects

1978 • 138 citations

[3H]Mianserin: differential labeling of serotonin and histamine receptors in rat brain.

1981 • 137 citations

Minireview: Histamine receptors in brain

1979 • 136 citations

cAMP-Mediated regulation of the permeability in the brain capillaries

1975 • 127 citations

Central actions of histamine: Microelectrophoretic studies

1977 • 125 citations

FETAL CEPHALOMETRY

1974 • 123 citations

Opiate-like and abstinence-like effects of intracerebral histamine administration in rats

1978 • 112 citations

Neurotransmitter receptor localizations: Brain lesion induced alterations in benzodiazepine, GABA, β-adrenergic and histamine H1-receptor binding

1980 • 108 citations

Chlorpromazine in Psychiatry: A Study of Therapeutic Innovation

1974 • 105 citations

CONCENTRATION OF HISTAMINE IN DIFFERENT PARTS OF BRAIN AND HYPOPHYSIS OF CAT AND ITS MODIFICATION BY DRUGS

1966 • 104 citations

Characteristics of histamine H1-receptors in peripheral tissues labeled with [3H]mepyramine.

1979 • 102 citations

HISTAMINE H₁‐RECEPTORS IN THE BRAIN OF THE GUINEA‐PIG AND THE RAT: DIFFERENCES IN LIGAND BINDING PROPERTIES AND REGIONAL DISTRIBUTION

1980 • 100 citations

A Comparison Study of Amitriptyline and Nortriptyline With Plasma Levels

1977 • 98 citations

ICI 125,211: A new gastric antisecretory agent acting on histamine H2-receptors

1979 • 96 citations

MECHANISM OF ACTION OF RESERPINE AND INSULIN ON GASTRIC AMINES AND GASTRIC ACID SECRETION, AND THE EFFECT OF MONOAMINE OXIDASE INHIBITION.

1963 • 95 citations

Comparison of the effects of biogenic amines on cyclic GMP and cyclic AMP levels in mouse cerebellumin vitro

1975 • 95 citations

Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea-pig hippocampus.

1978 • 94 citations

GAS CHROMATOGRAPHIC–MASS SPECTROMETRIC ANALYSIS OF BIOGENIC AMINES IN IDENTIFIED NEURONS AND TISSUES OF HIRUDO MEDICINALIS

1976 • 93 citations

Histamine H ₁ Receptor-Mediated Guanosine 3′,5′-Monophosphate Formation by Cultured Mouse Neuroblastoma Cells

1978 • 92 citations

In vivo occupation of cerebral histamine H1-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs

1979 • 92 citations

Histamine H₁‐Receptor Binding Sites in Guinea Pig Brain Membranes: Regulation of Agonist Interactions by Guanine Nucleotides and Cations

1980 • 91 citations

Evidence for selective loss of brain dopamine- and histamine-stimulated adenylate cyclase activities in rabbits with aging

1980 • 91 citations

Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide.

1977 • 89 citations

Age, disease, and cimetidine disposition in healthy subjects and chronically ill patients

1981 • 86 citations

Turnover of histamine in rat brain and its decrease under barbiturate anesthesia.

1974 • 84 citations

Dose and serum concentration relationships in cimetidine-associated mental confusion.

1980 • 81 citations

PREPARATION AND PROPERTIES OF A CELL‐FREE, HORMONALLY RESPONSIVE ADENYLATE CYCLASE FROM GUINEA PIG BRAIN¹

1974 • 75 citations

Effects of Serotonin Antagonists in Normal Subjects and Patients with Carcinoid Tumors

1957 • 74 citations

Autoradiographic localization of H1-histamine receptors in brain using 3H-mepyramine: Preliminary studies

1979 • 74 citations

Catecholamine-stimulated cyclic GMP accumulation in the rat pineal: apparent presynaptic site of action.

1976 • 73 citations

Histamine: action on single hypothalamic neurones

1974 • 68 citations

Cyclic Adenosine 3′,5′-Monophosphate in Guinea Pig Cerebral Cortical Slices

1973 • 64 citations

A comparison of triprolidine and clemastine on histamine antagonism and performance tests in man: Implications for the mechanism of drug induced drowsiness

1975 • 63 citations

Activity of antihistamines in laboratory antidepressant tests

1969 • 59 citations

Dose and serum concentration relationships in cimetidine-associated mental confusion

1980 • 59 citations

An improved GCMS method to measure tele-methylhistamine

1981 • 58 citations

[3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates

1981 • 56 citations

The role of calcium in the regulation of cyclic nucleotide levels in brain slices of rat and guinea pig

1978 • 56 citations

Histamine Receptors and Cyclic Nucleotides

1982 • 56 citations

Multiple binding sites of tricyclic antidepressant drugs to mammalian brain receptors

1978 • 54 citations

Binding of [3H]cimetidine to rat brain tissue

1980 • 52 citations

Antagonism of noradrenaline and histamine by desipramine in the isolated artery of the rabbit ear

1972 • 52 citations

Biochemical characterization of histamine-sensitive adenylate cyclase in mammalian brain

1977 • 51 citations

High affinity 3H-cimetidine binding in guinea-pig tissues

1980 • 50 citations

Prevention of Psychological Effects of d-Lysergic Acid Diethylamide (LSD 25) by its 2-Brom Derivative (BOL 148)

1956 • 49 citations

High affinity binding of tricyclic antidepressants to histamine H1-receptors: Fact and artifact

1980 • 47 citations

CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE FORMATION IN GUINEA‐PIG BRAIN SLICES: EFFECT OF H₁‐ AND H₂‐HISTAMINERGIC AGONISTS

1976 • 47 citations

Histamine H2 receptors and cyclic AMP in brain

1974 • 47 citations

The effects of diazepam or diphenhydramine on healthy human subjects

1971 • 46 citations

Hypersensitivity to histamine in the guinea-pig brain: Microiontophoretic and biochemical studies

1978 • 46 citations

H1and H2 histamine receptors on Aplysia neurones

1975 • 46 citations

Pharmacological properties of histamine-sensitive adenylate cyclase from mammalian brain.

1979 • 45 citations

HISTAMINE AND THE NERVOUS SYSTEM.

1964 • 44 citations

Histamine microiontophoresis on identified hypothalamic neurons: 3 patterns of response in the ventromedial nucleus of the rat

1976 • 43 citations

Histamine H₁‐ and H₂‐receptors in the central thermoregulatory pathways of the rat

1975 • 43 citations

Tricyclic antidepressants: Potent blockade of histamine H1 receptors of guinea pig ileum

1979 • 42 citations

Histamine hyperpolarizes hippocampal neurones in vitro

1981 • 42 citations

GABA, benzodiazepine and histamine-H1 receptors in the guinea pig cerebellum: effects of kainic acid injections studied by autoradiographic methods

1981 • 41 citations

Desensitization of histamine H1 receptor-mediated cyclic GMP formation in mouse neuroblastoma cells.

1979 • 41 citations

Cerebral glycogenolysis and stimulation of β-adrenoreceptors and histamine H2 receptors

1975 • 41 citations

Histamine receptors in brain as targets for tricyclic antidepressants

1981 • 40 citations

The accumulation of cyclic AMP and cyclic GMP in guinea pig brain slices

1977 • 40 citations

Regulation by histamine of cyclic nucleotide levels in sympathetic ganglia.

1978 • 40 citations

Labeling of histamine H1-receptors in the brain of the living mouse

1980 • 40 citations

Histamine modulates reactivity of hippocampal CA3 neurons to afferent stimulation in vitro

1981 • 38 citations

Central Nervous System-Mediated Stimulation of Prolactin Secretion by Cimetidine, a Histamine H₂- Receptor Antagonist: Impaired Responsiveness in Patients with Prolactin-Secreting Tumors and Idiopathic Hyperprolactinemia*

1980 • 38 citations

Neurotransmitter-sensitive adenylate cyclase in the hypothalami of guinea-pig, rat and monkey

1977 • 37 citations

Distinction of Receptor from Nonreceptor Interactions in Binding Studies

1979 • 35 citations

Methamphetamine and diphenhydramine effects on the rate of cognitive processing

1978 • 35 citations

Toxic Psychosis Due to Diphenhydramine Hydrochloride

1968 • 34 citations

Effect of psychotropic drugs on phosphodiesterase and cyclic AMP level in rat brainin vivo

1973 • 34 citations

Histamine H1-receptors labeled in vivo: Antidepressant and antihistamine interactions

1980 • 34 citations

Ontogeny of Histaminergic Neurotransmission in the Rat Brain: Concomitant Development of Neuronal Histamine, H‐1 Receptors, and H‐1 Receptor‐Mediated Stimulation of Phospholipid Turnover

1981 • 34 citations

Histamine actions on activity of cultured hypothalamic neurons: Evidence for mediation by H1- and H2-histamine receptors

1981 • 33 citations

Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism

1980 • 32 citations

Altered responsiveness of adenosine 3′,5′-monophosphate-generating systems in rat cortical slices after lesions of the medial forebrain bundle

1975 • 32 citations

Evidence for an ascending inhibitory histaminergic pathway to the cerebral cortex

1976 • 31 citations

Increased synthesis and release of 3H-histamine in rat brain by reserpine

1973 • 30 citations

Effects of kainic acid on histaminergic systems in guinea pig hippocampus

1978 • 29 citations

Ontogenetic Development of Histamine H_1‐ Receptor Binding in Rat Brain

1980 • 29 citations

Stimulation of cyclic adenosine 3′,5′-monophosphate in chick cerebral hemisphere slices: effects of H2 and H2 histaminergic agonists and antagonists

1977 • 27 citations

ERRORS IN THE MEASUREMENT OF AGONIST POTENCY‐RATIOS PRODUCED BY UPTAKE PROCESSES: A GENERAL MODEL APPLIED TO β‐ADRENOCEPTOR AGONISTS

1980 • 27 citations

Pharmacological assay of cardiac H2-receptor blockade by amitriptyline and lysergic acid diethylamide.

1980 • 27 citations

The effect of LSD and 2-bromo LSD on the striatal DOPA accumulation after decarboxylase inhibition in rats

1977 • 27 citations

EFFECTS OF MORPHINE ON BRAIN HISTAMINE, ANTINOCICEPTION AND ACTIVITY IN MICE

1976 • 27 citations

Histamine receptors in the guinea pig ileum

1979 • 26 citations

H1- and H2-histamine receptors linked to adenylate cyclase in cell-free preparations of guinea pig cerebral cortex

1978 • 26 citations

Excitatory and inhibitory effects of histamine on molluscan neurons

1980 • 25 citations

SOME ASPECTS OF THE PHARMACOLOGY OF DROPERIDOL

1972 • 25 citations

Histamine receptors in the brain: characterization by binding studies and biochemical effects.

1980 • 25 citations

Dimaprit-induced hypothermia in normal rats: Its attenuation by cimetidine and by tricyclic antidepressant drugs

1979 • 24 citations

Neuroleptic Blockade of the Effect of Various Neurotransmitter Substances

1978 • 22 citations

Are histamine H2-receptor depressions of neuronal activity in tissue cultures from rat hypothalamus mediated through cyclic adenosine monophosphate?

1979 • 21 citations

Effects of antihistamines on isolation-induced fighting in mice

1971 • 21 citations

EFFECTS OF THE HISTAMINE H₂‐RECEPTOR BLOCKING DRUGS BURIMAMIDE AND CIMETIDINE ON NORADRENERGIC TRANSMISSION IN THE ISOLATED AORTA OF THE RABBIT AND ATRIA OF THE GUINEA‐PIG

1979 • 20 citations

Action of neuroleptic agents on histamine-sensitive adenylate cyclase in rabbit cerebral cortex

1976 • 20 citations

Sensitization by caerulein of guinea-pig ileum to contractions by acetylcholine, histamine, 5-hydroxytryptamine and nicotine

1978 • 19 citations

Effects of histamine on phospholipid metabolism of rat brain in vivo

1975 • 19 citations

PROLACTIN RELEASE BY INTRAVENOUS CIMETIDINE IN MAN: EVIDENCE FOR A SUPRAPITUITARY LOCUS OF ACTION

1979 • 18 citations

The influence of 4-methylhistamine, an agonist of histamine H2 receptors on body temperature in rats

1980 • 18 citations

Tricyclic Antidepressant Drug Interactions with Histamine and α-Adrenergic Receptors

1980 • 18 citations

Uptake and metabolism of cyclic AMP in rabbit choroid plexus in vitro

1977 • 18 citations

Cooperative interactions of histamine and competitive antagonism by cimetidine at neuronal histamine receptors in the marine mollusc, Aplysia californica

1979 • 17 citations

Specific α-adrenoceptor blocking effect of droperidol on isolated smooth muscles

1977 • 17 citations

Regional distribution of neurohumoral responsive adenylate cyclase in rabbit brain microvessels

1981 • 15 citations

Toxicity of Histamine: Lethal Doses

1966 • 15 citations

Pharmacological analysis of the effects of substituted benzamides on the isolated guinea-pig ileum. Study of metoclopramide, sulpiride, bromopride, tiapride and sultopride.

1978 • 15 citations

Effects of antihistaminic agents upon the electrographic activity of the cat brain: A power spectral density study

1972 • 14 citations

Ethanol-induced alterations in histamine content and release in the rat hypothalamus

1978 • 14 citations

Effects of tricyclic compounds on the histamine response of isolated atria.

1974 • 13 citations

The multiple facets of histamine research

1981 • 13 citations

Decreased sensitivity of caudal neurons to microiontophoretic dopamine in dopamine-depleted caudate nucleus

1978 • 13 citations

Stimulated formation of cyclic amp in different areas of chick brain

1976 • 13 citations

Histamine-activated adenylate cyclase in brain homogenates of several species

1981 • 13 citations

Defining the histamine H2-receptor in brain: the interaction with LSD.

1978 • 13 citations

Extended mepyramine treatment and histamine H1-receptors in guinea-pig brain

1981 • 12 citations

Norepinephrine depletion and responsiveness of norepinephrine-sensitive cyclic AMP generating systems in guinea pig brain

1976 • 12 citations

Histamine and noradrenaline are blocked by amitriptyline on cortical neurones

1979 • 12 citations

Hallucinogens antagonize histamine H1 receptors of cultured mouse neuroblastoma cells

1979 • 11 citations

Effect of Histamine on Gastric Secretion

1966 • 10 citations

Chemistry and Structure-Activity Relationships of H2-Receptor Antagonists

1978 • 10 citations

Effects of LSD and 2-bromo LSD on striatal DOPAC levels

1977 • 9 citations

Methylhistamine excretion during treatment with a monamine oxidase inhibitor

1968 • 9 citations

A comparison of the EEG effects of the potent antihistaminic (DL-chlorpheniramine) with a less potent isomer (L-chlorpheniramine).

1972 • 9 citations

One agonist and two receptors mediating the same effect: histamine receptors linked to adenylate cyclase in the brain.

1980 • 9 citations

Histamine-induced decrease of membrane-bound calcium ions in the membrane fraction of rabbit taenia coli

1980 • 9 citations

Histamine-sensitive adenylate cyclase in monkey brain

1982 • 8 citations

The relative effectiveness of several hallucinogens in disrupting maze performance by rats

1969 • 8 citations

Histamine H1- and muscarinic receptor antagonist activity of cimetidine and tiotidine in the guinea pig isolated ileum

1981 • 8 citations

Decline of histidine decarboxylase activity and histamine levels in rat stomach after reserpine

1971 • 8 citations

The effect of the antihistaminic drugs on the central nervous system in rats and mice.

1953 • 8 citations

Histamine-stimulated adenylate cyclase: blockade by imipramine and its analogues.

1977 • 7 citations

Possible functions of brain histamine.

1980 • 6 citations

Effects of Cimetidine on the Secretion of Some Pituitary Hormones

1979 • 6 citations

DIPHENHYDRAMINE AS AN ANTIDEPRESSANT: A NEGATIVE FINDING.

1964 • 6 citations

Computer modelling of drug-receptor interactions

1982 • 6 citations

Analysis of histamine actions by intra- and extracellular recording in hippocampal slices of the rat

1981 • 5 citations

Modification of metrazol induced convulsions in rats by antihistaminics.

1966 • 5 citations

Hypercomplexities in the visual cortex

1978 • 5 citations

Histamine and psychotropic drugs.

1980 • 4 citations

Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol.

1978 • 3 citations

The pharmacologic absis for the control of motion sickness by drugs.

1968 • 3 citations

HISTAMINE RECEPTORS IN BRAIN: HIGH-AFFINITY BINDING AND THE HISTAMINE SENSITIVE ADENYLATE CYCLASE. J.P. Green

1978 • 2 citations