ERRORS IN THE MEASUREMENT OF AGONIST POTENCY‐RATIOS PRODUCED BY UPTAKE PROCESSES: A GENERAL MODEL APPLIED TO β‐ADRENOCEPTOR AGONISTS

Statistical methods

1967 • 19,533 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Differentiation of Receptor Systems activated by Sympathomimetic Amines

1967 • 2,054 citations

Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

1963 • 1,214 citations

The Classification of Adrenoceptors (Adrenergic Receptors). An Evaluation from the Standpoint of Receptor Theory

1972 • 812 citations

THE INHIBITION OF NORADRENALINE UPTAKE BY SYMPATHOMIMETIC AMINES IN THE RAT ISOLATED HEART

1965 • 266 citations

Convenient apparatus for recording contractions of isolated heart muscle

1965 • 136 citations

The effect of a saturable uptake mechanism on the slopes of dose-response curves for sympathomimetic amines and on the shifts of dose-response curves produced by a competitive antagonist.

1969 • 127 citations

Factors Influencing the Concentration of Catecholamines at the Receptors

1972 • 92 citations

Extraneuronal removal, accumulation and O-methylation of isoprenaline in the perfused heart

1974 • 77 citations

The effect of cocaine on the pacemaker of isolated guinea-pig atria.

1968 • 73 citations

THE POTENTIATION OF THE RESPONSES TO NORADRENALINE AND ISOPRENALINE OF THE GUINEA‐PIG ISOLATED TRACHEAL CHAIN PREPARATION BY DESIPRAMINE, COCAINE, PHENTOLAMINE, PHENOXYBENZAMINE, GUANETHIDINE, METANEPHRINE AND COOLING

1967 • 56 citations

The stability of noradrenaline in physiological saline solutions

1978 • 48 citations

An uptake of radioactivity from (±)‐³H‐isoprenaline and its inhibition by drugs which potentiate the responses to (—)‐isoprenaline in the guinea‐pig isolated trachea

1969 • 47 citations

THE CONTRIBUTION OF EXTRANEURONAL UPTAKE TO THE TRACHEA‐BLOOD VESSEL SELECTIVITY OF β‐ADRENOCEPTOR STIMULANTS in vitro IN GUINEA‐PIGS

1976 • 45 citations

Interaction of glucocorticoids and bronchodilators on isolated guinea pig tracheal and human bronchial smooth muscle.

1974 • 45 citations

The pharmacological classification of practolol and chloropractolol.

1978 • 39 citations

Temperature-dependent supersensitivity of isolated atria to catecholamines

1973 • 28 citations

On the mechanism of supersensitivity to norepinephrine in the denervated cat spleen.

1970 • 22 citations

Adrenotrophic β-receptors in the frog and chicken

1969 • 20 citations

The role of uptake of noradrenaline for its positive inotropic effect in relation to muscle geometry

1978 • 16 citations

Differential influence of block of catechol-O-methyl transferase (COMT) activity and of neuronal uptake on α- and β-adrenergic effects

1977 • 15 citations

EVIDENCE FOR BOTH β1 and β2 RECEPTORS IN GUINEA-PIG TRACHEAL SMOOTH MUSCLE AND VARIATION OF THE β1 : β2 RAT10 I N DIFFERENT ANIMALS

1977 • 8 citations