Nitric oxide in coronary artery disease: Roles in atherosclerosis, myocardial reperfusion and heart failure

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo

1995 • 1,632 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy

1993 • 1,218 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury

1989 • 1,061 citations

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

1990 • 1,020 citations

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

1994 • 941 citations

The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs

1984 • 937 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Endothelium-dependent vasodilation is attenuated in patients with heart failure.

1991 • 788 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

The power of words.

1951 • 744 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Endothelial function in chronic congestive heart failure

1992 • 562 citations

Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the MERCATOR study: a multicenter, randomized, double-blind placebo-controlled trial. Multicenter European Research Trial with Cilazapril after Angioplasty to Prevent Transluminal Coronary Obstruction and Restenosis (MERCATOR) Study Group.

1992 • 548 citations

Modulation of acute inflammation by endogenous nitric oxide

1992 • 543 citations

Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits.

1986 • 535 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia

1992 • 475 citations

The Nitric Oxide Synthase Family of Proteins

1994 • 465 citations

Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients

1993 • 462 citations

Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries.

1988 • 422 citations

Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium

1990 • 400 citations

Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion.

1994 • 378 citations

Increased superoxide anion release from human endothelial cells in response to cytokines.

1986 • 365 citations

Nitric oxide synthase activities in human myocardium

1993 • 358 citations

Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease.

1989 • 328 citations

Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation

1989 • 327 citations

Leukocytes and Ischemia-Induced Myocardial Injury

1986 • 321 citations

Differential role of extra‐ and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells

1988 • 321 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

1990 • 278 citations

EIGHTH GADDUM MEMORIAL LECTURE UNIVERSITY OF LONDON INSTITUTE OF EDUCATION DECEMBER 1980: BIOLOGICAL IMPORTANCE OF PROSTACYCLIN

1982 • 276 citations

Increased nitric oxide production in heart failure

1994 • 261 citations

Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.

1993 • 260 citations

Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries

1990 • 244 citations

Vascular effects of oxygen-derived free radicals

1988 • 242 citations

Preconditioning of the ischaemic myocardium; involvement of the <scp>l</scp>‐arginine nitric oxide pathway

1992 • 238 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans.

1993 • 233 citations

Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates.

1990 • 232 citations

Prostaglandins mediate arteriolar dilation to increased blood flow velocity in skeletal muscle microcirculation.

1990 • 206 citations

Towards an Understanding of the Mechanism of Action of Cyclic AMP and Cyclic GMP in Smooth Muscle Relaxation

1991 • 191 citations

Effects of Captopril on Atherosclerosis in Cynomolgus Monkeys

1990 • 187 citations

The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein

1992 • 179 citations

L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.

1991 • 165 citations

Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment.

1989 • 159 citations

Prostacyclin releases endothelium‐derived relaxing factor and potentiates its action in coronary arteries of the pig

1988 • 154 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans

1994 • 144 citations

Kinins mediate the antiproliferative effect of ramipril in rat carotid artery

1992 • 144 citations

Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide.

1993 • 143 citations

Role of Endothelium in the Control of Arterial Diameter by Blood Flow

1985 • 141 citations

Enhanced basal nitric oxide production in heart failure: another failed counter-regulatory vasodilator mechanism?

1994 • 139 citations

Contribution of endothelium-derived relaxing factor to exercise-induced vasodilation in humans

1993 • 124 citations

Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta

1990 • 116 citations

The development of positive inotropic agents for chronic heart failure: How have we gone astray?

1993 • 114 citations

Endothelium and the vasodilator action of rat calcitonin gene‐related peptide (CGRP)

1987 • 113 citations

Nitric Oxide in Cardiovascular Disorders

1995 • 112 citations

Endothelial dysfunction of hindquarter resistance vessels in experimental heart failure

1992 • 107 citations

Isoforms of nitric oxide synthase: functions in the cardiovascular system.

1993 • 106 citations

cGMP: The wayward child of the cyclic nucleotide family

1991 • 103 citations

Synergistic inhibition of platelet aggregation by endothelium derived relaxing factor and prostacyclin

1988 • 99 citations

The induction of nitric oxide synthase activity is inhibited by TGF-β1, PDGFAB and PDGFBB in vascular smooth muscle cells

1992 • 96 citations

Preservation of Endothelial Function by Ramipril in Rabbits on a Long-Term Atherogenic Diet

1991 • 94 citations

Other endothelium-derived vasoactive factors

1993 • 86 citations

Rabbit polymorphonuclear neutrophils elicit endothelium-dependent contraction in vascular smooth muscle.

1989 • 85 citations

Increased production of nitric oxide in coronary arteries during congestive heart failure.

1994 • 84 citations

Preservation of Endothelial Function by Ramipril in Rabbits on a Long-Term Atherogenic Diet

1991 • 79 citations

HOW DO FISH OILS AFFECT VASCULAR FUNCTION?

1995 • 77 citations

Nitric oxide and sensory nerves are involved in the vasodilator response to acetylcholine but not calcitonin gene‐related peptide in rat skin micro vasculature

1992 • 70 citations

Effects of ageing on sensory nerve function in rat skin

1994 • 67 citations

THERAPEUTIC RESTORATION OF ENDOTHELIAL FUNCTION IN HYPERCHOLESTEROLAEMIC SUBJECTS: EFFECT OF FISH OILS

1994 • 61 citations

Response of human coronary arteries to serotonin after injury by coronary angioplasty.

1993 • 60 citations

Cyclic nucleotide interactions involved in endothelium-dependent dilatation in rat aortic rings

1988 • 55 citations

Neointima formation impairs endothelial muscarinic receptors while enhancing prostacyclin-mediated responses in the rabbit carotid artery.

1991 • 51 citations

N‐nitro <scp>l</scp>‐arginine causes coronary vasoconstriction and inhibits endothelium‐dependent vasodilatation in anaesthetized greyhounds

1991 • 50 citations

Modulation of myocardial contraction by endocardial and coronary vascular endothelium

1993 • 50 citations

Inhibition of platelet-derived mitogen release by nitric oxide (EDRF)

1989 • 49 citations

Endothelial cells have a particulate enzyme system responsible for EDRF formation: Measurement by vascular relaxation

1991 • 48 citations

Myocardial ischaemia: What happens to the coronary arteries?

1993 • 41 citations

Prostacyclin and vascular function: Implications for hypertension and atherosclerosis

1990 • 40 citations

SUPPRESSION OF NITRIC OXIDE PRODUCTION BY CYCLOSPORIN A AND FK506A IN RAT VASCULAR SMOOTH MUSCLE CELLS

1994 • 40 citations

Supersensitivity to Vasoconstrictor Action of Serotonin Precedes the Development of Atheroma-Like Lesions in the Rabbit

1990 • 37 citations

Role of nitric oxide in the actions of substance P and other mediators of inflammation in rat skin microvasculature

1995 • 36 citations

Release of a neutrophil‐derived vascoconstrictor agent which augments platelet‐induced contractions of blood vessels in vitro

1990 • 34 citations

Impaired endothelium‐dependent relaxation of dog coronary arteries after myocardial ischaemia and reperfusion: prevention by amlodipine, propranolol and allopurinol

1992 • 30 citations

Vascular remodeling in systemic hypertension

1993 • 30 citations

Bradykinin-mediated metabolic effects in isolated perfused rat hearts.

1992 • 27 citations

Impaired vasodilatation of epicardial coronary arteries and resistance vessels following myocardial ischemia and reperfusion in anesthetized dogs

1990 • 27 citations

Does Nitric Oxide Inhibit Smooth Muscle Proliferation?

1991 • 23 citations

Does Nitric Oxide Inhibit Smooth Muscle Proliferation?

1991 • 21 citations

Angiotensin-converting enzyme inhibitors reduce neointimal thickening and maintain endothelial nitric oxide function in rabbit carotid arteries

1995 • 20 citations

THE ENDOGENOUS NITROVASODILATOR PRODUCED BY THE VASCULAR ENDOTHELIUM

1989 • 20 citations

Impaired Vasodilator Function of Nitric Oxide Associated with Developing Neo-lntima in Conscious Rabbits

1994 • 19 citations

Selective endothelial dysfunction in early atheroma-like lesions in the rabbit

1992 • 17 citations

Mechanism of the Hypertension Produced by Inhibition of Nitric Oxide Biosynthesis in Rats

1991 • 16 citations

Tumour Necrosis Factor a Augments the Release of an Endothelium-Dependent Vasoconstrictor from Human Polymorphonuclear Leukocytes

1992 • 15 citations

Mechanism of the Hypertension Produced by Inhibition of Nitric Oxide Biosynthesis in Rats

1991 • 15 citations

Nitric Oxide Hyperpolarizes Arterial Smooth Muscle

1991 • 15 citations

PAF ANTAGONISTS BLOCK INDUCTION OF NITRIC OXIDE SYNTHASE IN CULTURED MACROPHAGES AND VASCULAR SMOOTH MUSCLE CELLS

1995 • 14 citations

Prolonged Regional Vasoconstriction Produced by NG-Nitro-L-Arginine in Conscious Sheep

1994 • 12 citations

Nitric Oxide Hyperpolarizes Arterial Smooth Muscle

1991 • 9 citations

Deleted Work

1955 • 0 citations