Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS

1964 • 889 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 845 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

A new cytokine receptor superfamily

1990 • 506 citations

Expression of Thy-1 on human hematopoietic progenitor cells.

1993 • 477 citations

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

1994 • 459 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.

1994 • 407 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 341 citations

Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha

1988 • 331 citations

Hierarchical down-modulation of hemopoietic growth factor receptors

1985 • 314 citations

Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.

1990 • 304 citations

The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets

1995 • 286 citations

Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

1995 • 269 citations

Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells.

1996 • 250 citations

"Pure" Human Hematopoietic Progenitors: Permissive Action of Basic Fibroblast Growth Factor

1990 • 248 citations

Human erythropoietin receptor: cloning, expression, and biologic characterization

1990 • 242 citations

Purification of human blood burst‐forming units‐erythroid and demonstration of the evolution of erythropoietin receptors

1990 • 241 citations

Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors

1995 • 240 citations

Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases.

1984 • 222 citations

A stochastic model of self‐renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture

1982 • 199 citations

Discrimination of viable and non‐viable cells using propidium iodide in two color immunofluorescence

1987 • 190 citations

Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7.

1995 • 160 citations

Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors.

1992 • 155 citations

Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.

1994 • 151 citations

Human primitive hematopoietic progenitor cells are more enriched in KITlow cells than in KIThigh cells

1993 • 138 citations

Leukemia inhibitory factor differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hematopoietic stem cells

1990 • 133 citations

Unilineage megakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture

1995 • 131 citations

Expression of specific high-affinity binding sites for erythropoietin on rat and mouse megakaryocytes.

1989 • 129 citations

Quantitation of specific binding of erythropoietin to human erythroid colony‐forming cells

1988 • 129 citations

Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation

1994 • 128 citations

Differential expression and functional role of GATA-2, NF-E2, and GATA-1 in normal adult hematopoiesis.

1995 • 126 citations

Further phenotypic characterization and isolation of human hematopoietic progenitor cells using a monoclonal antibody to the c-kit receptor

1992 • 113 citations

Expression of the M-CSF receptor is controlled posttranscriptionally by the dominant actions of GM-CSF or multi-CSF

1990 • 109 citations

Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist

1996 • 109 citations

Regulation of surface expression of the granulocyte/macrophage colony-stimulating factor receptor in normal human myeloid cells.

1990 • 99 citations

In vitro human immunodeficiency virus-1 infection of purified hematopoietic progenitors in single-cell culture

1995 • 95 citations

Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation

1991 • 87 citations

Erythropoietin alone induces erythroid burst formation by human embryonic but not adult BFU-E in unicellular serum-free culture [see comments]

1989 • 83 citations

Interleukin 6 is a permissive factor for monocytic colony formation by human hematopoietic progenitor cells.

1992 • 80 citations

Retinoic acid downmodulates erythroid differentiation and GATA1 expression in purified adult-progenitor culture

1994 • 78 citations

Interleukin 6 is a differentiation factor for human megakaryocytes in vitro

1990 • 73 citations

Distribution of receptors for granulocyte-macrophage colony-stimulating factor on immature CD34+ bone marrow cells, differentiating monomyeloid progenitors, and mature blood cell subsets

1994 • 72 citations

Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA–1 and Sp1 motifs

1995 • 67 citations

Flow cytometric detection of receptors for interleukin-6 on bone marrow and peripheral blood cells of humans and rhesus monkeys

1993 • 63 citations

Isolation of small, primitive human hematopoietic stem cells: distribution of cell surface cytokine receptors and growth in SCID-Hu mice

1995 • 57 citations

Cascade transactivation of growth factor receptors in early human hematopoiesis

1993 • 56 citations

c-kit ligand reactivates fetal hemoglobin synthesis in serum-free culture of stringently purified normal adult burst-forming unit- erythroid

1993 • 56 citations

Modulation of retinoblastoma gene in normal adult hematopoiesis: peak expression and functional role in advanced erythroid differentiation.

1995 • 55 citations

Granulocyte‐macrophage colony formation in serum‐free culture: Effects of purified colony‐stimulating factors and modulation by hydrocortisone

1986 • 53 citations

Separation of myeloid and erythroid progenitors based on expression of CD34 and c-kit

1995 • 39 citations

Suppression of apoptosis during cytokine deprivation of 32D cells is not sufficient to induce complete granulocytic differentiation

1996 • 33 citations

Differential expression of receptors for interleukin-3 on subsets of CD34-expressing hematopoietic cells of rhesus monkeys

1995 • 30 citations

Expression and function of the human granulocyte-macrophage colony- stimulating factor receptor alpha subunit

1994 • 29 citations

Neutralizing and nonneutralizing monoclonal antibodies to the human granulocyte-macrophage colony-stimulating factor receptor alpha-chain

1993 • 23 citations

Thrombopoietin and its receptor, the proto-oncogene c-mpl

1995 • 9 citations

Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on neutrophil formation and function.

1994 • 8 citations

Hematopoietic growth-factor receptors.

1990 • 6 citations