A role for complement in phagocytosis of myelin.

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown

1981 • 259 citations

IMMUNOCYTOCHEMICAL LOCALIZATION OF THE TERMINAL COMPLEMENT COMPLEX IN MULTIPLE SCLEROSIS

1989 • 182 citations

Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG

1994 • 167 citations

Activated terminal complement in cerebrospinal fluid in Guillain-Barré syndrome and multiple sclerosis.

1986 • 163 citations

Complement activation by isolated myelin: activation of the classical pathway in the absence of myelin-specific antibodies.

1982 • 160 citations

THE ROLE OF COMPLEMENT IN THE PATHOGENESIS OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

1989 • 156 citations

TISSUE CULTURE STUDIES OF DEMYELINATION^*

1965 • 137 citations

Anti-macrophage CR3 antibody blocks myelin phagocytosis by macrophages in vitro

1990 • 134 citations

Receptor-mediated phagocytosis of myelin by macrophages and microglia: Effect of opsonization and receptor blocking agents

1996 • 121 citations

The role of complement in myelin phagocytosis during PNS wallerian degeneration

1991 • 105 citations

Attachment of myelin to coated pits on macrophages in experimental allergic encephalomyelitis

1983 • 88 citations

Relative frequency of autoantibodies to myelin basic protein and proteolipid protein in optic neuritis and multiple sclerosis cerebrospinal fluid

1994 • 84 citations

Presence of the terminal complement complex (C5b‐9) precedes myelin degradation in immune‐mediated demyelination of the rat peripheral nervous system

1991 • 77 citations

Opsonization with Antimyelin Antibody Increases the Uptake and Intracellular Metabolism of Myelin in Inflammatory Macrophages

1986 • 74 citations

The initial structural lesion in serum-induced demyelination in vitro.

1976 • 71 citations

Phagocytosis of myelin by microglia in vitro

1993 • 70 citations

Studies on demyelination in vitro: the requirement of membrane attack components of the complement system.

1983 • 68 citations

Interferon‐γ potentiates antibody‐mediated demyelination in vivo

1992 • 65 citations

Chemical Pathology of Diseases Involving Myelin

1977 • 60 citations

Immunohistochemical localisation of terminal complement component C9 in experimental allergic encephalomyelitis

1989 • 59 citations

Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid

1990 • 56 citations

Anti-glycolipid antibodies and their immune complexes in multiple sclerosis

1986 • 53 citations

In vitro demyelination by serum antibody from patients with guillain‐barré syndrome requires terminal complement complexes

1991 • 52 citations

Membrane attack complex of complement as a pathologic mediator.

1983 • 52 citations

Isolation of Membrane Attack Complex of Complement from Myelin Membranes Treated with Serum Complement

1984 • 45 citations

Hydrolysis of myelin basic protein in human myelin by terminal complement complexes.

1988 • 44 citations

In vivo demyelinating activity of sera from animals with chronic experimental allergic encephalomyelitis

1983 • 37 citations

Opsonization of normal myelin by anti-myelin antibodies and normal serum

1989 • 36 citations

TNF-α suppresses CR3-mediated myelin removal by macrophages

1992 • 35 citations

Autoantibodies to myelin basic protein are not present in the serum and CSF of MS patients

2009 • 31 citations

Induction of anti‐myelin antibodies in EAE and their possible role in demyelination

1991 • 31 citations

The membrane attack complex of complement mediates peripheral nervous system demyelination in vitro

1995 • 22 citations

EAE cerebrospinal fluid augments in vitro phagocytosis and metabolism of CNS myelin by macrophages

1992 • 16 citations

Phagocytosis of peripheral nerve myelin in vitro: Effect of antibody

1990 • 10 citations