Electron diffraction analysis of structural changes in the photocycle of bacteriorhodopsin.

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Cryo-electron microscopy of vitrified specimens

1988 • 2,252 citations

Bacteriorhodopsin: a light-driven proton pump in Halobacterium Halobium

1975 • 994 citations

Bacteriorhodopsin and the purple membrane of halobacteria

1979 • 909 citations

Controlled environment vitrification system: An improved sample preparation technique

1988 • 607 citations

Bacteriorhodopsin: a biological material for information processing

1991 • 306 citations

Bacteriorhodopsin, a membrane protein that uses light to translocate protons.

1988 • 293 citations

Structural changes in bacteriorhodopsin during proton translocation revealed by neutron diffraction.

1989 • 258 citations

Substitution of amino acids Asp-85, Asp-212, and Arg-82 in bacteriorhodopsin affects the proton release phase of the pump and the pK of the Schiff base.

1990 • 234 citations

Thermodynamics and energy coupling in the bacteriorhodopsin photocycle

1991 • 215 citations

Time-resolved X-ray diffraction study of structural changes associated with the photocycle of bacteriorhodopsin.

1991 • 213 citations

Domain closure in mitochondrial aspartate aminotransferase

1992 • 185 citations

A defective proton pump, point-mutated bacteriorhodopsin Asp96----Asn is fully reactivated by azide.

1989 • 185 citations

Distortions in the photocycle of bacteriorhodopsin at moderate dehydration

1991 • 136 citations

Structure-Function Studies on Bacteriorhodopsin

1989 • 109 citations

Analysis of high-resolution electron diffraction patterns from purple membrane labelled with heavy-atoms

1990 • 101 citations

Crystallographic characterization by X‐ray diffraction of the M‐intermediate from the photo‐cycle of bacteriorhodopsin at room temperature

1991 • 87 citations

Bacteriorhodopsin Mutants of Halobacterium sp. GRB

1989 • 87 citations

Replacement of leucine-93 by alanine or threonine slows down the decay of the N and O intermediates in the photocycle of bacteriorhodopsin: implications for proton uptake and 13-cis-retinal----all-trans-retinal reisomerization.

1991 • 86 citations

Replacement of aspartic residues 85, 96, 115, or 212 affects the quantum yield and kinetics of proton release and uptake by bacteriorhodopsin.

1989 • 84 citations

Electron diffraction analysis of the M412 intermediate of bacteriorhodopsin

1986 • 46 citations

Chromophore motion during the bacteriorhodopsin photocycle: polarized absorption spectroscopy of bacteriorhodopsin and its M-state in bacteriorhodopsin crystals.

1991 • 45 citations

Between the ground‐ and M‐state of bacteriorhodopsin the retinal transition dipole moment tilts out of the plane of the membrane by only 3°

1991 • 25 citations

Time-resolved x-ray diffraction study of photostimulated purple membrane

1985 • 24 citations