The role of CD26/dipeptidyl peptidase IV in cancer

Chemokines and leukocyte traffic

1998 • 2,755 citations

Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides

1999 • 1,258 citations

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

2003 • 864 citations

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

1990 • 677 citations

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

1994 • 522 citations

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

2003 • 291 citations

Molecular characterization of dipeptidyl peptidase activity in serum

2000 • 266 citations

Trafficking of the HIV Coreceptor CXCR4

1999 • 258 citations

Structural and Kinetic Analysis of the Substrate Specificity of Human Fibroblast Activation Protein α

2005 • 246 citations

A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

1994 • 242 citations

Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model.

2002 • 211 citations

Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response.

1996 • 209 citations

Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes.

1991 • 208 citations

The relevance of the CD4+ CD26- subset in the identification of circulating Sézary cells

2001 • 205 citations

Absence of CD26 Expression Is a Useful Marker for Diagnosis of T-Cell Lymphoma in Peripheral Blood

2001 • 199 citations

A Role for Dipeptidyl Peptidase IV in Suppressing the Malignant Phenotype of Melanocytic Cells

1999 • 191 citations

Positive and negative regulation of Src-family membrane kinases by CD45

1999 • 184 citations

PT-100, a Small Molecule Dipeptidyl Peptidase Inhibitor, Has Potent Antitumor Effects and Augments Antibody-Mediated Cytotoxicity via a Novel Immune Mechanism

2004 • 179 citations

Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26

2006 • 173 citations

CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO

2001 • 172 citations

Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation.

1992 • 171 citations

Lung Endothelial Dipeptidyl Peptidase IV Promotes Adhesion and Metastasis of Rat Breast Cancer Cells via Tumor Cell Surface-associated Fibronectin

1998 • 166 citations

Regulation of Fibroblast Migration on Collagenous Matrix by a Cell Surface Peptidase Complex

2002 • 163 citations

Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis

2003 • 160 citations

Skin homing of Sézary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV

2005 • 159 citations

Identification of the 170-kDa Melanoma Membrane-bound Gelatinase (Seprase) as a Serine Integral Membrane Protease

1997 • 155 citations

Profiling of the Tetraspanin Web of Human Colon Cancer Cells

2006 • 154 citations

The Protease Complex Consisting of Dipeptidyl Peptidase IV and Seprase Plays a Role in the Migration and Invasion of Human Endothelial Cells in Collagenous Matrices

2006 • 152 citations

Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases

2003 • 146 citations

The Cysteine-Rich Region of Dipeptidyl Peptidase IV (CD 26) Is the Collagen Binding Site

1995 • 142 citations

A Novel Consensus Motif in Fibronectin Mediates Dipeptidyl Peptidase IV Adhesion and Metastasis

2003 • 127 citations

A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells.

1990 • 125 citations

Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells

2004 • 122 citations

Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation

2000 • 118 citations

Seprase Promotes Rapid Tumor Growth and Increased Microvessel Density in a Mouse Model of Human Breast Cancer

2004 • 115 citations

Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV

2006 • 114 citations

Expression of the human nephron differentiation molecules in renal cell carcinomas.

1990 • 111 citations

Comodulation of CXCR4 and CD26 in Human Lymphocytes

2001 • 106 citations

Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma.

2002 • 105 citations

Crystal Structure of CD26/Dipeptidyl-peptidase IV in Complex with Adenosine Deaminase Reveals a Highly Amphiphilic Interface

2004 • 100 citations

‘Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer’

2004 • 95 citations

Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung-metastatic rat breast and prostate carcinoma cells.

1993 • 89 citations

The expression of CD26 and CD40 ligand is mutually exclusive in human T- cell non-Hodgkin's lymphomas/leukemias

1995 • 88 citations

Humanized Anti-CD26 Monoclonal Antibody as a Treatment for Malignant Mesothelioma Tumors

2007 • 87 citations

Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer

2000 • 82 citations

Dipeptidyl peptidase IV (DPPIV) inhibits cellular invasion of melanoma cells.

2000 • 81 citations

Extraenzymatic functions of the dipeptidyl peptidase IV‐related proteins DP8 and DP9 in cell adhesion, migration and apoptosis

2006 • 80 citations

Cross‐linking of CD26 by antibody induces tyrosine phosphorylation and activation of mitogen‐activated protein kinase

1997 • 80 citations

Seprase, a membrane-bound protease, is overexpressed by invasive ductal carcinoma cells of human breast cancers.

1998 • 79 citations

Aberrant dipeptidyl peptidase IV (DPP IV/CD26) expression in human hepatocellular carcinoma

1997 • 71 citations

The Expression of a Type II Transmembrane Serine Protease (Seprase) in Human Gastric Carcinoma

2004 • 71 citations

Dipeptidylpeptidase IV Activities Are Elevated in Prostate Cancers and Adjacent Benign Hyperplastic Glands

2000 • 70 citations

CD26 Regulates p38 Mitogen-Activated Protein Kinase–Dependent Phosphorylation of Integrin β1, Adhesion to Extracellular Matrix, and Tumorigenicity of T-Anaplastic Large Cell Lymphoma Karpas 299

2005 • 69 citations

In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.

2001 • 68 citations

Soluble CD26/dipeptidyl peptidase IV enhances transendothelial migration via its interaction with mannose 6-phosphate/insulin-like growth factor II receptor

2002 • 68 citations

Anti-CD26 Monoclonal Antibody–Mediated G1-S Arrest of Human Renal Clear Cell Carcinoma Caki-2 Is Associated with Retinoblastoma Substrate Dephosphorylation, Cyclin-Dependent Kinase 2 Reduction, p27kip1 Enhancement, and Disruption of Binding to the Extracellular Matrix

2006 • 66 citations

Absence of CD26 expression on skin-homing CLA+ CD4+ T lymphocytes in peripheral blood is a highly sensitive marker for early diagnosis and therapeutic monitoring of patients with Sezary syndrome

2005 • 66 citations

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase‒CD26 interaction

2002 • 66 citations

Cell surface antigens of human melanocytes and melanoma. Expression of adenosine deaminase binding protein is extinguished with melanocyte transformation.

1988 • 65 citations

Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens

1998 • 61 citations

Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer

2003 • 61 citations

Inhibitors of Dipeptidyl Peptidase IV (DP IV, CD26) Specifically Suppress Proliferation and Modulate Cytokine Production of Strongly CD26 Expressing U937 Cells

1994 • 60 citations

Dipeptidyl peptidase IV in tumor progression

2004 • 55 citations

Diagnostic utility of galectin‐3 and CD26/DPPIV as preoperative diagnostic markers for thyroid nodules

2002 • 52 citations

Characterization of the plasminogen receptors of normal and rheumatoid arthritis human synovial fibroblasts.

1994 • 51 citations

Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells

2001 • 51 citations

CD44-initiated Cell Spreading Induces Pyk2 Phosphorylation, Is Mediated by Src Family Kinases, and Is Negatively Regulated by CD45

2001 • 51 citations

Constitutive expression of CD26/dipeptidylpeptidase IV on peripheral blood B lymphocytes of patients with B chronic lymphocytic leukaemia

1999 • 50 citations

Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade

2003 • 48 citations

Increased Expression of Dipeptidyl Peptidase IV in Human Mesothelial Cells by Malignant Ascites from Ovarian Carcinoma Patients

2002 • 47 citations

Diagnostic usefulness of dipeptidyl aminopeptidase IV monoclonal antibody in paraffin‐embedded thyroid follicular tumours

1992 • 42 citations

Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway

2006 • 41 citations

T‐large granular lymphocyte lymphoproliferative disorder: expression of CD26 as a marker of clinically aggressive disease and characterization of marrow inhibition

2003 • 40 citations

Clinical and Oncologic Implications in Epigenetic Down-Regulation of CD26/ Dipeptidyl Peptidase IV in Adult T-Cell Leukemia Cells

2004 • 39 citations

CD26 expression determines lung metastasis in mutant F344 rats: involvement of NK cell function and soluble CD26

2003 • 38 citations

Adenosine Down-Regulates the Surface Expression of Dipeptidyl Peptidase IV on HT-29 Human Colorectal Carcinoma Cells

2004 • 38 citations

CD26/dipeptidyl peptidase IV expression in human lymphomas is restricted to CD30-positive anaplastic large cell and a subset of T-cell non-Hodgkin's lymphomas

1994 • 35 citations

Expression of dipeptidyl aminopeptidase IV activity in human lung carcinoma

1993 • 33 citations

Immunoelectron microscopic demonstration of the membrane proteases aminopeptidase N/CD13 and dipeptidyl peptidase IV/CD26 in normal and neoplastic renal parenchymal tissues and cells.

2000 • 32 citations

Soluble dipeptidyl peptidase IV (CD-26) in serum of patients with colorectal carcinoma.

2002 • 31 citations

G1/S cell cycle arrest provoked in human T cells by antibody to CD26

2002 • 31 citations

Expression of CD26 and its associated dipeptidyl peptidase IV enzyme activity enhances sensitivity to doxorubicin-induced cell cycle arrest at the G(2)/M checkpoint.

2001 • 31 citations

Trafficking of the HIV coreceptor CXCR4: Role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization.

2000 • 27 citations

Increased adhesion potency of ovarian carcinoma cells to mesothelial cells by overexpression of dipeptidyl peptidase IV

2003 • 26 citations

Increased activity of dipeptidyl peptidase IV in serum of hepatoma-bearing rats coincides with the loss of the enzyme from the hepatoma plasma membrane

1986 • 26 citations

Expression of CD26/dipeptidyl peptidase IV in adult T cell leukemia/lymphoma (ATLL)

1996 • 26 citations

CD26 Expression Correlates with a Reduced Sensitivity to 2′-Deoxycoformycin-Induced Growth Inhibition and Apoptosis in T-Cell Leukemia/Lymphomas

2004 • 26 citations

Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity

2005 • 25 citations

Regulation of p38 Phosphorylation and Topoisomerase IIα Expression in the B-Cell Lymphoma Line Jiyoye by CD26/Dipeptidyl Peptidase IV Is Associated with EnhancedIn vitroandIn vivoSensitivity to Doxorubicin

2005 • 25 citations

ELEVATION OF DIPEPTIDYLPEPTIDASE IV ACTIVITIES IN THE PROSTATE PERIPHERAL ZONE AND PROSTATIC SECRETIONS OF MEN WITH PROSTATE CANCER: POSSIBLE PROSTATE CANCER DISEASE MARKER

2005 • 22 citations

CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors

2003 • 20 citations

Dipeptidyl peptidase IV in the human lung and spinocellular lung cancer.

1991 • 17 citations

Reduced expression of dipeptidyl peptidase (DPP) IV in peripheral blood T lymphocytes of oral cancer patients

1996 • 17 citations

Decreased expression and release of dipeptidyl peptidase IV (CD26) in cultured peripheral blood T lymphocytes of oral cancer patients

1998 • 16 citations

Pentostatin in T-non-Hodgkin's lymphomas: Efficacy and effect on CD26+ T lymphocytes

2003 • 16 citations

Plasmin(ogen) carbohydrate chains mediate binding to dipeptidyl peptidase IV (CD 26) in rheumatoid arthritis human synovial fibroblasts

1998 • 13 citations

Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors

2003 • 12 citations

'Dipeptidyl peptidase-IV activity and/or structure homologs' (DASH) in growth-modulated glioma cell lines

2004 • 9 citations

Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral mem- brane protease.

1998 • 7 citations

Dipeptidyl peptidase IV in two human glioma cell lines

2009 • 4 citations