Phototransduction by microvillar photoreceptors of invertebrates: mediation of a visual cascade by inositol trisphosphate

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Lateral diffusion of rhodopsin in the photoreceptor membrane

1974 • 658 citations

The Drosophila ninaE gene encodes an opsin

1985 • 545 citations

Changes in time scale and sensitivity in the ommatidia of Limulus

1964 • 523 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Isolation and structure of a rhodopsin gene from D. melanogaster

1985 • 481 citations

Guanosine 5'-O-(2-thiodiphosphate). An inhibitor of adenylate cyclase stimulation by guanine nucleotides and fluoride ions.

1979 • 382 citations

Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment

1985 • 381 citations

Vertebrate rod outer segment membranes

1973 • 352 citations

Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate

1984 • 337 citations

The visualization of actin filament polarity in thin sections. Evidence for the uniform polarity of membrane-associated filaments.

1978 • 329 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

General physiology of cell specialization

1963 • 312 citations

myo-inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors

1984 • 310 citations

Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas

1984 • 305 citations

Lateral Diffusion of Visual Pigment in Photoreceptor Disk Membranes

1974 • 302 citations

Role of a guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4,5-bisphosphate by calcium-mobilizing hormones and the control of cell calcium. Studies utilizing aluminum fluoride.

1985 • 290 citations

Changes in Intracellular Free Calcium Concentration during Illumination of Invertebrate Photoreceptors

1974 • 287 citations

The Effects of Intracellular Iontophoretic Injection of Calcium and Sodium Ions on the Light Response of Limulus Ventral Photoreceptors

1972 • 260 citations

Voltage Noise in Limulus Visual Cells

1968 • 246 citations

The Ventral Photoreceptor Cells of Limulus

1969 • 236 citations

Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.

1982 • 221 citations

Myo-inositol Phosphates Obtained by Alkaline Hydrolysis of Beef Brain Phosphoinositide

1961 • 217 citations

Short Communication Inositol Tetrakis- And Pentakisphosphates In Gh4 Cells

1985 • 201 citations

Regulation of Cyclic Nucleotide Concentrations in Photoreceptors: An ATP-Dependent Stimulation of Cyclic Nucleotide Phosphodiesterase by Light

1973 • 186 citations

Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

1985 • 167 citations

Effects of intracellular injection of calcium buffers on light adaptation in Limulus ventral photoreceptors.

1975 • 166 citations

Measurement of the intracellular free calcium concentration in salamander rods

1986 • 153 citations

Detection of light‐induced changes of intracellular ionized calcium concentration in Limulus ventral photoreceptors using arsenazo III

1977 • 150 citations

MORPHOLOGY OF THE OMMATIDIA OF THE COMPOUND EYE OF LIMULUS

1957 • 137 citations

Excitation and adaptation of Limulus ventral photoreceptors by inositol 1,4,5 triphosphate result from a rise in intracellular calcium.

1986 • 134 citations

Restrictions on rotational and translational diffusion of pigment in the membranes of a rhabdomeric photoreceptor.

1977 • 132 citations

Local Membrane Current in the Outer Segments of Squid Photoreceptors

1962 • 128 citations

Pressure injection of calcium both excites and adapts Limulus ventral photoreceptors.

1986 • 127 citations

Fine structure of the visual system of the honeybee (Apis mellifera)

1969 • 127 citations

The Visual System of the Horseshoe Crab Limulus polyphemus

1975 • 121 citations

Vitamin A deprivation and Drosophila photopigments

1977 • 120 citations

Single photon signals and transduction in an insect eye

1977 • 118 citations

The dynamics of phototransduction in insects

1984 • 117 citations

Distinct lobes of Limulus ventral photoreceptors. II. Structure and ultrastructure.

1982 • 116 citations

A direct demonstration that inositol-trisphosphate induces an increase in intracellular calcium in limulus photoreceptors

1984 • 114 citations

Intracellular Ca modulates sensitivity and time scale in Limulus ventral photoreceptors

1975 • 107 citations

Relationship between light sensitivity and intracellular free Ca concentration in Limulus ventral photoreceptors. A quantitative study using Ca-selective microelectrodes.

1985 • 104 citations

Stereochemistry of the guanyl nucleotide binding site of transducin probed by phosphorothioate analogs of GTP and GDP

1985 • 102 citations

Complete Characterization of the Myo-inositol Polyphosphates from Beef Brain Phosphoinositide

1961 • 102 citations

Light-induced decreases in cGMP concentration precede changes in membrane permeability in frog rod photoreceptors.

1984 • 96 citations

Role of intracellular calcium and sodium in light adaptation in the retina of the honey bee drone (Apis mellifera, L).

1976 • 96 citations

Ionic Dependence of Reversal Voltage of the Light Response in Limulus Ventral Photoreceptors

1974 • 95 citations

Single-channel currents activated by light in Limulus ventral photoreceptors

1983 • 89 citations

Dispersion of latencies in photoreceptors of Limulus and the adapting-bump model.

1980 • 89 citations

Visual Responses in Limulus

1965 • 89 citations

Ca2+-sequestering smooth endoplasmic reticulum in an invertebrate photoreceptor. I. Intracellular topography as revealed by OsFeCN staining and in situ Ca accumulation.

1982 • 88 citations

Adapting bump model for ventral photoreceptors of Limulus.

1982 • 88 citations

Electrophysiological study of Drosophila rhodopsin mutants.

1986 • 87 citations

Light-regulated biochemical events in invertebrate photoreceptors. 2. Light-regulated phosphorylation of rhodopsin and phosphoinositides in squid photoreceptor membranes

1984 • 86 citations

Calcium ion, an intracellular messenger of light adaptation, also participates in excitation of Limulus photoreceptors.

1985 • 86 citations

Absence of Phosphatidylinositol Phosphodiesterase in the Head of a Drosophila Visual Mutant, norpA (no receptor potential A)1

1985 • 86 citations

Transient membrane shedding in Limulus photoreceptors: control mechanisms under natural lighting

1984 • 86 citations

An ordered membrane-cytoskeleton network in squid photoreceptor microvilli

1982 • 84 citations

Calcium-sequestering smooth endoplasmic reticulum in retinula cells of the blowfly

1982 • 84 citations

The dynamic behaviour of photoreceptor cells in the fly in response to random (white noise) stimulation at a range of temperatures.

1978 • 80 citations

Light-activated guanosinetriphosphatase in Musca eye membranes resembles the prolonged depolarizing afterpotential in photoreceptor cells.

1985 • 75 citations

Light-regulated biochemical events in invertebrate photoreceptors. 1. Light-activated guanosine triphosphatase, guanine nucleotide binding, and cholera toxin-catalyzed labeling of squid photoreceptor membranes

1984 • 73 citations

Distinct lobes of Limulus ventral photoreceptors. I. Functional and anatomical properties of lobes revealed by removal of glial cells.

1982 • 69 citations

Response of an insect photoreceptor: a simple log-normal model

1981 • 69 citations

Adapting-bump model for eccentric cells of Limulus.

1980 • 67 citations

Membrane-associated actin in the rhabdomeral microvilli of crayfish photoreceptors.

1984 • 67 citations

Light activation of bovine rod phosphodiesterase by non‐physiological visual pigments

1980 • 65 citations

Excitation of Limulus Photoreceptors by Vanadate and by a Hydrolysis-Resistant Analog of Guanosine Triphosphate

1981 • 65 citations

Blockade of Visual Excitation and Adaptation in Limulus Photoreceptor by GDP-β-S

1986 • 64 citations

The sensitivity of receptors in the posterior median eye of the nocturnal spider,Dinopis

1980 • 63 citations

Squid rhodopsin and GTP-binding protein crossreact with vertebrate photoreceptor enzymes.

1984 • 63 citations

A quantitative comparison of the effects of intracellular calcium injection and light adaptation on the photoresponse of Limulus ventral photoreceptors.

1977 • 63 citations

The initiation of excitation and light adaptation in Limulus ventral photoreceptors.

1979 • 62 citations

A light‐stimulated increase of cyclic GMP in squid photoreceptors

1984 • 59 citations

Rhodopsin Particles in the Photoreceptor Membrane of an Insect

1976 • 59 citations

Kinship of cephalopod photoreceptor G‐protein with vertebrate transducin

1986 • 58 citations

THE SITE OF ORIGIN OF ELECTRICAL RESPONSES IN VISUAL CELLS OF THE LEECH, HIRUDO MEDICINALIS

1969 • 56 citations

The initial response of Limulus ventral photoreceptors to bright flashes. Released calcium as a synergist to excitation.

1986 • 55 citations

Freeze-fracture study of the Drosophila photoreceptor membrane: mutations affecting membrane particle density.

1982 • 55 citations

THE PHYSIOLOGY OF EXCITABLE CELLS

1984 • 55 citations

Ca2+-sequestering smooth endoplasmic reticulum in an invertebrate photoreceptor. II. Its properties as revealed by microphotometric measurements.

1982 • 55 citations

Saturation of the response to light in Limulus ventral photoreceptor.

1979 • 54 citations

Injection of guanosine and adenosine nucleotides into Limulus ventral photoreceptor cells

1982 • 53 citations

Spatially Nonuniform Changes in Intracellular Calcium Ion Concentrations

1984 • 52 citations

Functional significance of voltage-dependent conductances in Limulus ventral photoreceptors.

1982 • 51 citations

Ultrastructural and molecular characteristics of crayfish photoreceptor membranes.

1976 • 50 citations

Biochemistry and Physiology of the Visual Pigments

1974 • 46 citations

Discrete Subthreshold Potentials from the Dimly Lit Insect Eye

1964 • 45 citations

Plasma membrane calcium fluxes in intact rods are inconsistent with the "calcium hypothesis".

1986 • 41 citations

The correlation of the receptor potential with the light induced transient increase in intracellular calcium-concentration measured by absorption change of arsenazo III injected into Limulus ventral nerve photoreceptor cell

1980 • 39 citations

Changes in intracellular calcium ion concentration, in the course of dark adaptation measured by Arsenazo III in the Limulus photoreceptor

1983 • 37 citations

Ion channels activated by light in Limulus ventral photoreceptors.

1986 • 37 citations

Rod outer segment phosphodiesterase: Factors affecting the hydrolysis of cyclic-AMP and cyclic-GMP

1974 • 36 citations

Chemical excitation of Limulus photoreceptors. I. Phosphatase inhibitors induce discrete-wave production in the dark.

1983 • 36 citations

Chemistry of photoreceptor membrane preparations from squid retinas

1978 • 36 citations

The characteristics of chemically induced noise inMusca photoreceptors

1985 • 36 citations

Bump latency distribution and bump adaptation of limulus ventral nerve photoreceptor in varied extracellular calcium concentrations

1983 • 35 citations

Characteristics of phospholipids in microvillar membranes of octopus photoreceptor cells

1979 • 35 citations

Both Photons and Fluoride Ions Excite Limulus Ventral Photoreceptors

1979 • 34 citations

Photoreceptor GTP binding protein mediates fluoride activation of phosphodiesterase.

1985 • 33 citations

Internal dialysis of Limulus ventral photoreceptors.

1982 • 32 citations

Influence of the Membrane Potential on the Intracellular Light Induced Ca²⁺ -Concentration Change of the Limulus Ventral Photoreceptor Monitored by Arsenazo III under Voltage Clamp Conditions

1984 • 28 citations

3',5'‐cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.

1984 • 28 citations

Dependence of bump rate and bump size in Limulus ventral nerve photoreceptor on light adaptation and calcium concentration

1980 • 27 citations

Electrophysiological measurement of photoreceptor membrane dichroism and polarization sensitivity in a Grapsid crab

1984 • 23 citations

Two effects of phosphodiesterase inhibitors on Limulus ventral photoreceptors

1979 • 20 citations

Architecture and dynamics of microvillar photoreceptor membranes of a cephalopod

1983 • 19 citations

The cytoskeleton of microvilli of leech photoreceptors

1983 • 17 citations

Initiation of Light Adaptation in Barnacle Photoreceptors

1978 • 16 citations

Local membrane current in Limulus photoreceptors

1975 • 16 citations

Localization of the photocurrent of Limulus ventral photoreceptors using a vibrating probe

1986 • 14 citations

Fluoride blocks an inactivation step of transduction in a locust photoreceptor

1982 • 13 citations

Longitudinal contunuity of the subrhabdomeric cisternae in the photoreceptors of the compound eye of the drone,Apis mellifera

1985 • 10 citations

Discrete potential waves in the photoreceptors of a gastropod mollusc,Hermissenda crassicornis

1982 • 9 citations

Progress in Understanding Adenovirus Architecture

1986 • 5 citations