ISCOMs and Immunostimulation with Viral Antigens

Solubilization of membranes by detergents

1975 • 2,909 citations

Protides of the Biological Fluids

1969 • 1,623 citations

Characterization of membrane proteins in detergent solutions

1976 • 853 citations

Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses

1984 • 696 citations

[63] Properties of detergents

1979 • 681 citations

Laboratory Techniques in Rabies.

1956 • 602 citations

Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins

1987 • 517 citations

Action of Saponin on Biological Cell Membranes

1962 • 506 citations

Tables for estimating sedimentation through linear concentration gradients of sucrose solution

1967 • 445 citations

Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions

1987 • 443 citations

Protides of the biological fluids

1973 • 289 citations

Laboratory Techniques in Rabies

1955 • 281 citations

[4] The preparation of antigenic Hapten-Carrier conjugates: A survey

1980 • 272 citations

Action of Saponin on Biological Cell Membranes

1962 • 250 citations

Structure and assembly of macromolecular lipid complexes composed of globular micelles

1964 • 250 citations

Electron Microscopic Observations on Rous Sarcoma Virus and Cell Membranes

1962 • 215 citations

N-<scp>d</scp>-Gluco-N-methylalkanamide compounds, a new class of non-ionic detergents for membrane biochemistry

1982 • 168 citations

The requirement of lipids for the formation of immunostimulating complexes (iscoms)

1988 • 158 citations

Three-dimensional structure of a specific pre-messenger RNP particle established by electron microscope tomography

1986 • 147 citations

Induction of protective immune response in cats by vaccination with feline leukemia virus iscom.

1985 • 144 citations

Saponin adjuvants

1974 • 139 citations

DISTRIBUTION OF ALCOHOL IN URINE AND SWEAT AFTER DRINKING

1968 • 138 citations

Subunit vaccines against enveloped viruses: virosomes, micelles and other protein complexes

1985 • 132 citations

The ISCOM: an immunostimulating complex

1987 • 128 citations

Effective subunit vaccines against an enveloped animal virus

1978 • 117 citations

Successful immunization with a totally synthetic diphtheria vaccine.

1982 • 115 citations

Nonrandom association of cellular antigens with HTLV-III virions

1987 • 113 citations

The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.

1980 • 112 citations

Direct identification of class II histocompatibility DR proteins in preparations of human T-cell lymphotropic virus type III

1987 • 107 citations

Prevention of Epstein-Barr (EB) Virus-induced Lymphoma in Cottontop Tamarins by Vaccination with the EB Virus Envelope Glycoprotein gp340 Incorporated into Immune-stimulating Complexes

1988 • 106 citations

Molecules on the Surface of Parasitic Nematodes as Probes of the Immune Response in Infection

1982 • 99 citations

Cellular Immune Responses in the Murine Lung to Local Immunization with Influenza A Virus Glycoproteins in Micelles and Immunostimulatory Complexes (Iscoms)

1988 • 98 citations

Measles Virus Fusion Protein Presented in an Immune-stimulating Complex (Iscom) Induces Haemolysis-inhibiting and Fusion-inhibiting Antibodies, Virus-specific T Cells and Protection in Mice

1988 • 98 citations

The organization of the envelope projections on the surface of HIV

1988 • 89 citations

The Serum Antibody Response Distributed in Subclasses and Isotypes after Intranasal and Subcutaneous Immunization with Influenza Virus Immunostimulating Complexes

1988 • 87 citations

Quantitative assay and potency test of antirabies serum and immunoglobulin.

1973 • 85 citations

Antigenic presentation of small molecules and peptides conjugated to a preformed iscom as carrier

1987 • 84 citations

Protection against lethal measles virus infection in mice by immune-stimulating complexes containing the hemagglutinin or fusion protein

1987 • 73 citations

Semliki Forest virus membrane proteins, preparation and characterization of spike complexes soluble in detergent-free medium

1976 • 71 citations

Canine Distemper Virus (CDV) Immune-stimulating Complexes (Iscoms), but Not Measles Virus Iscoms, Protect Dogs against CDV Infection

1988 • 69 citations

Guidelines for the production of polypeptide specific antisera using small synthetic oligopeptides as immunogens

1984 • 65 citations

Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein (gp120)

1989 • 59 citations

The structure of spherical viruses

1986 • 56 citations

Protein Subunit Vaccines of Parainfluenza Type 3 Virus: Immunogenic Effect in Lambs and Mice

1983 • 52 citations

Influenza virus ISCOMs: biochemical characterization

1988 • 46 citations

Vaccination of Balb/c mice against enteroviral mediated myocarditis

1990 • 44 citations

Local reactions of the saponin Quil A and a Quil A containing iscom measles vaccine after intramuscular injection of rats: A comparison with the effect of DPT-polio vaccine

1988 • 41 citations

Solubilization and Reconstitution of Membrane Proteins of Escherichia coli Using Alkanoyl-N-Methylglucamides1

1984 • 40 citations

Experimental polyvalent ISCOMs subunit vaccine induces antibodies that neutralize human and bovine respiratory syncytial virus

1989 • 39 citations

Bovine leukaemia virus ISCOMs: biochemical characterization

1989 • 34 citations

Formation and characterization of FeLV ISCOMs

1989 • 29 citations

Application of recombinant DNA techniques in the development of viral vaccines

1988 • 26 citations

Immunizing Effects in Mice of two Toxoplasma gondii Iscom Preparations

1988 • 26 citations

Monocyte and iscom enhancement of cell-mediated response to cytomegalovirus

1987 • 26 citations

Induction of antigen-specific antibody response in human peripheral blood lymphocytes in vitro by a dog kidney cell vaccine against rabies virus (DKCV).

1983 • 26 citations

Roles of vaccinia virus in the development of new vaccines

1988 • 25 citations

Thinlayer chromatographic fingerprinting of commercially available saponins.

1970 • 23 citations

A New Approach to the Preparation of a Toxoplasma gondii Membrane Antigen for Use in ELISA

1987 • 23 citations

Saponin Adjuvants. IV. Evaluation of The Adjuvant Quil a in the Vaccination of Cattle Against Foot-And-Mouth Disease

1977 • 22 citations

Obstacles to an AIDS Vaccine

1988 • 13 citations

Assessment of the dose of the immunological adjuvant Quil A in mice and guinea pigs, using sheep red blood cells as model antigen*

1984 • 12 citations

Demonstration of an Immunosuppressive Action of Detergent-disrupted Influenza Virus on the Antibody Response to Inactivated Whole Virus Vaccine

1987 • 12 citations

Receding hopes of AIDS vaccines

1988 • 11 citations

Comparison of serological responses in cats vaccinated with two different FeLV vaccine preparations

1987 • 11 citations

Assay of detergents by rocket electrophoresis in agarose gels containing red blood cells: “Rocket hemolysis”

1983 • 9 citations

Zur Analytik der Triterpene. 1. Mitteilung: Kolorimetrische Bestimmung des Gesamtgehaltes an Triterpensäuren in Labiaten

1954 • 7 citations

Protein Micelles and Virosomes from the Surface Glycoproteins of Parainfluenza 3 Virus

1982 • 4 citations

Immune response to immunostimulatory complexes prepared from human immunodeficiency virus and the external envelope glycoprotein

1989 • 2 citations

Perspectives of HIV vaccine developments

1987 • 2 citations